scholarly journals CORRELATION BETWEEN IMMUNOHISTOCHEMICAL EXPRESSION OF S100A4 WITH HISTOPATHOLOGICAL GRADING AND MOLECULAR SUBTYPE CLASSIFICATION IN NON-SPECIFIC INVASIVE BREAST CANCER

2021 ◽  
Vol 89 (1) ◽  
Author(s):  
Hengky Ardian ◽  
T. Ibnu Alferally ◽  
Dr. Delyuzar ◽  
Joko S Lukito ◽  
Dr. Soekimin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Immunohistochemical Expression ◽  
Subtype Classification ◽  
Histopathological Grading

scholarly journals Immunohistochemical Expressions of Senescence-Associated Secretory Phenotype and Its Association With Immune Microenvironments and Clinicopathological Factors in Invasive Breast Cancer

2021 ◽  
Vol 27 ◽  
Author(s):  
Min Hui Park ◽  
Jung Eun Choi ◽  
Jae-Ryong Kim ◽  
Young Kyung Bae
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Luminal A ◽  
Cancer Specific Survival ◽  
Ki 67 ◽  
Entire Cohort ◽  
Secretory Phenotype

This study was undertaken to investigate immunohistochemical expression of the senescence-associated secretory phenotype (SASP) in invasive breast cancer (IBC) tissues and to determine relationships between SASP positivity and tumor microenvironments and the clinicopathological characteristics of IBC. Immunohistochemistry for senescence markers, that is, high mobility group box-1 (HMGB1), p16, p15, and decoy receptor 2 (DCR2), was performed in tissue microarrays of 1140 IBC samples. Cases positive for at least one of these four markers were considered SASP-positive. Relations between SASP and tumor characteristics, including immune microenvironments (stromal tumor-infiltrating lymphocytes [sTILs] density and numbers of intraepithelial CD103-positive [iCD103 + ] lymphocytes) and clinical outcomes were retrospectively evaluated. HMGB1, p16, p15, or DCR2 was positive in 6.7%, 26.6%, 21.1%, and 26.5%, respectively, of the 1,140 cases. Six hundred and five (53.1%) cases were SASP positive, and SASP positivity was significantly associated with histologic grade 3, high-sTIL and iCD103 + lymphocyte counts, absence of ER or PR, and a high Ki-67 index. Although SASP did not predict breast cancer-specific survival (BCSS) or disease-free survival (DFS) in the entire cohort, SASP positivity in luminal A IBC was associated with poor BCSS and DFS. However, patients with SASP-positive TNBC showed better survival than those with SASP-negative TNBC. In multivariate analysis, SASP positivity was an independent prognostic factor in both luminal A IBC and TNBC, although the effect on prognosis was the opposite. In conclusion, SASP would be involved in the modulation of immune microenvironments and tumor progression in IBC, and its prognostic significance depends on molecular subtype.

scholarly journals Axillary Imaging Following a New Invasive Breast Cancer Diagnosis—A Radiologist’s Dilemma

2021 ◽  
Author(s):  
Vandana Dialani ◽  
Basak Dogan ◽  
Katerina Dodelzon ◽  
Brian N Dontchos ◽  
Neha Modi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Treatment Plan ◽  
Clinical Stage ◽  
Breast Cancer Diagnosis ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Axillary Metastasis ◽  
Image Guided

Abstract Traditionally, patients with newly diagnosed invasive breast cancer underwent axillary US to assess for suspicious axillary lymph nodes (LNs), which were then targeted for image-guided needle biopsy to determine the presence of metastasis. Over the past decade, there has been a shift towards axillary preservation. For patients with palpable lymphadenopathy, the decision to perform axillary imaging with documentation of the number and location of abnormal LNs in preparation for image-guided LN sampling is straightforward. Since LN involvement correlates with cancer size, it is reasonable to image the axilla in patients with tumors larger than 5 cm; however, for tumors smaller than 5 cm, axillary imaging is often deferred until after the tumor molecular subtype and treatment plan are established. Over the last decade, neoadjuvant chemotherapy (NACT) is increasingly used for smaller cancers with more aggressive molecular subtypes. In most cases, detecting axillary metastasis is critical when deciding whether the patient would benefit from NACT. There is increasing evidence that abnormal axillary US findings correlates with LN metastases and reliably establishes a baseline to monitor response to NACT. Depending on hormone receptor status, practices may choose to image the axilla in the setting of clinical stage T1 and T2 cancers to evaluate nodal status and help determine further steps in care. Radiologists should understand the nuances of axillary management and the scope and challenges of LN marking techniques that significantly increase the precision of limited axillary surgery.

scholarly journals Hubungan Grading Histopatologi dan Infiltrasi Limfovaskular dengan Subtipe Molekuler pada Kanker Payudara Invasif di Bagian Bedah RSUP. Dr. M. Djamil Padang

2016 ◽  
Vol 5 (1) ◽  
Author(s):  
Vashti Resti Putri Firdaus ◽  
Aswiyanti Asri ◽  
Daan Khambri ◽  
Wirsma Arif Harahap
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Cross Sectional Study ◽  
Prognosis Factors ◽  
Chi Square ◽  
Cross Sectional ◽  
Cancer Symptoms ◽  
Analysis System ◽  
Surgery Department

AbstrakGejala kanker payudara sering tidak disadari atau dirasakan dengan jelas oleh penderita, sehingga banyak penderita yang datang dalam keadaan stadium lanjut. Banyak faktor yang mempengaruhi prognosis dari kanker payudara, antara lain grading histopatologi, reseptor estrogen dan progesteron, HER2, serta infiltrasi limfovaskular. Tujuan penelitian ini adalah menentukan hubungan antara grading histopatologi dan infiltrasi limfovaskular terhadap subtipe molekuler pada kanker payudara invasif. Distribusi frekuensi dari grading histopatologi, infiltrasi limfovaskular, dan subtipe molekuler pada kanker payudara invasif di bagian bedah RSUP.Dr. M. Djamil Padang selama periode 1 Januari 2010 – 31 Desember 2013. Metode penelitian ini adalah observational analitik, dengan pendekatan cross sectional. Dalam penelitian ini didapatkan 424 kasus kanker payudara invasif, dengan 66 kasus yang dapat dianalisis. Analisis data yang digunakan univariat dan bivariat dengan menggunakan uji chi-square dengan derajat kemaknaan p<0,05. Ada hubungan yang bermakna antara grading histopatologi dengan subtipe molekuler (p=0,032). Hubungan infiltrasi limfovaskular dengan subtipe molekuler pada kanker payudara invasif didapatkan bermakna (p=0,000).Kata kunci: grading histopatologi, infiltrasi limfovaskular, subtipe molekuler, kanker payudara invasif AbstractBreast cancer symptoms are often not recognized or clearly perceived by the patient, so it makes most of patients come to doctor in late stage. There are many prognosis factors in breast cancer, such as hystopathology grading, estrogen and progesteron receptors, HER2, and lymphovascular infiltration.The objective of this study was to determine the association between hystopathology grading and lymphovascular infiltration with molecular subtype in invasive breast cancer. Determine the distribution and frequency of hystopatology grading, lymphovascular infiltration, and molecular subtype in invasive breast cancer at surgery department Dr. M. Djamil Hospital Padang period January 1, 2010 – December 31, 2013. The method of this research is analitic observational with cross sectional study. In this research obtained 424 cases of invasive breast cancer, with only 66 cases that could be analyzed. The analysis system that used is univariat and bivariat with chi-square (p<0,05). There is significant correlation between hystopathology grading with molecular subtype (p=0,032). There is significant correlation between lymphovascular infiltration with molecular subtype (p=0,000).Keywords: histopathology grading, lymphovascular infiltration, molecularsubtypes, invasive breast cancer

Prognostic significance of immunohistochemical expression of p53 gene product in invasive breast cancer

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 675-675
Author(s):  
Y.-R. Do ◽  
H.-S. Song ◽  
S. H. Kang ◽  
K.-Y. Jung ◽  
Y.-S. Kim ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Product ◽  
Invasive Breast Cancer ◽  
Prognostic Significance ◽  
P53 Gene ◽  
Immunohistochemical Expression

The effect of margin status and molecular subtype on women with invasive breast cancer treated with breast-conservation therapy.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 83-83
Author(s):  
Jared Forrester ◽  
Adam D. Currey ◽  
Bonifride Tuyishimire ◽  
Jonathan Lin ◽  
Amanda L. Kong
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Tumor Biology ◽  
Breast Conservation ◽  
Margin Status ◽  
Stage I ◽  
Luminal A ◽  
Luminal B ◽  
The Impact

83 Background: A consensus statement was recently published by SSO/ASTRO on margins for stage I and II invasive breast cancer treated with breast conserving surgery (BCS). We examined patients with invasive breast cancer who underwent BCS to determine if margin status and molecular subtype influence outcomes. Methods: We the reviewed charts of 754 Stage I-III breast cancer patients treated with BCS from 2003-2010. Margin status was defined as negative ≥ 2mm, close < 2mm and positive as tumor on ink. Conventional receptor analyses were used as markers for molecular subtype classification (luminal A, luminal B, Her2 positive, and basal). Clinicopathologic variables were tested using the Fisher’s exact, Chi-square, ANOVA F-test, and Kruskal-Wallis tests. A Cox proportional - Hazards model was used to measure the impact of these variables on locoregional recurrence (LRR), breast cancer-specific (BCSS) and overall survival (OS). Results: The median age of the cohort was 58 (range 27-89 years). Most were white (88%), had T1 tumors (76%), luminal A tumors (66%), invasive ductal histology (80%), and were node negative (76%). Of the 754 patients, 26% had close margins, 2% positive margins, and 9% unknown margins. With a median follow-up of 5.2 years, OS was 92%. Twenty eight patients had a LRR with a median time to recurrence of 5.1 years. On multivariate analysis, molecular subtype, pathologic grade (p=0.01), and use of radiation (p<0.0001) were the only significant predictors of LRR. Unknown subtype, compared to Luminal A, was less likely to have a LRR (p=0.04). Basal (p=0.0002), Her2+ (p=0.03), Luminal B (p=0.002) and unknown subtype (p=0.04) had worse BCSS compared to Luminal A tumors. Margins had no impact on LRR or BCSS but those with close margins and unknown margins had worse OS compared to negative margins (p=0.01, p=0.007). Variables predictive of OS were margins, age, race, node status, chemotherapy, anti-endocrine therapy, and radiation. Conclusions: In this cohort treated with BCS, molecular subtype was a predictor of LRR and BCSS but not OS. Margin status did not impact LRR and BCSS. Although margin status was a predictor of OS, tumor biology remains the significant determinant of outcome.

Does Breast Cancer Subtype Impact Margin Status in Patients Undergoing Partial Mastectomy?

2022 ◽  
pp. 000313482110697
Author(s):  
Ileana Horattas ◽  
Andrew Fenton ◽  
Joseph Gabra ◽  
Amanda Mendiola ◽  
Fanyong Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Molecular Subtype ◽  
Breast Cancer Subtype ◽  
Positive Margin ◽  
Margin Status ◽  
Partial Mastectomy ◽  
Positive Margin Rate ◽  
Cancer Subtype ◽  
The Impact

Background Molecular subtype in invasive breast cancer guides systemic therapy. It is unknown whether molecular subtype should also be considered to tailor surgical therapy. The present investigation was designed to evaluate whether breast cancer subtype impacted surgical margins in patients with invasive breast cancer stage I through III undergoing breast-conserving therapy. Methods Data from 2 randomized trials evaluating cavity shave margins (CSM) on margin status in patients undergoing partial mastectomy (PM) were used for this analysis. Patients were included if invasive carcinoma was present in the PM specimen and data for all 3 receptors (ER, PR, and HER2) were known. Patients were classified as luminal if they were ER and/or PR positive; HER2 enriched if they were ER and PR negative but HER2 positive; and TN if they were negative for all 3 receptors. The impact of subtype on the margin status was evaluated at completion of standard PM, prior to randomization to CSM versus no CSM. Non-parametric statistical analyses were performed using SPSS Version 26. Results Molecular subtype was significantly correlated with race ( P = .011), palpability ( P = .007), and grade ( P < .001). Subtype did not correlate with Hispanic ethnicity ( P = .760) or lymphovascular invasion ( P = .756). In this cohort, the overall positive margin rate was 33.7%. This did not vary based on molecular subtype (positive margin rate 33.7% for patients with luminal tumors vs 36.4% for those with TN tumors, P = .425). Discussion Molecular subtype does not predict margin status. Therefore, molecular subtype should not, independent of other factors, influence surgical decision-making.

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