scholarly journals Prevalence of Coronary Heart Disease (CHD) and Selected Risk Factors of CHD, Among People Aged 30-64 Years in the District of Gampaha, Sri Lanka

2021 ◽  
Vol 04 (06) ◽  
Author(s):  
Athula Liyanapathirana ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Sri Lanka ◽  
Alcohol Use ◽  
Tobacco Smoking ◽  
Physical Inactivity ◽  
Harmful Alcohol ◽  
Unhealthy Diet

Background- Coronary heart disease (CHD) is the leading cause of hospital deaths in Sri Lanka. The underlying risk factors include; tobacco smoking, unhealthy diet, harmful alcohol use, physical inactivity, and medical conditions; hypertension, diabetes mellitus, obesity, dyslipidaemia. Objective of this study was to determine prevalence of CHD and risk factors among people aged 30-64 in Gampaha District, Sri Lanka. Methods- A community based cross-sectional study was conducted among 1192 people aged 30-64 years in district of Gampaha, recruited by probability proportionate to the population size, cluster sampling. Data were collected using a pre-tested interviewer-administered questionnaire on prevalence of CHD, hypertension, diabetes mellitus, dyslipidaemia, obesity, harmful alcohol use, unhealthy diet, physical inactivity and tobacco smoking and anthropometric measurements by trained data collectors. Twelve-lead ECG, blood pressure, fasting plasma glucose and lipid levels were done for previously undiagnosed. Data were analyzed using SPSS-21. Results- The estimated prevalence of CHD based on already diagnosed cases and Rose positive angina 6.9% (95% CI 5.4% – 8.4%), CHD based on already diagnosed cases and ECG 6.4 (95% CI 4.9% – 7.8%), hypertension 37.5% (95% CI 34.7% to 40.3%), diabetes mellitus 17.4% (95% CI 15.2% to 19.6%), dyslipidaemia 66.5% (95% CI 63.8% – 69.2%). The estimated prevalence of other modifiable risk factors of generalized obesity (BMI≥25.0) (44.0%, 95%CI41.1-46.9), sub-optimal quality diet (71.9%, 95%CI 69.3-74.5), low level of physical activity (21.7%, 95%CI 19.3-24.1), heavy or high-risk drinking 11.4% (95%CI 9.56-13.2), smoking 14.2% (95%CI 12.2-16.2). Conclusions- Estimated prevalence of CHD and selected risk factors were high in Gampaha District with a large proportion of previously undiagnosed disease. Immediate public health action is needed including training programs for healthcare workers on detection of risk factors and awareness among the public for screening for risk factors.

scholarly journals Lack of association between peroxisome proliferator-activated receptor-gamma-2 gene variants and the occurrence of coronary heart disease in patients with diabetes mellitus

2002 ◽  
pp. 545-551 ◽  
Author(s):  
M Bluher ◽  
T Klemm ◽  
T Gerike ◽  
H Krankenberg ◽  
G Schuler ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Multiple Logistic Regression Analysis ◽  
Peroxisome Proliferator ◽  
Haemoglobin A1c ◽  
Peroxisome Proliferator Activated Receptor ◽  
Patients With Diabetes ◽  
Reduced Risk

OBJECTIVE: Recent evidence indicates that peroxisome proliferator-activated receptor-gamma (PPARgamma) is expressed at high levels in foam cells of atherosclerotic lesions, that PPARgamma agonists may directly modulate vessel wall function and that mutations in the PPARgamma-2 gene are associated with a reduced risk of coronary artery disease. METHODS: We investigated whether known variants in the PPARgamma-2 gene are associated with the occurrence of coronary heart disease (CHD) in 365 patients with type 2 diabetes, prospectively characterised for the presence or absence of CHD. The Pro115Gln, Pro12Ala, Pro467Leu, Val290Met mutations and two polymorphisms C478T and C161T of the PPARgamma-2 gene were examined using PCR, denaturing gradient gel electrophoresis and direct sequencing. RESULTS: The distribution of the Pro12Ala, Ala12Ala, C161T and T161T variants was not significantly different between patients with and without CHD, independent of the gender. The Pro12Ala (P=0.011) and the Ala12Ala (P=0.006) variant were associated with a higher body mass index (BMI) compared with the Pro12Pro genotype. A multiple logistic regression analysis introducing the typical risk factors for CHD (age, sex, hypertension, smoking, BMI >26 kg/m2, elevated low density lipoprotein cholesterol and haemoglobin A1c >7%) identified age >60, male gender, hypertension and a higher BMI, but not the PPARgamma-2 variants, as significant risk factors for CHD in our study groups. CONCLUSION: The PPARgamma-2 genotype was not associated with an increased or reduced risk of the occurrence of CHD and can therefore not be regarded as an independent risk factor for CHD in patients with diabetes mellitus.

scholarly journals The Impact of Risk Factors for Coronary Heart Disease on Related Disability in Older Irish Adults

2017 ◽  
Vol 31 (1) ◽  
pp. 165-184 ◽  
Author(s):  
Sharon M. Cruise ◽  
John Hughes ◽  
Kathleen Bennett ◽  
Anne Kouvonen ◽  
Frank Kee
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Northern Ireland ◽  
Physical Inactivity ◽  
Relative Risks ◽  
Chd Risk ◽  
Health And Social Care ◽  
Chd Risk Factors ◽  
The Impact

Objective: The aim of this study is to examine the prevalence of coronary heart disease (CHD)–related disability (hereafter also “disability”) and the impact of CHD risk factors on disability in older adults in the Republic of Ireland (ROI) and Northern Ireland (NI). Method: Population attributable fractions were calculated using risk factor relative risks and disability prevalence derived from The Irish Longitudinal Study on Ageing and the Northern Ireland Health Survey. Results: Disability was significantly lower in ROI (4.1% vs. 8.8%). Smoking and diabetes prevalence rates, and the fraction of disability that could be attributed to smoking (ROI: 6.6%; NI: 6.1%), obesity (ROI: 13.8%; NI: 11.3%), and diabetes (ROI: 6.2%; NI: 7.2%), were comparable in both countries. Physical inactivity (31.3% vs. 54.8%) and depression (10.2% vs. 17.6%) were lower in ROI. Disability attributable to depression (ROI: 16.3%; NI: 25.2%) and physical inactivity (ROI: 27.5%; NI: 39.9%) was lower in ROI. Discussion: Country-specific similarities and differences in the prevalence of disability and associated risk factors will inform public health and social care policy in both countries.

scholarly journals Faktor Risiko Terjadinya Penyakit Jantung Koroner pada Pasien di Unit Rawat Jalan Rumah Sakit Panti Rapih Yogyakarta

2020 ◽  
Vol 1 (1) ◽  
pp. 21-30
Author(s):  
Deviana Widayanti ◽  
Chatarina Setya Widyastuti
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family History ◽  
Disease Risk ◽  
Sampling Technique ◽  
Excess Body Weight ◽  
History Of ◽  
Lack Of Exercise

Background: Coronary Heart Disease (CHD) Is a condition when the arteries that supply blood to the heart wall experience hardening and narrowing. It is estimated that 30% of coronary heart disease causes death worldwide. Objective: This study aims to determine the risk factors for CHD in Panti Rapih Hospital. Methods: This descriptive study aims to determine the risk factors for CHD in outpatients at Panti Rapih Hospital. The population is patients who have been diagnosed with coronary heart disease and the sample was taken by 50 respondents with non-random accidental sampling technique. This research take the data use questionnaire and make univariat analysis. Results: Risk factors for CHD are a number of factors that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight42% and lack of exercise 38%. Conclusion: Risk factors for CHD that cannot be changed: family history of 42%, age = 40 years 95% in men and 95% age = 65 years in women. Factors that can be changed are: Smoking 78%, history of hypertension 68%, history of diabetes mellitus 28%, dyslipidemic 90%, excess body weight 42% and lack of exercise 38%.     Keywords: coronary heart disease, risk factors

scholarly journals Analisis Survival Penyakit Jantung Koroner Berulang

2018 ◽  
Vol 6 (1) ◽  
pp. 43
Author(s):  
Fidya Panorama Damayanti ◽  
Arief Wibowo
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Survival Data ◽  
Recurrent Event ◽  
Observational Research ◽  
Research Approach ◽  
Hypertension Status ◽  
Cox Regression Analysis

Survival analysis is one of data analysis the result showing certain times had happened. Cox regression analysis is one of the most powerful and commonly used for analyzing survival data since the result of this method showing nearly similar result to parametric model. This study aim is to determine case of recurrent Coronary Heart Disease risk factors, and to know how many survival in day of recurrent Coronary Heart Disease based on the risk factors at RS Islam Surabaya in 2015 – 2016. Measurement in research subjects was conducted in the medical record. This research using observational research approach. Subjects were 63 Coronary Heart Disease inpatients in RS Islam Surabaya. Measurement was conducted to obtain information of examined variables. Independent variables were data sensor status, survival time (measured in day), sex, age, hypertension, hyperlipidemia, and diabetes mellitus. This analysis showing the occurrence time average of recurrent CHDs in Coronary Heart Disease patients in general is 614 days. Rate of reccurence had similar risks for all age groups, gender, hypertension, hyperlipidemia, and diabetes mellitus. CHD patients with hypertension status have risk of 9.291 times greater than no hypertension status. This research can be used by RS Islam Surabaya to gave Communication, Information, and Education to the patient and their relatives especially for patient with hypertension status to have continuous check-up in order not to get another recurrent event of CHD in the near future.

scholarly journals Atrial fibrillation risk factors in patients with ischemic stroke

2021 ◽  
Vol 17 (1) ◽  
pp. 19-24
Author(s):  
Paweł Wańkowicz ◽  
Przemysław Nowacki ◽  
Monika Gołąb-Janowska
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Nonvalvular Atrial Fibrillation ◽  
Multivariable Logistic Regression Model ◽  
Lipid Metabolism Disorders

IntroductionAtrial fibrillation (AF) is the most common heart arrhythmia. The condition is known to increase the risk of ischemic stroke (IS). Classical risk factors for the development of AF include advanced age, hypertension, diabetes mellitus, coronary heart disease and lipid metabolism disorders. Importantly, these are also recognized risk factors for ischemic stroke. Therefore, the purpose of this study was to investigate AF risk factors in patients with IS.Material and methodsThis is single-centre retrospective study which included 696 patients with acute ischemic stroke and nonvalvular atrial fibrillation and 1678 patients with acute ischemic stroke without atrial fibrillation.ResultsIn this study we found – based on a univariable and multivariable logistic regression model – that compared to the patients with IS without AF, the group of patients which suffered from IS with nonvalvular atrial fibrillation (NVAF) had a higher proportion of patients who smoked cigarettes (OR = 15.742, p < 0.01; OR = 41.1, p < 0.01), had hypertension (OR = 5.161, p < 0.01; OR = 5.666, p < 0.01), history of previous stroke (OR = 3.951, p < 0.01; OR = 4.792, p < 0.01), dyslipidemia (OR = 2.312, p < 0.01; OR = 1.592, p < 0.01), coronary heart disease (OR = 2.306, p < 0.01; OR = 1.988, p < 0.01), a greater proportion of female patients (OR = 1.717, p < 0.01; OR = 2.095, p < 0.01), higher incidence of diabetes mellitus (OR = 1.341, p < 0.01; OR = 1.261, p = 0.106) and more patients in old age (OR = 1.084, p < 0.01; OR = 1.101, p < 0.01).ConclusionsOur study demonstrates a need for thorough and systematic monitoring of post-ischemic stroke patients in whom AF has not been detected and who display other important risk factors. Regardless of the stroke, these factors may be responsible for development of AF.

Risk factors and glycation end products in patients with different forms of coronary heart disease and type 2 diabetes mellitus

2015 ◽  
Vol 87 (10) ◽  
pp. 19
Author(s):  
E. V. Ivannikova ◽  
V. Yu. Kalashnikov ◽  
O. M. Smirnova ◽  
I. V. Kononenko ◽  
A. B. Kuznetsov ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Glycation End Products ◽  
End Products

scholarly journals Risk factors of coronary heart disease: attitude and behaviour in family practice in Saudi Arabia

1999 ◽  
Vol 5 (1) ◽  
pp. 35-45 ◽  
Author(s):  
M. S. Khattab ◽  
M. A. Abolfotouh ◽  
W. Alakija ◽  
M. A. Al Humaidi ◽  
S. Al Wahat
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family Practice ◽  
Physical Inactivity ◽  
Fat Intake ◽  
Significant Difference ◽  
Lifestyle Questionnaire ◽  
Males And Females ◽  
The Mean

To study risk factors of attitudes and behaviour towards coronary heart disease [CHD], 280 Saudis > or = 20 years attending a family practice answered a structured health and lifestyle questionnaire and had their weight, height, blood pressure and random total cholesterol measured. Significant difference was found between males and females in the mean number of cardiovascular risk factors [t = -3.03, P < 0.01]. Few people with high dietary fat intake, obesity or physical inactivity perceived their behaviour as harmful. The number of people who perceived an associated risk to their health increased with incidence of smoking and obesity but not with high fat intake. Physically inactive people were least likely to perceive their behaviour as harmful

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