scholarly journals Quantitative real-time imaging of molecular dynamics during cancer cell invasion and metastasis in vivo

2009 ◽  
Vol 3 (4) ◽  
pp. 351-354 ◽  
Author(s):  
Paul Timpson ◽  
Alan Serrels ◽  
Marta Canel ◽  
Margaret C. Frame ◽  
Valerie G. Brunton ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Real Time ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Real Time Imaging

scholarly journals Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer

2021 ◽  
Author(s):  
Samantha L Payne ◽  
Priyanka Ram ◽  
Deepti H Srinivasan ◽  
Thanh T Le ◽  
Michael Levin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Potassium Channel ◽  
Cancer Cell ◽  
Metastatic Disease ◽  
Triple Negative Breast Cancer ◽  
Cell Invasion ◽  
Triple Negative ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

There is a critical need to better understand the mechanisms that drive local cell invasion and metastasis to develop new therapeutics targeting metastatic disease. Bioelectricity is an important mediator of cellular processes and changes in the resting membrane potential (RMP) are associated with increased cancer cell invasion. However, the mechanism is not well understood. Our data demonstrate that altering the RMP of triple-negative breast cancer (TNBC) cells by manipulating potassium channel expression increases in vitro invasion, in vivo tumor growth, and metastasis, and is accompanied by changes in gene expression associated with cell adhesion. We describe a novel mechanism for RMP-mediated cell migration involving cadherin-11 and the MAPK pathway. Importantly, we identify a new strategy to target metastatic TNBC in vivo by repurposing FDA-approved potassium channel blockers. Our results provide an understanding of the mechanisms by which bioelectricity regulates cancer cell invasion and metastasis that could lead to a new class of therapeutics for patients with metastatic disease.

scholarly journals Id-1 as a molecular target in therapy for breast cancer cell invasion and metastasis

2003 ◽  
Vol 100 (23) ◽  
pp. 13543-13548 ◽  
Author(s):  
S. Fong ◽  
Y. Itahana ◽  
T. Sumida ◽  
J. Singh ◽  
J.-P. Coppe ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Molecular Target ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Breast Cancer Cell Invasion

scholarly journals Sunitinib-suppressed miR-452-5p facilitates renal cancer cell invasion and metastasis through modulating SMAD4/SMAD7 signals

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Wei Zhai ◽  
Saiyang Li ◽  
Jin Zhang ◽  
Yonghui Chen ◽  
Junjie Ma ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Renal Cancer ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Renal Cancer Cell

scholarly journals Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling

Oncotarget ◽  
2015 ◽  
Vol 6 (38) ◽  
pp. 41324-41338 ◽  
Author(s):  
You-Take Oh ◽  
Ping Yue ◽  
Dongsheng Wang ◽  
Jing-Shan Tong ◽  
Zhuo G. Chen ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Death Receptor ◽  
Caspase 8 ◽  
Death Receptor 5 ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis

scholarly journals The Role of WAVE2 Signaling in Cancer

Biomedicines ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1217
Author(s):  
Priyanka Shailendra Rana ◽  
Akram Alkrekshi ◽  
Wei Wang ◽  
Vesna Markovic ◽  
Khalid Sossey-Alaoui
Keyword(s):  
Actin Cytoskeleton ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Critical Role ◽  
Therapeutic Strategies ◽  
Small Gtpases ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Regulatory Complex

The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE)—WAVE1, WAVE2 and WAVE3 regulate rapid reorganization of cortical actin filaments and have been shown to form a key link between small GTPases and the actin cytoskeleton. Upon receiving upstream signals from Rho-family GTPases, the WASP and WAVE family proteins play a significant role in polymerization of actin cytoskeleton through activation of actin-related protein 2/3 complex (Arp2/3). The Arp2/3 complex, once activated, forms actin-based membrane protrusions essential for cell migration and cancer cell invasion. Thus, by activation of Arp2/3 complex, the WAVE and WASP family proteins, as part of the WAVE regulatory complex (WRC), have been shown to play a critical role in cancer cell invasion and metastasis, drawing significant research interest over recent years. Several studies have highlighted the potential for targeting the genes encoding either part of or a complete protein from the WASP/WAVE family as therapeutic strategies for preventing the invasion and metastasis of cancer cells. WAVE2 is well documented to be associated with the pathogenesis of several human cancers, including lung, liver, pancreatic, prostate, colorectal and breast cancer, as well as other hematologic malignancies. This review focuses mainly on the role of WAVE2 in the development, invasion and metastasis of different types of cancer. This review also summarizes the molecular mechanisms that regulate the activity of WAVE2, as well as those oncogenic pathways that are regulated by WAVE2 to promote the cancer phenotype. Finally, we discuss potential therapeutic strategies that target WAVE2 or the WAVE regulatory complex, aimed at preventing or inhibiting cancer invasion and metastasis.

scholarly journals Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling

Oncogene ◽  
2011 ◽  
Vol 31 (25) ◽  
pp. 3086-3097 ◽  
Author(s):  
Y C Liao ◽  
J W Ruan ◽  
I Lua ◽  
M H Li ◽  
W L Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
Breast Cancer Cell Invasion

Autophagic stress; a new cellular response to nanoparticles. Could it be a new strategy for inhibition of liver cancer cell invasion and metastasis?

Nanoscale ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 6556-6561 ◽  
Author(s):  
Chalermchai Pilapong ◽  
Thipjutha Phatruengdet ◽  
Saowalak Krungchanuchat
Keyword(s):  
Liver Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Cellular Response ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Liver Cancer Cell ◽  
Cancer Cell Invasion ◽  
Invasion And Metastasis ◽  
New Strategy

The autophagic stress induced by Fe–TA NPs is capable of reducing liver cancer cell migration and invasion. This would be a new tactic to treat liver cancer.

Sign in / Sign up

Export Citation Format

Share Document