scholarly journals Application of Peak Nasal Inspiratory Flow reference values in the treatment of allergic rhinitis

2014 ◽  
Vol 52 (2) ◽  
pp. 133-136 ◽  
Author(s):  
S. de Souza Campos Fernandes ◽  
C. Ribeiro de Andrade ◽  
C. da Cunha Ibiapina
Keyword(s):  
Allergic Rhinitis ◽  
Reference Values ◽  
Inspiratory Flow ◽  
Peak Nasal Inspiratory Flow

scholarly journals Reference values for peak nasal inspiratory flow in children and adolescents in Brazil

2011 ◽  
Vol 49 (3) ◽  
pp. 304-308
Author(s):  
C. da Cunha Ibiapina ◽  
C. Ribeiro de Andrade ◽  
P.A. Moreira Camargos ◽  
C. Gonçalves Alvim ◽  
A. Augusto Cruz
Keyword(s):  
Allergic Rhinitis ◽  
Public Schools ◽  
Regression Model ◽  
Children And Adolescents ◽  
Reference Values ◽  
School Children ◽  
Inspiratory Flow ◽  
Public Health Issue ◽  
Global Public Health ◽  
Peak Nasal Inspiratory Flow

Statement of the problem: Allergic rhinitis is a global public health issue. Peak nasal inspiratory flow (PNIF) can help in the assessment of patients with allergic rhinitis. However, reference values in the literature for PNIF in school children and adolescents are limited. THE AIM OF THIS STUDY was to identify reference values of PNIF among children and adolescents. Methods: We conducted a cross-sectional study to identify reference values of PNIF among healthy school children and adolescents aged from eight to fifteen years old, selected from 14 randomly selected public schools. Participants performed measurements of PNIF using the In-check-inspiratory flow meter (Clement Clarke, Harlow, England). PNIF values were correlated to gender, age, height, weight and body mass index. Results: A total of 526 subjects participated in the study. The final linear regression model for PNIF allowed obtaining the following equation for subjects aged from eight to 15 years old: PNIF (l/m) = height (centimeters) x 0.7 + 11.2, for boys and PNIF (l/m) = height (centimeters) x 0.7, for girls. Conclusion: the equations of the final regression model resulted in a simple formula to obtain reference values of PNIF for subjects aged from 8 to 15 years old.

scholarly journals Peak nasal inspiratory flow: a comparative study in our day to day practice

2018 ◽  
Vol 4 (5) ◽  
pp. 1293
Author(s):  
Vijay Kumar ◽  
Harshvradhan . ◽  
Kranti Bhavana ◽  
Bhartendu Bharti
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Septum ◽  
Normal Subjects ◽  
Neck Surgery ◽  
Inspiratory Flow ◽  
Response To Treatment ◽  
Medical Sciences ◽  
Deviated Nasal Septum ◽  
Monitoring Treatment ◽  
Peak Nasal Inspiratory Flow

<p class="abstract"><strong>Background:</strong> The peak nasal inspiratory flow is an objective measurement of nasal airway obstruction. It also helps in assessing response to treatment regardless of etiology. With this background this study was undertaken to establish diagnosis and monitoring treatment efficacy of PNIF in patients of allergic rhinitis and deviated nasal septum.</p><p class="abstract"><strong>Methods:</strong> This prospective observational study involved 150 subjects who were selected among the patients attending the outpatient department of ENT and Head-Neck surgery, All India Institute of Medical Sciences, Patna. Thorough history was taken of all patients followed by general systemic and ENT examination. Each subject was asked to complete a SNOT 20 questionnaire. SPSS software was used for data analysis.  </p><p class="abstract"><strong>Results:</strong> Out of total 150 subjects, 50 had deviated nasal septum (DNS), 50 had allergic rhinitis and 50 were normal subjects. Normal subjects had mean PNIF value 80 liter per minute with a range of minimum to maximum; 60 L/min to 150 L/min. Patients with symptomatic deviated nasal septum (DNS) had mean PNIF value 50 L/min with a range 20–80 L/min. Patients with symptomatic allergic rhinitis had mean PNIF value 65 L/min with a range of minimum 40 L/min to maximum 90 L/min.</p><p class="abstract"><strong>Conclusions:</strong> On OPD basis, measurements of PNIF using Youlten peak flow meter can easily suggest anatomical &amp; pathological variations in the nose and nasal cavity and can correlated well with patient’s symptoms and severity.</p>

scholarly journals Application of Peak Nasal Inspiratory Flow reference values in the treatment of allergic rhinitis

2014 ◽  
Vol 52 (2) ◽  
pp. 133-136
Author(s):  
S. de Souza Campos Fernandes ◽  
C. Ribeiro de Andrade ◽  
C. da Cunha Ibiapina
Keyword(s):  
Allergic Rhinitis ◽  
Significant Influence ◽  
Physiological Saline ◽  
Clinical Score ◽  
Inspiratory Flow ◽  
Intranasal Corticosteroids ◽  
Anova Model ◽  
Significant Difference ◽  
Peak Nasal Inspiratory Flow

Objective: To assess the applicability of the Peak Nasal Inspiratory Flow (PNIF) curves in follow-up of children in the treatment of allergic rhinitis. Methods: Prospective study of 40 patients with AR, grouped in corticosteroid spray versus physiological saline solution use. Follow up for 10 weeks through clinical score and PNIF percentages in relation to the reference curves, with was-out at week 8. Statistical assessment of the effect of treatment on variation of PNIF and clinical score was calculated by ANOVA model and Multiple Comparison of Means Test - Least Significant Difference. Results: There was a statistically significant influence of the group, time and interaction between time and group on PNIF percentages. Throughout follow up, patients from the treatment group had mean PNIF percentages significantly higher than the placebo group. Clinical score results also demonstrated a statistically significant influence between the groups, time and interaction between time and group. Conclusion: Increase in PNIF percentage values observed in children treated with intranasal corticosteroids revealed the applicability of PNIF curves in their follow up.

Role of sphingosine 1-phosphate receptor expression in eosinophils of patients with allergic rhinitis, and effect of topical nasal steroid treatment on this receptor expression

2008 ◽  
Vol 122 (12) ◽  
pp. 1309-1317 ◽  
Author(s):  
T Mackle ◽  
S S Gendy ◽  
M Walsh ◽  
R McConn-Walsh ◽  
R W Costello ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Flow Measurement ◽  
Allergen Challenge ◽  
Treated Group ◽  
Inspiratory Flow ◽  
Receptor Expression ◽  
Eosinophil Migration ◽  
Before And After ◽  
Sphingosine 1 Phosphate ◽  
Peak Nasal Inspiratory Flow

AbstractObjective:Recent research has indicated that sphingosine 1-phosphate plays a role in allergy. This study examined the effect of allergen challenge on the expression of sphingosine 1-phosphate receptors on the eosinophils of allergic rhinitis patients, and the effect of steroid treatment on this expression.Study design:A prospective, non-randomised study.Methods:The study had three parts. Firstly, sphingosine 1-phosphate receptor expression on the eosinophils of allergic rhinitis patients and control patients was determined. Secondly, sphingosine 1-phosphate receptor expression was quantified pre- and post-allergen challenge, before and after a short course of fluticasone propionate; all patients underwent symptom scoring and peak nasal inspiratory flow measurement pre- and post-allergen challenge, both before and after steroid or saline treatment. Thirdly, the effect of sphingosine 1-phosphate on eosinophil migration was examined.Results:The eosinophils of both allergic rhinitis patients and controls expressed sphingosine 1-phosphate1, 3, 4, and 5. Eosinophils from all allergic rhinitis patients demonstrated up-regulation in sphingosine 1-phosphate expression after allergen challenge. These changes were statistically very significant for sphingosine 1-phosphate1, 4, and 5, and moderately significant for sphingosine 1-phosphate3. Sphingosine 1-phosphate receptor expression up-regulation was abolished in the steroid-treated group after allergen challenge; however, the saline-treated group showed no change in sphingosine 1-phosphate receptor expression after allergen challenge. Peak nasal inspiratory flow scores were significantly diminished after allergen challenge prior to treatment, but not after a course of topical nasal steroids. Sphingosine 1-phosphate induced eosinophil chemotaxis was increased following allergen challenge in allergic rhinitis subjects.Conclusions:Local intranasal steroid therapy acts directly to block allergen-induced up-regulation of sphingosine 1-phosphate receptors on the peripheral eosinophils of allergic rhinitis patients, and this is coincident with post-challenge peak nasal inspiratory flow measurement improvements. These observations support the idea that such an increase in sphingosine 1-phosphate receptor expression is clinically relevant in allergic rhinitis, with potential consequences for eosinophil migration and survival.

scholarly journals Effects of Exposure to New Car Interiors in Patients With Asthma and Allergic Rhinitis

2018 ◽  
Vol 9 ◽  
pp. 215265671880006
Author(s):  
Amber N. Pepper ◽  
Adeeb Bulkhi ◽  
Catherine R. Smith ◽  
Matthias Colli ◽  
Karl-Christian Bergmann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Allergic Rhinitis ◽  
Vital Capacity ◽  
Linear Mixed Model ◽  
Forced Expiratory Volume ◽  
Exhaled Nitric Oxide ◽  
Inspiratory Flow ◽  
Clinical Effects ◽  
Fractional Exhaled Nitric Oxide ◽  
Peak Nasal Inspiratory Flow

Rationale Vehicle interiors are an important microenvironment for atopic subjects. This study evaluated the subjective and objective physiologic and clinical effects of exposing subjects with asthma and allergic rhinitis to new 2017 Mercedes vehicles during 90-minute rides. Methods Ten adult asthmatics with allergic rhinitis were assessed before and 45 and 90 minutes into rides in a 2017 Mercedes-Benz S-Class sedan and GLE-Class SUV on 2 separate days. Assessments included spirometry, fractional exhaled nitric oxide, peak nasal inspiratory flow, asthma symptom scores, and physical examinations. Results Of the 10 subjects, 6 were women, mean age was 32 years, and 6 and 4 were using chronic asthma controllers or intranasal corticosteroids, respectively. None of the subjects had worsening of asthma or rhinitis symptoms during the rides. There were no statistically significant changes from baseline in forced expiratory volume in 1 second, forced expiratory volume in 1 second:forced vital capacity ratio, forced expiratory flow at 25%–75% of vital capacity, fractional exhaled nitric oxide, or peak nasal inspiratory flow at 45 or 90 minutes into the rides with either Mercedes vehicle (all P values > .1 using generalized linear mixed model). Conclusion The interior environment of the tested Mercedes vehicles did not cause changes in subjective or objective measures of asthma and allergic rhinitis. We suggest that this model system can be used to test other vehicles for putatively adverse effects on patients with allergic respiratory disorders.

scholarly journals Perbandingan terapi radiofrekuensi disertai steroid topikal dan steroid topikal saja pada rinitis alergi persisten

2013 ◽  
Vol 43 (1) ◽  
Author(s):  
Meila Sutanti ◽  
Retno Sulistyo Wardani ◽  
Nina Irawati ◽  
Arini Setiawati
Keyword(s):  
Allergic Rhinitis ◽  
Statistical Significance ◽  
Combined Treatment ◽  
Inferior Turbinate ◽  
Inspiratory Flow ◽  
Added Value ◽  
Treatment Groups ◽  
Persistent Allergic Rhinitis ◽  
Nasal Steroid ◽  
Peak Nasal Inspiratory Flow

Latar belakang: Kasus rinitis alergi dengan gejala persisten sedang-berat di RSCM ditemukan pada 357pasien selama 2 tahun. Terjadinya gejala sedang-berat pada rinitis alergi lebih sering menimbulkan penurunankualitas hidup dan produktivitas kerja. Efektivitas terapi steroid topikal adalah 67%, dibandingkan plasebo 39%.Penelitian yang menilai efek tambah reduksi konka radiofrekuensi terhadap terapi rinitis alergi persisten sedangberat(steroid topikal hidung) belum pernah ada. Tujuan: Untuk mendapatkan gambaran hasil terapi reduksikonka radiofrekuensi disertai dengan steroid topikal dibandingkan steroid topikal saja pada rinitis alergi persistensedang-berat. Metode: Penelitian pendahuluan dengan metode uji klinis acak. Sebanyak 14 pasien dilakukanreduksi konka radiofrekuensi disertai steroid topikal hidung, 16 pasien mendapat steroid topikal saja. Penilaianskala analog visual (SAV) terhadap 4 gejala utama rinitis alergi, nasoendoskopi untuk menilai ukuran konkainferior, pemeriksaan peak nasal inspiratory flow (PNIF) dilakukan sebelum terapi dan minggu ke-6 pascaterapi.Hasil: Perbedaan bermakna pada minggu ke-6 pascaterapi antara kedua kelompok didapati pada nilai SAV gatalhidung. Perbedaan bermakna nilai SAV bersin, gatal hidung, ingus encer, dan sumbatan hidung, sebelum terapidengan minggu ke-6 pascaterapi, ditemukan baik pada kelompok reduksi konka radiofrekuensi maupunkelompok steroid topikal saja. Perbedaan bermakna nilai PNIF sebelum terapi dengan minggu ke-6 pascaterapihanya ditemukan pada kelompok terapi reduksi konka radiofrekuensi disertai steroid topikal. Kesimpulan: Baikreduksi konka radiofrekuensi disertai steroid topikal maupun steroid topikal saja memberikan perbaikan gejalarinitis alergi persisten sedang-berat. Pada penelitian ini, penambahan terapi reduksi konka radiofrekuensimengurangi keluhan gatal hidung dan meningkatkan nilai PNIF pada minggu ke-6 pascaterapi.Kata kunci: rinitis alergi persisten sedang-berat, reduksi konka radiofrekuensi, steroid topikal hidung, skalaanalog visual, peak nasal inspiratory flow.ABSTRACTBackground: There were 357 patients with moderate/severe persistent allergic rhinitis in 2 years period at Dr.Cipto Mangunkusumo Hospital. Moderate/severe symptoms in allergic rhinitis reduce quality of life and productivity.Efectivity of nasal steroid in controlling allergic rhinitis symptoms is 67% compared to placebo 39%. The effect ofradiofrequency turbinoplasty added to nasal steroid in controlling allergic rhinitis symptoms were sought. Purpose:This study was performed to evaluate added value of radiofrequency turbinoplasty to nasal steroid in treatment ofmoderate/severe allergic rhinitis. Methods: A pilot study of randomized clinical trial was designed. Fourteen patientswere given combined treatment consist of radiofrequency turbinoplasty and nasal steroid, sixteen patients were givennasal steroid only. Visual analogue scale (VAS) for 4 major symptoms of allergic rhinitis (sneezing, nose itching,rhinorhea, nose obstruction), nasoendoscopy to evaluate inferior turbinate size, peak nasal inspiratory flow (PNIF)were performed before treatment and 6 weeks after treatment. Results: Statistical significance was found only in noseitching symptom if compared between 2 treatment group at 6 weeks after treatment. If comparison performed withintreatment group itself (before treatment and 6 weeks after treatment), there were improvement in all major symptomsof allergic rhinitis. Peak nasal inspiratory flow was found statiscally significance within group, only in group treatedwith combined treatment. Conclusion: Both treatment groups give improvement in all symptoms of allergic rhinitis. Inthis research, addition of radiofrequency turbinoplasty reduces nose itching compared to nasal steroid alone and alsoincreases result of PNIF within 6 weeks of treatment.Keywords: moderate/severe persistent allergic rhinitis, radiofrequency turbinoplasty, nasal steroid, visualanalogue scale, peak nasal inspiratory flow.

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