BACKGROUND Sepsis is a potentially life threatening medical emergency. It should be diagnosed at the earliest and treated effectively to prevent mortality. Therefore, there is a need for parameters which are simple, reliable and cost effective which help in predicting the prognosis and help in managing the patient with sepsis more efficaciously. METHODS A total of seventy patients, 42 male and 28 female patients, over a period of one year, who fulfilled the inclusion and exclusion criteria was included in the study. In this study various clinical variables and biochemical markers including serum lactate dehydrogenase (LDH) were compared among survivor and non–survivor groups and analysed. RESULTS In this study out of 70 patients, 36 patients [51.4 %] expired. Various clinical variables and biochemical markers including serum LDH [on day 1 & day 3], were compared among survivor and non–survivor groups and analysed. Pulse rate, mean arterial pressure (MAP), total leucocyte count, renal function test (RFT), liver function test (LFT), day 3 LDH levels and requirement of ventilator support showed statistically significant difference among the survivor and non-survivor groups. CONCLUSIONS Despite the recent medical advances, sepsis is a multiorgan disease with significant mortality. Hence, we need simple and effective parameters which are essential in assessing the prognosis and in guiding the treatment protocols. This study focused on simple clinical and biochemical parameters with special reference to LDH, which helped us in predicting the mortality. KEYWORDS Markers, Serum LDH, Sepsis, Survival
The prognostic significance of serum lactate dehydrogenase-to-albumin ratio in colorectal cancer
