campylobacter infection
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2022 ◽  
Vol 2022 ◽  
pp. 1-3
Author(s):  
Krystal Hasel ◽  
Ahlaa Salim ◽  
Paul Adjei ◽  
Jeremy D. Gradon

Intra-abdominal abscesses mostly derive from the intra-abdominal viscera. Campylobacter spp. are Gram-negative rods which are known to cause oral infections but rarely have been documented to cause extra-intestinal infections resulting in abscesses. We report an atypical case of Campylobacter rectus (C. rectus) and Peptostreptococcus spp. bacteria isolated from a perinephric abscess presenting as abdominal pain. Abscesses originating from outside the gastrointestinal tract have been reported in other similar case reports infecting the head, brain, and thoracic wall amongst others. The potential source and development of such a Campylobacter infection could be due to multiple hypotheses. This is a first case report of perinephric abscess development. Studies have suggested person-to-person (fecal-oral) transmission along with insects serving as primary reservoirs. Seeding of bacteria through infections in the oral cavity or through infections in the bowel microperforations has also been considered as plausible reasons. Since C. rectus has been isolated in such rare instances, it should be kept in mind when considering differential diagnosis of potential causative agents for extra-oral infections such as invasive abscess formations.


2022 ◽  
Vol 14 (1) ◽  
pp. 56-62
Author(s):  
Blair Merrick ◽  
Aravind Gokul Tamilarasan ◽  
Raphael Luber ◽  
Patrick F. K. Yong ◽  
Kuldeep Cheent ◽  
...  

There is limited evidence to guide successful treatment of recurrent Campylobacter infection in patients with common variable immunodeficiency (CVID) already managed on regular immunoglobulin therapy. The role of faecal microbiota transplant (FMT) is uncertain. We report a case of recurrent Campylobacter jejuni infection in a patient with CVID treated with repeated FMT with 18 months of symptom resolution prior to relapse.


2022 ◽  
Vol 4 (1) ◽  
Author(s):  
Maxine Ty ◽  
Khaled Taha-Abdelaziz ◽  
Vanessa Demey ◽  
Mathieu Castex ◽  
Shayan Sharif ◽  
...  

Abstract Background Antibiotic growth promoters (AGPs) are commonly used within poultry production to improve feed conversion, bird growth, and reduce morbidity and mortality from clinical and subclinical diseases. Due to the association between AGP usage and rising antimicrobial resistance, the industry has explored new strategies including the use of probiotics and other microbial-based interventions to promote the development of a healthy microbiome in birds and mitigate against infections associated with food safety and food security. While previous studies have largely focused on the ability of probiotics to protect against Clostridium perfringens and Salmonella enterica, much less is known concerning their impact on Campylobacter jejuni, a near commensal of the chicken gut microbiome that nevertheless is a major cause of food poisoning in humans. Results Here we compare the efficacy of four microbial interventions (two single strain probiotics, the bacterium—Pediococcus acidilactici, and the yeast—Saccharomyces cerevisiae boulardii; and two complex, competitive exclusion, consortia—Aviguard and CEL) to bacitracin, a commonly used AGP, to modulate chicken gut microbiota and subsequently impact C. jejuni infection in poultry. Cecal samples were harvested at 30- and 39-days post hatch to assess Campylobacter burden and examine their impact on the gut microbiota. While the different treatments did not significantly decrease C. jejuni burden relative to the untreated controls, both complex consortia resulted in significant decreases relative to treatment with bacitracin. Analysis of 16S rDNA profiles revealed a distinct microbial signature associated with each microbial intervention. For example, treatment with Aviguard and CEL increased the relative abundance of Bacteroidaceae and Rikenellaceae respectively. Furthermore, Aviguard promoted a less complex microbial community compared to other treatments. Conclusions Depending upon the individual needs of the producer, our results illustrate the potential of each microbial interventions to serve flock-specific requirements.


2021 ◽  
Vol 888 (1) ◽  
pp. 012021
Author(s):  
N Herlina ◽  
N D Yanthi ◽  
R D Pratiwi ◽  
K S Dewi ◽  
F Setiyoningrum ◽  
...  

Abstract The cytolethal distending toxins (cdt) is a multi-subunit toxin consisted of three subunit encoded cdtA, cdtB and cdtC. The cdt played an important role as a virulence factor of Campylobacter infection, including C. fetus subsp venerealis. The cdtA which responsible for binding the cdt to cell membrane, was cloned in plasmid expression and inserted into bacterial cells of Escherichia coli BL21(DE3). The research was conducted to evaluate the transformation using the heat shock method of a plasmid containing cdtA3 gene and the protein expression induced by various concentration of IPTG. Transformation was done using the heat shock method at 42oC for 90 second. Evaluation of the transformation was observed on the presence of E. coli BL21(DE3) colonies on Luria Bertani agar containing Ampicillin antibiotic with 100 µg/mL dosage. The recombinant protein was expressed using IPTG-induction with various concentration (0.1mM, 0.25mM, 0.5mM, 0.75mM and 1 mM). The result showed that the transformation and IPTG-induction 0.1 mM produced higher concentration of protein than other concentration applied. The protein characterization was observed with SDS PAGE and cdtA3 protein was detected on 23,4 kDa.


Author(s):  
Wayne T. Muraoka ◽  
Anna A. Korchagina ◽  
Qingqing Xia ◽  
Sergey A. Shein ◽  
Xi Jing ◽  
...  

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 85-85
Author(s):  
Ziming Dou ◽  
Elena Naumova ◽  
Ryan Simpson ◽  
Lauren E Sallade ◽  
Yutong Zhang ◽  
...  

Abstract Objectives In order to effectively mitigate the effects of climate change on human health, spatiotemporal relationships between Campylobacter infections and environmental drivers have to be systematically examined to determine whether common seasonal summer peaks observed in Campylobacter infections are well aligned with peaks in raising ambient temperatures.  This study aims to evaluate the seasonal relationship between monthly ambient temperature and the monthly Campylobacter infections routinely collected by the CDC Foodborne Diseases Active Surveillance Network (FoodNet) in the United States in 2010–2019. Methods We created time series of monthly Campylobacter infection rates from the FoodNet Fast platform for ten participating states from January 2010 to December 2019 (120 months). We estimated average monthly temperatures for the ten states for the study period using the National Climate and Data Center's Global Summary of the Day database. To assess the seasonal synchronization and determine the lag effect, we used serial cross-correlation analysis. To examine the associations between Campylobacter rates with ambient temperature and adjust for seasonality and trend, we applied a harmonic negative binomial mixed-effects regression model. We also estimated peak timing and amplitude for infections and temperature using the δ-method. Results Serial synchronization between monthly Campylobacter infection rates and ambient temperature was observed in all FoodNet Surveillance states except for California. A one-month delay in peak infection after the peak in temperature was detected in Colorado, Connecticut, Maryland, Minnesota, New Mexico, New York, and Oregon.  After adjusting for seasonality and trend across ten states, the relative risk of infection rates increased by 5% with the increase in monthly average temperature by 5.45°C equivalent to a shift from 75th to 95th percentile (95%CI: 1.02–1.09, p < 0.002). Conclusions An increase in monthly average temperature is associated with an increased risk of Campylobacter infection after adjusting for common summer seasonal patterns. Knowledge of the relationship will potentially improve the reliability and accuracy of integrated early warning outbreak forecasts and could guide climate mitigation strategies. Funding Sources None.


2021 ◽  
pp. 219-228
Author(s):  
Pooja Choudhary ◽  
Aruna Punia ◽  
Sweety Dahiya ◽  
Namita Sharma ◽  
Meenakshi Balhara ◽  
...  

2021 ◽  
Vol 27 (4) ◽  
pp. 1133-1140
Author(s):  
Katrin Gaardbo Kuhn ◽  
Anne Kathrine Hvass ◽  
Annette Hartvig Christiansen ◽  
Steen Ethelberg ◽  
Susan Alice Cowan

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