scholarly journals Intercalation of Ciprofloxacin in Naturally Occurring Smectite from Bana: Potentiality as Drug Delivery System and Antimicrobial Effects on <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>

2021 ◽  
Vol 09 (08) ◽  
pp. 21-40
Author(s):  
Carine Feudjio Memenfo ◽  
Nicolas Tabary ◽  
Jean Aimé Mbey ◽  
Stéphanie Degoutin ◽  
Frédéric Cazaux ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Drug Delivery System ◽  
Delivery System ◽  
Antimicrobial Effects ◽  
Naturally Occurring

scholarly journals Antibacterial Activity of Mucoadhesive Gastroretentive Drug Delivery System of Alginate Beads Containing Turmeric Extract - PVP Solid Dispersion

2019 ◽  
Vol 7 (22) ◽  
pp. 3868-3873
Author(s):  
Hakim Bangun ◽  
Anayanti Arianto ◽  
Yuni Sari Bangun ◽  
Marline Nainggolan
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Dispersion ◽  
Alginate Beads ◽  
Diffusion Method ◽  
Turmeric Extract

BACKGROUND: Turmeric extract is less effective because the main ingredient of curcumin has a low solubility. Therefore, it is necessary to convert turmeric extract into a solid dispersion form to increase the dissolution of curcumin. AIM: To determine the antibacterial activity of mucoadhesive gastroretentive drug delivery system of alginate beads containing solid dispersion of turmeric extract. METHODS: Turmeric powder was macerated with 96% ethanol for 8 days. The macerate was evaporated with a rotary evaporator at 50°C to obtain concentrated extract. Solid dispersion of turmeric extract was prepared by solvent method by using polyvinylpyrrolidone (PVP) K30 with a ratio of 1: 1 and 1: 2. The solid dispersion of turmeric extract was encapsulated with alginate gel by gelation method. The antibacterial of alginate beads containing solid dispersion of turmeric extract was tested by using hole agar plate diffusion method against Staphylococcus aureus and Escherichia coli as bacterial models. RESULTS: The size of alginate beads containing turmeric extract-PVP solid dispersion was about 1.3 mm. Antibacterial activity test against Staphylococcus aureus and Escherichia coli showed that alginate beads containing turmeric extract-PVP solid dispersion gave stronger antibacterial activity than those containing turmeric extract without solid dispersion. The antibacterial activity of alginate beads turmeric extract-PVP (1: 2) solid dispersion was stronger than those containing turmeric-extract (1: 1) solid dispersion. CONCLUSION: Based on the results of this study it can be concluded that alginate beads containing turmeric extract-PVP solid dispersion gives the stronger antibacterial activity than those containing turmeric extract without solid dispersion.

scholarly journals “Design and Synthesis of Some Cyclic Carbohydrates with Norfloxacin as Surface moiety. A Study of Sustained Relax of Drugs”.

2019 ◽  
Vol 35 (2) ◽  
pp. 577-590
Author(s):  
J. Dhevaraj ◽  
S. Vembu ◽  
S. Pazhamalai ◽  
M. Gopalakrishnan
Keyword(s):  
Escherichia Coli ◽  
Drug Delivery ◽  
Antibacterial Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Synthetic Polymer ◽  
Hydroxyl Group ◽  
Standard Drug ◽  
Polymeric Structure ◽  
Uv Spectrometry

Biocompatible and biodegradable sustained drug delivery system has been constructed from reaction between norfloxacin and cyclodextrin through secondary amine of piperazine ring and hydroxyl group of the carbohydrate. Covalent bond polymeric structure is designed by the help of chloroacetyl chloride, target dendrimer formed by removing two hydrochloride molecules. The development of cyclodextrin core drug delivery system with twenty one norfloxacin surface moiety has been synthesized by only two steps. The synthesized polymeric structure was thoroughly studied by NMR, FT-IR, MALDI and UV- spectrometry. Sustained release assessment of synthetic polymer studied through different buffer solution by UV spectrometry and norfloxacin releases rate of synthetic polymer was controlled by the concentration and the experimental medium. The microbial assessments through kinetic studies by using Escherichia coli also reveal that the norfloxacin released possesses potential antimicrobial activity. Antibacterial activity of synthesized drug delivery system has been investigated with gram-negative and gram-positive species like Escherichia coli (mtcc 443), bacillus subtilis (mtcc 2063), pseudomonas (mtcc 741), staphylococcus (mtcc 737) and proteus mirabilis (mtcc 425). The hydrophobic and hydrophilic balance and the repeat drug unit of this synthesized system are responsible for effective antibacterial activity. The minimum inhibitor concentration values of this system are very small to 100 µg/mL-1, synthesized compound shown five times improved activity against organism on comparism with standard drug. The in-vitro release of norfloxacin from obtained dendrimer was investigated.

scholarly journals Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Rong Huang ◽  
Guang-Qing Cai ◽  
Jian Li ◽  
Xi-Sheng Li ◽  
Hai-Ting Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Drug Delivery System ◽  
Delivery System ◽  
Metal Organic Framework ◽  
Platelet Membrane ◽  
Nano Drug Delivery ◽  
Metal Organic ◽  
Mrsa Infection ◽  
Silver Metal

Abstract Background Due to the intelligent survival strategy and self-preservation of methicillin-resistant Staphylococcus aureus (MRSA), many antibiotics are ineffective in treating MRSA infections. Nano-drug delivery systems have emerged as a new method to overcome this barrier. The aim of this study was to construct a novel nano-drug delivery system for the treatment of MRSA infection, and to evaluate the therapeutic effect and biotoxicity of this system. We prepared a nano silver metal-organic framework using 2-methylimidazole as ligand and silver nitrate as ion provider. Vancomycin (Vanc) was loaded with Ag-MOF, and nano-sized platelet vesicles were prepared to encapsulate Ag-MOF-Vanc, thus forming the novel platelet membrane-camouflaged nanoparticles PLT@Ag-MOF-Vanc. Results The synthesized Ag-MOF particles had uniform size and shape of radiating corona. The mean nanoparticle size and zeta potential of PLT@Ag-MOF-Vanc were 148 nm and − 25.6 mV, respectively. The encapsulation efficiency (EE) and loading efficiency (LE) of vancomycin were 81.0 and 64.7 %, respectively. PLT@Ag-MOF-Vanc was shown to be a pH-responsive nano-drug delivery system with good biocompatibility. Ag-MOF had a good inhibitory effect on the growth of three common clinical strains (Escherichia coli, Pseudomonas aeruginosa, and S. aureus). PLT@Ag-MOF-Vanc showed better antibacterial activity against common clinical strains in vitro than free vancomycin. PLT@Ag-MOF-Vanc killed MRSA through multiple approaches, including interfering with the metabolism of bacteria, catalyzing reactive oxygen species production, destroying the integrity of cell membrane, and inhibiting biofilm formation. Due to the encapsulation of the platelet membrane, PLT@Ag-MOF-Vanc can bind to the surface of the MRSA bacteria and the sites of MRSA infection. PLT@Ag-MOF-Vanc had a good anti-infective effect in mouse MRSA pneumonia model, which was significantly superior to free vancomycin, and has no obvious toxicity. Conclusions PLT@Ag-MOF-Vanc is a novel effective targeted drug delivery system, which is expected to be used safely in anti-infective therapy of MRSA. Graphic abstract

scholarly journals PENGEMBANGAN NANOPARTIKEL EKSTRAK DAUN KERSEN(Muntingia calabura.L) DENGAN TEKNIK SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) UNTUK APLIKASI ANTIBAKTERI

2020 ◽  
Vol 1 (2) ◽  
pp. 27-34
Author(s):  
Septiana Indratmoko ◽  
Asep Nurrahman ◽  
Axl Aprizal Herawan
Keyword(s):  
Drug Delivery ◽  
Staphylococcus Aureus ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Loading ◽  
Tween 80 ◽  
Peg 400

Kandungan flavonoid dan tanin pada daun kersen dapat  menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk mengetahui pengaruh formulasi nanoemulsi daun kersen (Mutingia calabura.L) terhadap karakteristik nanoemulsi menggunakan teknik Self Nano Emulsifying Drug Delivery System (SNEDDS) dan  pengaruhnya sebagai antibakteri Staphylococcus aureus. Ekstrak etanol daun kersen diformulasi dengan surfaktan, kosurfaktan dan minyak terpilih. Kemudian nanoemulsi ekstrak daun kersen diuji ukuran partikel, potensial zeta, drug loading dan stabilitas nanoemulsi. Nanoemulsi ekstrak etanol daun kersen dapat dihasilkan dengan formula Tween 80, PEG 400 dan VCO perbandingan 6:1:1. Ukuran partikel nanoemulsi 12,4 nm, potensial zeta 30,8 mV, drug loading yaitu 125 mg/ml dan stabil. Nanoemulsi ekstrak daun kersen dapat memberikan aktivitas antibakteri lebih baik daripada ekstrak daun kersen.

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