Zumba®!: An Antidote for Uncontrolled Weight Gain Associated with Polycystic Ovarian Syndrome with Subclinical Hypothyroidism?

Aim of Study. To assess status of thyroid function and thyroid disorders particularly subclinical hypothyroidism (SCH) in subjects with polycystic ovarian syndrome (PCOS) and impact of SCH on various clinical and biochemical parameters and cardiovascular risk in PCOS.Methods. Hundred females diagnosed with PCOS as per Rotterdam criteria and 100 normal controls were recruited and were subjected to elaborate anthropometric, clinical, and biochemical assessment.Results. Notable findings included significantly higher frequency of subjects with subclinical hypothyroidism (p=0.0002), autoimmune thyroiditis (p<0.001), and goitre (p=0.02) in polycystic ovarian syndrome subjects compared to control subjects. Further SCH PCOS subjects were found to harbor significantly higher HOMA-IR (p<0.05) and frequency of subjects with dyslipidemia (p<0.05) compared to both euthyroid PCOS and euthyroid control subjects. Though frequency of subjects with cardiovascular risk factors was higher in SCH PCOS group than euthyroid PCOS group, it failed to reach statistical significance.Conclusion. We concluded that PCOS is associated with high incidence of SCH and AIT compared to normal population and SCH poses increased risk of cardiovascular disorder in PCOS.

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A Study on Subfertile Women Suffering from Polycystic Ovarian Syndrome with Hyperprolactinaemia and Hypothyroidism as Associated Factors

Journal of Bangladesh College of Physicians and Surgeons ◽

10.3329/jbcps.v31i3.20980 ◽

2014 ◽

Vol 31 (3) ◽

pp. 140-143

Author(s):

SA Anwary ◽

S Chowdhury ◽

P Fatima ◽

M Alfazzaman ◽

N Begum ◽

...

Keyword(s):

Subclinical Hypothyroidism ◽

Associated Factors ◽

Polycystic Ovarian Syndrome ◽

Serum Prolactin ◽

Lower Abdomen ◽

Obstetrics And Gynaecology ◽

Serum Lh ◽

Medical University ◽

Ovarian Syndrome ◽

Serum Tsh

Objective: This study tried to evaluate association of other factors of subfertility in women suffering from polycystic ovarian syndrome (PCOS). Methods: Fifty subfertile women suffering from PCOS attending infertility unit of the Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, during July 2010 and June 2011, were evaluated. Results: In out study, Age, BMI and duration of marriage range was 20 38 years, 17.70 33.20 kg/m2 and 1 16 years, respectively. Serum FSH was normal (1.0 10.0 mIU/ml) in all 50 (100%) women. Hyperprolactinaemia (serum prolactin >25 ng/ml) was seen in 60%. Hypothyroidism (serum TSH >4 ìIU/ml) was seen in 74% women. Serum LH (>10 mIU/ml) was raised in 74%. USG finding of lower abdomen was abnormal in 75% cases. Conclusion: This study concludes that hyperprolactinaemia and subclinical hypothyroidism were associated causes of subfertility other than PCOS. DOI: http://dx.doi.org/10.3329/jbcps.v31i3.20980 J Bangladesh Coll Phys Surg 2013; 31: 140-143

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Is Weight Gain the Precipitating Factor for Polycystic Ovarian Syndrome? A Hypothesis Based on a Retrospective Study

Chettinad Health City Medical Journal ◽

10.36503/chcmj4(3)-03 ◽

2015 ◽

Vol 4 (3) ◽

Keyword(s):

Retrospective Study ◽

Weight Gain ◽

Polycystic Ovarian Syndrome ◽

Ovarian Syndrome ◽

Precipitating Factor

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Maternal polycystic ovarian syndrome and offspring growth: the Upstate KIDS Study

Journal of Epidemiology & Community Health ◽

10.1136/jech-2017-210004 ◽

2018 ◽

Vol 72 (9) ◽

pp. 852-855 ◽

Cited By ~ 2

Author(s):

Griffith A Bell ◽

Rajeshwari Sundaram ◽

Sunni L Mumford ◽

Hyojun Park ◽

Miranda Broadney ◽

...

Keyword(s):

New York ◽

Cohort Study ◽

Weight Gain ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Polycystic Ovarian Syndrome ◽

New York State ◽

Rapid Weight Gain ◽

Offspring Growth ◽

Ovarian Syndrome

BackgroundPolycystic ovarian syndrome (PCOS) is the most common cause of female infertility and is associated with higher levels of circulating androgens. Exposure to higher levels of androgens in utero may be a risk factor for obesity among children of women with PCOS.MethodsWe examined whether maternal PCOS was associated with differences in offspring growth and obesity in the Upstate KIDS study, a prospective cohort study of infants born in New York State (excluding New York City) oversampled for fertility treatments and multiple births. Measurements of offspring length/height and weight were recorded at doctor’s visits through 3 years of age. PCOS diagnosis was self-reported by mothers at baseline. We used linear mixed models with robust SEs to estimate differences in growth by maternal PCOS exposure. We used logistic regression to examine whether infants experienced rapid weight gain at 4, 9 and 12 months. Growth measures were reported by 4098 mothers for 4949 children (1745 twins). Of these, 435 mothers (10.6%) had a diagnosis of PCOS.ResultsCompared with children born to mothers without PCOS, children of mothers with PCOS did not have significant differences in weight (4.81 g, 95% CI −95.1 to 104.7), length/height (0.18 cm, 95% CI −0.16 to 0.52) and body mass index (−0.14 kg/m2, 95% CI −0.30 to 0.01) through 3 years of age. We also observed no association between maternal PCOS and offspring rapid weight gain.ConclusionsOverall, we found little evidence to suggest that maternal PCOS influences early childhood growth in this large, prospective cohort study.

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Association of Thyroid Stimulating Hormone with Insulin Resistance in Women with Polycystic Ovarian Syndrome

Journal of Armed Forces Medical College Bangladesh ◽

10.3329/jafmc.v11i1.30676 ◽

2016 ◽

Vol 11 (1) ◽

pp. 69-73

Author(s):

Salma Naher ◽

Sultana Rajia Begum ◽

Liaquat Ali ◽

Maksumul Hakim

Keyword(s):

Insulin Resistance ◽

Insulin Sensitivity ◽

Subclinical Hypothyroidism ◽

Polycystic Ovarian Syndrome ◽

Thyroid Stimulating Hormone ◽

Model Assessment ◽

C Peptide ◽

Ovarian Syndrome ◽

Serum Tsh ◽

Stimulating Hormone

Introduction: Polycystic Ovarian Syndrome (PCOS) is a major cause of female infertility which is thought to be associated with Insulin Resistance (IR). However the nature and degree of IR have been shown to vary in different populations. PCOS women have also been reported to have increased prevalence of subclinical hypothyroidism which has been postulated to be determinants of IR. The natures of thyroid involvement have also been shown to vary between populations.Objectives: The study was undertaken to explore the distribution of IR and thyroid dysfunction as assessed by Thyroid Stimulating Hormone (TSH) levels among PCOS subjects and also to investigate the association of IR with TSH in women with PCOS.Materials and Methods: One hundred and fifty one PCOS patients (age in years 24±5; M±SD) were studied. PCOS was diagnosed by Rotterdam criteria. Fasting serum C-peptide was measured by Enzyme Linked Immuno Sorbide Essay (ELISA) and serum TSH was measured by Microparticle Enzyme Immunoassay (MEIA). Serum glucose was estimated by Glucose-Oxidase method (GOD-PAP). Insulin sensitivity was assessed by using Homeostasis Model Assessment (HOMA).Results: The mean serum C-peptide (nmol/l) and HOMA%S were 0.67 (±0.35) and 85 (±42) respectively. The median (Range) serum TSH level (?lU/ml) of the study subjects was found to be 2.49 (0.66 to 20.86). Insulin sensitivity was found to be 26%, 47%, 17% and 10% in those who had HOMA%S level at the range of <50, 50-100, 101-150 and >150 respectively. Of the total PCOS subjects, 85% had normal level of TSH value whereas only 15% PCOS subjects had subclinical hypothyroidism. The median serum TSH level of the insulin resistance and non-resistance groups were 2.25 (0.89-5.71) and 2.58 (0.74-20.86) respectively. On Pearson's correlation analysis insulin sensitivity was not found to be any significant association with TSH in the PCOS subjects.Conclusion: The study revealed that there was no significant association with IR and TSH in the PCOS subjects.Journal of Armed Forces Medical College Bangladesh Vol.11(1) 2015: 69-73

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Altered Thyroid Function amongst the Infertile Insulin Resistant Women with Polycystic Ovarian Syndrome

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i34a31825 ◽

2021 ◽

pp. 73-80

Author(s):

Urooj Zafar ◽

Aliya Irshad Sani ◽

Hira Ahmed Malik ◽

Aisha Faraz ◽

Rabeea Rizwan ◽

...

Keyword(s):

Insulin Resistance ◽

Subclinical Hypothyroidism ◽

Polycystic Ovarian Syndrome ◽

Metformin Treatment ◽

Insulin Resistant ◽

Child Bearing ◽

Group B ◽

Altered Thyroid ◽

Ovarian Syndrome ◽

Tsh Levels

Background: Polycystic ovarian syndrome (PCOS) is a hormonal disorder common among women of the child-bearing age. Likewise, women with PCOS are more likely to be obese or overweight, which may be due to their higher Insulin resistance and TSH levels. Aim: The study's objectives were to assess the prevalence of subclinical hypothyroidism in infertile PCOS, distribution of insulin resistant in PCOS women with subclinical hypothyroidism, and the efficacy of Metformin treatment in these women. Methods: It was a single-center study which included all infertile patients who visited the Department of Obstetrics and Gynecology at a Karachi hospital between January 2019 and September 2019. The infertile PCOS patients were then divided into two groups: Group A (Insulin Resistant with Subclinical Hypothyroidism) and Group B. (Non-Insulin Resistant with Subclinical Hypothyroidism). Following the written consent, both the treatment groups received Metformin 500mg T.D. for three months. Results: The infertile PCOS patients showed a higher prevalence of subclinical hypothyroidism. Insulin resistance was found to be 63.3% among subclinical hypothyroid PCOS women. Finally, three months of Metformin treatment resulted in a significant reduction in TSH levels in Insulin resistant PCOS women. Conclusion: We identified a positive link between TSH levels and insulin resistance in PCOS women, both in terms of incidence and treatment.

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