Birth MCV and MCH are Quite Reliable Parameters for the Prediction of Alpha Thalassemia Trait

2009 ◽  
Vol 2 ◽  
pp. CMBD.S1927
Author(s):  
Al-Hilali Akram ◽  
Abu Saud Khalida ◽  
Sofi Sawsan ◽  
La Cock Charles
Keyword(s):  
Prospective Study ◽  
Blood Parameters ◽  
The Other ◽  
Alpha Thalassemia ◽  
Other Hand ◽  
Strong Indicator ◽  
Thalassemia Minor ◽  
Thalassemia Trait ◽  
A Prospective Study

To assess some simple blood parameters at birth that can be used as a basis to suspect α-thalassemia minor (ATM), a prospective study involving 202 consecutive neonates with MCV of less than 95 fl or less were checked for Hb Barts by HPLC. The group was divided into two, one with an MCV of 90-95 (89 cases) and the other with an MCV below 90 (113 cases). For control, 104 consecutive neonates with an MCV ≥ 95 fl were similarly checked. It has been confirmed that an MCV that is below 90 fl, especially with and MCH of ≤30 pg is a strong indicator of the presence of ATM (109/113). On the other hand, MCV of 90 or more, especially with an MCH of 30 or more is a strong negative indicator for ATM (70/89). Firm diagnosis of ATM at birth can thus be secured in majority of neonates.

Surgery of the Lacrimal System

2011 ◽  
Author(s):  
Roger A. Dailey ◽  
Mauricio R. Chavez
Keyword(s):  
Prospective Study ◽  
Success Rate ◽  
Nasolacrimal Duct ◽  
The Other ◽  
Success Rates ◽  
Lacrimal Sac ◽  
Other Hand ◽  
A Prospective Study ◽  
External Dcr

Obstruction of the tear outflow system can occur anywhere along its course from the tear lake to the inferior meatus of the nose. Surgical techniques designed to relieve this functional or complete obstruction have been available for a long time. Toti of Italy described the dacryocystorhinostomy (DCR) procedure in 1908 as a treatment modality for obstruction of the nasolacrimal duct. His technique did not make use of mucosal flaps. Dupuy-Dutemps of France, on the other hand, encouraged the use of flaps. He recommended suturing together the nasal mucosal and lacrimal sac flaps. The success rate of the operation improved dramatically. Today the external DCR procedure makes use of modifications of both of these historically described procedures. In recent years, intranasal DCR has enjoyed renewed popularity. This procedure had been performed by Lester Jones and others for years but was dropped because the success rate was 80% at best. Although the use of endoscopic techniques and laser technology has been advocated by some authorities, the success rate (approximately 70%) with relatively short-term follow-up has limited its acceptance. More recently, Javate and associates reported a series of patients undergoing endoscopic DCR with the radiofrequency Ellman unit. Their reported success rate of 90% compared favorably with a 94% success rate in 50 age-matched patients undergoing external DCR with a follow-up of 9 months. This rate also compares favorably to the present authors’ success rate of approximately 95% in uncomplicated cases undergoing external DCR and a similar rate with the endoscopic approach without use of a laser. Therefore, the laser does not appear to offer any significant advantage over more traditional intranasal approaches, and the cost may actually be a financial disincentive to its use. The benefit of mitomycin continues to be debated. You and associates performed a prospective study showing favorable long-term success rates with the use of mitomycin. On the other hand, Liu and associates performed a prospective study that demonstrated no benefit. While the DCR works well for lacrimal sac or nasolacrimal duct obstruction, it does not address obstructions of the puncta and canaliculi.

Lifespan of peripheral intravenous short catheters in hospitalized children: A prospective study

2021 ◽  
pp. 112972982110052
Author(s):  
Maria Elizabeth Gómez-Neva ◽  
Martin Alonso Rondon Sepulveda ◽  
Adriana Buitrago-Lopez
Keyword(s):  
Cohort Study ◽  
Prospective Study ◽  
The Other ◽  
Hospitalized Children ◽  
Intravenous Catheter ◽  
Survival Analyses ◽  
Median Lifespan ◽  
Pediatric Services ◽  
A Prospective Study ◽  
Intravenous Catheters

Objective: To estimate the recommended lifespan of 223 peripheral intravenous accesses in pediatric services. Method: In this cohort study, we monitored the time of intravenous catheter between insertion and removal in children aged up to 15 years old in a Hospital from Bogotá-Colombia. The routine catheter observations was registered in questionnaires during nursing shifts. Survival analyses were performed to analyze the lifespan of the catheter free of complications. Results: The median lifespan of peripheral intravenous catheters without complications was 129 h (IQR 73.6–393.4 h). This median time free from complications was much lower for children ⩽1 year 98.3 h (IQR 63–141 h), than for participants aged >1 year 207.4 h (IQR 100–393 h). Catheters of 24 G (gauge) caliber had a median complication free time of 128 h (IQR 69–207 h) and 22 G calibers 144 h (IQR 103–393 h). Conclusions: In this study, 75% of peripheral indwell catheters remained free from complications for 74 h, the other extreme 25% of these patients could remain up to 393 h.

scholarly journals Bridge-therapy with enoxaparin in the preoperative period of endarterectomy

2010 ◽  
Vol 68 (5) ◽  
pp. 775-777
Author(s):  
Jair Leopoldo Raso ◽  
Rogério Zenóbio Darwich ◽  
Francisco de Lucca Jr ◽  
Romeu Valle Santana ◽  
Marco Túlio Tanure ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Mortality Rate ◽  
Prospective Study ◽  
Low Molecular Weight Heparin ◽  
The Other ◽  
Low Molecular Weight ◽  
Preoperative Period ◽  
Safe Strategy ◽  
A Prospective Study ◽  
Bridge Therapy

Cervical clot is one of the complications of endarterectomy. This risk may be higher in patients using aspirin or clopidogrel. On the other hand, stroke may occur if the medication is interrupted before surgery. We carried out a prospective study of 124 endarterectomies in 119 patients in which aspirin or clopidogrel was stopped and a bridge-therapy with enoxaparin was administered preoperatively. There was no case of stroke during the period of the bridge-therapy. One patient developed cervical clot (0.8%) in the fifth postoperative day. Mortality rate in this series was 0.8%. There was no complication directly related to the use of enoxaparin. Bridge-therapy with low molecular weight heparin is a safe strategy for patients elected for endarterectomy

scholarly journals Interaction between Hb Hasharon and alpha-thalassemia: an approach to the problem of the number of human alpha loci

Blood ◽  
1978 ◽  
Vol 51 (2) ◽  
pp. 339-346
Author(s):  
P Pich ◽  
G Saglio ◽  
C Camaschella ◽  
O David ◽  
MA Vasino ◽  
...  
Keyword(s):  
Northern Italy ◽  
The Other ◽  
Structural Genes ◽  
Delta Region ◽  
Alpha Thalassemia ◽  
Other Hand ◽  
Alpha Gene ◽  
Po Delta ◽  
Infant Girl ◽  
Biosynthetic Studies

We report the case of an Italian infant girl from Polesine (Po delta region in northern Italy) who was heterozygous for Hb Hasharon and alpha-thalassemia, did not synthesize any normal HbA, and had 3% HbH on electrophoresis. Hematologic and biosynthetic studies on Hb Hasharon carriers of the propositus' family suggest the possibility that the Hb Hasharon gene is linked to an alpha-thalassemia gene. On the other hand, in the Askenazy carriers of Hb Hasharon, Hb Harsharon is probably linked to a normal alpha gene. In comparing Hb Hasharon's behavior with that of other alpha variants, particularly HbG Philadelphia, frequent recombinations between alpha structural genes were suggested. The possible identity between the single alpha locus and the alpha2- thalassemia genotype is discussed.

Relationship Between Pressure Passivity and Subependymal/Intraventricular Hemorrhage as Assessed by Pulsed Doppler Ultrasound

PEDIATRICS ◽  
1983 ◽  
Vol 72 (5) ◽  
pp. 665-669
Author(s):  
Peter A. Ahmann ◽  
Francine D. Dykes ◽  
Anthony Lazzara ◽  
Philip J. Holt ◽  
Don P. Giddens ◽  
...  
Keyword(s):  
Prospective Study ◽  
Doppler Ultrasound ◽  
Intraventricular Hemorrhage ◽  
Anterior Cerebral Artery ◽  
The Other ◽  
Passive State ◽  
Pulsed Doppler ◽  
Noninvasive Technique ◽  
Pulsed Doppler Ultrasound ◽  
A Prospective Study

A prospective study was undertaken using a range-gated, pulsed Doppler velocimeter to study flowpressure relationships in the anterior cerebral artery. Serial velocity and pressure studies were performed with each infant serving as his or her own control. The hypothesis tested was that ill preterm infants sustaining subependymal/intraventricular hemorrhage would have absent autoregulation. The hypothesis has been tested in 88 studies on 32 infants. Of 32 infants studied, 15 were judged to be pressure passive; nine of these children bled. The other 17 infants were not pressure passive; eight of these children bled (P > .05). From these studies, it may be concluded that the pressure passive state is not the final common link in the genesis of subependymal/intravertricular hemorrhage. Pulsed Doppler ultrasound may provide an extremely useful noninvasive technique for studing both the arterial and venous sides of the cerebral circulation.

A Prospective Study of Patient Assaults on Nursing Staff in a Psychogeriatric Unit

1989 ◽  
Vol 34 (5) ◽  
pp. 399-404 ◽  
Author(s):  
A.J. Cooper ◽  
J.D. Mendonca
Keyword(s):  
Prospective Study ◽  
Mental Hospital ◽  
The Other ◽  
Physical Restraints ◽  
Base Rates ◽  
Geriatric Unit ◽  
Number Of Patients ◽  
Patient Assaults ◽  
Disproportionate Number ◽  
A Prospective Study

A 27 month prospective study concerned with aspects of patient-nurse assaults on the geriatric unit (three wards) of a Canadian provincial mental hospital was conducted. The findings were compared with those for the other wards. The incidence of assaults was approximately the same in both areas (0.24–0.25 assaults/occupied bed/year respectively). In the former, the commonest diagnoses associated with assaultiveness were dementia followed by schizophrenia and in the rest of the hospital, schizophrenia. However, when base rates of assaultiveness were calculated allowing for the disproportionate number of patients with these conditions, mental retardation, and dementia were approximately twice as likely to be related to assaultiveness as schizophrenia; regardless of where the patients were located. In the geriatric unit attacks were more likely when patients were being physically guided or led and during the administration of drugs; elsewhere whilst physical restraints were being applied. In both hospital areas a comparatively small number of patients accounted for a disproportionate number of assaults and a few nurses were attacked repeatedly. The majority of episodes were trivial but in isolated cases personnel were off work for several months. The discussion focuses on the possibility of generalizing results.

scholarly journals A prospective study of microscope-integrated intraoperative fluorescein videoangiography during arteriovenous malformation surgery: preliminary results

2014 ◽  
Vol 36 (2) ◽  
pp. E15 ◽  
Author(s):  
Brandon C. Lane ◽  
Aaron A. Cohen-Gadol
Keyword(s):  
Arteriovenous Malformation ◽  
Prospective Study ◽  
Fluorescein Angiography ◽  
Low Dose ◽  
Venous Drainage ◽  
Senior Author ◽  
The Other ◽  
Preliminary Results ◽  
A Prospective Study ◽  
Unique Ability

Object The authors report on the use of a recently developed microscope-integrated fluorescent module using low-dose intravenous fluorescein for videoangiography during arteriovenous malformation (AVM) surgery. Methods The authors analyzed the application of a low-dose intraoperative fluorescein in 4 consecutive patients undergoing AVM surgery. The ability to distinguish the associated vessels of the AVM from normal vessels and to assess the degree of AVM obliteration based on videoangiography of venous drainage was specifically analyzed. Results All 4 patients underwent fluorescein angiography without complication. In each case, videoangiography confirmed recognition of feeding arteries and draining veins through the operating oculars under the fluorescent mode. In one case involving a large frontal AVM, videoangiography demonstrated mainly cortical veins on the surface of the AVM and alerted the senior author to first tackle the feeding arteries in the interhemispheric space. While evaluating the flow within the different draining veins after most of the AVM was disconnected, videoangiography also prioritized the order for disconnection of large draining veins to allow mobilization the AVM and exposure of the remaining deep arterial feeders. In the other 3 cases, videoangiography allowed easy recognition of the angioarchitecture of the AVMs, estimated its cortical boundaries, and most importantly, assessed the flow within the draining veins before their disconnection. Conclusions The authors found fluorescein videoangiography to be a useful adjunct in resection of AVMs. This technology offers the unique ability to visualize fluorescent vessels and nonfluorescent tissues in near-natural colors simultaneously and permits microsurgical manipulation of relevant structures under the fluorescent mode. Largerscale studies are needed to establish its efficacy and wider applicability.

scholarly journals Interaction between Hb Hasharon and alpha-thalassemia: an approach to the problem of the number of human alpha loci

Blood ◽  
1978 ◽  
Vol 51 (2) ◽  
pp. 339-346 ◽  
Author(s):  
P Pich ◽  
G Saglio ◽  
C Camaschella ◽  
O David ◽  
MA Vasino ◽  
...  
Keyword(s):  
Northern Italy ◽  
The Other ◽  
Structural Genes ◽  
Delta Region ◽  
Alpha Thalassemia ◽  
Other Hand ◽  
Alpha Gene ◽  
Po Delta ◽  
Infant Girl ◽  
Biosynthetic Studies

Abstract We report the case of an Italian infant girl from Polesine (Po delta region in northern Italy) who was heterozygous for Hb Hasharon and alpha-thalassemia, did not synthesize any normal HbA, and had 3% HbH on electrophoresis. Hematologic and biosynthetic studies on Hb Hasharon carriers of the propositus' family suggest the possibility that the Hb Hasharon gene is linked to an alpha-thalassemia gene. On the other hand, in the Askenazy carriers of Hb Hasharon, Hb Harsharon is probably linked to a normal alpha gene. In comparing Hb Hasharon's behavior with that of other alpha variants, particularly HbG Philadelphia, frequent recombinations between alpha structural genes were suggested. The possible identity between the single alpha locus and the alpha2- thalassemia genotype is discussed.

scholarly journals Effects of Storage Duration and Temperature on the Values of Haematological Parameters in Bovine and Ovine Blood Samples

2018 ◽  
Vol 68 (2) ◽  
pp. 145
Author(s):  
A. H. KIRMIZIGUL ◽  
E. GOKCE ◽  
M. SOZMEN
Keyword(s):  
Venous Blood ◽  
Blood Parameters ◽  
The Other ◽  
Haematological Parameters ◽  
Bovine Blood ◽  
Storage Duration ◽  
Blood Samples ◽  
Study Material ◽  
Other Hand ◽  
Haematological Values

The purpose of the present study was to determine the alterations in haematological values at 0, 12, 24, 36, 48, 60, 72, 84 and 96 hours of storage in bovine and ovine venous blood samples stored at 4˚C and 24˚C in EDTA-coated tubes. Twenty healthy animals, including ten 4-year-old cattle and ten 2-year-old sheep constituted the study material. Bovine blood samples stored at 4˚C produced reliable results for the WBC, RBC, Hb, PCV, MCV, MCH and MCHC levels with the exception of PLT level as PLT levels decreased when the PLT stored 24 hours or longer times. On the other hand ovine blood samples stored at 4˚C for 24 hours or longer, all the parameters measured (WBC, RBC, Hb, PCV, MCV, MCH, MCHC and PLT levels) gave reliable results indicating that ovine blood parameters can be used effectively and safely. Furthermore, in the bovine blood samples, MCHC levels were decreased as from 60 hours stored at 24°C and WBC levels were decreased in the ovine blood samples stored 48 hours or longer at 24°C. However, the blood samples stored at 24°C, the measurement of the RBC, Hb, PCV, MCV, MCH and PLT levels produced reliable results.

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