Short Communication: Effect of silymarin (Silybum marianum) treatment on prolactin concentrations in cyclic sows

2013 ◽  
Vol 93 (2) ◽  
pp. 227-230 ◽  
Author(s):  
F. Loisel ◽  
H. Quesnel ◽  
C. Farmer
Keyword(s):  
Dose Response ◽  
Short Communication ◽  
The Other ◽  
Milk Thistle ◽  
Silybum Marianum ◽  
Blood Samples ◽  
Communication Effect ◽  
Dose Response Study ◽  
Estradiol 17Β

Loisel, F., Quesnel, H. and Farmer, C. 2013. Short Communication: Effect of silymarin (Silybum marianum) treatment on prolactin concentrations in cyclic sows. Can. J. Anim. Sci. 93: 227–230. An extract (silymarin) from the plant Silybum marianum (milk thistle) was shown to increase circulating concentrations of prolactin in cycling rats. A dose-response study was undertaken to determine if silymarin does have hyperprolactinemic properties in cycling swine. Forty-four weaned sows were allotted to four groups receiving 0, 1, 2 or 4 g d−1 of silymarin over a period of 8 d. Blood samples were obtained on days 1 (first day of treatment starting 24 to 48 h after the onset of the standing estrus), 2, 3, and 9. Prolactin, progesterone, estradiol-17β and leptin concentrations were determined. Silymarin did not increase prolactin concentrations at any of the doses studied, nor did it affect concentrations of the other hormones (P>0.1).

scholarly journals Rumen degradability and whole tract digestibility of flavonolignans from milk thistle (Silybum marianum) fruit expeller in dairy cows

2011 ◽  
Vol 56 (No. 6) ◽  
pp. 269-278 ◽  
Author(s):  
L. Křížová ◽  
J. Watzková ◽  
J. Třináctý ◽  
M. Richter ◽  
M. Buchta
Keyword(s):  
Dairy Cows ◽  
Dry Matter ◽  
Daily Intake ◽  
The Other ◽  
Milk Thistle ◽  
Adaptation Period ◽  
Maize Silage ◽  
Silybum Marianum ◽  
Mass Percentage ◽  
Ad Libitum

The objective of this study was to determine rumen degradability and total digestibility of flavonolignans from a milk thistle fruit expeller in dairy cows considering milk production and changes in plasma flavonolignans. The experiment was carried out on three lactating Holstein cows and was divided into three periods as follows: preliminary period (Pr, 3 days) was used for the diet stabilization followed by the adaptation period (A, 6 days) in which the treatment was applied and by the balance period (B, 4 days). Cows were fed individually twice a day (6:40 and 16:40 h) ad libitum the diet based on maize silage, lucerne hay and supplemental mixture. In the periods A and B the diet was supplemented with 150 g/day of milk thistle fruit expeller applied in two equal portions at each feeding. Average daily intake of dry matter and basic nutrients was similar in all periods (P > 0.05). Milk yield and composition were not affected by the treatment (P > 0.05). The milk thistle fruit expeller used in this experiment contained 4.10 ± 0.10 mass percentage of the silymarin complex. Digestibility of silybin A and silybin B was 40.0 and 45.5%, respectively. Digestibility of other components of the silymarin complex was 100%. The highest value of the effective degradation was found for taxifolin (59.11%), while the effective degradation of the other flavonolignans ranged from 23.28 to 35.19%. Animals receiving the milk thistle fruit expeller had a higher content of plasma conjugated silybin (P < 0.001) than those without its supplementation.

Control of Horseweed (Conyza canadensis) with Growth Regulator Herbicides

2010 ◽  
Vol 24 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Greg R. Kruger ◽  
Vince M. Davis ◽  
Stephen C. Weller ◽  
William G. Johnson
Keyword(s):  
Field Study ◽  
Growth Regulators ◽  
Dose Response ◽  
Growth Regulator ◽  
The Other ◽  
Conyza Canadensis ◽  
Appropriate Use ◽  
Dose Response Study

The growth regulator herbicides 2,4-D and dicamba are used to control glyphosate-resistant horseweed before crops are planted. With the impending release of 2,4-D–resistant and dicamba-resistant crops, use of these growth regulator herbicides postemergence will likely increase. The objective of this study was to determine the effectiveness of various growth regulators on Indiana horseweed populations. A greenhouse dose–response study was conducted to evaluate the effectiveness of 2,4-D ester, diglycolamine salt of dicamba, and dimethylamine salt of dicamba on control of four populations of horseweed in the greenhouse. Population 66 expressed twofold levels of tolerance to 2,4-D ester and diglycolamine salt of dicamba. Population 43 expressed an enhanced level of tolerance to diglycolamine salt of dicamba but not to the other herbicides. Diglycolamine salt of dicamba provided the best overall control of populations 3 and 34. Additionally, a field study was conducted to evaluate standard use rates of 2,4-D amine, 2,4-D ester, diglycolamine salt of dicamba, and dimethylamine salt of dicamba on control of various sized glyphosate-resistant horseweed plants. Control of plants 30 cm or less in height was 90% or greater for all four herbicides. On plants greater than 30 cm tall, diglycolamine salt of dicamba provided 97% control while 2,4-D amine provided 81% control. Diglycolamine salt of dicamba provided the highest level of control of glyphosate-resistant horseweed, followed by dimethylamine salt of dicamba, 2,4-D ester and 2,4-D amine, respectively. This research demonstrates that horseweed populations respond differently to the various salts of 2,4-D and dicamba, and it will be important to determine the appropriate use rates of each salt to control glyphosate-resistant horseweed.

Reduction of insulin clearance during hyperglycemic clamp. Dose-response study in normal humans

Diabetes ◽  
1988 ◽  
Vol 37 (10) ◽  
pp. 1351-1357 ◽  
Author(s):  
H. Tillil ◽  
E. T. Shapiro ◽  
A. H. Rubenstein ◽  
J. A. Galloway ◽  
K. S. Polonsky
Keyword(s):  
Dose Response ◽  
Insulin Clearance ◽  
Hyperglycemic Clamp ◽  
Normal Humans ◽  
Dose Response Study

The pathogen of Milk Thistle (Silybum marianum (L.) Gaertn.) in the Czech Republic

2015 ◽  
Vol 5 (1) ◽  
pp. 538-544
Author(s):  
Ivana Safrankova ◽  
Kolackova P ◽  
Rutivckova G
Keyword(s):  
Czech Republic ◽  
Environmental Factors ◽  
Active Compound ◽  
Fungal Species ◽  
Medicinal Herb ◽  
Milk Thistle ◽  
Silybum Marianum ◽  
The Czech Republic

Milk thistle is grown in the Czech Republic as a medicinal herb; silymarin is isolated from its achenes and used for the production of liver and gallbladder medicine. The quality and content of the active compound is influenced not only by environmental factors, but also by pests and pathogens. The occurrence of pests of milk thistle variety Silyb was observed in two localities during the years 2011 2013. In the year 2011 the mycoflora of seeds of four milk thistle varieties was determined. Representatives of 15 species were isolated from the seeds, most of them saprophytic. 21 fungal species were isolated and identified from milk thistle plants during the vegetation; Septoria silybi among the most important ones. Possibilities of protection of milt thistle against pathogens are discussed.

scholarly journals Predicting chromosome damage in astronauts participating in international space station missions

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alan Feiveson ◽  
Kerry George ◽  
Mark Shavers ◽  
Maria Moreno-Villanueva ◽  
Ye Zhang ◽  
...  
Keyword(s):  
International Space Station ◽  
Dose Response ◽  
Ex Vivo ◽  
Space Station ◽  
Space Radiation ◽  
Blood Samples ◽  
International Space ◽  
Significant Difference ◽  
Subject Specific

AbstractSpace radiation consists of energetic protons and other heavier ions. During the International Space Station program, chromosome aberrations in lymphocytes of astronauts have been analyzed to estimate received biological doses of space radiation. More specifically, pre-flight blood samples were exposed ex vivo to varying doses of gamma rays, while post-flight blood samples were collected shortly and several months after landing. Here, in a study of 43 crew-missions, we investigated whether individual radiosensitivity, as determined by the ex vivo dose–response of the pre-flight chromosome aberration rate (CAR), contributes to the prediction of the post-flight CAR incurred from the radiation exposure during missions. Random-effects Poisson regression was used to estimate subject-specific radiosensitivities from the preflight dose–response data, which were in turn used to predict post-flight CAR and subject-specific relative biological effectiveness (RBEs) between space radiation and gamma radiation. Covariates age, gender were also considered. Results indicate that there is predictive value in background CAR as well as radiosensitivity determined preflight for explaining individual differences in post-flight CAR over and above that which could be explained by BFO dose alone. The in vivo RBE for space radiation was estimated to be approximately 3 relative to the ex vivo dose response to gamma irradiation. In addition, pre-flight radiosensitivity tended to be higher for individuals having a higher background CAR, suggesting that individuals with greater radiosensitivity can be more sensitive to other environmental stressors encountered in daily life. We also noted that both background CAR and radiosensitivity tend to increase with age, although both are highly variable. Finally, we observed no significant difference between the observed CAR shortly after mission and at > 6 months post-mission.

Sign in / Sign up

Export Citation Format

Share Document