scholarly journals Males' non-enhancement of bruce and whitten effects in female albino mice - Mus musculus

2010 ◽  
Vol 6 (3) ◽  
Author(s):  
IS Ochiogu ◽  
CF Oguejiofor ◽  
AN Nwagbo
Keyword(s):  
Mus Musculus ◽  
Albino Mice

scholarly journals Effect of Poly (N-IsoPropylAcrylamide) “PNIPAM” on Hepatic Cells of Swiss Albino Mice, Mus musculus

2013 ◽  
Vol 1 (4) ◽  
pp. 208-213 ◽  
Author(s):  
Md. Imtiyaz Aslam ◽  
Rohit Kumar Verma ◽  
Richa Roy ◽  
S. P. Roy
Keyword(s):  
Aqueous Solution ◽  
Mus Musculus ◽  
Quantitative Estimation ◽  
Polymeric Compound ◽  
Swiss Albino Mice ◽  
Hepatic Cells ◽  
Isopropyl Acrylamide ◽  
Albino Mice ◽  
Xenobiotic Compound ◽  
Histological Result

The present paper deals with the effect of polymeric compound poly (N-isopropyl acrylamide) “PNIPAM” for their toxicity on hepatic cells. The nanoparticle is a xenobiotic compound that accumulates in the liver for their metabolism. Non-metabolizing xenobiotic compounds such as PNIPAM produces anomalies in the hepatic cells. Certain enzymes such as ALT and ALP can be assayed for the hepatocytic toxicity.An attempt has been made to know the toxic effect of “PNIPAM” in a concentration of 0.8mg/ml on the hepatic cells of Swiss Albino mice, Mus musculus. The ALT and ALP analysis were performed through test kits for their quantitative estimation. The histological result shows that several lesions were produced after the introduction of aqueous solution of PNIPAM for an incubation period of 48 hours. The toxicity was confirmed Spectrophotometrically by the assessment of enzyme ALT and ALP. The increased concentration of ALT (55.0 IU/L) and slight decrease in ALP (40.0 IU/L) concentration was responsible for the metabolic alteration and production of hepatocytic anomalies in the mice.DOI: http://dx.doi.org/10.3126/ijasbt.v1i4.9104    Int J Appl Sci Biotechnol, Vol. 1(4): 208-213

scholarly journals Arsenic induced genotoxic and histopathological changes in male Swiss albino mice, Mus musculus

2011 ◽  
Vol 3 (2) ◽  
pp. 329-339
Author(s):  
Animesh K. Mohapatra ◽  
Deepika Rai ◽  
Anika Tyagi
Keyword(s):  
Arsenic Trioxide ◽  
Mus Musculus ◽  
Seminiferous Tubules ◽  
Histopathological Changes ◽  
Histological Changes ◽  
Hydropic Degeneration ◽  
Swiss Albino Mice ◽  
Cytoplasmic Vacuolization ◽  
Liver And Kidney ◽  
Albino Mice

The present study was carried out to investigate the effect of arsenic trioxide on the DNA and histomorphology of testis, liver and kidney of Swiss albino mice, Mus musculus. Oral administration of arsenic trioxide induced DNA damage in the testis, liver and kidney marked by light pink staining of nuclei after Feulgen’s reaction with reduced fine chromatin. Simultaneously severe histological changes were noted like distortion of seminiferous tubules, disorganization of spermatogonia, spermatocytes and spermatids with cytoplasmic vacuolization and nuclear pycnosis in testis. There was almost disappearance of sinusoids due to disruption of hepatic plates, inflammatory cellular infiltration around central veins and cytoplasmic vacuolization in hepatocytes with large irregular nuclei in liver of treated mice. Disorganized glomeruli with distorted Bowman’s capsules and mild to severe multifocal cloudy and hydropic degeneration with necrosis of tubules were observed in the kidney of treated mice. Inference drawn from the study indicated that arsenic induced both genotoxic histotoxic lesions.

scholarly journals PENGARUH TRITERPEN TOTAL PEGAGAN (Centella asiatica (L) Urban) TERHADAP FUNGSI KOGNITIF BELAJAR DAN MENGINGAT PADA MENCIT JANTAN ALBINO (Mus musculus) YANG DIHAMBAT DENGAN SKOPOLAMIN

Molekul ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. 89
Author(s):  
Herlina Herlina
Keyword(s):  
Cognitive Function ◽  
Learning And Memory ◽  
Mus Musculus ◽  
Memory Performance ◽  
Centella Asiatica ◽  
Positive Control ◽  
Negative Control ◽  
Learning Ability ◽  
Control Group ◽  
Albino Mice

Pegagan (Centella asiatica (L) Urban) has been described to posses CNS effects such as improving cognitive function, learning and memory. The aim of the research was to evaluate the effects of total triterpen’s pegagan extract on cognitive functions as the learning and memory performance in male albino mice (Mus musculus) inhibited by scopolamine. The research design was Complete Randomized Design (RAL) – factorial on thirty six mice divided into 4 groups. One control group received only aquabidest (negative control). Three treatment groups received total triterpen 16 mg/kg BW, 32 mg/kg BW orally and piracetam 500 mg/kg BW by intra peritoneally (positive control) for 21 days. Data indicating learning and memory process of all subjects were obtained from one-trial passive avoidance test. Data were analyzed by two way ANOVA and BNT (p<0,05). Result showed that total triterpen 32 mg/kg BW had significantly prolonged the retention time compared to control group indicating improvement in cognitive function (505,03 second vs -18,53 second) (p<0,05) and it was not significantly different to piracetam 500 mg/kg BW group (505,03 second vs 522,48 second) (p>0,05). In conclusion, total triterpen from pegagan (Centella asiatica (L) Urban) improved learning ability and memory of male albino mice (Mus musculus) even though, it was inhibited by scopolamine.

scholarly journals RUELLIA TUBEROSA LINN. ACTS AS ANTI-FERTILITY AGENT THAT REDUCES SPERM COUNT, MOTILITY AND VIABILITY IN MALE SWISS ALBINO MICE (MUS-MUSCULUS)

2016 ◽  
Vol 9 (1) ◽  
pp. 105
Author(s):  
Pardeshi M. H. ◽  
Deshmukh A. A. ◽  
Gajare K. A.
Keyword(s):  
Mus Musculus ◽  
Sperm Count ◽  
Positive Control ◽  
Male Reproduction ◽  
Control Group ◽  
Global Public Health ◽  
Control Groups ◽  
Swiss Albino Mice ◽  
Sperm Suspension ◽  
Albino Mice

Objective: Fertility control is an issue of global public health. Many of the contraceptives available today have one or the other side effects. Many plants and plant products are suggested as contraceptives in folk and traditional systems of medicine. However, that are least exploited in this regard. In the present investigation, root powder of Ruellia tuberosa was studied for its effect on male reproduction in mice.Methods: The Swiss albino mice, Mus musculus of age three months were grouped into four, i)control group, fed on standard pellet, ii)experimental groups I and II received root powder of Ruellia tuberosa 50 mg/mouse/days for 15 d and 30 d respectively in the pellets, iii)positive control groups I and II received cotton seed oil 25 µl/mouse/day for 15 and 30 d and iv)recovery group received Ruellia tuberosa (50 mg/mouse/days) containing pellets for 15 d and later standard pellet for 15 d. Cauda epididymis sperm suspension was analyzed for sperm count, motility and viability.Results: There was a highly significant decrease in sperm count, motility and viability (p<0.001) in experimental groups I and II and positive control groups I and II. The sperm count was reduced to 19.24±1.74 million/ml and 15.97±5.61 million/ml as compared to sperm count in control group (55.12±4.63 million/ml) in experimental groups. Partial reversal of the effect was noticed in a recovery group.Conclusion: The results suggest that Ruellia tuberosa can be a potent member of reversible oral male contraceptives.

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