Self-assembling polyrotaxanes: drug carriers for anticancer drugs?

In situ self-assembling of prodrug molecules into nanomedicine can elevate the therapeutic efficacy of anticancer medications by enhancing the targeting and enrichment of anticancer drugs at tumor sites. However, the...

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Novel Protein Therapeutics Created Using the Elastin-like Polypeptide Platform

Physiology ◽

10.1152/physiol.00026.2021 ◽

2021 ◽

Author(s):

Gene L Bidwell

Keyword(s):

Drug Delivery ◽

Slow Release ◽

Physical Property ◽

Drug Carriers ◽

Property A ◽

Self Assembling ◽

Release Drug ◽

Unique Physical Property ◽

Thermally Triggered ◽

Novel Protein

Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.

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Self-assembling cyclic systems as drug carriers

Applied Nanoscience ◽

10.1007/s13204-012-0154-0 ◽

2012 ◽

Vol 3 (6) ◽

pp. 515-528 ◽

Cited By ~ 2

Author(s):

A. Banerjee ◽

A. Yadav

Keyword(s):

Drug Carriers ◽

Self Assembling ◽

Cyclic Systems

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Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

ISRN Nanotechnology ◽

10.1155/2013/629510 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Ali Shakeri-Zadeh ◽

Samideh Khoei ◽

Sepideh Khoee ◽

Ali Mohammad Sharifi ◽

Mohammad-Bagher Shiran

Keyword(s):

Drug Release ◽

Anticancer Drugs ◽

Polymeric Nanoparticles ◽

Control Release ◽

Controlled Drug Release ◽

Drug Carriers ◽

Chemotherapeutic Agents ◽

Drug Uptake ◽

Cancerous Cell ◽

Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

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Self-assembling anticancer drugs

Materials Today ◽

10.1016/j.mattod.2020.10.015 ◽

2020 ◽

Vol 41 ◽

pp. 3

Author(s):

David Bradley

Keyword(s):

Anticancer Drugs ◽

Self Assembling

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Computational investigation of metal organic frameworks for storage and delivery of anticancer drugs

Journal of Materials Chemistry B ◽

10.1039/c7tb01764b ◽

2017 ◽

Vol 5 (35) ◽

pp. 7342-7351 ◽

Cited By ~ 21

Author(s):

Ilknur Erucar ◽

Seda Keskin

Keyword(s):

Anticancer Drugs ◽

Anticancer Drug ◽

Metal Organic Frameworks ◽

Drug Carriers ◽

Computational Investigation ◽

Drug Molecules ◽

Metal Organic

The potential of metal organic frameworks (MOFs) as binary drug carriers was computationally investigated for storage and delivery of two anticancer drug molecules, methotrexate (MTX) and 5-fluorouracil (5-FU).

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Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers

Biopolymers ◽

10.1002/bip.20648 ◽

2007 ◽

Vol 88 (2) ◽

pp. 115-121 ◽

Cited By ~ 34

Author(s):

Antonella Accardo ◽

Diego Tesauro ◽

Gaetano Mangiapia ◽

Carlo Pedone ◽

Giancarlo Morelli

Keyword(s):

Drug Carriers ◽

Peptide Amphiphile ◽

Self Assembling

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Towards smart polymeric drug carriers: self-assembling γ-substituted polycaprolactones with highly tunable thermoresponsive behavior

Journal of Materials Chemistry B ◽

10.1039/c3tb21488e ◽

2013 ◽

Vol 1 (47) ◽

pp. 6532 ◽

Cited By ~ 25

Author(s):

Elizabeth A. Rainbolt ◽

Katherine E. Washington ◽

Michael C. Biewer ◽

Mihaela C. Stefan

Keyword(s):

Drug Carriers ◽

Self Assembling ◽

Polymeric Drug

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Synthesis of water-dispersible silicon-containing hydroxyapatite nanoparticles with adjustable degradation rates and their applications as pH-responsive drug carriers

RSC Advances ◽

10.1039/c6ra24005d ◽

2016 ◽

Vol 6 (115) ◽

pp. 114852-114858 ◽

Cited By ~ 3

Author(s):

Kaili Lin ◽

Na Zhang ◽

Zhilan Yin ◽

Yuhui Shen ◽

Weibin Zhang

Keyword(s):

Drug Release ◽

Anticancer Drugs ◽

Environmentally Friendly ◽

Drug Carriers ◽

Hydroxyapatite Nanoparticles ◽

Ph Responsive ◽

Water Dispersible ◽

Degradation Rates ◽

Ph Dependent ◽

Environmentally Friendly Method

An environmentally friendly method was developed to synthesize water-dispersible Si-HAp nanoparticles with adjustable degradation rates, high loading capacities for anticancer drugs, and sustained and pH-dependent drug release properties.

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