scholarly journals High seroprevalence of specific Toxoplasma gondii IgG antibodies among HIV/AIDS patients with immunological failure attending a tertiary hospital in northwestern Tanzania

2015 ◽  
Vol 18 (1) ◽  
Author(s):  
Mariam M. Mirambo ◽  
Charles Kivambe ◽  
Martha F. Mushi ◽  
Maria Zinga ◽  
Elifuraha B. Mngumi ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Treatment Failure ◽  
World Health ◽  
Igg Antibodies ◽  
Aids Patients ◽  
Immunological Failure ◽  
Immunological Treatment ◽  
Study Participants ◽  
Immunological Treatment Failure ◽  
Hiv Aids

 Toxoplasmosis is a major cause of morbidity and mortality among patients with advanced HIV disease. However, there is limited data on the magnitude of toxoplasmosis among HIV patients with immunological treatment failure. Therefore, this study was designed to determine the seroprevalence of specific Toxoplasma gondii IgG antibodies among HIV/AIDS patients attending Bugando Medical Centre in Mwanza, Tanzania. Immunological treatment failure was defined using the World Health Organization (WHO) criteria and specific T.gondii IgG antibodies were determined using indirect enzyme linked immunosorbent (ELISA). A total of 178 non-repetitive sera from HIV/AIDS patients were analyzed. The mean age of study participants was 38.5±11.3 years. Majority of study participants were males 120 (67.42%). Out of 178 patients, 38 (21.34%) were diagnosed to have immunological failure. T.gondii specific IgG antibodies were found in 26 (68.4%) of the patients with immunological failure compared to 46 (32.86%) of those without immunological failure (OR: 4.42, CI: 2.05-9.55; p<0.001). The seroprevalence of T.gondii infection is high among patients with immunological treatment failure and place them at a high risk of T. gondii encephalitis necessitating sustained trimethoprim-sulfamethaxazole prophylaxis to prevent reactivation.   

Factors associated to first line antiretroviral therapy (ART) failure among HIV/AIDS patients at Sanglah Hospital, Bali

2017 ◽  
pp. 4
Author(s):  
Cok Istri Sri Dharma Astiti ◽  
A.A Sagung Sawitri ◽  
Tuti Parwati
Keyword(s):  
Risk Factors ◽  
Treatment Failure ◽  
Clinical Stage ◽  
Hiv And Aids ◽  
First Line ◽  
Aids Patients ◽  
Factors Associated ◽  
Art Initiation ◽  
Risk Of Treatment ◽  
Hiv Aids

Background and purpose: The incidence of first line ART failure is increasing in the South East Asia region. The main referral hospital in Bali has recorded an increased use of second line ART due to the first line ART failure. This study aims to explore risk factors associated to first line ART failure.Methods: A case control study was conducted among people living with HIV and AIDS at Sanglah Hospital Denpasar who started first line ART between 2004 and 2013. Cases were those who diagnosed as having clinical treatment failure and still on treatment in 2015. Controls were those with no treatment failure. Sex and year of ART initiation were matched between case and control. Data were obtained from medical records that include initial regiments, HIV mode of transmission, the WHO HIV clinical stage, CD4 count, opportunistic infections, body mass index, hemoglobin level, and drug substitution at the beginning and during treatment. Risk factors were analysed using logistic regression.Results: Out of 68 HIV/AIDS patients with clinical ART failure, 72.1% were confirmed with immunological and 36.8% were confirmed with virological failure. Median time before treatment failure was 3.5 years. Factors associated to ART failure were HIV clinical stage IV with (AOR=3.43; 95%CI=1.65-7.13) and being widow/widower (AOR=4.85; 95%CI=1.52-15.53). Patients with TB co-infection have a lower risk for treatment failure due to early diagnosis and treatment through TB-HIV program with (AOR=0.32; 95%CI=0.14-0.70).Conclusions: Higher HIV clinical stage at ART initiation increases the risk of treatment failure. HIV-TB co-infection indirectly reduces the risk of treatment failure.

scholarly journals Toxoplasmosis in Pregnant Women and HIV/AIDS Patients in Ethiopia: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Daniel Getacher Feleke ◽  
Angesom Gebreweld ◽  
Gashaw Zewde
Keyword(s):  
Systematic Review ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Group Analysis ◽  
Aids Patients ◽  
Pooled Prevalence ◽  
Women And Hiv ◽  
And Control ◽  
Hiv Aids

Background. Although Toxoplasma gondii infection in immune-competent individuals is usually asymptomatic or causes a mild flu-like illness, it may become severe and can occasionally be fatal in immune-compromised people, such as AIDS patients or pregnant women. Method. Electronic English databases (Pubmed, Google Scholar, Science Direct, and Scopus), parasitology congresses, and theses of Ethiopian medical universities, were systematically searched (published or unpublished data). Full-length articles and abstracts were collected using keywords such as Toxoplasma gondii, Toxoplasmosis, pregnant women, HIV/AIDS, and Ethiopia. Results. Analysis of seroprevalence estimates was pooled using a random effects meta-analysis. Seventeen studies were included in the present systematic review and meta-analysis. One of these studies reported seroprevalence of T. gondii in HIV/AIDS patients and pregnant women. In this review, a total of 4,030 individuals were included and analyzed. The pooled prevalence of T. gondii in this review was 81.00% (95% CI = 69.10–89.78). Sub-group analysis showed that 2,557 pregnant women were evaluated. In pregnant women, the pooled sero-prevalence was 71.2 (95% CI = [51.9%, 87.1%]. In HIV/AIDS patients, 1,473 individuals were evaluated and the pooled seroprevalence was 88.45 (95% CI = 80.87%–94.31%). Conclusion. This systematic review and meta-analysis identified a high seroprevalence of Toxoplasma infection of 81% among immunocompromised patients. Scaling up prevention and control methods mainly strengthening educational efforts are necessary to avoid reactivation and to stop the spread of T. gondii infection.

scholarly journals Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China

2016 ◽  
Vol 54 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Guoqiang Shen ◽  
Xiaoming Wang ◽  
Hui Sun ◽  
Yaying Gao
Keyword(s):  
Toxoplasma Gondii ◽  
Eastern China ◽  
Aids Patients ◽  
Hiv Aids

scholarly journals Epidemiology of Pneumococcal Carriage among HIV-Infected Individuals in the Conjugate Vaccine Era: A Study in Southern Ghana

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Nicholas TKD Dayie ◽  
Michael Baffuor-Asare ◽  
Appiah-Korang Labi ◽  
Noah Obeng-Nkrumah ◽  
Edeghonghon Olayemi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Pneumococcal Disease ◽  
Latex Agglutination ◽  
Sub Saharan Africa ◽  
Aids Patients ◽  
Cross Sectional ◽  
Pneumococcal Carriage ◽  
Study Participants ◽  
Southern Ghana ◽  
Hiv Aids

Carriage of pneumococcus is considered as the precursor for development of pneumococcal disease. In sub-Saharan Africa, very little research has been done on the pneumococcus in relation to people with HIV infection in the era of pneumococcal conjugate vaccines. This study investigated pneumococcal carriage among HIV/AIDS patients in southern Ghana to determine the prevalence, risk factors, serotypes and antibiotic resistance of the organism. This was a cross sectional study involving 245 HIV/AIDS patients recruited from Korle Bu Teaching Hospital and Princess Marie Louis Hospital in Accra from November 2016 to March 2017. Epidemiological data on demographic, household and clinical features of the study participants were collected. Nasopharyngeal (NP) swabs were also collected from the study participants and cultured for Streptococcus pneumoniae; the isolates were serotyped by latex agglutination and Quellung reaction. Antimicrobial disc susceptibility was performed on the isolates, and antibiotics tested included tetracycline, erythromycin, cotrimoxazole, levofloxacin, oxacillin and ceftriaxone. Prevalence of pneumococcal carriage among the study participants was 11% (95% CI: 7.4 to 15.6); carriage among children and adults was 25% (95% CI: 14% to 38.9%) and 7.3% (95% CI: 4% to 11.9%) respectively. School attendance (p=0.001) and history of pneumococcal disease in the past year (p=0.001) were significantly associated with pneumococcal carriage. The most prevalent pneumococcal serotypes carried by the study participants were 19A (15.4%) and 23F (15.4%). Serotype coverage of the various pneumococcal vaccines were PCV10 (23.1%), PCV13 (42.3%) and PPV23 (50%). The prevalence of pneumococcal multidrug resistance was 18.5%. In conclusion, pneumococcal carriage among HIV-infected children was three-fold higher compared to carriage among HIV-infected adults. Pneumococcal carriage among both HIV-infected children and adults in the study area tends to be characterized by a predominance of non-vaccine serotypes and a considerable level of multidrug resistance.

scholarly journals Sero-Molecular Detection of Toxoplasma Gondii Infection among HIV-Positive Patients in Khartoum : A Cross Sectional Study

2021 ◽  
pp. 125-131
Author(s):  
Elghazali Mohammed ◽  
Mustafa Yassin ◽  
Khalid Anan ◽  
Awadalkareem Omer ◽  
Mutaz A. Elsir ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Blood Donors ◽  
Demographic Data ◽  
Clinical Stage ◽  
Hiv Positive ◽  
Aids Patients ◽  
Cross Sectional ◽  
Igm Antibodies ◽  
Toxoplasma Gondii Infection ◽  
Hiv Aids

Background and Aim : Toxoplasmosis is one of the most common comorbidities in HIV-positive patients with CD4+ T lymphocytes below 200 cells/μl. Toxoplasmosis with encephalitis may affect HIV infection, in particular in patients with developing AIDS. Early diagnosis and treatment of toxoplasmosis reduces the mortality rate in HIV-positive people. The aim of this study was to estimate the seroprevalence of Toxoplasma gondii infection in HIV-positive patients in Khartoum, Sudan using serological and molecular methods. Methods : This was a descriptive cross sectional, hospital based study, blood sample were collected from 100 participants; out of them were 50 HIV/AIDS patients and 50 were healthy Blood donors attending HIV Center -Omdurman Hospital, and Sudan Heart Center blood bank respectively. Socio- demographic data were collected by structured questionnaire. Of the 50 HIV/AIDS patients, 25 (50%) were from each gender, their age ranged between 22 and 62 with mean of 39.5+10.69. They were classified into two age groups; from 22 to 42 years, and from 43 to 62 years, and their distribution was 29 (58%), and 21 (42%) respectively. According to the clinical stage they were classified into the four clinical-stage groups and their distribution was as following: 06 (12.0%) in stage 1, 02 (04%) in stage 2, 40 (80.0%) in stage 3, and 02 (04.0%) in stage 4. Twelve of them (22%) were under ART treatments. The 50 blood donors on their hand were all males, their age was ranged between 18 and 42 years old. Regarding their educatio, 15 (30%) were educated, while the remaining 35 (70%) were none educated. Mentioning their marital status 10 (20%) were married, while 40 (80%) were single. Regarding the contact with cats 25 (50%) has contact with cats. All samples collected were tested for anti-Toxoplasma IgG and IgM antibodies by ELISA, and by PCR for detection of Toxoplasma DNA.. Results: Out of the 50 HIV/AIDS patients; Anti-Toxoplasma IgM was detected in two patients (04%), while IgG was detected in 08 (16%) patients, the Toxoplasma DNA was detected in three (06%) patients.Regarding the blood donors group; all studied blood donors showed negative results for anti-toxoplasma IgM, while 16 (32%) showed positive anti-Toxoplasma IgG.No blood donors sample was detected positive for Toxoplasma DNA with PCR. There were no significant differences in comparison between the blood donors and the HIV/AIDS patients regarding serological and molecular toxoplasma test results. Conclusion : The current study showed a relatively high seroprevalance of anti-T.gondii IgG and low IgM antibodies in HIV-positive patients in comparison with previous studies in Sudan. Considering the relatively high seroprevalance rate of toxoplasma infection in blood donors reported in this study, toxoplasmosis should be considered as a significant transfusion risk.

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