scholarly journals Perbandingan terapi radiofrekuensi disertai steroid topikal dan steroid topikal saja pada rinitis alergi persisten

2013 ◽  
Vol 43 (1) ◽  
Author(s):  
Meila Sutanti ◽  
Retno Sulistyo Wardani ◽  
Nina Irawati ◽  
Arini Setiawati
Keyword(s):  
Allergic Rhinitis ◽  
Statistical Significance ◽  
Combined Treatment ◽  
Inferior Turbinate ◽  
Inspiratory Flow ◽  
Added Value ◽  
Treatment Groups ◽  
Persistent Allergic Rhinitis ◽  
Nasal Steroid ◽  
Peak Nasal Inspiratory Flow

Latar belakang: Kasus rinitis alergi dengan gejala persisten sedang-berat di RSCM ditemukan pada 357pasien selama 2 tahun. Terjadinya gejala sedang-berat pada rinitis alergi lebih sering menimbulkan penurunankualitas hidup dan produktivitas kerja. Efektivitas terapi steroid topikal adalah 67%, dibandingkan plasebo 39%.Penelitian yang menilai efek tambah reduksi konka radiofrekuensi terhadap terapi rinitis alergi persisten sedangberat(steroid topikal hidung) belum pernah ada. Tujuan: Untuk mendapatkan gambaran hasil terapi reduksikonka radiofrekuensi disertai dengan steroid topikal dibandingkan steroid topikal saja pada rinitis alergi persistensedang-berat. Metode: Penelitian pendahuluan dengan metode uji klinis acak. Sebanyak 14 pasien dilakukanreduksi konka radiofrekuensi disertai steroid topikal hidung, 16 pasien mendapat steroid topikal saja. Penilaianskala analog visual (SAV) terhadap 4 gejala utama rinitis alergi, nasoendoskopi untuk menilai ukuran konkainferior, pemeriksaan peak nasal inspiratory flow (PNIF) dilakukan sebelum terapi dan minggu ke-6 pascaterapi.Hasil: Perbedaan bermakna pada minggu ke-6 pascaterapi antara kedua kelompok didapati pada nilai SAV gatalhidung. Perbedaan bermakna nilai SAV bersin, gatal hidung, ingus encer, dan sumbatan hidung, sebelum terapidengan minggu ke-6 pascaterapi, ditemukan baik pada kelompok reduksi konka radiofrekuensi maupunkelompok steroid topikal saja. Perbedaan bermakna nilai PNIF sebelum terapi dengan minggu ke-6 pascaterapihanya ditemukan pada kelompok terapi reduksi konka radiofrekuensi disertai steroid topikal. Kesimpulan: Baikreduksi konka radiofrekuensi disertai steroid topikal maupun steroid topikal saja memberikan perbaikan gejalarinitis alergi persisten sedang-berat. Pada penelitian ini, penambahan terapi reduksi konka radiofrekuensimengurangi keluhan gatal hidung dan meningkatkan nilai PNIF pada minggu ke-6 pascaterapi.Kata kunci: rinitis alergi persisten sedang-berat, reduksi konka radiofrekuensi, steroid topikal hidung, skalaanalog visual, peak nasal inspiratory flow.ABSTRACTBackground: There were 357 patients with moderate/severe persistent allergic rhinitis in 2 years period at Dr.Cipto Mangunkusumo Hospital. Moderate/severe symptoms in allergic rhinitis reduce quality of life and productivity.Efectivity of nasal steroid in controlling allergic rhinitis symptoms is 67% compared to placebo 39%. The effect ofradiofrequency turbinoplasty added to nasal steroid in controlling allergic rhinitis symptoms were sought. Purpose:This study was performed to evaluate added value of radiofrequency turbinoplasty to nasal steroid in treatment ofmoderate/severe allergic rhinitis. Methods: A pilot study of randomized clinical trial was designed. Fourteen patientswere given combined treatment consist of radiofrequency turbinoplasty and nasal steroid, sixteen patients were givennasal steroid only. Visual analogue scale (VAS) for 4 major symptoms of allergic rhinitis (sneezing, nose itching,rhinorhea, nose obstruction), nasoendoscopy to evaluate inferior turbinate size, peak nasal inspiratory flow (PNIF)were performed before treatment and 6 weeks after treatment. Results: Statistical significance was found only in noseitching symptom if compared between 2 treatment group at 6 weeks after treatment. If comparison performed withintreatment group itself (before treatment and 6 weeks after treatment), there were improvement in all major symptomsof allergic rhinitis. Peak nasal inspiratory flow was found statiscally significance within group, only in group treatedwith combined treatment. Conclusion: Both treatment groups give improvement in all symptoms of allergic rhinitis. Inthis research, addition of radiofrequency turbinoplasty reduces nose itching compared to nasal steroid alone and alsoincreases result of PNIF within 6 weeks of treatment.Keywords: moderate/severe persistent allergic rhinitis, radiofrequency turbinoplasty, nasal steroid, visualanalogue scale, peak nasal inspiratory flow.

scholarly journals TLR4 and TLR9 Expression in Different Phenotypes of Rhinitis

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Maria Lauriello ◽  
Alessandra Micera ◽  
Paola Muzi ◽  
Lino Di Rienzo Businco ◽  
Sergio Bonini
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Inferior Turbinate ◽  
Vasomotor Rhinitis ◽  
Tlr9 Expression ◽  
Persistent Allergic Rhinitis ◽  
Evolutionarily Conserved ◽  
Chronic Rhino Sinusitis ◽  
Nasal Inflammation ◽  
Severity Of The Disease

Background. Toll-like receptors (TLRs) represent a family of evolutionarily conserved proteins, that represent a fundamental link between innate and adaptive immune responses.Aim. The purpose of this study was to investigate the expression of TLR4 and TLR9 in the normal nasal mucosa and in the mucosa of subjects with different phenotypes of rhinitis.Methodology. A confocal analysis of TLR4 and TLR9 (co)expression was carried out on biopsies from the inferior turbinate obtained from 4 patients affected by persistent allergic rhinitis, 8 patients with chronic rhino-sinusitis, and 6 patients with vasomotor rhinitis The results were compared with those of specimens obtained from 4 subjects undergoing nasal surgery, but with signs of nasal inflammation.Results. TLR4 and TLR9 were expressed in the healthy nasal mucosa; TLR4 and TLR9 expression was significantly decreased in allergic rhinitis. TLR4 was over expressed in the epithelium of chronic rhino-sinusitis. Both TLRs were co-expressed in the sub-epithelial infiltrate of chronic and vasomotor rhinitis, even though this expression was higher in the former compared with the latter.Conclusions. This study indicates that TLR4 and TLR9 show a different pattern of expression in different phenotypes of rhinitis, possibly related to the type and severity of the disease.

scholarly journals Application of Peak Nasal Inspiratory Flow reference values in the treatment of allergic rhinitis

2014 ◽  
Vol 52 (2) ◽  
pp. 133-136 ◽  
Author(s):  
S. de Souza Campos Fernandes ◽  
C. Ribeiro de Andrade ◽  
C. da Cunha Ibiapina
Keyword(s):  
Allergic Rhinitis ◽  
Reference Values ◽  
Inspiratory Flow ◽  
Peak Nasal Inspiratory Flow

scholarly journals Peak nasal inspiratory flow: a comparative study in our day to day practice

2018 ◽  
Vol 4 (5) ◽  
pp. 1293
Author(s):  
Vijay Kumar ◽  
Harshvradhan . ◽  
Kranti Bhavana ◽  
Bhartendu Bharti
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Septum ◽  
Normal Subjects ◽  
Neck Surgery ◽  
Inspiratory Flow ◽  
Response To Treatment ◽  
Medical Sciences ◽  
Deviated Nasal Septum ◽  
Monitoring Treatment ◽  
Peak Nasal Inspiratory Flow

<p class="abstract"><strong>Background:</strong> The peak nasal inspiratory flow is an objective measurement of nasal airway obstruction. It also helps in assessing response to treatment regardless of etiology. With this background this study was undertaken to establish diagnosis and monitoring treatment efficacy of PNIF in patients of allergic rhinitis and deviated nasal septum.</p><p class="abstract"><strong>Methods:</strong> This prospective observational study involved 150 subjects who were selected among the patients attending the outpatient department of ENT and Head-Neck surgery, All India Institute of Medical Sciences, Patna. Thorough history was taken of all patients followed by general systemic and ENT examination. Each subject was asked to complete a SNOT 20 questionnaire. SPSS software was used for data analysis.  </p><p class="abstract"><strong>Results:</strong> Out of total 150 subjects, 50 had deviated nasal septum (DNS), 50 had allergic rhinitis and 50 were normal subjects. Normal subjects had mean PNIF value 80 liter per minute with a range of minimum to maximum; 60 L/min to 150 L/min. Patients with symptomatic deviated nasal septum (DNS) had mean PNIF value 50 L/min with a range 20–80 L/min. Patients with symptomatic allergic rhinitis had mean PNIF value 65 L/min with a range of minimum 40 L/min to maximum 90 L/min.</p><p class="abstract"><strong>Conclusions:</strong> On OPD basis, measurements of PNIF using Youlten peak flow meter can easily suggest anatomical &amp; pathological variations in the nose and nasal cavity and can correlated well with patient’s symptoms and severity.</p>

scholarly journals Application of Peak Nasal Inspiratory Flow reference values in the treatment of allergic rhinitis

2014 ◽  
Vol 52 (2) ◽  
pp. 133-136
Author(s):  
S. de Souza Campos Fernandes ◽  
C. Ribeiro de Andrade ◽  
C. da Cunha Ibiapina
Keyword(s):  
Allergic Rhinitis ◽  
Significant Influence ◽  
Physiological Saline ◽  
Clinical Score ◽  
Inspiratory Flow ◽  
Intranasal Corticosteroids ◽  
Anova Model ◽  
Significant Difference ◽  
Peak Nasal Inspiratory Flow

Objective: To assess the applicability of the Peak Nasal Inspiratory Flow (PNIF) curves in follow-up of children in the treatment of allergic rhinitis. Methods: Prospective study of 40 patients with AR, grouped in corticosteroid spray versus physiological saline solution use. Follow up for 10 weeks through clinical score and PNIF percentages in relation to the reference curves, with was-out at week 8. Statistical assessment of the effect of treatment on variation of PNIF and clinical score was calculated by ANOVA model and Multiple Comparison of Means Test - Least Significant Difference. Results: There was a statistically significant influence of the group, time and interaction between time and group on PNIF percentages. Throughout follow up, patients from the treatment group had mean PNIF percentages significantly higher than the placebo group. Clinical score results also demonstrated a statistically significant influence between the groups, time and interaction between time and group. Conclusion: Increase in PNIF percentage values observed in children treated with intranasal corticosteroids revealed the applicability of PNIF curves in their follow up.

scholarly journals Efficacy of Oral Bilastine in Comparison with Levocetirizine in Allergic Rhinitis- A Randomised Clinical Study

2021 ◽  
Author(s):  
M Vanitha ◽  
K Sowmini ◽  
K Santha Sheela Kumari ◽  
Resu Neha Reddy
Keyword(s):  
Allergic Rhinitis ◽  
Immunoglobulin E ◽  
Statistical Significance ◽  
Post Treatment ◽  
Once Daily ◽  
Treatment Groups ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Antihistaminic Drugs

Introduction: Allergic rhinitis is a heterogeneous disorder characterised by major symptoms like sneezing, itching, nasal congestion and rhinorrhea. Because of bothersome side effects of first-generation antihistaminic drugs, second generation antihistaminic drugs have been used since few years. Recent studies have showed that novel drug Bilastine has been approved as an effective treatment in Allergic rhinitis. Aim: To evaluate Total Nasal Symptom Scores (TNSS), Serum Immunoglobulin E (IgE), Serum Absolute Eosinophil Count (AEC) in patients with allergic rhinitis, pre and post-treatment with Bilastine and Levocetirizine. Materials and Methods: A randomised, open-labelled, study was conducted between January 2020 to March 2020. Hundred patients with allergic rhinitis were enrolled into the study. They were randomised into two groups of which group A received tablet Bilastine 20 mg once daily for two weeks and group B received tablet Levocetirizine 5 mg once daily for two weeks. The results of TNSS, IgE, AEC and pre and post-treatment values were compared in both the treatment groups. Unpaired t-test was used as the test of significance between the two treatment groups. Results: The prevalence of allergic rhinitis in the study was 49% in males and 51% in females. The mean difference in pre and post-treatment in TNSS (group A=1.627, group B=1.143), serum IgE (A=33.118, B=49.653), serum AEC (A=28.00, B=27.245) showed no statistically significant difference between two groups (p-value >0.05). Conclusion: Bilastine and levocetirizine are equally efficacious. Though there is clinical significance in treatment of allergic rhinitis between the groups, there is no statistical significance which would prove Bilastine is clinically superior to Levocetirizine for the allergic rhinitis treatment.

scholarly journals PENGARUH ASAP ROKOK TERHADAP KUALITAS HIDUP TOTAL PENDERITA RINITIS ALERGI PERSISTEN

2016 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
Roy David Sarumpaet ◽  
Mohammad Juffrie ◽  
Suprihati . ◽  
Indwiani Astuti
Keyword(s):  
Quality Of Life ◽  
Allergic Rhinitis ◽  
Cigarette Smoke ◽  
Total Quality ◽  
Treatment Groups ◽  
Side Stream ◽  
Persistent Allergic Rhinitis ◽  
And Control ◽  
The Relationship

ABSTRAK Pendahuluan: Pengaruh asap rokok pada penderita Rinitis Alergi Persisten (RAP) yang prevalensinya semakin meningkat di Indonesia belum mendapat perhatian untuk diteliti, meskipun jumlah penduduk yang merokok semakin bertambah. Tujuan: Menganalisis hubungan asap rokok “side-stream” (SS)  dengan  perubahan kualitas hidup (KH) total penderita Rinitis Alergi Persisten (RAP).  Metode: Penelitian ini adalah dengan desain kasus kontrol, dimana 63  penderita RAP  sedang-berat yang dibuktikan dengan tes alergi dibagi menjadi kelompok perlakuan (32) dan kontrol (31) secara acak. 32 penderita RAP dipaparkan dengan asap rokok (SS) dari 5 batang rokok selama 2 jam dalam  suatu  ruangan. Seluruh responden diminta mengisi kuesioner kualitas hidup dari Juniper’s RQLQ. Hasil: KH total antara kelompok perlakuan dengan kontrol tidak berbeda bermakna. KH total yang terpapar asap rokok setiap hari  berbeda bermakna. Diskusi: Asap rokok yang dipaparkan pada penderita RAP tidak menyebabkan perubahan kualitas hidup.ABSTRACT Introduction: The effect of cigarette smoke on Persistent Allergic Rhinitis patients (RAP) prevalence is increasing in Indonesia. Although the number of people who smoke is increasing yet  it has not received attention for examination. Objective: To analyze the relationship between cigarette smoking "side-stream" (SS) with the change in total quality of life (TQL) among patients with Persistent Allergic Rhinitis (PAR). Method: This study is a case-control design, in which 63 patients with moderate-severe RAP evidenced by allergy tests are divided into treatment groups (32) and control (31) randomly. RAP 32 patients were exposed to cigarette smoke (SS) from 5 cigarettes for 2 hours in a room. All respondents were asked to fill out questionnaires quality of life of Juniper's RQLQ. Results: KH total between treatment groups was not significantly different with control. KH total exposed to secondhand smoke every day significantly different. Discussion: Cigarette smoke described in patients with RAP does not lead to changes in the quality of life.

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