scholarly journals Cerebral Palsy and Stroke—Early and Late Brain Lesion Present Differences in Systemic Biomarkers and Gene Expression Related to Muscle Contractures

2021 ◽  
Vol 11 (01) ◽  
pp. 34-47
Author(s):  
Jessica Pingel ◽  
Camille Potts ◽  
Theis Wolter Petersen ◽  
Jens Bo Nielsen
Keyword(s):  
Gene Expression ◽  
Cerebral Palsy ◽  
Brain Lesion

scholarly journals Risk factors for hip dislocation in dyskinetic cerebral palsy

2021 ◽  
Vol 29 (1) ◽  
pp. 230949902110011
Author(s):  
Kyoko Okuno ◽  
Yukihiro Kitai ◽  
Toru Shibata ◽  
Hiroshi Arai
Keyword(s):  
Risk Factors ◽  
Cerebral Palsy ◽  
Birth Weight ◽  
Gestational Age ◽  
Brain Mri ◽  
Brain Lesion ◽  
Brain Lesions ◽  
Lesion Location ◽  
Hip Displacement ◽  
Gmfcs Level

Purpose: To investigate the risk factors for hip displacement in patients with dyskinetic cerebral palsy (DCP). Methods: We evaluated 81 patients with DCP, 45 males and 36 females, aged 10–22 years, risk factors for hip displacement were evaluated using multivariate logistic regression analysis with primary brain lesions, Gross Motor Function Classification System (GMFCS) level, gestational age, birth weight, Cobb’s angle, and complication of epilepsy as independent factors. Hip displacement was defined as migration percentage >30%. Primary brain lesions were classified into globus pallidus (GP), thalamus and putamen (TP), and others using brain magnetic resonance imaging (MRI). Perinatal and clinical features were compared between patients with GP lesions and those with TP lesions. Results: Hip displacement was observed in 53 patients (67%). Higher GMFCS levels (p = 0.013, odds ratio [OR] 2.6) and the presence of GP lesions (p = 0.04, OR 16.5) were independent risk factors for hip displacement. Patients with GP lesions showed significantly higher GMFCS levels, more frequent hip displacement, and lower gestational age and birth weight than those with TP lesions. Conclusion: Primary brain lesion location may be an important factor in predicting hip displacement among patients with DCP. Appropriate risk assessment using brain MRI may contribute to the early detection and intervention of hip displacement because brain lesion location can be assessed during infancy before GMFCS level is decided.

Cerebral Palsy

1995 ◽  
Vol 16 (11) ◽  
pp. 411-418
Author(s):  
Lawrence T. Taft
Keyword(s):  
Cerebral Palsy ◽  
Prevalence Rate ◽  
Brain Lesion ◽  
Motor Deficit ◽  
Motor Disorder ◽  
Term Infants ◽  
Live Births ◽  
The Past ◽  
Technological Advances ◽  
Static Encephalopathy

To be classified as cerebral palsy (CP), there must be difficulty in neuromotor control, a nonprogressive brain lesion, and an injury to the brain that occurred before it was fully mature. The term "cerebral palsy" should be used only if a static encephalopathy exists. If there is any question that a progressive central nervous system disorder exists, the term "cerebral palsy" should not be used diagnostically until the status of the lesion is clarified. Although the primary abnormality must be a motor deficit, often there are many associated symptoms of cerebral dysfunction present. Incidence and Prevalence The prevalence of CP has changed very little over the past 40 years, in spite of many technological advances that have decreased mortality in compromised preterm and full-term infants. The prevalence rate has been estimated to be between 2 and 5 per 1000 live births. At 12 months of age, the prevalence rate was estimated to be 5.2 per 1000, but at 7 years of age, the rate was estimated to be 2 per 1000 live births. This indicates that many children who showed signs or experienced symptoms suggesting a motor disorder did not have CP on follow-up. The past 3 decades have seen an increased survival rate of very small preterm infants, resulting in a change in the percentage rates of the different clinical types of motor disabilities among patients classified as having CP.

scholarly journals Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy

2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Mark A. Corbett ◽  
Clare L. van Eyk ◽  
Dani L. Webber ◽  
Stephen J. Bent ◽  
Morgan Newman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cerebral Palsy ◽  
Copy Number ◽  
Copy Number Variants ◽  
Affect Gene Expression

scholarly journals The Level of Children’s Independence with Cerebral Palsy in Several Regions in Java and Sumatra

2020 ◽  
Vol 5 (1) ◽  
pp. 1-12
Author(s):  
Bambang Trisnowiyanto
Keyword(s):  
Cerebral Palsy ◽  
Health Workers ◽  
Brain Lesion ◽  
Clinical Manifestations ◽  
Total Sample ◽  
Body Parts ◽  
Research Subjects ◽  
Cross Sectional ◽  
Children With Cerebral Palsy ◽  
Gmfcs Level

Background:  The most common disorder or disability in childhood is cerebral palsy, obtained during the antenatal, perinatal or early postnatal period. Cerebral palsy is a non-progressive injury or brain lesion with very variable clinical manifestations. children with cerebral palsy have impaired movement, ability levels and functional limitations and affected body parts. Therefore, to find out the level of independence in children with cerebral palsy, it is necessary to have an examination carried out by health workers, especially physiotherapy. In this case, an examination using the Gross Motor Function Classification System (GMFCS). The purpose of this study was to determine the degree of independence of children with cerebral palsy in several regions in Java and Sumatra. Methods: A total of 315 children with cerebral palsy (mean ± SD)  participated in this cross-sectional study design. The research was conducted in March-June 2019. GMFCS data was collected from children with cerebral palsy in the parent community of cerebral palsy in 10 cities. The Kolmogorov-Smirnov test used for data normality test. Result: Overall research subjects from 10 cerebral palsy communities with a total sample of 315 children, most cerebral palsy with GMFCS level 4 as many as 117 children (37.1%), then GMFCS level 3 as many as 84 children (26.7%), GMFCS level 5 is 67 children (21.3%), level 2 GMFCS is 24 children (7.6%), and at least children with level 1 GMFCS are 23 children (7.3%). Conclusion: The conclusion is from a total of 315 children with cerebral palsy, the level of Indonesian children's independence based on GMFCS most of them are less independent.

scholarly journals Do mirror movements relate to hand function and timing of the brain lesion in children with unilateral cerebral palsy?

2015 ◽  
Vol 58 (7) ◽  
pp. 735-742 ◽  
Author(s):  
Katrijn Klingels ◽  
Ellen Jaspers ◽  
Martin Staudt ◽  
Andrea Guzzetta ◽  
Lisa Mailleux ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Hand Function ◽  
Brain Lesion ◽  
Mirror Movements ◽  
Unilateral Cerebral Palsy ◽  
The Brain

SPECIAL ARTICLE

PEDIATRICS ◽  
1956 ◽  
Vol 18 (5) ◽  
pp. 841-852
Author(s):  
W. L. Minear
Keyword(s):  
Cerebral Palsy ◽  
American Academy ◽  
Medical Record ◽  
Muscle Tone ◽  
Brain Lesion ◽  
Good Deal ◽  
The Other ◽  
Anatomical Site ◽  
First Choice

The majority of the members of the American Academy for Cerebral Palsy voted to exclude progressive neurological diseases and neoplastic diseases of the brain from the classification of cerebral palsy. The lesion left by the removal of a brain tumor, however, is still considered one of the etiological factors of cerebral palsy. Cerebral palsy comprises the motor and other symptom complexes caused by a non-progressive brain lesion (or lesions). The nomenclature and classification questionnaires indicate that the members of the American Academy for Cerebral Palsy wish to accept a motor classification, listing each type of cerebral palsy separately: Spastic, Athetoid, Tremor, Rigidity, Ataxic, Atonic, and Mixed. The following choices as a basis for classification of cerebral palsy were made by the American Academy for Cerebral Palsy: First choice: Motor Symptoms Second choice: Topographic Involvement Third choice: Etiology Fourth choice: Anatomical Site (of lesion) Fifth choice: Severity of Involvement Sixth choice: Degree of Muscle Tone Seventh choice: Supplemental Data The first 3 choices above should be used by the medical record librarian and by doctors discharging patients with cerebral palsy from hospitals or institutions so as to establish a common understanding and uniformity to hospital records. It is understood that the neuroanatomical classification (Fourth choice) is to be used when it can be proven, but not by presumption. The majority of the members approve of tension, non-tension, dystonic, and tremor-like types of athetosis. The other types were rejected for various reasons. Probably, some of the other types would have been accepted if understood by the members. Each type is described and defined herein. There is a general lack of agreement on the various terms used in cerebral palsy. Definitions of these terms are now being made by a committee for a meeting in 1955. There is a good deal of evidence that neurological signs and symptoms change in the child with cerebral palsy as the nervous system matures and that one must be cautious in making a final descriptive or symptomatic diagnosis in infancy. The pattern of changing neurological symptoms from infancy through childhood should be studied. The high cervical syndrome described by Fay is being confused with cerebral palsy. This syndrome needs further study. It should be determined whether the term cerebrospinal palsy would not be more appropriate for the entire neurological group. The American Medical Association's Standard Nomenclature of Diseases and Operations (Fourth Edition), commonly used by medical record librarians, is not suitable for the classification of cerebral palsy. In this edition, all cerebral palsy is coded "Cerebral spastic infantile paralysis" with supplementary terms added to denote various types. A complete classification for cerebral palsy is presented, using the majority opinion from questionnaires sent to the members of the American Academy for Cerebral Palsy during 1953 as a basis.

scholarly journals Impairments of Visuospatial Attention in Children with Unilateral Spastic Cerebral Palsy

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Gaétan Ickx ◽  
Samar M. Hatem ◽  
Inmaculada Riquelme ◽  
Kathleen M. Friel ◽  
Camille Henne ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Brain Lesion ◽  
Visuospatial Attention ◽  
Attention Deficits ◽  
Spastic Cerebral Palsy ◽  
Motor Impairments ◽  
Rehabilitation Process ◽  
Visuospatial Deficits ◽  
Periventricular Lesion ◽  
The Brain

Aim. This observational study aimed at assessing the prevalence of visuospatial attention deficits in children with unilateral spastic cerebral palsy (USCP), taking into consideration the affected hemibody and the localization of the brain lesion. Method. Seventy-five children with USCP were assessed with four visuospatial attention tests: star cancellation, Ogden figure copy, line bisection, and proprioceptive pointing. Results. A majority (64%) of children with USCP presented a deficit in at least one test compared to the reference values. The alterations observed in children with left or right USCP were related to egocentric or allocentric neglect, respectively. Children with cortico/subcortical lesion presented more often visuospatial attention deficits than children with periventricular lesion. Visuospatial attention deficits were not associated with brain lesion locations. Interpretation. Visuospatial attention deficits are prevalent in children with USCP and should be taken into account during their rehabilitation process. The present results shed new light on the interpretation of motor impairments in children with USCP as they may be influenced by the frequent presence of visuospatial deficits.

scholarly journals How does the interaction of presumed timing, location and extent of the underlying brain lesion relate to upper limb function in children with unilateral cerebral palsy?

2017 ◽  
Vol 21 (5) ◽  
pp. 763-772 ◽  
Author(s):  
Lisa Mailleux ◽  
Katrijn Klingels ◽  
Simona Fiori ◽  
Cristina Simon-Martinez ◽  
Philippe Demaerel ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Upper Limb ◽  
Brain Lesion ◽  
Limb Function ◽  
Upper Limb Function ◽  
Unilateral Cerebral Palsy
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