Mice Pups Breastfed by Foster Mothers Whose Breast Milk Contains Plasmodium falciparum Recombinant SE36 Antigen Develop Specific Antibodies

SUMMAYWe studied the relationship between IgA anti–campylobacter flagellin antibodies in breast milk samples and protection of breastfed infants living in a rural Mexican village from campylobacter infection. There were fewer episodes of campylobacter infection (symptomatic and asymptomatic combined) in infants breastfed with milk containing specific anti-flagellin antibodies (1.2/child/year, 95% CI 0.6–1.8) versus non–breastfed children (3.3/child/year, 95% CI 1.8–4.8; P < 0.01). Infants breastfed with milk that was antiflagellin antibody negative by ELISA also had fewer episodes of infection compared with non-breastfed children, but the difference did not reach statistical significance (1.8/child/year, 95% CI 0.7–3.0 versus 3.3/child/year, 95% CI 1.8–4.8, P > 0.05). Breastfeeding has a protective effect against campylobacter infection and is associated with the presence of specific antibodies directed against campylobacter flagellin.

Download Full-text

Isotypic analysis of Plasmodium falciparum-specific antibodies and their relation to protection in Madagascar.

Infection and Immunity ◽

10.1128/iai.61.10.4498-4500.1993 ◽

1993 ◽

Vol 61 (10) ◽

pp. 4498-4500 ◽

Cited By ~ 8

Author(s):

B Dubois ◽

P Deloron ◽

P Astagneau ◽

C Chougnet ◽

J P Lepers

Keyword(s):

Plasmodium Falciparum ◽

Specific Antibodies

Download Full-text

The association between naturally acquired IgG subclass specific antibodies to the PfRH5 invasion complex and protection from Plasmodium falciparum malaria

Scientific Reports ◽

10.1038/srep33094 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 32

Author(s):

Rupert Weaver ◽

Linda Reiling ◽

Gaoqian Feng ◽

Damien R. Drew ◽

Ivo Mueller ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Falciparum Malaria ◽

Plasmodium Falciparum Malaria ◽

Igg Subclass ◽

Specific Antibodies

Download Full-text

Placental Malaria Induces Variant-Specific Antibodies of the Cytophilic Subtypes Immunoglobulin G1 (IgG1) and IgG3 That Correlate with Adhesion Inhibitory Activity

Infection and Immunity ◽

10.1128/iai.73.9.5903-5907.2005 ◽

2005 ◽

Vol 73 (9) ◽

pp. 5903-5907 ◽

Cited By ~ 27

Author(s):

Salenna R. Elliott ◽

Amy K. Brennan ◽

James G. Beeson ◽

Eyob Tadesse ◽

Malcolm E. Molyneux ◽

...

Keyword(s):

Plasmodium Falciparum ◽

Inhibitory Activity ◽

Placental Malaria ◽

Surface Antigens ◽

Phagocytic Cells ◽

Specific Antibodies ◽

Variant Surface Antigens ◽

And Control ◽

Chondroitin Sulfate A ◽

In Pregnancy

ABSTRACT Antibodies targeting variant antigens on the surfaces of chondroitin sulfate A (CSA)-binding malaria-infected erythrocytes have been linked to protection against the complications of malaria in pregnancy. We examined the isotype/subtype profiles of antibodies that bound to variant surface antigens expressed by CSA-adherent Plasmodium falciparum in pregnant Malawian women with and without histologically defined placental malaria. Women in their first pregnancy with placental malaria produced significantly greater amounts of immunoglobulin G1 (IgG1) and IgG3 reactive with surface antigens of malaria-infected erythrocytes than uninfected women of the same gravidity. IgG1 and IgG3 levels in infected and control women in later pregnancies were similar to those in infected women in their first pregnancy. Levels of IgG2 and IgG4 were similarly low in infected and uninfected women of all gravidities. IgM that bound to the surface of CSA-adherent P. falciparum occurred in all groups of women and malaria-naïve controls. There was a significant correlation between IgG1 and IgG3 levels, indicating that women usually produced both subtypes. Levels of IgG1 and IgG3 correlated with the ability of serum or plasma to inhibit parasite adhesion to CSA. Taken together, these data suggest that IgG1 and IgG3 dominate the IgG response to placental-type variant surface antigens. They may function by blocking parasite adhesion to placental CSA, but given their cytophilic nature, they might also opsonize malaria-infected erythrocytes for interaction with Fc receptors on phagocytic cells.

Download Full-text