scholarly journals Interleukin 1β—A Potential Salivary Biomarker for Cancer Progression?

2015 ◽  
Vol 7 ◽  
pp. BIC.S25375 ◽  
Author(s):  
Adi Idris ◽  
Nur B. Ghazali ◽  
David Koh
Keyword(s):  
Cancer Progression ◽  
Biological Fluid ◽  
Short Review ◽  
The Body ◽  
Immunological Factors ◽  
Cancer And Inflammation ◽  
The Relationship ◽  
Pathological Consequence ◽  
Potential Cancer

The relationship between cancer and inflammation is a complex but intimate one. Decades of work has shown to us that cancer progression is influenced by a multitude of factors, including genetic, environmental, and immunological factors. We often overlook that cancer progression is also a pathological consequence of a dysregulated inflammatory control in the body. A current emerging topic in cancer research is the role of inflammasomes in carcinogenesis. The inflammasome is a multicomplex protein platform that when activated results in the release of proinflammatory cytokines, such as interleukin (IL)-1β. There is increasing evidence suggesting that IL-1β plays a pivotal role in cancer progression. This short review proposes the possibility of using IL-1β as a potential cancer progression biomarker and discusses the use of saliva as a model biological fluid for measuring physiological IL-1β levels in the body.

scholarly journals The Role of Immunotherapy in the Treatment of Malignant Pleural Mesothelioma

2021 ◽  
Vol 28 (6) ◽  
pp. 4542-4552
Author(s):  
Shantanu Banerji ◽  
Daniel E. Meyers ◽  
Craig Harlos ◽  
David E. Dawe
Keyword(s):  
Cancer Progression ◽  
Malignant Pleural Mesothelioma ◽  
Late Phase ◽  
Eligible Patient ◽  
The Body ◽  
Pleural Mesothelioma ◽  
Modest Improvement ◽  
Immune Therapies ◽  
The Relationship

Malignant pleural mesothelioma is a rare and aggressive malignancy arising from mesothelial cells that line the serous membranes of the body. Cytotoxic chemotherapy has been a mainstay of therapy, resulting in a modest improvement in overall survival, but toxicity limits the eligible patient population. Few targeted agents beyond bevacizumab have demonstrated superior efficacy compared to placebos. With an improved understanding of the relationship between the immune system and cancer progression, immunotherapies are playing a greater role in the treatment of many cancers. Several early- and late-phase trials in malignant pleural mesothelioma, including assessments of the first-line efficacy of combination ipilimumab/nivolumab treatment, have now demonstrated promising results for both immune checkpoint inhibition and cell-based therapies. These immune therapies are likely to play a central role in the treatment of this disease going forward.

Cancer Fighting SiRNA-RRM2 Loaded Nanorobots

2020 ◽  
Vol 8 (2) ◽  
pp. 79-90
Author(s):  
Arjun Sharma ◽  
Pravir Kumar ◽  
Rashmi K. Ambasta
Keyword(s):  
Cancer Therapy ◽  
Dna Synthesis ◽  
Cancer Progression ◽  
Sirna Delivery ◽  
Predictive Marker ◽  
The Body ◽  
Tumor Site ◽  
Target Delivery ◽  
Target Effect

Background: Silencing of several genes is critical for cancer therapy. These genes may be apoptotic gene, cell proliferation gene, DNA synthesis gene, etc. The two subunits of Ribonucleotide Reductase (RR), RRM1 and RRM2, are critical for DNA synthesis. Hence, targeting the blockage of DNA synthesis at tumor site can be a smart mode of cancer therapy. Specific targeting of blockage of RRM2 is done effectively by SiRNA. The drawbacks of siRNA delivery in the body include the poor uptake by all kinds of cells, questionable stability under physiological condition, non-target effect and ability to trigger the immune response. These obstacles may be overcome by target delivery of siRNA at the tumor site. This review presents a holistic overview regarding the role of RRM2 in controlling cancer progression. The nanoparticles are more effective due to specific characteristics like cell membrane penetration capacity, less toxicity, etc. RRM2 have been found to be elevated in different types of cancer and identified as the prognostic and predictive marker of the disease. Reductase RRM1 and RRM2 regulate the protein and gene expression of E2F, which is critical for protein expression and progression of cell cycle and cancer. The knockdown of RRM2 leads to apoptosis via Bcl2 in cancer. Both Bcl2 and E2F are critical in the progression of cancer, hence a gene that can affect both in regulating DNA replication is essential for cancer therapy. Aim: The aim of the review is to identify the related gene whose silencing may inhibit cancer progression. Conclusion: In this review, we illuminate the critical link between RRM-E2F, RRM-Bcl2, RRM-HDAC for the therapy of cancer. Altogether, this review presents an overview of all types of SiRNA targeted for cancer therapy with special emphasis on RRM2 for controlling the tumor progression.

Living with Barren Truths: A Tale of Triumphalism and Tribulations of a Technology

2021 ◽  
pp. 097168582110159
Author(s):  
Sital Mohanty ◽  
Subhasis Sahoo ◽  
Pranay Kumar Swain
Keyword(s):  
Gender Discrimination ◽  
New Technologies ◽  
The Body ◽  
Social Scientists ◽  
Social Fact ◽  
Science Technology ◽  
The Subject ◽  
And Gender ◽  
The Relationship

Science, technology and human values have been the subject of enquiry in the last few years for social scientists and eventually the relationship between science and gender is the subject of an ongoing debate. This is due to the event of globalization which led to the exponential growth of new technologies like assisted reproductive technology (ART). ART, one of the most iconic technological innovations of the twentieth century, has become increasingly a normal social fact of life. Since ART invades multiple human discourses—thereby transforming culture, society and politics—it is important what is sociological about ART as well as what is biological. This article argues in commendation of sociology of technology, which is alert to its democratic potential but does not concurrently conceal the historical and continuing role of technology in legitimizing gender discrimination. The article draws the empirical insights from local articulations (i.e., Odisha state in eastern India) for the understandings of motherhood, freedom and choice, reproductive right and rights over the body to which ART has contributed. Sociologically, the article has been supplemented within the broader perspectives of determinism, compatibilism alongside feminism.

scholarly journals Microbiota Alterations in Precancerous Colon Lesions: A Systematic Review

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3061
Author(s):  
Francesca Aprile ◽  
Giovanni Bruno ◽  
Rossella Palma ◽  
Maria Teresa Mascellino ◽  
Cristina Panetta ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Endoscopic Resection ◽  
Causative Role ◽  
Health It ◽  
Microbial Dysbiosis ◽  
Pubmed Database ◽  
The Impact ◽  
The Relationship ◽  
Preventive Role

Gut microbiota plays an important role in human health. It may promote carcinogenesis and is related to several diseases of the gastrointestinal tract. This study of microbial dysbiosis in the etiology of colorectal adenoma aimed to investigate the possible causative role of microbiota in the adenoma–carcinoma sequence and its possible preventive role. A systematic, PRISMA-guided review was performed. The PubMed database was searched using “adenoma microbiota” and selecting original articles between January 2010 and May 2020 independently screened. A higher prevalence of Proteobacteria, Fusobacteria, and Bacteroidetes phyla was observed in the fecal luminal and mucosa-associated microbiota of patients with adenoma. However, other studies provided evidence of depletion of Clostridium, Faecalibacterium, Bacteroides and Romboutsia. Results on the relationship between adenoma endoscopic resection and microbiota were inconsistent. In conclusion, none of the analyzed studies developed a predictive model that could differentiate adenoma from non-adenoma patients, and therefore, to prevent cancer progression. The impact of adenoma’s endoscopic resection on microbiota was investigated, but the results were inconclusive. Further research in the field is required.

The central role of mitochondria in the relationship between dietary lipids and cancer progression

2021 ◽  
Author(s):  
Alfonso Varela-López ◽  
Laura Vera-Ramírez ◽  
Francesca Giampieri ◽  
María D. Navarro-Hortal ◽  
Tamara Y. Forbes-Hernández ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Dietary Lipids ◽  
The Relationship

The Role of the Coelomic Fluid in the Movements of Earthworms

1950 ◽  
Vol 27 (1) ◽  
pp. 110-122 ◽  
Author(s):  
G. E. NEWELL
Keyword(s):  
Short Review ◽  
The Body ◽  
Coelomic Fluid ◽  
Average Pressure ◽  
Normal Range ◽  
Tail Region ◽  
X Ray ◽  
Effective Barrier ◽  
Intrinsic Muscles

1. A short review is given of the coelom and of its morphological relations in the earthworm. 2. The arrangement of the intrinsic muscles in a typical septum is described. Four main sets of muscles are recognized: viz. radial muscles, circular muscles, oblique muscles, and the sphincter around the ventral foramen. 3. It is suggested that the function of the radial, circular and possibly of the oblique muscles is to control bulging of the septa, and so serve to localize differences in pressure in the coelomic fluid. Normally, in active worms, the sphincter of the ventral foramen is contracted and forms an effective barrier to the passage of fluid from one coelomic compartment to the next. This was verified experimentally and by X-ray photography. 4. A series of measurements of the pressure in the coelomic fluid in different regions of active worms was recorded by means of a capillary manometer and by the use of a spoon-gauge apparatus. Manometric measurements showed the average pressure in the anterior third of the body to be 16.0 cm. water and in the tail region to be 8.0 cm. water. The corresponding figures obtained with a spoon gauge were 13.5 and 8.5 cm. water. The pressure in narcotized worms is zero. 5. These results are discussed, and it is pointed out that the manometer readings suffer from the disadvantage of failing to show the rapid fluctuations in pressure which occur during wriggling movements of the worms. 6. It is calculated from these pressure readings that a worm can exert a forward thrust equivalent to forces of between 1.5 and 8.0 g. These figures agree well with those obtained by Gray & Lissman by the use of a special torsion balance. 7. The burrowing movements of earthworms are briefly described. 8. It is shown that the sphincters of the dorsal pores and of the nephridiopores do not normally allow of the escape of coelomic fluid, and will withstand a pressure well outside the normal range.

scholarly journals The Relationship between Dramatic Text and Performance with the Centrality of the Body with a Look at Anne Bogart’s Rendition of The Persians

1970 ◽  
Vol 2 (2) ◽  
pp. 25-31
Author(s):  
Samin Gheitasy ◽  
Leila Montazeri ◽  
Simin Dolatkhah
Keyword(s):  
The Body ◽  
Physical Approach ◽  
The World ◽  
Dramatic Text ◽  
And Performance ◽  
Anne Bogart ◽  
The Relationship ◽  
Sociological View

The dramatic text defines, to some extent, the structure of the work but the type of performance and the physical approach to the text can represent different meanings. The body of the actor, as a means of conveying concepts from the text to the audience, can be effective in creating different interpretations and meanings of the text. Since eons ago, directors have used the body of the actor with different approaches, and the application of body on the stage has always been underdoing changes. Anne Bogart is one of the few directors who is less known in the Iranian theater despite possessing the most updated and well-known methods of practice and performance in the world. Using her viewpoint method, she brings live and dynamic bodies to the stage; bodies that are able to convey the hidden meanings of the text to the audience in the most suitable way. The overall purpose of this research is to find the relationship between the dramatic text and the performance with the centrality of the body with a sociological view toward the body. To this end, by presenting Foucault's theories, the researchers defines the role of the body in the society and its extent of effectivity and impressibility. Finally, this study explores the implications of this role in each element of Aeschylus’s The Persians, and it shall show how Bogart beautifully represents them using the bodies of her actors during performance.

scholarly journals The Role of Autophagy in the Progression and Treatment of Tumors

2021 ◽  
Vol 1 ◽  
pp. 62-71
Author(s):  
Ismail Al-Janabi
Keyword(s):  
Clinical Trials ◽  
Cancer Progression ◽  
Cancer Type ◽  
Homeostatic Mechanism ◽  
Context Dependent ◽  
Initiation Stage ◽  
The Relationship

Autophagy is a conserved homeostatic mechanism enabling cells to cope with various stresses. The pathways leading up to the activation of autophagy are interconnected with those of tumorigenesis. However, the relationship between the two events is not a straightforward one and very often context-dependent. Generally, autophagy appears to act against the tumor during the initiation stage and most often drives cancer progression subsequently. Published clinical trials for the treatment of various tumors, where autophagy was pharmacologically inhibited, were obtained and tabulated. Targeting autophagy for the treatment of tumors can be rewarding in the appropriate context, such as cancer type, grade, and microenvironment.

Nourish the soul or damage the body? Belief in the connection between Christian moral failure and diminished health

2018 ◽  
Vol 65 (2) ◽  
pp. 247-262
Author(s):  
Steven L Foy ◽  
Collin W Mueller
Keyword(s):  
South Carolina ◽  
Religious Involvement ◽  
The Body ◽  
Religion And Health ◽  
Telephone Interviews ◽  
Moral Failure ◽  
Physical Health Outcomes ◽  
Using Data ◽  
The Relationship

Scholars have increasingly noted mechanisms by which religion may be detrimental to one’s health, but few have explored how individuals understand linkages between religious involvement and adverse health. Using data gathered from telephone interviews with Protestants and Catholics in North Carolina and South Carolina, we explore how individuals understand the role of religious moral failure in shaping health consequences. When asked to discuss the relationship between religion and health, 23 respondents described experiences or beliefs regarding how failing to meet the expectations of their religion corresponded with a range of reduced mental and physical health outcomes. Findings underscore the need for additional research on the role of religious involvement and life course experiences in shaping expectations that health declines result from moral failure.

From Analytical Аnthropology to Generative Anthropology

2021 ◽  
Vol 32 (5) ◽  
pp. 103
Author(s):  
Nina Sosna
Keyword(s):  
The Body ◽  
Active Researcher ◽  
Comprehension Ability ◽  
External Position ◽  
Time Distance ◽  
The Relationship ◽  
Generative Anthropology ◽  
Affective Interaction ◽  
Radical Interaction

This article discusses the role of the technical in V.A. Podoroga's project of studying the literature worlds as archives of human experience. On the level of content, among many other components of these worlds he distinguished working and non-working machines, “gizmos” and various optical devices, including the mechanic eye, camera, mounting, etc. Formally, the action of these machines can be assessed as alienation, though in the context of modern media studies and exploration of the perspectives of anthropology, they can also be described as a problematic contact zone between the human and non-human, with a bias towards breaking the already historically disrupted bodily-affective interaction with the “outside”. Studies of Andrei Platonov's show the most radical interaction with the technical, in this case causing dissimilation of the human. However, even for this “inhuman” material, Podoroga chooses a form of human-measured approximation and distancing, which allows defending the position of an active researcher, observer, anthropologist. His efforts produce a kind of reconstruction, which at a certain time distance reveals the “seams”, “folds”, “cuts”, “plexuses”, “gaps” that formed at once the experience of the body and experience of writing. This is how the components of literature worlds are extracted, and from them “a picture of the universe can be deduced”. Although an external position to technics is considered to be the only guarantee of the human, even if it is strange, symptomatic, seizure-like, a different understanding of the technical is possible. Without claiming that a “machine” can assemble components in the absence of the observer's (reader's) comprehension ability, it seems nevertheless possible to relate the technical to more general principles: the methods of dispersion and gathering that form the form, the principles of intervalization and binding the heterogeneous, and most importantly, the principle of generating conditions for detecting an event. Then it will be necessary to clarify the relationship between techne and literature in the broader sense of poiesis, in the process of which elements can be formed from the indivisible “compressed”.

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