Stabil Angina Pektorisli Hastalarda Arteriyel Sertlik Ve Aort Augmentasyon İndeksinin Koroner Arter Hastalığı İle İlişkisi

2021 ◽  
Vol 6 (13) ◽  
pp. 61-67
Author(s):  
Ali UYSAL ◽  
Serhat ÇALIŞKAN ◽  
Şeyda GÜNAY ◽  
Mehmet ATAY ◽  
Osman Akın SERDAR
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Patient Group ◽  
Augmentation Index ◽  
Area Under The Curve ◽  
Control Group ◽  
Gensini Score ◽  
Artery Disease ◽  
The Relationship

Objective : Many studies have indicated arterial stiffness as an independent predictor of hypertension, stroke, cardiovascular events, and mortality. However, the relationship between the severity of coronary artery disease(CAD) and arterial stiffness is still unclear. In this study, it was aimed to examine the relationship between augmentation index which is a marker of arterial stiffness with CAD and its prevalence. Methods: A total of 80 patients (22 women, mean age 59±8) who were scheduled for coronary angiography with a preliminary diagnosis of coronary artery disease by evaluating their symptoms and findings and coronary risk profiles were included. The other group have 20 healthy patients without any chronic disease history. The augmentation index (AIX), which is an indicator of arterial stiffness, was measured in all cases with the BP+ Central Blood Pressure CardioScope II device in all groups. Gensini score of the patient group was calculated. Results: It was found to be 131% (79-198mmHg) in the AIX patient group and 72.5% (69-96mmHg) in the control group (p<0.001). A positive correlation was observed between AIX and Gensini score, LDL-cholesterol, body mass index and HbA1c in the patient group. In the ROC analysis, the area under the curve (AUC) for AIX was calculated as 0.701 (P<0.001). While AIX was 121% above normal, it predicted coronary artery disease with 94.8% sensitivity and 80.9% specificity. Conclusion: In our study, a relationship was found between coronary artery disease with its severity and arterial stiffness. Augmentation index can be used effectively with low cost in predicting coronary artery disease.

scholarly journals The Association between theLPAGene Polymorphism and Coronary Artery Disease in Chinese Han Population

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Zi-Kai Song ◽  
Hai-Di Wu ◽  
Hong-Yan Cao ◽  
Ling Qin
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chinese Han Population ◽  
Control Group ◽  
Case Group ◽  
Chinese Han ◽  
Han Population ◽  
Increased Risk ◽  
Artery Disease ◽  
The Relationship

Lp(a) has been well known as an independent risk factor for coronary artery disease (CAD). TheLPAgene, as it encodes apo(a) of the Lp(a) lipoprotein particle, was associated with increased risk of CAD. The purpose of this study was to analyze the relationship between the polymorphisms ofLPAgene and CAD in Chinese Han population. Five SNPs (rs1367211, rs3127596, rs6415085, rs9347438, and rs9364559) in theLPAgene were genotyped using Sequenom MassARRAY time-of-flight mass spectrometer (TOF) in 560 CAD patients as case group and 531 non-CAD subjects as control group. The numbers of these two groups were from Chinese Han ancestry. The results showed that allele (P=0.046) and genotype (P=0.026) of rs9364559 in theLPAgene was associated with CAD. The frequency of rs9364559 minor allele (G) in case group was obviously higher than that in control group. Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population. This study explored rs9364559 in theLPAgene may be associated with the pathogenesis of CAD; and the risk of CAD might be higher in the population carrying 4 haplotypes of different blocks in theLPAgene.

The Relationship Between the Gensini Score and Complete Blood Count Parameters in Coronary Artery Disease

2012 ◽  
Vol 15 (2) ◽  
pp. 51-54 ◽  
Author(s):  
Muhammet Raşit Sayın ◽  
Mehmet Ali Çetiner ◽  
Turgut Karabağ ◽  
Sait Meut Doğan ◽  
Mustafa Aydın ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Blood Count ◽  
Complete Blood Count ◽  
Gensini Score ◽  
Artery Disease ◽  
The Relationship

Serum Selenium and Glutathione Peroxidase Concentrations in Iranian Patients with Angiography-Defined Coronary Artery Disease

Angiology ◽  
2008 ◽  
Vol 60 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Parizadeh Seyyed Mohammad Reza ◽  
Mohsen Moohebati ◽  
Fahimeh Ghafoori ◽  
Majid Ghayour-Mobarhan ◽  
Seyyed Mohammad Reza Kazemi-Bajestani ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Glutathione Peroxidase ◽  
Fasting Blood Glucose ◽  
Mean Value ◽  
Control Group ◽  
Serum Selenium ◽  
Artery Disease ◽  
The Relationship ◽  
Iranian Patients

This study investigated the relationship between serum selenium (Se) and glutathione peroxidase (GPx) levels and the presence of coronary artery disease (CAD) among Iranian patients. Three groups were compared: patients undergoing angiography with angiographically defined CAD, individuals with a normal angiogram, and apparently healthy controls with no evidence of overt CAD. Anthropometric measurements, blood pressure, fasting blood glucose and lipid profiles, serum Se and GPx measurements, and angiographic assessment were carried out using standard protocols. Mean serum Se concentrations were not significantly different between patients with and without CAD and the control group. The mean value of serum GPx in the control group was significantly higher than in patients with or without CAD. Selenium status did not differentiate between patients with and without CAD, which may be related to the fact that angiography is not a very sensitive index of global atherosclerosis, and it is possible that patients who were CAD negative by angiogram still have significant disease. It may also be that Se is not a good marker of CAD.

The Relationship between Glucose Tolerance and Severity of Coronary Artery Disease Using the Gensini Score

Angiology ◽  
2010 ◽  
Vol 61 (8) ◽  
pp. 751-755 ◽  
Author(s):  
Zekeriya Nurkalem ◽  
Hakan Hasdemir ◽  
Mehmet Ergelen ◽  
Huseyin Aksu ◽  
Irfan Sahin ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Glucose Tolerance ◽  
Gensini Score ◽  
Artery Disease ◽  
The Relationship

scholarly journals Component Analysis of HPLC Profiles of Unique Lipoprotein Subclass Cholesterols for Detection of Coronary Artery Disease

2006 ◽  
Vol 52 (11) ◽  
pp. 2049-2053 ◽  
Author(s):  
Mitsuyo Okazaki ◽  
Shinichi Usui ◽  
Akio Fukui ◽  
Isao Kubota ◽  
Hitonobu Tomoike
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Patient Group ◽  
Particle Diameter ◽  
Component Analysis ◽  
Control Group ◽  
Mathematical Treatment ◽  
Lipoprotein Subclass ◽  
Lipoprotein Subclasses ◽  
Artery Disease

Abstract Background: Patients with coronary artery disease (CAD) are known to have several lipoprotein abnormalities. We examined plasma cholesterol concentrations of major lipoproteins and their subclasses, using a gel permeation HPLC, to establish an association between a lipoprotein subclass pattern and the presence of CAD. Methods: We performed a simple and fully automated HPLC, followed by mathematical treatment on chromatograms, for measuring cholesterol concentrations of major lipoproteins and their subclasses in 62 male patients (45 with CAD and 17 controls without CAD) who underwent cardiac catheterization. Results: For major lipoprotein classes, the patient group had a significantly (P &lt;0.05) higher LDL-cholesterol (LDL-C) and lower HDL-cholesterol (HDL-C), but no difference in VLDL-cholesterol (VLDL-C) concentrations. For lipoprotein subclasses, the patient group had a significantly higher small VLDL-C (mean particle diameter of 31.3 nm, P &lt;0.001), small LDL-C (23.0 nm, P &lt;0.05), and very small LDL-C (16.7–20.7 nm, P &lt;0.001), but a significantly lower large HDL-C (12.1 nm, P &lt;0.001) concentrations. Combined variables of “small VLDL-C + small LDL-C + very small LDL-C – large HDL-C” differentiated the patient from the control group more clearly than single-subclass measurements or calculated traditional lipid markers. Conclusions: These results suggest the usefulness of multiple and simultaneous subclass analysis of proatherogenic and antiatherogenic lipoproteins and indicate that HPLC and its component analysis can be used for easy detection and evaluation of abnormal distribution of lipoprotein subclasses associated with CAD.

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals Nonalcoholic Fatty Liver Disease-Associated Liver Fibrosis Is Linked with the Severity of Coronary Artery Disease Mediated by Systemic Inflammation

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Ling-zi Chen ◽  
Xu-bin Jing ◽  
Chao-fen Wu ◽  
Yi-cheng Zeng ◽  
Yan-chun Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Fatty Liver Disease ◽  
Gensini Score ◽  
Inflammation Markers ◽  
Nonalcoholic Fatty Liver ◽  
Severe Coronary Artery ◽  
Artery Disease ◽  
The Relationship

Background and Aim. Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor for cardiovascular disease. Hepatic fibrosis is the most significant determinant of all-cause- and liver -related mortality in NAFLD. However, the relationship between NAFLD fibrosis and severe coronary artery disease (CAD) remains unclear. Methods and Results. We conducted a retrospective study of 531 patients with ultrasonogram-confirmed NAFLD who underwent percutaneous coronary intervention (PCI). Then, all patients were separated into four categories by Gensini score (0, 0-9, 9-48, and ≥48) for use in ordinal logistic regression analysis to determine whether NAFLD fibrosis was associated with increased Gensini scores. Mediation analysis was used to investigate whether systemic inflammation is a mediating factor in the association between NAFLD fibrosis and CAD severity. FIB − 4 > 2.67 ( OR = 5.67 , 95% CI 2.59-12.38) and APRI > 1.5 ( OR = 14.8 , 95% CI 3.24-67.60) remained to be independent risk factors for the severity of CAD after adjusting for conventional risk factors, whereas among the inflammation markers, only neutrophils and neutrophil-to-lymphocyte ratio (NLR) were independently associated with CAD. Multivariable ordinal regression analysis suggested that increasing Gensini score (0, 0-9, 9-48, and ≥48) was associated with advanced NAFLD fibrosis. ROC curve showed that either fibrosis markers or inflammation markers, integrating with traditional risk factors, could increase the predictive capacity for determining CAD. Inflammation markers, especially neutrophils and NLR, were mediators of the relationship between NAFLD fibrosis and CAD severity. Conclusions. NAFLD patients with advanced fibrosis are at a high risk of severe coronary artery stenosis, and inflammation might mediate the association between NAFLD fibrosis and CAD severity.

scholarly journals The relationship between lipoprotein(a) and coronary artery disease, as well as its variable nature following myocardial infarction

2011 ◽  
Vol 34 (1) ◽  
pp. 14 ◽  
Author(s):  
Ender Ornek ◽  
Sani Murat ◽  
Mustafa Duran ◽  
Murat Turfan ◽  
Alparslan Kurtul ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Angina Pectoris ◽  
Control Group ◽  
Clinical Form ◽  
Variable Nature ◽  
Acute Mi ◽  
Artery Disease ◽  
The Relationship

Purpose: The present study aimed to investigate the relationship between the severity of coronary artery disease (CAD) and level of Lipoprotein (LP)(a). Methods: The study included 52 CAD patients and a control group consisting of 38 individuals. The patients were classified into three groups based on the clinical form of CAD (stable angina pectoris, SAP, unstable angina pectoris,UAP, and myocardial infarction,MI), and were further divided into three groups based on CAD severity (1-, 2- and 3-vessel). Serum Lp(a) levels were monitored 4, 8, and 24 h, 10 and 30 days following acute MI in 18 patients. Results: Based on regression analysis, Lp(a) was not correlated with other lipoproteins or with risk factors of CAD, such as body mass index, smoking, family history, diabetes, age, gender, and hypertension (r = 0.08-0.22). 72% of the patients in the CAD group and 24% of the control group had an Lp(a) level > 30 mg dL–1 (P = 0.004), and Lp(a) levels were higher in 3-vessel patients than in 2-vessel and 1-vessel CAD patients (86% vs. 68%, P = 0.02 and 86% vs. 62%, P=0.01, respectively). Serum Lp(a) levels were higher in the UAP and MI groups than in the SAP group (48 ± 44.7 mg dL–1, 49 ± 36.1 mg dL–1 and 31.2 ± 22.3 mg dL–1 , respectively,P=0.02). Lp(a) levels increased after acute MI, and reached peak levels 10 days post-MI (41% increase, P=0.001) and remained considerably elevated (18%) 30 days post-MI (P=0.01). Conclusion: Serum Lp(a) was higher in the UAP and MI patients in comparison with the SAP patients, and was higher in 3-vessel CAD in comparison with 1- and 2-vessel CAD patients.

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