Contribution to the measurement of mode-specific effects in long-term psychoanalytic psychotherapy

Abstract The responses of corals and other marine calcifying organisms to ocean acidification (OA) are variable and span from no effect to severe responses. Here we investigated the effect of long-term exposure to OA on skeletal parameters of four tropical zooxanthellate corals living at two CO2 vents in Papua New Guinea, namely in Dobu and Upa Upasina. The skeletal porosity of Galaxea fascicularis, Acropora millepora, and Pocillopora damicornis was higher (from 17% to 38%, depending on the species) at the seep site compared to the control only at Upa Upasina. Massive Porites showed no differences at any of the locations. Pocillopora damicornis also showed a ~ 7% decrease of micro-density and an increase of the volume fraction of the larger pores, a decrease of the intraskeletal organic matrix content with an increase of the intraskeletal water content, and no variation in the organic matrix related strain and crystallite size. The fact that the skeletal parameters varied only at one of the two seep sites suggests that other local environmental conditions interact with OA to modify the coral skeletal parameters. This might also contribute to explain the great deal of responses to OA reported for corals and other marine calcifying organisms.

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Microplastics - an emerging silent menace to public health

Life Sciences, Medicine and Biomedicine ◽

10.28916/lsmb.5.10.2021.72 ◽

2021 ◽

Vol 5 (10) ◽

Author(s):

Li-Yin Pang ◽

Shola Sonagara ◽

Oreoluwatomide Oduwole ◽

Christopher Gibbins ◽

Ting Kang Nee

Keyword(s):

Public Health ◽

Health Effects ◽

Mammalian Cells ◽

Circulatory System ◽

Epidemiological Studies ◽

Specific Effects ◽

Important Pathway ◽

Living Organisms ◽

Respiratory Conditions

Over the past few decades, microplastics have become increasingly ubiquitous in the environment and now contaminate the bodies of many living organisms, including humans. Microplastics, as defined here, are plastics within the size range 0.1 μm and 5 mm and are a worrying form of pollution due to public health concerns. This mini-review aims to summarise the route of entry of microplastics into humans and explore the potential detrimental health effects of microplastics. Trophic transfer is an important pathway for microplastic to be transferred across different groups of organisms, with ingestion is regarded as one of the major routes of exposure for humans. Other pathways include inhalation and dermal contact. The health consequences of microplastics manifest because these materials can translocate into the circulatory system and accumulate in the lungs, liver, kidney, and even brain, regardless of the route of entry. Health effects include gastrointestinal disturbances such as inflammation and gut microbiota disruption, respiratory conditions, neurotoxicity and potential cancers. Overall, while it is apparent that microplastics are causing adverse effects on different biological groups and ecosystems, current research is largely focused on marine organisms and aquaculture. Therefore, more studies are needed to investigate specific effects in mammalian cells and tissues, with more long-term epidemiological studies needed on human population considered to be at high-risk due to socioeconomic or other circumstance. Knowledge of the toxicity and long-term health impacts of microplastics is currently limited and requires urgent attention.

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Sex-specific effects of in vitro fertilization on adult metabolic phenotypes and hepatic transcriptomic and proteomic pathways in mouse

10.1101/2020.09.23.309989 ◽

2020 ◽

Author(s):

Laren Narapareddy ◽

Eric A. Rhon-Calderon ◽

Lisa A. Vrooman ◽

Josue Baeza ◽

Duy K. Nguyen ◽

...

Keyword(s):

Regulatory Element ◽

Perinatal Outcomes ◽

Vitro Fertilization ◽

Specific Effects ◽

Cholesterol Levels ◽

Element Binding Protein ◽

Fat Composition ◽

Sterol Regulatory Element

AbstractAlthough in vitro fertilization (IVF) is associated with adverse perinatal outcomes, an increasing concern is the long-term health implications. We augmented our IVF mouse model to longitudinally investigate cardiometabolic outcomes in offspring from optimal neonatal litter sizes. We found that IVF-conceived females had higher body weight and cholesterol levels compared to naturally-conceived females, whereas IVF-conceived males had higher levels of triglycerides and insulin, and increased body fat composition. Through transcriptomics and proteomics of adult liver, we identified sexually-dimorphic dysregulation of the sterol regulatory element binding protein (SREBP) pathways that are associated with the sex-specfic phenotypes. We also found that global loss of DNA methylation in placenta was linked to higher cholesterol levels in IVF-conceived females. Our findings indicate that IVF procedures have long-lasting sex-specific effects on metabolic health of offspring and lay the foundation to utilize the placenta as a predictor of long-term outcomes.

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Abstract WP379: Sex-specific Effects of Comorbid Diabetes and Depression on Post-stroke Mortality in Individuals With Atrial Fibrillation

Stroke ◽

10.1161/str.51.suppl_1.wp379 ◽

2020 ◽

Vol 51 (Suppl_1) ◽

Author(s):

Jodi Edwards ◽

Jessica Colby-Milley ◽

Jiming Fang ◽

Limei Zhou ◽

Baiju R Shah ◽

...

Keyword(s):

Atrial Fibrillation ◽

Hospital Mortality ◽

Recurrent Stroke ◽

Stroke Patients ◽

Comorbid Depression ◽

Term Care ◽

Post Stroke ◽

Specific Effects ◽

Long Term Mortality

Background: Comorbid diabetes and depression are highly prevalent in atrial fibrillation (AF) and increase the risk of stroke. Women with AF show higher mortality rates and have worse functional outcomes post-stroke. However, the sex-specific effects of comorbid diabetes and depression on mortality and other adverse outcomes in stroke patients with a history of AF is unclear. Methods: Prospectively collected consecutive patients with ischemic stroke and known AF presenting to designated stroke centres in Ontario (2003-2013). Multinomial regression was used to determine sex-specific associations between diabetes and depression and in-hospital mortality post-stroke in individuals with AF. Cox proportional hazards regression was used to estimate the adjusted hazard of long-term mortality post-stroke and competing risks models to estimate hazards of recurrent stroke/TIA, admission to long-term care, and incident dementia post-discharge. Results: Among 5082 stroke patients with known AF (median age=80, IQR:73-85), female patients were more likely to have comorbid depression than males (63.5% vs. 36.5%) and those with comorbid diabetes and depression were younger (77 yrs) and had more vascular history (HTN, CAD, hyperlipidemia) than those with AF only. For males, comorbid diabetes increased the likelihood of in-hospital mortality post-stroke by 53% (OR=1.53, 95% CI=1.16-2.02), after adjustment for stroke severity, demographic and clinical factors, while comorbid depression did not significantly impact in-hospital mortality and neither diabetes or depression affected in-hospital mortality post-stroke for females. However, diabetes was independently associated with increased hazard of long-term mortality for both female (HR=1.15, 95%CI=1.02-1.29) and male AF stroke patients (HR=1.35, 95%CI=1.19-1.53). No associations with recurrent stroke/TIA, institutionalization or dementia post-stroke were observed for either females or males. Conclusion: In stroke patients with known AF, comorbid diabetes but not depression was independently associated with increased in-hospital mortality for males and increased long-term mortality post-stroke for both females and males.

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Age-dependent, steroid-specific effects of oestrogen on long-term potentiation in rat hippocampal slices

The Journal of Physiology ◽

10.1111/j.1469-7793.1999.209ad.x ◽

1999 ◽

Vol 515 (1) ◽

pp. 209-220 ◽

Cited By ~ 47

Author(s):

K.-I. Ito ◽

K. L. Skinkle ◽

T. P. Hicks

Keyword(s):

Hippocampal Slices ◽

Long Term Potentiation ◽

Specific Effects ◽

Term Potentiation ◽

Age Dependent

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Circadian- and temperature-specific effects of early deprivation on rat maternal care and pup development: Short-term markers for long-term effects?

Developmental Psychobiology ◽

10.1002/dev.20014 ◽

2004 ◽

Vol 45 (2) ◽

pp. 59-71 ◽

Cited By ~ 30

Author(s):

Daniela Rüedi-Bettschen ◽

Joram Feldon ◽

Christopher R. Pryce

Keyword(s):

Maternal Care ◽

Long Term Effects ◽

Short Term ◽

Early Deprivation ◽

Specific Effects ◽

Pup Development

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Pre-learning stress that is temporally removed from acquisition exerts sex-specific effects on long-term memory

Neurobiology of Learning and Memory ◽

10.1016/j.nlm.2012.12.012 ◽

2013 ◽

Vol 100 ◽

pp. 77-87 ◽

Cited By ~ 22

Author(s):

Phillip R. Zoladz ◽

Ashlee J. Warnecke ◽

Sarah A. Woelke ◽

Hanna M. Burke ◽

Rachael M. Frigo ◽

...

Keyword(s):

Long Term Memory ◽

Term Memory ◽

Specific Effects ◽

Learning Stress

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Inadequate Standards Currently Applied by Local Authorities to Determine Statutory Nuisance from LF and Infrasound

Journal of Low Frequency Noise Vibration and Active Control ◽

10.1260/026309203769018031 ◽

2003 ◽

Vol 22 (1) ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Hazel Guest

Keyword(s):

Local Authority ◽

Low Frequency ◽

Measurement Information ◽

Frequency Noise ◽

Local Authorities ◽

Low Frequencies ◽

Specific Effects ◽

Basic Understanding

Knowledge of the latest results in Low Frequency Noise (LFN) and infrasound research are not being transmitted, either to government whose job it is to legislate on standards of noise and vibration, or to local authority officers whose job it is to look into complaints and enforce standards. The dismissal of complaints is frequently based on inappropriate techniques such as the application of A-weighting, a lack of understanding of vibration transmission including building resonance, and a lack of basic understanding about the perception of low frequencies by complainants, for instance the lowering of the lower audibility threshold arising from exposure. This paper asks those involved in research to ensure that their relevant findings are more widely disseminated, along with advice to legislators and local authorities on measurement, information on LF and infrasound resonance in buildings, recommendations for appropriate standards to be used in assessing LF and infrasound as a Statutory Nuisance, and information about the effects of long-term exposure. There is a need for more research in situ into specific effects.

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