Research Article Association of HLA-G 14-base pair insertion/deletion polymorphism with breast cancer in Saudi Arabia

Background Nephrotic syndrome is related to immune system dysfunction. Soluble human leukocyte antigen-G has been suggested to have an immunomodulatory role. Additionally, human leukocyte antigen-G expression may be influenced by the 14-base pair insertion/deletion polymorphism. However, this molecule has not been investigated in nephrotic syndrome. Methods Fifty-five children with nephrotic syndrome were enrolled: 24 primary nephrotic syndrome patients and 31 recurrent nephrotic syndrome patients. A group of 120 healthy subjects were included as reference controls. Additionally, 22 patients in nephrotic syndrome remission after treatments were also included. Both nephrotic syndrome patients and healthy subjects were genotyped for the 14-base pair insertion/deletion polymorphism. Plasma soluble human leukocyte antigen-G concentrations and serum immunoglobulin concentrations were determined. Results Nephrotic syndrome patients showed significantly higher levels of both soluble human leukocyte antigen-G and immunoglobulin E compared to normal controls. Nephrotic syndrome patients presented a higher frequency of the −14-base pair allele than did normal controls. Soluble human leukocyte antigen-G concentrations in remission patients were dramatically lower compared to in nephrotic syndrome patients. Moreover, soluble human leukocyte antigen-G and immunoglobulin E were moderately correlated in nephrotic syndrome patients. Conclusions The present study demonstrated that plasma soluble human leukocyte antigen-G concentrations were significantly elevated and that a relationship between serum total immunoglobulin E in nephrotic syndrome patients and the human leukocyte antigen-G −14-base pair allele may be a risk factor for nephrotic syndrome. These findings suggest that soluble human leukocyte antigen-G may be used as a monitoring marker for nephrotic syndrome patients' condition.

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Lack of association between 4-base pair insertion/deletion (rs3783553) polymorphism within the 3′UTR of IL1A and breast cancer: A preliminary report

Gene Reports ◽

10.1016/j.genrep.2021.101067 ◽

2021 ◽

Vol 23 ◽

pp. 101067

Author(s):

Shima Karami ◽

Sahel Sarabandi ◽

Pouria Pourzand ◽

Farhad Tabasi ◽

Mohammad Hashemi ◽

...

Keyword(s):

Breast Cancer ◽

Base Pair ◽

Preliminary Report ◽

Base Pair Insertion

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The role of primary care centers in Saudi Arabia in the early detection of breast cancer

International Journal of Medicine in Developing Countries ◽

10.24911/ijmdc.51-1547634537 ◽

2019 ◽

pp. 620-624

Author(s):

Saad Alhumaidi ◽

Abdullah Alshehri ◽

Abdullah Altowairqi ◽

Ahmad Alharthy ◽

Bader Malki

Keyword(s):

Breast Cancer ◽

Primary Care ◽

Saudi Arabia ◽

Early Detection

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Knowledge, attitude, and practice of breast self-examination toward breast cancer among female students at King Saud University in Riyadh, Saudi Arabia

International Journal of Medicine in Developing Countries ◽

10.24911/ijmdc.51-1576668182 ◽

2020 ◽

pp. 429-434

Author(s):

Abdullah Alomair ◽

Dania Felemban ◽

Mohannad Felemban ◽

Jameel Awadain ◽

Ammar Altowairqi ◽

...

Keyword(s):

Breast Cancer ◽

Saudi Arabia ◽

Female Students ◽

Breast Self Examination ◽

King Saud University ◽

Attitude And Practice ◽

Self Examination ◽

Knowledge Attitude And Practice

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IS tRNA DRIVING BREAST CANCER PROGRESSION?

Pakistan Journal of Medicine and Dentistry ◽

10.36283/pjmd8-4/011 ◽

2019 ◽

Author(s):

Zil-e- Rubab

Keyword(s):

Breast Cancer ◽

Gene Expression ◽

Developing Countries ◽

Molecular Mechanism ◽

Cancer Progression ◽

Critical Review ◽

Driving Forces ◽

Treatment Modalities ◽

Critical Research ◽

Research Article

This critical research periodical is mainly based on critical review of research article titled ‘Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression published in Cell by Goodarzi et al1. According to Globocan, 2008 report2, breast is among the leading site of new cancer cases and deaths (691,300/268,900) in females of developing countries and second leading site in USA (Globocan, 2012)3. The extensive research is in progress on different aspects of molecular mechanism of driving forces and different treatment modalities to ease this burden. The above mentioned research article is also part of this effort.

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The Level of Lymphedema Awareness among Women with Breast Cancer in the Kingdom of Saudi Arabia

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18020627 ◽

2021 ◽

Vol 18 (2) ◽

pp. 627

Author(s):

Fatmah Alsharif ◽

Wedad Almutairi ◽

Faygah Shibily ◽

Fatmah Alhothari ◽

Fidaa Batwa ◽

...

Keyword(s):

Breast Cancer ◽

Saudi Arabia ◽

Soft Tissues ◽

Demographic Data ◽

Medical Team ◽

Online Questionnaire ◽

Kingdom Of Saudi Arabia ◽

Cross Sectional ◽

Convenience Sample ◽

The Status

Background: Lymphedema is a condition in which excessive fluid accumulates in soft tissues. It is a common complication of breast cancer treatments. It can lead to serious consequences and interfere with the activity of daily living. This study aimed to determine the level of awareness of breast-cancer-related lymphedema (BCRL) among women with breast cancer in the Kingdom of Saudi Arabia. This was a descriptive quantitative cross-sectional design that included a convenience sample of women diagnosed with breast cancer in the Kingdom of Saudi Arabia. Data were collected by distributing a self-administrated online questionnaire consisting of four parts, including demographic data (five items), the status of education about BCRL (three items), basic medical history of breast cancer (six items), and BCRL level of awareness of risk factors and management (nine items). Results: In total, 95 out of 135 of participants did not know about lymphedema, 119 of the participants (88.1%) did not receive any explanation about the possibility of lymphedema from their medical team before surgery, and 121 of them (89.6%) did not receive it after surgery. The most significant factor affecting participants’ level of awareness regarding BCRL was the lack of information about the possibility of BCRL occurrence, which was not provided to them by the medical team. Recommendation: Early and continuous education for future management is essential to prevent problems related to BCRL and improve quality of life.

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