scholarly journals CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways

2021 ◽  
Author(s):  
Dafné Moreno Lorenzana ◽  
María del Rocío Juárez Velázquez ◽  
Adriana Reyes León ◽  
Daniel Martínez Anaya ◽  
Adrián Hernández Monterde ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Signaling Pathways ◽  
Lymphoblastic Leukemia ◽  
Surrogate Markers ◽  
Gene Fusions ◽  
Mexican Children ◽  
Recurrent Gene Fusions

scholarly journals Glutamine: Beneficial to prevent oral mucositis in Mexican children with acute lymphoblastic leukemia?

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Miriam R. Caselin-García ◽  
Katja Stein ◽  
Miguel R. Kumazawa-Ichikawa ◽  
Oscar González-Ramella ◽  
Edgar M. Vásquez-Garibay ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Oral Mucositis ◽  
Lymphoblastic Leukemia ◽  
Mexican Children

The frequency, hematological characteristics, and end-of induction residual disease in B-acute lymphoblastic leukemia with BCR-ABL1-like chimeric gene fusions in a high-risk cohort from India

2021 ◽  
pp. 1-5
Author(s):  
Praveen Sharma ◽  
Sonia Rana ◽  
Harpreet Virk ◽  
Man Updesh Singh Sachdeva ◽  
Prashant Sharma ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
High Risk ◽  
Residual Disease ◽  
Lymphoblastic Leukemia ◽  
Chimeric Gene ◽  
Gene Fusions ◽  
High Risk Cohort

New MLLT10 gene recombinations in pediatric T-acute lymphoblastic leukemia

Blood ◽  
2013 ◽  
Vol 121 (25) ◽  
pp. 5064-5067 ◽  
Author(s):  
Lucia Brandimarte ◽  
Valentina Pierini ◽  
Danika Di Giacomo ◽  
Chiara Borga ◽  
Filomena Nozza ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Expression Profile ◽  
Lymphoblastic Leukemia ◽  
Gene Fusions ◽  
Specific Expression ◽  
Key Points

Key Points In pediatric T-ALL, MLLT10 emerged as a promiscuous gene, maintaining the critical leukemogenic OM-LZ domain in all fusions. MLLT10 gene fusions were associated with a specific expression profile within the HOXA subgroup of pediatric T-ALL.

scholarly journals Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Juan Carlos Núñez-Enríquez ◽  
Ana Elena Gil-Hernández ◽  
Elva Jiménez-Hernández ◽  
Arturo Fajardo-Gutiérrez ◽  
Aurora Medina-Sansón ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Overweight And Obesity ◽  
Early Mortality ◽  
Multicenter Cohort Study ◽  
Mexican Children ◽  
Multicenter Cohort

Abstract 478: Predicting interactome networks perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia

2014 ◽  
Author(s):  
Leon Hajingabo ◽  
Sarah Daakour ◽  
Maud Martin ◽  
Reinhard Grausenburger ◽  
Renate Panzer-Grümayer ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Human Cancer ◽  
Lymphoblastic Leukemia ◽  
Gene Fusions

scholarly journals Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia

2019 ◽  
Vol 20 (10) ◽  
pp. 2394 ◽  
Author(s):  
Minerva Mata-Rocha ◽  
Angelica Rangel-López ◽  
Elva Jiménez-Hernández ◽  
Blanca Angélica Morales-Castillo ◽  
Carolina González-Torres ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Fusion Gene ◽  
Lymphoblastic Leukemia ◽  
Fusion Genes ◽  
Cancer Etiology ◽  
Mexican Children ◽  
Genes Encoding ◽  
Identification And Characterization ◽  
Current Risk

Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one of the highest incidences and mortality rates of this cancer. It has previously been recognized that chromosomal translocations are important in cancer etiology. Specific fusion genes have been considered as important treatment targets in childhood acute lymphoblastic leukemia (ALL). The present research aimed at the identification and characterization of novel fusion genes with potential clinical implications in Mexican children with acute lymphoblastic leukemia. The RNA-sequencing approach was used. Four fusion genes not previously reported were identified: CREBBP-SRGAP2B, DNAH14-IKZF1, ETV6-SNUPN, ETV6-NUFIP1. Although a fusion gene is not sufficient to cause leukemia, it could be involved in the pathogenesis of the disease. Notably, these new translocations were found in genes encoding for hematopoietic transcription factors which are known to play an important role in leukemogenesis and disease prognosis such as IKZF1, CREBBP, and ETV6. In addition, they may have an impact on the prognosis of Mexican pediatric patients with ALL, with the potential to be included in the current risk stratification schemes or used as therapeutic targets.

Transcriptome Analysis (Rnaseq) Detects Gene Fusions and Point Mutations Associated with Ph-Like Acute Lymphoblastic Leukemia

2015 ◽  
Vol 208 (6) ◽  
pp. 358
Author(s):  
Kai Lee Yap ◽  
Chaitanya Bandlamudi ◽  
Christopher Mariani ◽  
Larissa Furtado ◽  
Gordana Raca
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Transcriptome Analysis ◽  
Lymphoblastic Leukemia ◽  
Point Mutations ◽  
Gene Fusions

Copy Number Alterations Associated with Acute Lymphoblastic Leukemia in Mexican Children. A report from The Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia

2016 ◽  
Vol 47 (8) ◽  
pp. 706-711 ◽  
Author(s):  
Beatriz Rosales-Rodríguez ◽  
Fernando Fernández-Ramírez ◽  
Juan Carlos Núñez-Enríquez ◽  
Ana Claudia Velázquez-Wong ◽  
Aurora Medina-Sansón ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Copy Number ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Copy Number Alterations ◽  
Mexican Children

scholarly journals Long non-coding RNAs defining major subtypes of B cell precursor acute lymphoblastic leukemia

2018 ◽  
Author(s):  
Alva Rani James ◽  
Michael P Schroeder ◽  
Martin Neumann ◽  
Lorenz Bastian ◽  
Cornelia Eckert ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Signaling Pathways ◽  
Relapse Rate ◽  
Molecular Subtypes ◽  
Lymphoblastic Leukemia ◽  
Cell Precursor ◽  
High Relapse Rate ◽  
Non Coding Rnas

AbstractRecent studies implicated that long non-coding RNAs (lncRNAs) may play a role in the progression and development of acute lymphoblastic leukemia, however, this role is not yet clear. In order to unravel the role of lncRNAs associated with B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL) subtypes, we performed transcriptome sequencing and DNA methylation array across 82 BCP-ALL samples from three molecular subtypes (DUX4, Ph-like, and Near Haploid or High Hyperdiploidy). Unsupervised clustering of BCP-ALL samples on the basis of their lncRNAs on transcriptome and DNA methylation profiles revealed robust clusters separating three molecular subtypes. Using extensive computational analysis, we developed a comprehensive catalog of 1235 aberrantly dysregulated BCP-ALL subtype-specific lncRNAs with altered expression and methylation patterns from three subtypes of BCP-ALL. By analyzing the co-expression of subtype-specific lncRNAs and protein-coding genes, we inferred key molecular processes in BCP-ALL subtypes. A strong correlation was identified between the DUX4 specific lncRNAs and activation of TGF-β and Hippo signaling pathways. Similarly, Ph-like specific lncRNAs were correlated with genes involved in activation of PI3K-AKT, mTOR, and JAK-STAT signaling pathways. Interestingly, the relapse-specific differentially expressed lncRNAs correlated with the activation of metabolic and signaling pathways. Finally, we showed a set of epigenetically altered lncRNAs facilitating the expression of tumor genes located at theircislocation. Overall, our study provides a comprehensive set of novel subtype and relapse-specific lncRNAs in BCP-ALL. Our findings suggest a wide range of molecular pathways are associated with lncRNAs in BCP-ALL subtypes and provide a foundation for functional investigations that could lead to new therapeutic approaches.Author SummaryAcute lymphoblastic leukemia is a heterogeneous blood cancer, with multiple molecular subtypes, and with high relapse rate. We are far from the complete understanding of the rationale behind these subtypes and high relapse rate. Long non-coding (lncRNAs) has emerged as a novel class of RNA due to its diverse mechanism in cancer development and progression. LncRNAs does not code for proteins and represent around 70% of human transcripts. Recently, there are a number of studies used lncRNAs expression profile in the classification of various cancers subtypes and displayed their correlation with genomic, epigenetic, pathological and clinical features in diverse cancers. Therefore, lncRNAs can account for heterogeneity and has independent prognostic value in various cancer subtypes. However, lncRNAs defining the molecular subtypes of BCP-ALL are not portrayed yet. Here, we describe a set of relapse and subtype-specific lncRNAs from three major BCP-ALL subtypes and define their potential functions and epigenetic regulation. Our data uncover the diverse mechanism of action of lncRNAs in BCP-ALL subtypes defining how lncRNAs are involved in the pathogenesis of disease and the relevance in the stratification of BCP-ALL subtypes.

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