US federal task force broadens definition of scientific integrity

2022 ◽  
pp. 16-16
Author(s):  
Andrea Widener
Keyword(s):  
Task Force ◽  
Scientific Integrity ◽  
Definition Of

scholarly journals Post-infections and sepsis associated myocardial infarction: casuistic masks

2021 ◽  
Vol 16 (7-8) ◽  
pp. 106-109
Author(s):  
L.O. Malsteva ◽  
W.W. Nikonov ◽  
N.A. Kazimirova ◽  
A.A. Lopata
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricle ◽  
Task Force ◽  
Laboratory Data ◽  
Myocardial Damage ◽  
Time Frame ◽  
Diagnostic Value ◽  
Epidemiological Studies ◽  
Definition Of ◽  
Post Infectious

The review aims to present the chronological sequence of developing universal definitions of myocardial infarction, new ideas for improving the screening of post-infectious and sepsis-associated myocardial infarction (MI) (casuistic masks of myocardial infarction). The stages of the development of the common and global definition of myocardial infarction are outlined: 1 — by WHO working groups based on ECG for epidemiological studies; 2 — by the European Society of Cardiology and the American College of Cardio-logy using clinical and biochemical approaches; 3 — the Global Task Force consensus document of universal definition with subsequent classification of MI into five subtypes (spontaneous, dissonance in oxygen delivery and consumption; lethal outcome before the rise of specific markers of myocardial damage; PCI-associated; CABG- associated); 4 — review by the Joint Task Force of the above document based on the inclusion of more sensitive markers — troponins; 5 — the allocation of 17 non-ischemic myocardial damage, accompanied by an increase in the level of troponin; 6 — characteristic of the atrial natriuretic peptide from the standpoint of its synthesis, storage, release, diagnostic value as a biomarker of acute myocardial dama­ge; 7 — a clinical definition of myocardial infarction, presented in materials of the III Consensus on myocardial infarction 2017. The diagnosis of myocardial infarction using the criteria set in this document requires the integration of clinical data, ECG patterns, laboratory data, imaging findings, and, in some cases, pathological results, which are considered in the context of the time frame of the suspec­ted event. K. Thygesen et al. consider the additional use of: 1) cardiovascular magnetic resonance to determine the etiology of myocardial damage; 2) computer coronary angiography with suspected myocardial infarction. Myocardial infarction is a combination of specific cardio markers with at least one of the symptoms listed above. The formation of myocardial infarction can occur during/after acute respiratory infection. Causal relationships between these two states are established. Post-infectious myocardial infarction is strongly recommended to be individualized as a separate diagnostic entity. In sepsis, global myocardial ischemia with ischemic myocardial damage arises as a result of humoral and cellular factors, accompanied by an increase in troponins, a decrease in the ejection fraction of the left ventricle by 45 % and an increase in the final diastolic size of the left ventricle, the development of sepsis-associated multiple organ fai­lure, which is an unfavourable prognosis factor.

Comment on a Standard Definition of Response Rates

1984 ◽  
Vol 21 (3) ◽  
pp. 336-338 ◽  
Author(s):  
Frederick Wiseman ◽  
Maryann Billington
Keyword(s):  
Task Force ◽  
Marketing Research ◽  
Response Rates ◽  
Research Community ◽  
Journal Articles ◽  
Quality Of Data ◽  
Standard Definition ◽  
Industry Standard ◽  
Definition Of

The lack of a standard definition of response rates in surveys has resulted in problems in the marketing research community, including ambiguity in pricing and evaluating research proposals and in assessing the quality of data used in industry reports and journal articles. This comment highlights the work of an industry task force which has considered the implications of different definitions and proposed an industry standard.

Do Patients With HIV-Associated Minor Cognitive/Motor Disorder Exhibit a “Subcortical” Memory Profile? Evidence Using the California Verbal Learning Test

Assessment ◽  
1995 ◽  
Vol 2 (2) ◽  
pp. 151-165 ◽  
Author(s):  
Dean C. Delis ◽  
Guerry Peavy ◽  
Robert Heaton ◽  
Nelson Butters ◽  
David P. Salmon ◽  
...  
Keyword(s):  
Task Force ◽  
Verbal Learning ◽  
Diagnostic Category ◽  
Disease Process ◽  
California Verbal Learning Test ◽  
Motor Disorder ◽  
Hiv Patients ◽  
Learning Test ◽  
Definition Of ◽  
Cortical Involvement

A new diagnostic category for HIV seropositive patients–Minor Cognitive/Motor Disorder (MCMD)—was recently proposed by an AIDS task force sponsored by the American Academy of Neurology. Based on past memory research with HIV+ patients who were diagnosed according to the Center for Disease Control (CDC) definition of AIDS, we predicted that HIV+ patients who met the new criteria for MCMD would exhibit a “subcortical” memory profile (i.e., they would display primarily a retrieval deficit). This hypothesis was generally supported, but with some exceptions. The HIV+ patients with MCMD were found to have a mild encoding deficit (suggestive of some cortical involvement) superimposed on a pronounced retrieval deficit (suggestive of more extensive subcortical involvement). These findings are consonant with those from a recent neuropathological study indicating an increase in cortical involvement, in addition to predominately subcortical involvement, in more advance stages of the HIV disease process.

The Texas Rehabilitation Commission System for Measuring Quality Rehabilitation

1992 ◽  
Vol 23 (2) ◽  
pp. 21-25 ◽  
Author(s):  
A. James Schwab ◽  
John A. Fenoglio
Keyword(s):  
Needs Assessment ◽  
Client Satisfaction ◽  
Task Force ◽  
Community Relations ◽  
First Year ◽  
Four Dimensions ◽  
Task Forces ◽  
Definition Of ◽  
Client Needs

The Texas Rehabilitation Commission appointed two task forces over a two-year period to develop a system for measuring quality rehabilitation. The first task force developed a definition of quality rehabilitation and identified four dimensions of quality that it believed were possible to measure: client satisfaction, client needs assessment fulfillment, casefolder review, and advocacy/community relations. The second quality committee refined the measurable elements and developed a system for awarding quality points for the first year of implementation.

scholarly journals Responsiveness in Rheumatoid Arthritis. A Report from the OMERACT 11 Ultrasound Workshop

2013 ◽  
Vol 41 (2) ◽  
pp. 379-382 ◽  
Author(s):  
Annamaria Iagnocco ◽  
Esperanza Naredo ◽  
Richard Wakefield ◽  
George A.W. Bruyn ◽  
Paz Collado ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Task Force ◽  
Power Doppler ◽  
Consensus Definition ◽  
Synovitis Score ◽  
The Us ◽  
Definition Of ◽  
Acceptable Reliability ◽  
Power Doppler Signal

Objective.To summarize the work performed by the Outcome Measures in Rheumatology (OMERACT) Ultrasound (US) Task Force on the validity of different US measures in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) presented during the OMERACT 11 Workshop.Methods.The Task Force is an international group aiming to iteratively improve the role of US in arthritis clinical trials. Recently a major focus of the group has been the assessment of responsiveness of a person-level US synovitis score in RA: the US Global Synovitis Score (US-GLOSS) combines synovial hypertrophy and power Doppler signal in a composite score detected at joint level. Work has also commenced examining assessment of tenosynovitis in RA and the role of US in JIA.Results.The US-GLOSS was tested in a large RA cohort treated with biologic therapy. It showed early signs of improvement in synovitis starting at Day 7 and increasing to Month 6, and demonstrated sensitivity to change of the proposed grading. Subsequent voting questions concerning the application of the US-GLOSS were endorsed by > 80% of OMERACT delegates. A standardized US scoring system for detecting and grading severity of RA tenosynovitis and tendon damage has been developed, and acceptable reliability data were presented from a series of exercises. A preliminary consensus definition of US synovitis in pediatric arthritis has been developed and requires further testing.Conclusion.At OMERACT 11, consensus was achieved on the application of the US-GLOSS for evaluating synovitis in RA; and work continues on development of RA tenosynovitis scales as well as in JIA synovitis.

Implementation of the concept of “politically exposed persons (PEPs)” in India

2017 ◽  
Vol 20 (1) ◽  
pp. 89-98 ◽  
Author(s):  
Ramandeep Kaur Chhina
Keyword(s):  
Money Laundering ◽  
Regulatory Focus ◽  
Task Force ◽  
International Standards ◽  
Regulatory Requirements ◽  
Content Type ◽  
Reserve Bank ◽  
Financial Action Task ◽  
Definition Of ◽  
Effective Development

Purpose The purpose of this paper is to critically examine the concept of “politically exposed persons (PEPs)” as provided under the Indian anti-money laundering (AML) regime, particularly focussing on the Reserve Bank of India guidelines to its supervised banks on dealing with the potential money laundering risks posed by PEPs. Design/methodology/approach The definition of PEPs as provided by international standard setters and the concept as defined by the Indian AML regime was examined to examine the extend of the compliance of the Indian AML regime with the mandatory requirements of revised 2012 Financial Action Task Force (FATF) recommendations and other international standards. Findings The paper clearly establishes that the current AML regime of India does not fully comply with the mandatory requirements of the revised 2012 FATF recommendations, and the RBI guidelines do not provide any clear indications to its supervised banks on the effective development and implementation of AML PEPs control. The paper argues that it is high time for India to increase its regulatory focus on the issue of PEPs and to expand its definition of PEPs by including both domestic PEPs and “close associates” of PEPs within the definition. Originality/value The paper demonstrates in an exceptional way that despite variations in the scope of the PEPs definition at an international level, all the standard setters have included certain key individuals (both domestic and foreign PEPs and “close associates” of PEPs) within the scope of the definition and how the legal and regulatory requirements in India are falling short of compliance even with these minimum key requirements. By adopting a step-by-step approach in critically examining the current legal and regulatory requirements enforced on banks in India to efficiently deal with the money laundering risks posed by PEPs, the paper makes a valuable contribution in highlighting the steps that might be taken to strengthen PEPs’ AML controls in India.

scholarly journals DESIGNING DRUG TRIALS FOR SARCOPENIA IN OLDER ADULTS WITH HIP FRACTURE – A TASK FORCE FROM THE INTERNATIONAL CONFERENCE ON FRAILTY AND SARCOPENIA RESEARCH (ICFSR)

2014 ◽  
pp. 1-6
Author(s):  
B. VELLAS ◽  
R. FIELDING ◽  
R. MILLER ◽  
Y. ROLLAND ◽  
S. BHASIN ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Hip Fracture ◽  
Diagnostic Criteria ◽  
Task Force ◽  
National Institutes Of Health ◽  
Pharmaceutical Companies ◽  
Working Definition ◽  
Age Related ◽  
Increased Risk ◽  
Definition Of

In May 2012, a Sarcopenia Consensus Summit was convened by the Foundation of the National Institutes of Health (FNIH), National Institute of Aging (NIA), and the U.S. Food and Drug Administration (FDA); and co-sponsored by five pharmaceutical companies. At this summit, sarcopenia experts from around the world worked to develop agreement on a working definition of sarcopenia, building on the work of previous efforts to generate a consensus. With the ultimate goal of improving function and independence in individuals with sarcopenia, the Task Force focused its attention on people at greatly increased risk of muscle atrophy as a consequence of hip fracture. The rationale for looking at this population is that since hip fracture is a recognized condition, there is a clear regulatory path forward for developing interventions. Moreover, patients with hip fracture may provide an appropriate population to advance understanding of sarcopenia, for example helping to define diagnostic criteria, develop biomarkers, understand the mechanisms that underlie the age-related loss of muscle mass and strength, and identify endpoints for clinical trials that are reliable, objective, and clinically meaningful. Task Force members agreed that progress in treating sarcopenia will require strengthening of partnerships between academia, industry, and government agencies, and across continents to reach consensus on diagnostic criteria, optimization of clinical trials design, and identification of improved treatment and preventive strategies. In this report, the main results of the Task Force discussion are presented.

scholarly journals CLINICALLY MEANINGFUL CHANGE FOR PHYSICAL PERFORMANCE: PERSPECTIVES OF THE ICFSR TASK FORCE

2019 ◽  
pp. 1-5
Author(s):  
J. Guralnik ◽  
K. Bandeen-Roche ◽  
S.a.r. Bhasin ◽  
S. Eremenco ◽  
F. Landi ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Physical Performance ◽  
Performance Measures ◽  
Patient Reported Outcomes ◽  
Task Force ◽  
Meaningful Change ◽  
Patient Reported ◽  
Research Task ◽  
Definition Of ◽  
Clinical Meaningfulness

For clinical studies of sarcopenia and frailty, clinically meaningful outcome measures are needed to monitor disease progression, evaluate efficacy of interventions, and plan clinical trials. Physical performance measures including measures of gait speed and other aspects of mobility and strength have been used in many studies, although a definition of clinically meaningful change in performance has remained unclear. The International Conference on Frailty and Sarcopenia Research Task Force (ICFSR-TF), a group of academic and industry scientists investigating frailty and sarcopenia, met in Miami Beach, Florida, USA in February 2019 to explore approaches for establishing clinical meaningfulness in a manner aligned with regulatory authorities. They concluded that clinical meaningful change is contextually dependent, and that both anchor- based and distribution-based methods of quantifying physical function are informative and should be evaluated relative to patient-reported outcomes. In addition, they identified additional research needed to enable setting criteria for clinical meaningful change in trials.

scholarly journals Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations

2019 ◽  
Vol 46 (5) ◽  
pp. 518-522 ◽  
Author(s):  
Peter Stoustrup ◽  
Cory M. Resnick ◽  
Thomas Klit Pedersen ◽  
Shelly Abramowicz ◽  
Ambra Michelotti ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Task Force ◽  
Healthcare Providers ◽  
Validity Testing ◽  
Dentofacial Deformity ◽  
External Expert ◽  
Assessment Approach ◽  
Multidisciplinary Group ◽  
Definition Of ◽  
Method Of Assessment

Objective.To propose multidisciplinary, consensus-based, standardization of operational terminology and method of assessment for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA).Methods.Using a sequential expert group–defined terminology and methods-of-assessment approach by (1) establishment of task force, (2) item generation, (3) working group consensus, (4) external expert content validity testing, and (5) multidisciplinary group of experts final Delphi survey consensus.Results.Seven standardized operational terms were defined: TMJ arthritis, TMJ involvement, TMJ arthritis management, dentofacial deformity, TMJ deformity, TMJ symptoms, and TMJ dysfunction.Conclusion.Definition of 7 operational standardized terms provides an optimal platform for communication across healthcare providers involved in JIA-TMJ arthritis management.

Development of an Individualized Service Plan Tool and Rules for Case Management in Québec

2009 ◽  
Vol 10 (3) ◽  
pp. 89-99 ◽  
Author(s):  
Dominique Somme ◽  
Lucie Bonin ◽  
Paule Lebel ◽  
Réjean Hébert ◽  
François Blanchard
Keyword(s):  
Social Services ◽  
Assessment Tool ◽  
Task Force ◽  
Action Plan ◽  
Case Managers ◽  
Clinical Tool ◽  
Integration Of Services ◽  
Service Plan ◽  
Definition Of ◽  
User Friendly

From past experience with integrated service delivery, there appears to be a need for a clinical tool to help case managers plan, monitor, and coordinate services. In this context the Québec Ministry of Health and Social Services created a task force to suggest improvements to the Individualized Service Plan tool included in the Multiclientele Assessment Tool. This article reports the findings of this multidisciplinary task force working with various clienteles (older, with physical or mental disabilities, mental diseases). Based on a literature review and recent results from the Program of Research on the Integration of Services for the Maintenance of Autonomy, the task force proposed a dynamic, concise, user-friendly tool and a clear definition of how it should be used. The Individualized Service Plan must list the patient’s needs, with an orientation regarding the action plan for each, and a list of services allocated in response to these needs that work in the defined direction. The tool must also contain a section for analyzing variations between the services needed and allocated. This tool was presented to case managers for validation and received an enthusiastic response. It should be implemented in the coming years in the provincial Multiclientele Assessment Tool.

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