On the Relationship between Memory and Language in the Dementia Spectrum of Depression, Alzheimer Syndrome, and Normal Aging

2013 ◽  
pp. 41-78
Keyword(s):  
Normal Aging ◽  
The Relationship

scholarly journals The relationship between memory complaints and age in normal aging

2009 ◽  
Vol 3 (2) ◽  
pp. 94-100 ◽  
Author(s):  
Thaís Bento Lima-Silva ◽  
Mônica Sanches Yassuda
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Digit Span ◽  
Normal Aging ◽  
Screening Tests ◽  
Memory Complaint ◽  
Memory Complaints ◽  
The Impact ◽  
The Relationship

Abstract Normal aging can be characterized by a gradual decline in some cognitive functions, such as memory. Memory complaints are common among older adults, and may indicate depression, anxiety, or cognitive decline. Objectives: To investigate the association between memory complaints and age in cognitively unimpaired older adults, and the relationship between memory complaints and memory performance. Methods: Cognitive screening tests as well as memory complaint questionnaires validated for the Brazilian population were used: the Mini-Mental State Examination (MMSE), Geriatric Depression Scale (GDS), Memory Complaint Questionnaire (MAC-Q), Memory test of 18 pictures, Forward and Backward Digit Span (WAIS-III). Fifty seven regular members of the SESC social club participated (50 women), having a mean age of 71.4 years, and 4 to 8 years of education - 34 from 4 to 7 years and 23 with 8 years of education. Results: Results revealed no significant association between cognitive complaints and age or cognitive performance. Older participants in this sample did not show worse performance or a higher level of complaints. There was no significant association between age and GDS scores. Conclusions: The studied sample constitutes a particular group of older adults whose participation in activities may be protecting them from cognitive decline, thus highlighting the impact of lifestyle on cognitive performance during the aging process.

scholarly journals Dysfunction of the Glymphatic System Might Be Related to Iron Deposition in the Normal Aging Brain

2020 ◽  
Vol 12 ◽  
Author(s):  
Wei Zhou ◽  
Bo Shen ◽  
Wei-qiang Shen ◽  
Hao Chen ◽  
Yi-feng Zheng ◽  
...  
Keyword(s):  
Red Nucleus ◽  
Normal Aging ◽  
Iron Deposition ◽  
Aging Brain ◽  
Brain Iron ◽  
Glymphatic System ◽  
The Alps ◽  
The Mean ◽  
The Relationship ◽  
Healthy Participants

Objective: The study aims to detect the potential relationship between iron deposition and the function of the glymphatic system in the normal aging brain.Methods: We recruited 213 healthy participants. We evaluated the function of the glymphatic system using the index for diffusivity along the perivascular space (ALPS-index), assessed iron deposition on quantitative susceptibility mapping (QSM), and analyzed their relationship.Results: The mean age of participants was 60.1 ± 7.3, and 107 (50.2%) were female. The mean ALPS-index was 1.4 ± 0.2. The QSM values of the caudate nucleus, putamen, globus pallidus, thalamus, red nucleus, substantia nigra, and dentate nucleus were all related to the ALPS-index (all P < 0.001).Conclusions: The main finding of the current study is that the regional brain iron deposition was related to the function of the glymphatic system.Advances in knowledge: We first evaluated the relationship between deposition of brain iron and the dysfunction of the glymphatic system.

The Relationship Of Serum Testosterone To Erectile Function In Normal Aging Men

2002 ◽  
pp. 1745-1748 ◽  
Author(s):  
ERNANI LUIS RHODEN ◽  
CLAUDIO TELOKEN ◽  
PAULO ROBERTO SOGARI ◽  
CARLOS ARY VARGAS SOUTO
Keyword(s):  
Erectile Function ◽  
Serum Testosterone ◽  
Normal Aging ◽  
Aging Men ◽  
Relationship Of ◽  
The Relationship

The aging-related decrease in cVEMP amplitude cannot be accounted for by normalization

2021 ◽  
pp. 1-6
Author(s):  
Maxime Maheu ◽  
Mujda Nooristani ◽  
Brahim Kaci ◽  
Karina Moïn-Darbari ◽  
Benoit-Antoine Bacon ◽  
...  
Keyword(s):  
Age Groups ◽  
Tone Burst ◽  
Normal Aging ◽  
Vestibular Evoked Myogenic Potentials ◽  
Emg Activity ◽  
Asymmetry Ratio ◽  
Clinical Level ◽  
The Relationship ◽  
Healthy Participants ◽  
Two Age Groups

BACKGROUND: Cervical Vestibular Evoked Myogenic Potentials (cVEMP) is an electromyogenic measure commonly used in clinic to assess saccule function. The main parameters are peak-peak amplitude and interaural asymmetry ratio (IAR). Several non-vestibular factors may influence these parameters. Notably, a greater EMG contraction level prior to stimulation leads to an increased amplitude. As aging impacts both vestibular structures and muscle propreties, it is still a matter of debate whether the decrease in cVEMP amplitude observed in normal aging is due to EMG differences prior to stimulation or to the effect of aging on the sacculo-collic reflex pathway. At the clinical level, understanding the effect of aging on the relationship between EMG activity and cVEMP response (amplitude, asymmetry ratio) and the effect of normalization is crucial to improving the categorization of healthy versus pathological responses. OBJECTIVE: To investigate whether normalization modifies cVEMP amplitude and asymmetry ratios differently in younger and older heatlhy adults. METHOD: cVEMP recordings were conducted in 42 normal healthy participants divided in two age groups: younger (n = 29): mean = 22.79 years old SD = 1.66; and older (n = 13): mean = 69.00 years old SD = 3.61. Air-conducted cVEMP were recorded using Eclipse (Interacoustics, Denmark). The stimulus was a 95 dBnHL tone burst (500 Hz) with rise, plateau and fall time of 1 ms. cVEMP were recorded only when EMG levels were between 50μV and 150μV, using the Eclipse (Interacoustic, Denmark) monitoring system. RESULTS: No significant differences were observed for prestimulus EMG levels between younger and older participants (F(1,83) = 1.13, p = 0.291). However, significant differences between groups were observed for raw cVEMP amplitude (F(1,83) = 14.78; p <  0.001) and corrected cVEMP amplitude (F(1,83) = 21.85; p <  0.0001). A significant positive linear relationship between prestimulus EMG contraction level (RMS) and raw cVEMP amplitude was observed in younger participants (r2 = 0.234; p <  0.001), but not in older adults (r2 = –0.0144; p = 0.056). Finally, no significant differences between younger and older participants were observed for raw amplitude asymmetry ratios (F(1,41) = 0.124, p = 0.726) or normalized asymmetry ratios (F(1,41) = 0.726, p = 0.508). CONCLUSION: Our results suggest that when EMG is monitored and activation of the SCM is sufficient, the observed decline in cVEMP amplitude with normal aging does not seem to be caused by EMG differences and is therefore likely due to the known histopathological modifications of the vestibular system that occurs with normal aging.

Entorhinal Tau Predicts Hippocampal Activation and Memory Deficits in Alzheimer’s Disease

2020 ◽  
Vol 78 (4) ◽  
pp. 1601-1614
Author(s):  
Nils Richter ◽  
Gérard N. Bischof ◽  
Julian Dronse ◽  
Nils Nellessen ◽  
Bernd Neumaier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medial Temporal Lobe ◽  
Memory Task ◽  
Normal Aging ◽  
Item Memory ◽  
Neural Activation ◽  
Cognitively Normal ◽  
Mild Dementia ◽  
The Relationship

Background: To date, it remains unclear how amyloid plaques and neurofibrillary tangles are related to neural activation and, consequently, cognition in Alzheimer’s disease (AD). Recent findings indicate that tau accumulation may drive hippocampal hyperactivity in cognitively normal aging, but it remains to be elucidated how tau accumulation is related to neural activation in AD. Objective: To determine whether the association between tau accumulation and hippocampal hyperactivation persists in mild cognitive impairment (MCI) and mild dementia or if the two measures dissociate with disease progression, we investigated the relationship between local tau deposits and memory-related neural activation in MCI and mild dementia due to AD. Methods: Fifteen patients with MCI or mild dementia due to AD underwent a neuropsychological assessment and performed an item memory task during functional magnetic resonance imaging. Cerebral tau accumulation was assessed using positron emission tomography and [18F]-AV-1451. Results: Entorhinal, but not global tau accumulation, was highly correlated with hippocampal activation due to visual item memory encoding and predicted memory loss over time. Neural activation in the posterior cingulate cortex and the fusiform gyrus was not significantly correlated with tau accumulation. Conclusion: These findings extend previous observations in cognitively normal aging, demonstrating that entorhinal tau continues to be closely associated with hippocampal hyperactivity and memory performance in MCI and mild dementia due to AD. Furthermore, data suggest that this association is strongest in medial temporal lobe structures. In summary, our data provide novel insights into the relationship of tau accumulation to neural activation and memory in AD.

Striatal 18F-DOPA Uptake: Absence of an Aging Effect

1993 ◽  
Vol 13 (5) ◽  
pp. 881-888 ◽  
Author(s):  
D. Eidelberg ◽  
S. Takikawa ◽  
V. Dhawan ◽  
T. Chaly ◽  
W. Robeson ◽  
...  
Keyword(s):  
Aging Process ◽  
Aging Effect ◽  
Normal Subjects ◽  
Normal Aging ◽  
Kinetic Rate ◽  
Positron Emission ◽  
Kinetic Rate Constants ◽  
The Subject ◽  
Relationship Of ◽  
The Relationship

l-[18F]6-Fluoro-DOPA (l-[18F]6-fluoro-3,4-dihydroxyphenylalanine; FDOPA) has been used with quantitative positron emission tomography (PET) to assess presynaptic nigrostriatal dopaminergic function in life. The relationship of estimated kinetic rate constants for striatal FDOPA uptake [ Ki(FDOPA)] to the normal aging process has been the subject of conflicting reports. Resolution of this issue has been hampered by methodological differences in previous FDOPA/PET investigations. We studied 19 healthy normal subjects (aged 27–77 years) and measured striatal Ki-(FDOPA) according to each of the earlier methods. While significant correlations (p < 0.005) existed between Ki(FDOPA) values estimated by the various techniques, none correlated with normal aging. We conclude that normal striatal Ki(FDOPA) values estimated using quantitative FDOPA/PET are uncorrelated with the aging process.

The relationship between white matter brain metabolites and cognition in normal aging: The GENIE study

2007 ◽  
Vol 1164 ◽  
pp. 108-116 ◽  
Author(s):  
R.A. Charlton ◽  
D.J.O. McIntyre ◽  
F.A. Howe ◽  
R.G. Morris ◽  
H.S. Markus
Keyword(s):  
White Matter ◽  
Normal Aging ◽  
Brain Metabolites ◽  
The Relationship

Bicaudate Index on Magnetic Resonance Imaging: Effects of Normal Aging

1994 ◽  
Vol 7 (1) ◽  
pp. 13-17 ◽  
Author(s):  
P. Murali Doraiswamy ◽  
Linda Patterson ◽  
Chul Na ◽  
Mustafa M. Husain ◽  
Orest Boyko ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cerebral Atrophy ◽  
Normal Aging ◽  
Resonance Imaging ◽  
Huntington's Chorea ◽  
Caudate Nuclei ◽  
Computed Tomographic ◽  
Magnetic Resonance Imaging Mri ◽  
The Relationship

The bicaudate and bifrontal indices have been used in prior computed tomographic studies to investigate atrophy of the caudate nuclei in patients with Huntington's chorea and cerebral atrophy. However, the relationship between these indices and caudate volume has not been documented previously. In this study, we used high-field magnetic resonance imaging (MRI) to determine the effects of normal aging on the bicaudate and bifrontal indices and to study the relationship between these indices and caudate volume. The subjects were 49 normal volunteers, aged 22 to 82 years, who were without any significant neurologic or psychiatric disorders. Age was positively correlated with bicaudate index ( r = .59; P < .0001) and bifrontal index ( r = .40; P < .0047). Age was negatively correlated with caudate nuclei volume ( r = -.47; P < .0005). Caudate volume was negatively correlated with bicaudate ( r = -.27; P < .06) and bifrontal ( r = -.31; P < .03) indices. These findings are consistent with prior reports of caudate nuclei degeneration with increasing age. Linear and volumetric caudate measurements with MRI may prove useful in the investigation of caudate nuclei function in the neuromotor decline with normal aging and in disorders such as Huntington's chorea.

scholarly journals The relationship between fasting serum glucose and cerebral glucose metabolism in late-life depression and normal aging

2014 ◽  
Vol 222 (1-2) ◽  
pp. 84-90 ◽  
Author(s):  
Christopher M. Marano ◽  
Clifford I. Workman ◽  
Christopher H. Lyman ◽  
Elisse Kramer ◽  
Carol R. Hermann ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Late Life ◽  
Normal Aging ◽  
Serum Glucose ◽  
Cerebral Glucose Metabolism ◽  
Late Life Depression ◽  
Fasting Serum ◽  
Fasting Serum Glucose ◽  
The Relationship
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