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2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Thierry Roland Kang ◽  
Jerome Nyhalah Dinga ◽  
Ayuk Elizabeth Orock ◽  
Elvis Monya ◽  
Moses Njutain Ngemenya

Onchocerciasis is a parasitic infection affecting a relatively small population globally but has very devastating pathological outcomes. Ivermectin and recently moxidectin are the only drugs approved for clinical management of the disease, both of which have several limitations. In particular, they are efficacious against microfilariae (microfilaricidal) with no activity against adult worms (nonmacrofilaricidal). Promising anthelmintic activity has been reported in some lichens. This study investigated three lichens, Usnea articulata, Parmotrema tinctorum, and Heterodermia obscurata, found on Mount Cameroon, for potential macrofilaricidal activity. Organic extracts were screened for anti-Onchocerca activity against Onchocerca ochengi isolated from cattle skin using worm motility and MTT formazan assays. Toxicity of highly active extracts was investigated on monkey kidney epithelial (LLCMK2) cells and in BALB/c mice (2000 mg/kg body weight) including effects on liver enzymes. The methanol extract of P. tinctorum (Pammet) was the most active against adult male worms ( I C 50 = 8.1  μg/mL) with the highest selectivity index ( SI = 21.3 ). U. articulata was the most active against the adult female ( I C 50 = 36.3  μg/mL) but had a low SI value (3.4). No mortality and no adverse effects were recorded in the acute toxicity test. These two most active extracts had no significant effect on liver enzymes, alanine aminotransferase, and aspartate ( P values < 0.05), but a high AST : ALT ratio (2.59) for Pammet indicates likely reversible adverse hepatic toxicity. The high macrofilaricidal activity and selectivity of P. tinctorum suggest it is a potential source of new macrofilaricides which should be further investigated to identify its bioactive constituents.


Author(s):  
Yvonne Poufone Koffi ◽  
Jorelle Larissa Meli'i ◽  
Zakari Aretouyap ◽  
Marthe Mbond Ariane Gweth ◽  
Salomon César Nguemhe Fils ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Irene Ule Ngole Sumbele ◽  
Rene Ning Teh ◽  
Gillian Asoba Nkeudem ◽  
Sorelle Mekachie Sandie ◽  
Marcel Nyuylam Moyeh ◽  
...  

Abstract Background The Mount Cameroon area has experienced a 57.2% decline in confirmed malaria cases between 2006 and 2013 with the implementation of different control measures but, the disease is still of public health concern. The objective of the study was to assess the burden of asymptomatic and sub-microscopic Plasmodium infection, altitudinal influence on it, their effect on haematological parameters as well as identify the risk factors of infection. Methodology A cross-sectional community-based survey involving 1319 children of both sexes aged 6 months to 14 years was conducted between July 2017 and May 2018. Malaria parasitaemia was confirmed by Giemsa-stained microscopy, sub-microscopic Plasmodium infection by 18S mRNA using nested PCR and full blood count analysis was done using an auto haematology analyser. Results Malaria parasite, asymptomatic malaria parasitaemia and sub-microscopic Plasmodium infection and anaemia were prevalent in 36.4%, 34.0%, 43.8% and 62.3% of the children, respectively. The risk of having sub-microscopic Plasmodium infection was highest in children 5‒9 (OR = 3.13, P < 0.001) and 10‒14 years of age (OR = 8.18, P < 0.001), non-insecticide treated net users (OR = 1.69, P < 0.04) and those anaemic (OR = 9.01, P < 0.001). Children with sub-microscopic infection had a significantly lower mean haemoglobin (9.86 ± 1.7 g/dL, P < 0.001), red blood cell counts (4.48 ± 1.1 × 1012/L, P < 0.001), haematocrit (31.92%, P < 0.001), mean corpuscular haemoglobin concentration (313.25 ± 47.36, P = 0.035) and platelet counts (280.83 ± 112.62, P < 0.001) than their negative counterparts. Children < 5 years old (73.8%), having asymptomatic (69.8%) and sub-microscopic Plasmodium infection (78.3%) as well as resident in the middle belt (72.7%) had a higher prevalence of anaemia than their peers. Conclusion The meaningful individual-level heterogeneity in the burden of asymptomatic and sub-microscopic Plasmodium infection in addition to its corollary on haematological variables among children in the different attitudinal sites of the Mount Cameroon Region accentuate the need for strategic context specific planning of malaria control and preventative measures.


2021 ◽  
Vol 15 (8) ◽  
pp. 303-319
Author(s):  
Raoul Nkoue Ndondo Gustave ◽  
Eneke Takem Eyong Gloria ◽  
Ndjama Josephine ◽  
Eric Komba David ◽  
Ngo Boum Suzanne ◽  
...  

Author(s):  
Joseph Legrand TCHOP ◽  
Victor METANG ◽  
Jacques DİLİ-RAKE ◽  
Gaelle NANA ◽  
Pauline WOKWENMENDAM NGUET ◽  
...  

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Rene Ning Teh ◽  
Irene Ule Ngole Sumbele ◽  
Derick Ndelle Meduke ◽  
Gillian Asoba Nkeudem ◽  
Samuel Takang Ojong ◽  
...  

Abstract Background Insecticide-treated nets (ITNs) are the most widely used interventions for malaria control in Africa. The aim of this study was to assess the ownership and utilization of ITNs and the knowledge of malaria and their effects on malariometric and haematological indices in children living in the Mount Cameroon area. Methods A community-based cross-sectional study involving a total of 405 children aged between 6 months and 14 years living in Batoke–Limbe was carried out between July and October 2017. A semi-structured questionnaire was used to document demographic status, knowledge on malaria and ITN ownership and usage. Venous blood sample was collected from each child to determine the prevalence and intensity of parasitaemia by Giemsa-stained microscopy and full blood count by auto haematology analysis to obtain white blood cell (WBC) and red blood cell (RBC) counts, haemoglobin (Hb) level, haematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC). A multilinear regression model was used to determine the relationship between haematological parameter as dependent variable and the independent variables. Results The overall prevalence of parasitaemia, anaemia, knowledge about malaria, ITN ownership, usage and effective usage was 46.7%, 54.7%, 40.7%, 78.8%, 50.9% and 29.9%, respectively. The prevalence of parasitaemia was significantly higher (P < 0.001) in children who ineffectively utilized ITNs (54.9%) than effective users (27.3%). Having knowledge of malaria, negatively correlated with WBC counts (P = 0.005), but positively correlated with Hb levels (P < 0.001), RBC counts (P < 0.001), Hct (P < 0.001), MCV (P < 0.001) and MCH (P < 0.001). ITN use positively correlated with WBC counts (P = 0.005) but negatively with Hb levels (P = 0.004), RBC counts (P = 0.006), and MCH (P < 0.001). Meanwhile, parasitaemia negatively correlated with Hb levels (P = 0.004), RBC counts (P = 0.01), Hct (P = 0.04) and MCHC (P = 0.015). Conclusion There is need for more sensitization on the benefits of using the ITNs to meet up with the intended and expected impact of the free distribution of ITNs.


Kew Bulletin ◽  
2021 ◽  
Author(s):  
Martin Cheek ◽  
Nouhou Ndam ◽  
Andrew Budden

SummaryThis paper reports a further discovery of a new endemic threatened species to science in the context of botanical surveys in the lowland coastal forests of Mount Cameroon in the Cross River-Sanaga interval of west-central Africa. These studies now focus on species discovery and conservation through the Tropical Important Plant Areas programme. New species to science continue to be discovered from Mt Cameroon. Most of these species are rare, highly localised, and threatened by habitat destruction, increasing the justification for improved conservation management of surviving habitat. Drypetes burnleyae is placed in and keyed out in Drypetes sect. Stipulares, a group mostly confined to Lower Guinea, here adjusted to accommodate nine species. The conservation status of Drypetes burnleyae is assessed as Endangered (EN B1+2ab(iii)) according to the 2012 criteria of the International Union for the Conservation of Nature. An updated overview of the plant endemics of Mt Cameroon is presented.


Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1161
Author(s):  
Štěpán Janeček ◽  
Kryštof Chmel ◽  
Francis Luma Ewome ◽  
Karolína Hrubá ◽  
Yannick Klomberg ◽  
...  

Despite a growing number of studies, the role of pollinators as a selection agent for nectar traits remains unclear. Moreover, the lack of data from some biogeographic regions prohibits us from determining their general importance and global patterns. We analyzed nectar carbohydrate traits and determined the main pollinators of 66 plant species in the tropical forests of Mount Cameroon (tropical West Africa). The measured nectar traits included total sugar amounts and proportions of sucrose and hexoses (i.e., glucose and fructose). We report the nectar properties for plants visited by five pollinator groups (bees, butterflies, moths, hoverflies, and specialized birds). Our results indicate that, rather than specific evolution in each of the five plant groups, there was a unique nectar-trait evolution in plants pollinated by specialized birds. The ornithophilous plants had a higher proportion of sucrose and produced larger sugar amounts than the plants pollinated by insects. We also demonstrated a significant phylogenetic signal in the nectar properties in some lineages of the studied plants.


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