scholarly journals Novel Protein Therapeutics Created Using the Elastin-like Polypeptide Platform

Physiology ◽  
2021 ◽  
Author(s):  
Gene L Bidwell
Keyword(s):  
Drug Delivery ◽  
Slow Release ◽  
Physical Property ◽  
Drug Carriers ◽  
Property A ◽  
Self Assembling ◽  
Release Drug ◽  
Unique Physical Property ◽  
Thermally Triggered ◽  
Novel Protein

Elastin-like polypeptides (ELPs) are bioengineered proteins that have a unique physical property, a thermally triggered inverse phase transition, that can be exploited for drug delivery. ELP-fusion proteins can be used as soluble biologics, thermally targeted drug carriers, self-assembling nanoparticles, and slow-release drug depots. Because of their unique physical characteristics and versatility for delivery of nearly any type of therapeutic, ELP-based drug delivery systems represent a promising platform for biologics development.

In Vitro Evaluation of Polymeric Matrix and Porous Biodegradable Reservoir Devices for Slow-release Drug Delivery

1996 ◽  
Vol 27 (5) ◽  
pp. 384-391
Author(s):  
Gholam A Peyman ◽  
Dachuan Yang ◽  
Bahram Khoobehi ◽  
Mohamad H Rahimy ◽  
So Y Chin
Keyword(s):  
Drug Delivery ◽  
Slow Release ◽  
Polymeric Matrix ◽  
In Vitro Evaluation ◽  
Release Drug

A Review on Research of the Sustained Release Drug Delivery System Based on Magnesium Aluminate Layered Double Hydroxide

2013 ◽  
Vol 320 ◽  
pp. 495-504 ◽  
Author(s):  
Guo Jing Gou ◽  
Li E Dong ◽  
Feng Juan Bao ◽  
Zhi Yu Wang ◽  
Lin Jiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
Slow Release ◽  
Supramolecular Assembly ◽  
Magnesium Aluminate ◽  
Release Mechanism ◽  
Release Drug ◽  
Double Hydroxide

This paper reviewed our research progress in respects of th intercalation law of acetylsalicylic acid (ASP) with magnesium aluminate layered double hydroxide (LDH), the drug release mechanism and the tablet preparation effect of LDH-ASP system. We also discussed the propositions about the composite assembly rules, slow-release mechanism, and dosage form processing of the layered double hydroxide drug delivery system. Intercalation way and drug structure should be taken into consideration in assembly LDH-drugs system. The characteristic parameter of the composite LDH-drug reflected finely their loading efficiency and correlated definitely with drug release property. It had been found that the release rate and extent of intercalated drug was closely linked to the retarding status of LDH interlayer, which was dependent on the exchange mole ratio of n(drug) with n[HnPO4(3-n)-]. In addition, the grafting reaction and phase transformation degree of LDH layer was hinged on the acidity of solution. The slow-release function of the LDH-drug system could be improved significantly by compositing with dextran (DET). A sustained-release skeleton tablet was producted with DET-LDH-ASP drug delivery system and hydrophilic gel material HPMC, which could effectively overcome the "first pass effect" and " burst release problem" of LDH-drug oral agents. The slow-release effect of LDH drug delivery system could be ulteriorly improved in systemic circulation environments, attributed to the triple control of HPMC-DET-LDH, DET-LDH-drugs three-level supramolecular assembly and the special circulation in vivo. Key words: Layered double hydroxide, Supramolecular assembly, Release control, Slow controlled release drug delivery system

Self-assembling Peptides in Current Nanomedicine: Versatile Nanomaterials for Drug Delivery

2020 ◽  
Vol 27 (29) ◽  
pp. 4855-4881 ◽  
Author(s):  
Fei Peng ◽  
Wensheng Zhang ◽  
Feng Qiu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Slow Release ◽  
Therapeutic Effects ◽  
Peptide Amphiphile ◽  
Self Assembling ◽  
Synthetic Materials ◽  
Peptide Materials ◽  
Structural Compatibility ◽  
Drug Complex

Background: The development of modern nanomedicine greatly depends on the involvement of novel materials as drug delivery system. In order to maximize the therapeutic effects of drugs and minimize their side effects, a number of natural or synthetic materials have been widely investigated for drug delivery. Among these materials, biomimetic self-assembling peptides (SAPs) have received more attention in recent years. Considering the rapidly growing number of SAPs designed for drug delivery, a summary of how SAPs-based drug delivery systems were designed, would be beneficial. Method: We outlined research works on different SAPs that have been investigated as carriers for different drugs, focusing on the design of SAPs nanomaterials and how they were used for drug delivery in different strategies. Results: Based on the principle rules of chemical complementarity and structural compatibility, SAPs such as ionic self-complementary peptide, peptide amphiphile and surfactant-like peptide could be designed. Determined by the features of peptide materials and the drugs to be delivered, different strategies such as hydrogel embedding, hydrophobic interaction, electrostatic interaction, covalent conjugation or the combination of them could be employed to fabricate SAPs-drug complex, which could achieve slow release, targeted or environment-responsive delivery of drugs. Furthermore, some SAPs could also be combined with other types of materials for drug delivery, or even act as drug by themselves. Conclusion: Various types of SAPs have been designed and used for drug delivery following various strategies, suggesting that SAPs as a category of versatile nanomaterials have promising potential in the field of nanomedicine.

scholarly journals pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1899 ◽  
Author(s):  
Evgeny Apartsin ◽  
Nadezhda Knauer ◽  
Valeria Arkhipova ◽  
Ekaterina Pashkina ◽  
Alina Aktanova ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Loading ◽  
Drug Carriers ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Smart Vehicles ◽  
New Class ◽  
Self Assembling ◽  
Anti Cancer ◽  
Cancer Drug Delivery

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species—triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.

Dual-Layer Surface Coating of PLGA-Based Nanoparticles Provides Slow-Release Drug Delivery To Achieve Metronomic Therapy in a Paclitaxel-Resistant Murine Ovarian Cancer Model

2014 ◽  
Vol 15 (11) ◽  
pp. 4187-4194 ◽  
Author(s):  
Zohreh Amoozgar ◽  
Lei Wang ◽  
Tania Brandstoetter ◽  
Samuel S. Wallis ◽  
Erin M. Wilson ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Drug Delivery ◽  
Surface Coating ◽  
Slow Release ◽  
Layer Surface ◽  
Cancer Model ◽  
Release Drug ◽  
Metronomic Therapy

scholarly journals Protein nano-cages: Novel carriers for optimized targeted remedy

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1541 ◽  
Author(s):  
Negar Etehad Roudi ◽  
Neda Saraygord-Afshari ◽  
Maryam Hemmaty
Keyword(s):  
Drug Delivery ◽  
Targeted Delivery ◽  
Large Scale ◽  
Drug Carriers ◽  
The Body ◽  
Nano Particles ◽  
Diagnostic Tools ◽  
Multiple Protein ◽  
Low Toxicity ◽  
Novel Protein

Since 1980, when the idea of drug-delivery was proposed, various drug-carriers have been developed, including DNA, proteins, liposomes and several other polymer cages, consisting of many well established natural and synthetic nano-particles. All these drug-carriers can self-assemble in the body and can be manipulated for safer delivery into target tissues. By definition, nano-scale drug delivery systems encompass any structure (either cage or particle) in the form of solid colloids, which range in size from 10 nm to 100 nm. Today, optimization of these nano drug-vehicles is a topic in many research centers. Researchers are trying to improve the carrier’s solubility and their loading capacity and also wish to increase the half-life of drug delivery cargos in target tissues. Efforts in recent years have led to the introduction of novel protein nano-cages composed of multiple protein subunits, which self-assemble within a superfine and precise format. Science their introduction these promising structure have shown many unique characteristics, including low toxicity, bio-system compatibility, minor immunogenicity, high solubility, and a relatively easy production in large scale. Herein, we review and discuss the recently developed protein nano-carriers that are used as drug cargos for targeted delivery and/or diagnostic tools.

scholarly journals Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

10.3791/51563 ◽  
2014 ◽  
Author(s):  
Lavinia Fiorani ◽  
Rita Maccarone ◽  
Nilisha Fernando ◽  
Linda Colecchi ◽  
Silvia Bisti ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chronic Conditions ◽  
Slow Release ◽  
Rat Retina ◽  
Release Drug
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