scholarly journals Predictive hematological and immunological parameters associated with postpartum progressed Covid-19 disease

2021 ◽  
Vol 21 (4) ◽  
pp. 1567-73
Author(s):  
Fatma Bozkurt ◽  
Omer Coskun ◽  
Sevda Yelec
Keyword(s):  
Blood Cell ◽  
Pregnant Women ◽  
Inflammatory Markers ◽  
Immunological Parameters ◽  
Laboratory Findings ◽  
Neutrophil Lymphocyte Ratio ◽  
Infection Disease ◽  
D Dimer ◽  
High Bmi ◽  
In Pregnancy

Background: In pregnancy, Coronavirus disease-2019 (COVID-19) infection disease may be more severe due to existingphysiological changes. Similarly, changes during and after birth can make the patient more subceptible. Objective: To investigate possible laboratory findings that was related to postpartum progression of COVID-19 disease. Methods: Pregnant women who are pregnant at 28 weeks or more and who are COVID-19 positive at the time of delivery were investigated in this study. Progressed post- delivery and non-progressed COVID-19 positive pregnants’ laboratory findings were analyzed. Hematological and immunological parameters associated with postpartum progressed COVID-19 disease were evaluated. Results: Totally 151 individuals were conducted to the study. In the prenatal analysis, higher BMI and lower albumin levels were detected in the progressed group (p<0.05). In the postpartum analysis; White Blood Cell, lymphocyte and albumin were increased, while neutrophil, NLR, LDH, CK, D-DIMER, Ferritin, CRP and IL-6 were decreased in the non-progressed group as opposite of the progressed group (p<005). Conclusion: We observed that prenatal low albumin and high BMI may be related to progression of the COVID-19 disease after delivery. In progressed group, inflammatory markers were increased after delivery while in non-progressed group they were improved. These markers may be warning for the postpartum progression of COVID-19 disease. Keywords: COVID-19; delivery; albumin; neutrophil-lymphocyte ratio; pregnancy.

Concentration of fibrin monomer in pregnancy and during the postpartum period

2019 ◽  
Vol 56 (6) ◽  
pp. 692-700
Author(s):  
Ann Helen Kristoffersen ◽  
Per Hyltoft Petersen ◽  
Line Bjørge ◽  
Thomas Røraas ◽  
Sverre Sandberg
Keyword(s):  
Venous Thromboembolism ◽  
Pregnant Women ◽  
Postpartum Period ◽  
Monomer Concentration ◽  
Blood Samples ◽  
Fibrin Monomer ◽  
Three Samples ◽  
Pregnancy And Postpartum ◽  
D Dimer ◽  
In Pregnancy

Background D-dimer increases during pregnancy and is problematic to use in the diagnosis of venous thromboembolism. Fibrin monomer represents an alternative biomarker for venous thromboembolism. However, to be useful in pregnancy, the fibrin monomer concentration should be stable throughout pregnancy and during postpartum. Methods To describe the course of fibrin monomer concentration during pregnancy and the postpartum period in healthy pregnant women and to compare their within-subject biological variation (CVI) with non-pregnant women. Blood samples were obtained every fourth week during pregnancy and three samples after delivery in 20 healthy women and every fourth week during a 40-week period in 19 healthy non-pregnant women. Fibrin monomer (STA Liatest FM, Stago) was analysed in duplicates for all samples. Concentrations of fibrin monomer in pregnant and non-pregnant women were compared and the CVI for fibrin monomer was calculated. Results The median fibrin monomer concentration in pregnant women was 6.2 mg/L (2.5 and 97.5 percentiles 3.7–10.8 mg/L) and in non-pregnant women 4.8 mg/L (3.6–8.2) ( P < 0.01). The fibrin monomer concentration was relatively stable during pregnancy, although a few unexplained high fibrin monomer concentrations were found during pregnancy/postpartum. Fibrin monomer CVI in pregnancy and postpartum was 20.6% (95% CI 18.3, 23.5) and in non-pregnant 16.1% (13.7, 18.9). Conclusions For clinical purposes, fibrin monomer concentration can be considered stable during pregnancy, although it is slightly higher than in non-pregnant women. Pregnant and non-pregnant women have the same CVI. The suitability of fibrin monomer in venous thromboembolism diagnosis in pregnant women should be validated in further studies.

A Red Blood Cell Agglutination d-Dimer Test to Exclude Deep Venous Thrombosis in Pregnancy

2008 ◽  
Vol 63 (1) ◽  
pp. 1-2
Author(s):  
Wee-Shian Chan ◽  
Sanjeev Chunilal ◽  
Agnes Lee ◽  
Mark Crowther ◽  
Jeffrey S. Ginsberg
Keyword(s):  
Blood Cell ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Red Blood Cell ◽  
Cell Agglutination ◽  
D Dimer ◽  
In Pregnancy

A Red Blood Cell Agglutination d-Dimer Test to Exclude Deep Venous Thrombosis in Pregnancy

2007 ◽  
Vol 147 (3) ◽  
pp. 165 ◽  
Author(s):  
Wee-Shian Chan ◽  
Sanjeev Chunilal ◽  
Agnes Lee ◽  
Mark Crowther ◽  
Marc Rodger ◽  
...  
Keyword(s):  
Blood Cell ◽  
Venous Thrombosis ◽  
Deep Venous Thrombosis ◽  
Red Blood Cell ◽  
Cell Agglutination ◽  
D Dimer ◽  
In Pregnancy

scholarly journals Perinatal determinants of D-dimer levels in a cross-sectional study of low risk pregnant women

2016 ◽  
Vol 9 (2) ◽  
pp. 78-82
Author(s):  
NM Murphy ◽  
AS Khashan ◽  
DI Broadhurst ◽  
O Gilligan ◽  
K O’Donoghue ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Pregnant Women ◽  
Vaginal Delivery ◽  
Elective Caesarean Section ◽  
Mode Of Delivery ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
D Dimer ◽  
In Pregnancy

Background To examine perinatal determinants of the antenatal levels of D-dimers. Methods Cross-sectional study of 760 low risk pregnant women recruited into five gestational groups. Variables examined in antenatal groups included maternal age, body mass index, parity, smoking, family history venous thromboembolism (VTE) and previous use of the oral contraceptive pill (OCP). Onset of labour and mode of delivery were also examined in the post-natal group. Results D-dimer levels in group 4 (38–40 + 6) were significantly lower in the women with a history of taking the OCP when compared to those that had not taken it in the past ( P = 0.027). In the day 2 post-natal group, the median level of D-dimer was significantly higher in primparous when compared to multiparous women ( P = 0.015). The median D-dimer levels were significantly lower in the elective Caesarean section group in comparison to spontaneous onset ( P = 0.003) and induction of labour ( P = 0.016). When the mode of delivery was examined, the median D-dimer levels were significantly lower in those that had an elective Caesarean section when compared to normal vaginal delivery ( P = 0.008) and instrumental vaginal delivery ( P = 0.007). Women post elective Caesarean section had a significantly lower D-dimer than those after emergency Caesarean section ( P = 0.008). Discussion There are some significant differences in D-dimer levels when certain perinatal determinants are examined. This work is potentially beneficial to the future diagnosis of VTE in pregnancy as it supports previously published recommended D-dimer levels for the diagnosis of VTE in pregnancy.

scholarly journals Inflammatory laboratory findings associated with severe illness among hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional study

F1000Research ◽  
2022 ◽  
Vol 10 ◽  
pp. 1246
Author(s):  
Darmadi Darmadi ◽  
Cennikon Pakpahan ◽  
Riska Habriel Ruslie ◽  
Andri Rezano
Keyword(s):  
Cross Sectional Study ◽  
Tnf Alpha ◽  
Severe Illness ◽  
Cytokine Storm ◽  
Sectional Study ◽  
Laboratory Findings ◽  
Cross Sectional ◽  
Ifn Gamma ◽  
Neutrophil Lymphocyte Ratio ◽  
D Dimer

Background: Coronavirus disease (COVID-19) remains a global health problem. COVID-19 patients with severe pneumonia have a higher risk for critical illness, mostly complicated by acute respiratory distress syndrome. The inflammatory response is critical, and the cytokine storm increases the severity of COVID-19. Many factors could be associated with a cytokine storm but they are incompletely understood. This study presents characteristics of COVID-19 patients and explore the clinical and inflammatory parameters of severe and critically ill COVID-19 patients in the intensive care unit (ICU). Method: This cross-sectional study was conducted in all severe COVID-19 patients admitted to the ICU. Peripheral blood was taken for laboratory examination within 24 hours of admission. Haematologic parameters, serum electrolyte, renal function, liver function, pancreas enzyme, D-dimer, inflammatory cytokines interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP) were assessed in this study. Comparative analyses were done between sex, existing comorbidities, body mass index (BMI), and COVID-19 vaccination status. Results: A total of 80 subjects were included in the study. The most frequent comorbidities found among the subjects were obesity (36.35%) and diabetes (22.5%). Only 13.75% of subjects were vaccinated. Laboratory results indicated leucocytosis and neutrophilia, with a neutrophil-lymphocyte-ratio (NLR) of 7. The mean inflammatory findings (IL-6, IL-10, TNF-alpha, IFN-gamma, MCP-1), D-dimer, CRP, and lipase increased. Lipase levels were higher in men (p = 0.003) and in comorbidity groups. No significant differences were found among different BMI groups. Lipase, IL-6, and MCP-1 levels were significantly higher (p=0.019, <0.0001, and 0.03, respectively) in the non-vaccinated group. Conclusions: Most patients with severe COVID-19 have comorbidities and increased inflammatory markers.

scholarly journals Red blood cell alloimmunization in pregnancy: A 10-year single-centre study

2021 ◽  
pp. 16-16
Author(s):  
Nevenka Bujandric ◽  
Jasmina Grujic ◽  
Zorana Budakov-Obradovic
Keyword(s):  
Blood Cell ◽  
Pregnant Women ◽  
Red Blood Cell ◽  
Developed Countries ◽  
Subsequent Pregnancy ◽  
Automated System ◽  
Published Data ◽  
The South ◽  
Negative Effects ◽  
In Pregnancy

Background/Aim. Pregnancy-induced red blood cell (RBC) alloimmunization is important not only because of the possible negative effects on subsequent pregnancy outcomes, in case the fetus carries the antigen, but also because of the optimal transfusion management in cases of obstetric haemorrhage. Timely detection of RBC antibodies is part of a testing, prevention and treatment strategy aimed at achieving better outcomes for alloimmunized mothers with an affected fetus. The aim was to determine the frequency and specificity of alloantibodies among pregnant women from the South Backa District, with special attention to the incidence of anti-D alloantibody. Methods. A retrospective study was conducted from January 1, 2010 to December 31, 2019 in the Blood Transfusion Institute of Vojvodina. Screening and antibody identification were performed by an indirect antiglobulin test in gel-microcards (ID-Card Liss/Coombs) with two test RBC (ID-DiaCell I-II screening cells, Bio-Rad, Cressier, Switzerland), on an automated system (IH-500, Bio-Rad). Results. Among 25694 tested pregnant women 1.38% were actively immunized, while 1.12% antibodies was identified in the current pregnancy. Among 3622 (14.09%) RhD-negative women 1.77% with anti-D produced during the ongoing pregnancy were found. Distribution of antibody specificity was: anti-D 23.34%, anti-M 11.85%, anti-E 9.41%, anti-K 9.41%, anti-C 5.92%, anti-Fyb 5.92%, anti-c 3.13%, anti-S 3.13%, anti-Lea 3.13%, anti-Leb 3.13%, anti-Cw 1.75%, anti-Jka 1.40%, anti-P 1.05%, anti-Lub 0.70%, anti-Fya 0.35%, autoantibody of undetermined specificity 0.70%, and irregular antibodies of undetermined specificity 15.68%. Conclusion. Immune globulin prophylaxis has led to a significant reduction in the frequency of D alloimmunization among pregnant women in the South Backa District over the last ten years, but the incidence of anti-D is still significantly higher than in published data for developed countries. We also identified the other, less commonly present, clinically significant antibodies. There is a need to introduce uniform recommendations for immunohematological testing in pregnancy on the territory of the Republic of Serbia, in accordance with modern requirements.

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