Clinical methodology and data

2018 ◽  
pp. 77-80
Author(s):  
Michael Robbins
Keyword(s):  
1998 ◽  
Vol 50 (2-3) ◽  
pp. 163-173 ◽  
Author(s):  
Elie G Hantouche ◽  
Hagop S Akiskal ◽  
Sylvie Lancrenon ◽  
Jean-François Allilaire ◽  
Daniel Sechter ◽  
...  

Author(s):  
Bruce Ecker

This chapter examines how the effectiveness and unification of psychotherapy are advanced by neuroscientists’ findings on memory reconsolidation, the brain’s innate mechanism for profound unlearning. Research relevant to psychotherapy is reviewed and mapped unambiguously into a clinical methodology of transformational change, the therapeutic reconsolidation process (TRP), applicable to all symptoms arising from memory contents. The TRP is defined as a set of experiences required by the brain, allowing implementation by any suitable experiential techniques, without dictating particular forms of therapy. Detection of TRP fulfillment in published case studies from diverse therapy systems suggests that the TRP provides psychotherapy unification and, functioning as both a specific and a common factor, may be responsible for transformational change occurring in any therapy sessions, which would confirm and advance the “corrective experience” paradigm. A coherence therapy case example serves to demonstrate TRP implementation, and research priorities are suggested.


1977 ◽  
Vol 23 (1) ◽  
pp. 5-12 ◽  
Author(s):  
T Peters

Abstract Major discoveries have been made in the past few years on the structure and mode of biosynthesis of serum albumin. The complete amino acid sequence of this protein has been determined, and its covalent structure shown to be a single peptide chain grouped into a series of nine disulfide-bonded loops. These loops appear to associate into three similar domains. By study of isolated fragments of the molecule it can be demonstrated that the binding of billirubin and the primary binding of long-chain fatty acids are functions of separate domains. The biosynthesis of albumin has been found to involve a precursor form, termed "proalbumin", in which a basic hexapeptide is attached to the amino end of the chain. Similar precursor forms are now known to have a role in the formation of other secreted proteins, but in the case of albumin the purpose of the additional peptide is not clear. Clinical methodology for albumin assay has advanced but little despite--or perhaps in part because of--the increasing use of automation. Hope for improvement is foreseen in the advent of immunochemical procedures and in a better understanding of the specificity of dye-binding reactions.


Author(s):  
T. A. Ban ◽  
J. M. Bordeleau ◽  
H. R. Debray ◽  
M. Hamilton ◽  
H. Itoh ◽  
...  
Keyword(s):  

2008 ◽  
Vol 9 (5) ◽  
pp. 357-364 ◽  
Author(s):  
David A. Gunn ◽  
Peter G. Murray ◽  
Cyrena C. Tomlin ◽  
Helle Rexbye ◽  
Kaare Christensen ◽  
...  

2015 ◽  
Vol 64 (5) ◽  
Author(s):  
Giampaolo Ghilardi ◽  
Vittoradolfo Tambone

Il presente lavoro analizza i presupposti ontologici della metodologia scientifica identificata nella formula “riduzione consapevole e cooperante”. Viene studiata l’idea di essere sottesa alle riduzioni scientifiche, distinguendo tra riduzioni legittime e riduzionismo inadeguato, per valutare all’interno della metodologia clinica la complessità dell’agire scientifico. Si sono quindi ricercate le radici ontologiche della complessità nella scienza, approdando così al realismo dimensionale teorizzato per primo da Viktor Frankl. La rigorizzazione di questo modello analitico ci ha condotti a recuperare il tema filosofico dell’analogia quale strumento importante per la razionalità scientifica, in grado mantenere in tensione feconda tra loro i diversi elementi del discorso epistemologico. Questo percorso si è quindi sviluppato sulle condizioni di possibilità della conoscenza umana, rintracciando nella nozione di “potenzialità futura” il tratto distintivo dell’impresa conoscitiva. Il tema è quindi stato approfondito nei suoi fondamenti ontologici principali, analizzando i concetti di potenzialità e possibilità applicati all’ambito conoscitivo. La fondazione ontologica del modello conoscitivo analizzato viene pertanto trovata in un essere analogico, vale a dire composto su diversi livelli non esauribili concettualmente dall’indagine scientifica, ma neppure estranei alla capacità d’indagine umana. ---------- The present work develops the ontological presuppositions of scientific methodology labeled as “aware and cooperative reduction”. The idea of being underlying scientific reduction is analyzed by distinguishing among legitimate and improper reductionism. This framework is useful to assess within the context of clinical methodology the complexity of scientific practice. We also focus on the ontological roots of complexity in science, reaching to what Viktor Frankl has named “dimensional realism”. Thanks to this analytical model we recovered the theme of analogy as an important instrument of scientific rationality, which allows to keep together both the objective and the subjective instances of the epistemological domain. This speculative path lead us to ask about the conditions of possibility of human knowledge. In so doing, we have found the notion of “future potentiality” to be the mark of human knowledge. The result of our inquiry is that “analogical being” is the ontological foundation of scientific methodology. The ontological idea of “analogy” conveys an understanding of being constituted by different levels, or dimensions, which are not conceptually exhaustible within scientific research, but which are nevertheless accessible by human investigation.


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