Preoperative Serum Markers Prognostic Evaluation in Colon Cancer Patients

Abstract Background: Surgery combined with chemo-radiotherapy is a recognized model for the treatment of gastric and colon cancers. Lymph node metastasis determines the patient's surgical or comprehensive treatment plan. This analytical study aims to compare preoperative prediction scores to better predict lymph node metastasis in gastric and colon cancer patients.Methods: This study comprised 768 patients, which included 312 patients with gastric cancer and 462 with colon cancer. Preoperative clinical tumor characteristics, serum markers, and immune indices were evaluated using single-factor analysis. Logistic analysis was designed to recognize independent predictors of lymph node metastasis in these patients. The independent risk factors were integrated into preoperative prediction scores, which were accurately assessed using receiver operating characteristic (ROC) curves.Results: Results showed that serum markers (CA125, hemoglobin, albumin), immune indices (S100, CD31, d2–40), and tumor characteristics (pathological type, size) were independent risk factors for lymph node metastasis in patients with gastric and colon cancer. The preoperative prediction scores reliably predicted lymph node metastasis in gastric and colon cancer patients with a higher area under the ROC curve (0.901). The area was 0.923 and 0.870 in gastric cancer and colon cancer, respectively. Based on the ROC curve, the ideal cutoff value of preoperative prediction scores to predict lymph node metastasis was established to be 287. Conclusion: The preoperative prediction scores is a useful indicator that can be applied to predict lymph node metastasis in gastric and colon cancer patients.

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Combining single‐cell sequencing to identify key immune genes and construct the prognostic evaluation model for colon cancer patients

Clinical and Translational Medicine ◽

10.1002/ctm2.465 ◽

2021 ◽

Vol 11 (7) ◽

Author(s):

Jiasheng Xu ◽

Siqi Dai ◽

Kai Jiang ◽

Qian Xiao ◽

Ying Yuan ◽

...

Keyword(s):

Colon Cancer ◽

Single Cell ◽

Cancer Patients ◽

Evaluation Model ◽

Prognostic Evaluation ◽

Immune Genes ◽

Single Cell Sequencing

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Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy. Results of a secondary analysis of a large scale adjuvant trial

Annales de Chirurgie ◽

10.1016/s0003-3944(02)00859-3 ◽

2002 ◽

Vol 127 (8) ◽

pp. 661-662

Keyword(s):

Colon Cancer ◽

Cancer Patients ◽

Large Scale ◽

Secondary Analysis ◽

Adjuvant Trial ◽

Prognostic Evaluation

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Prognostic Evaluation of Stage B Colon Cancer Patients is Improved by an Adequate Lymphadenectomy

Annals of Surgery ◽

10.1097/00000658-200204000-00002 ◽

2002 ◽

Vol 235 (4) ◽

pp. 458-463 ◽

Cited By ~ 232

Author(s):

Mario Prandi ◽

Rita Lionetto ◽

Antonio Bini ◽

Gianfranco Francioni ◽

Giuseppe Accarpio ◽

...

Keyword(s):

Colon Cancer ◽

Cancer Patients ◽

Prognostic Evaluation

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Mucin 16 and kallikrein 13 as potential prognostic factors in colon cancer: Results of an oncological 92-multiplex immunoassay

Tumor Biology ◽

10.1177/1010428319860728 ◽

2019 ◽

Vol 41 (7) ◽

pp. 101042831986072

Author(s):

Kajsa Björkman ◽

Harri Mustonen ◽

Tuomas Kaprio ◽

Caj Haglund ◽

Camilla Böckelman

Keyword(s):

Colon Cancer ◽

Confidence Interval ◽

Cancer Patients ◽

Poor Prognosis ◽

Transforming Growth Factor ◽

Prognostic Markers ◽

Hazard Ratio ◽

Rank Test ◽

Preoperative Serum ◽

Low Levels

Colon cancer represents one of the most common cancers in the world. Despite improved treatment, mortality remains high. In order to improve the assessment of prognosis for colon cancer patients, identifying new prognostic markers remains necessary. We analyzed preoperative serum samples from 148 colon cancer patients surgically treated at Helsinki University Hospital from 1998 through 2002 using a multiplex proximity extension assay (Oncology II panel, Olink Bioscience, Uppsala, Sweden), a panel constituting 92 immunological and oncological markers. We performed univariate and multivariate analyses on these patients and calculated the disease-specific survival among patients using the log-rank test for Kaplan–Meier estimates. In the univariate survival analysis of 92 biomarkers, 26 resulted in p < 0.1. Among these, eight biomarkers emerged as statistically significant (p < 0.05). Patients with low levels of kallikrein 13 had a poor prognosis. Moreover, patients with high levels of amphiregulin, carcinoembryonic antigen-related adhesion molecule 5, interleukin 6, mucin 16, syndecan 1, transforming growth factor alpha, and vimentin also had a poor prognosis. In the multivariate analysis, kallikrein 13 and mucin 16 emerged as independent prognostic markers. The role of kallikrein 13, a member of the serine protease kallikrein biomarker family, in tumorigenesis remains unclear. Mucin 16 is also known as carbohydrate antigen 125, a well-known ovarian cancer biomarker. Patients with low levels of kallikrein 13 (hazard ratio: 0.36; 95% confidence interval: 0.14–0.92; p = 0.033) and high levels of mucin 16 (hazard ratio: 3.15; 95% confidence interval: 1.68–5.93; p < 0.005) had a poor prognosis. Mucin 16 and kallikrein 13 represent independent prognostic markers for colon cancer. Furthermore, the clinical utility of mucin 16 and kallikrein 13 serum tests warrants additional investigation.

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Preoperative serum markers for individual patient prognosis in stage I–III colon cancer

Tumor Biology ◽

10.1007/s13277-015-3522-z ◽

2015 ◽

Vol 36 (10) ◽

pp. 7897-7906 ◽

Cited By ~ 16

Author(s):

Clemens Giessen-Jung ◽

Dorothea Nagel ◽

Maria Glas ◽

Fritz Spelsberg ◽

Ulla Lau-Werner ◽

...

Keyword(s):

Colon Cancer ◽

Serum Markers ◽

Stage I ◽

Preoperative Serum ◽

Patient Prognosis

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Prognostic value of serum aquaporin-1, aquaporin-3 and galectin-3 for young patients with colon cancer

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563220961752 ◽

2020 ◽

Vol 57 (6) ◽

pp. 404-411

Author(s):

Yanyan Hong ◽

Zhendong Chen ◽

Na Li ◽

Mingjun Zhang

Keyword(s):

Colon Cancer ◽

Cancer Patients ◽

Benign Lesion ◽

Young Patients ◽

Lesion Group ◽

Control Group ◽

Preoperative Serum ◽

Galectin 3 ◽

Long Term Prognosis

Background This study aimed to investigate the long-term prognosis value of serum galectin-3, aquaporin (AQP)-1 and AQP-3 in young patients with colon cancer. Methods A total of 100 young patients with colon cancer, 100 cases of benign colon and 100 healthy people were collected. All colon cancer patients were followed up for 42 months. Results Compared with the benign lesion group and the control group, preoperative serum galectin-3, AQP-1 and AQP-3 concentrations were significantly increased in patients with colon cancer ( P < 0.05). The immunohistochemistry scores of galectin-3, AQP-1 and AQP-3 in colon cancer patients were positively correlated with serum galectin-3, AQP-1 and AQP-3 concentrations ( P < 0.05). Serum galectin-3, AQP-1 and AQP-3 concentrations were positively correlated with TNM staging (galectin-3: rPearson = 0.502, P < 0.001; AQP-1: rPearson = 0.415, P < 0.001; AQP-3: rPearson = 0.454, P < 0.001) and differentiation (galectin-3: rPearson = 0.377, P = 0.004; AQP-1: rPearson = 0.411, P = 0.001; AQP-3: rPearson = 0.483, P < 0.001). Receiver operator characteristic curve (ROC) analysis showed that the area under ROC curve (AUC) of the combination of galectin-3, AQP-1 and AQP-3 in distinguishing colon cancer was 0.907. The sensitivity in the parallel mode was 87.6%, and the specificity in the serial mode was 98.2%. Compared with the low galectin-3 group, low AQP-1 group and low AQP-3 group, the survival time of patients in the high galectin-3 group (χ2 = 13.929, P < 0.001), high AQP-1 group (χ2 = 10.157, P = 0.001) and high AQP-3 group (χ2 = 4.364, P = 0.037) were significantly shortened. Conclusion Galectin-3 combined with AQP-1 and AQP-3 had important value in the identification of young patients with colon cancer and was of great value in evaluating long-term prognosis.

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