scholarly journals SIADH (Syndrome of Inappropriate ADH Secretion): Perplexing Look of Dengue Fever

2021 ◽  
pp. 1-4
Author(s):  
Richmond Ronald Gomes ◽  
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Animal Studies ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Fluid Extravasation ◽  
Health Organization ◽  
Expanded Dengue Syndrome

Dengue is a mosquito-borne disease (female mosquitoes of the Aedes genus, principally Aedes aegypti) caused by any one of four closely related dengue viruses. It is endemic in tropical and subtropical continent. World health organization (WHO) currently estimates there may be 50 -100 million dengue infections worldwide every year with over 2.5 billion people at risk of dengue. Symptomatic dengue virus infection may manifests as undifferentiated fever, classical dengue fever (with or without unusual hemorrhages), and dengue hemorrhagic fever (with or without shock). Isolated organopathy or expanded dengue syndrome (EDS) was coined by WHO in the year 2012 to describe cases, which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. The atypical manifestations noted in expanded dengue are multisystemic and multifaceted with organ involvement, such as liver, brain, heart, kidney, central/peripheral nervous system, gastrointestinal tract, lympho reticular system. Dengue virus has long been considered as a non-neurotropic virus, as animal studies have shown that virus does not cross blood brain barrier. Hyponatremia may be found in association with dengue fever and is thought to be caused by peripheral fluid extravasation and resulting intravascular hypovolaemia. But hyponatremia due to syndrome of inappropriate secretion of anti-diuretic hormone (SIADH) in Dengue fever is rare. We report a 40 years old male who was diagnosed as Dengue fever (Dengue Ns1Ag positive) with thrombocytopenia and hyponatremia. He was admitted and further investigations revealed SIADH. He responded well to cautious sodium replacement and addition of tolvaptan. He recovered completely and was discharged after one week. Thus, all clinicians should keep in mind the possibility of SIADH as a part of expanded dengue syndrome.

scholarly journals Expanded Dengue Syndrome Presenting as Acute Pancreatitis

2021 ◽  
Vol 3 (9) ◽  
pp. 01-06
Author(s):  
Richmond R Gomes
Keyword(s):  
Acute Pancreatitis ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Serum Lipase ◽  
Atypical Manifestations ◽  
Health Organization ◽  
Upper Abdominal ◽  
Expanded Dengue Syndrome

Dengue is a painful, debilitating mosquito-borne disease(female mosquitoes of the Aedes genus, principally Aedes aegypti)caused by any one of four closely related dengue viruses.It is endemic in tropical and subtropical continent. World health organization (WHO) currently estimates there may be 50 -100 million dengue infections worldwide every year with over 2.5 billion people at risk of dengue. Symptomatic dengue virus infection may manifests as undifferentiated fever, classical dengue fever (with or without unusual hemorrhages), and dengue hemorrhagic fever(with or without shock). Expanded dengue syndrome (EDS) was coined by WHO in the year 2012 to describe cases, which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. The atypical manifestations noted in expanded dengue are multisystemic and multifaceted with organ involvement, such as liver, brain, heart, kidney, central/peripheral nervous system, gastrointestinal tract, lympho reticular system. Here we present a case of 35 years old female without any comorbidities who was serologically diagnosed with dengue developed severe upper abdominal pain on 2ndafebrile day and eventually diagnosed as acute pancreatitis both by raised serum lipase and ultrasonographic evidence of swollen pancreas. She was treated conservatively and improved. Thus, all clinicians should keep in mind the possibility of acute pancreatitis as a part of expanded dengue syndrome.

scholarly journals Dengue: Foreshadowing from Ancient Foe

2021 ◽  
Vol 5 (3) ◽  
Keyword(s):  
Nervous System ◽  
Dengue Hemorrhagic Fever ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
World Health ◽  
Dengue Virus Infection ◽  
Atypical Manifestations ◽  
Reticular System ◽  
Health Organization ◽  
Expanded Dengue Syndrome

Dengue is a painful, debilitating mosquito-borne disease(female mosquitoes of the Aedes genus, principally Aedes aegypti)caused by any one of four closely related dengue viruses. It is endemic in tropical and subtropical continent. World health organization (WHO) currently estimates there may be 50 -100 million dengue infections worldwide every year with over 2.5 billion people at risk of dengue. Symptomatic dengue virus infection may manifest as undifferentiated fever, classical dengue fever (with or without unusual hemorrhages), and dengue hemorrhagic fever (with or without shock). Expanded dengue syndrome(EDS) was coined by WHO in the year 2012 to describe cases, which do not fall into either dengue shock syndrome or dengue hemorrhagic fever. The atypical manifestations noted in expanded dengue are multisystem and multifaceted with organ involvement, such as liver, brain, heart, kidney, central/peripheral nervous system, gastrointestinal tract, lympho reticular system.

scholarly journals Clinical profile of dengue fever infection in patients admitted in NC Medical College, Haryana in the year 2019

2020 ◽  
Vol 8 (8) ◽  
pp. 3027
Author(s):  
Mohd Y. Shah ◽  
Faisal Y. Shah ◽  
Ifrah S. Kitab ◽  
Faizan Y. Shah
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Clinical Profile ◽  
Host Immune Responses ◽  
Medical College

Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at NCMC.Methods: This retrospective study included 24 patients infected with dengue virus, aged 19 years to 45 years. Laboratory and haematological data were included.Results Peak of infection occurred in November 2019 and no cases were recorded in October 2019. Common clinical symptoms were fever, joint pains, headache and rash. Common haematological abnormalities were thrombocytopenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations.

scholarly journals Clinical profile of dengue fever infection in patients admitted in NCMC medical college, Panipat, Haryana, India

2018 ◽  
Vol 6 (3) ◽  
pp. 878
Author(s):  
Mohd Younus Shah ◽  
Faisal Y. Shah ◽  
Faizan Y. Shah ◽  
Saurabh Satya
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Clinical Profile ◽  
Host Immune Responses ◽  
Medical College

Background: Dengue infections can result in a wide spectrum of disease severity ranging from an influenza-like illness (dengue fever; DF) to the life-threatening dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). The study was aimed to compare the clinical profile of all patients diagnosed with dengue viral infection at NCMC.Methods: This retrospective study included 136 patients infected with dengue virus, age 2 years to 68 years. Laboratory and haematological data were included.Results: Peak of infection occurred in Nov. 2017 and least number of cases were recorded in September 2017. Common clinical symptoms were fever, headache and myalgia. Common haematological abnormalities were thrombocytopenia and leucopoenia. All patients survived. There was no case of dengue hemorrhagic fever or dengue shock syndrome.Conclusions: Significant differences in the clinical profile is possibly because of infection with different serotypes of dengue virus (DENV), concurrent/sequential infection of more than one serotype, and differences in host immune responses associated with host genetic variations.

scholarly journals Dengue worldwide: an overview of the current situation and the implications for Europe

2007 ◽  
Vol 12 (25) ◽  
Author(s):  
Collective Diseases of Environmental and Zoonotic Origin Team, ECDC
Keyword(s):  
At Risk ◽  
World Health Organization ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hemorrhagic Fever ◽  
Current Situation ◽  
Annual Incidence ◽  
World Health ◽  
The World ◽  
Health Organization

The annual incidence of dengue fever and dengue hemorrhagic fever has increased dramatically around the world in recent decades; the World Health Organization estimates that over 2.5 billion people are currently at risk from dengue viruses worldwide.

scholarly journals A prospective study to analyze the clinical, biochemical and hematological parameters of dengue fever in Mahatma Gandhi Memorial Hospital, Warangal, Telangana, India

2017 ◽  
Vol 4 (1) ◽  
pp. 218 ◽  
Author(s):  
E. Chandra Shekar ◽  
. Laxminarayana ◽  
B. Kishan ◽  
Suresh Kumar ◽  
Bikshapati Rao
Keyword(s):  
Dengue Virus ◽  
Dengue Fever ◽  
Dengue Hemorrhagic Fever ◽  
Hematological Parameters ◽  
Dengue Shock Syndrome ◽  
Hemorrhagic Fever ◽  
Memorial Hospital ◽  
Female Ratio ◽  
Mahatma Gandhi ◽  
Function Tests

Background: Dengue is the most common mosquito borne endemo-epidemic arboviral infection in many of the tropical and subtropical regions of the world. Dengue virus (DEN) is a small single-stranded RNA virus comprising of four distinct serotypes (DEN-1 to -4). Dengue virus infections were grouped into three categories: undifferentiated fever, dengue fever (DF) and dengue haemorrhagic fever (DHF). This study was done to analyze the clinical, biochemical and hematological parameters of dengue fever.Methods: 100 patients admitted to AMC / IMC / WARDS of Mahatma Gandhi Memorial Hospital Warangal, Telangana, India during the period November 2012 - October 2013, presenting with acute febrile illness who are IgM seropositive for dengue and satisfying inclusion and exclusion criteria. Patients belonging to the age group of above 12 years, belonging to both sexes were selected and included in the study group.Results: A total of 100 patients admitted to our hospital with fever and IgM dengue positive were studied. Out of 100 patients, 81 (81%) patients were diagnosed to have DF. 10 (10%) patients were diagnosed to have dengue hemorrhagic fever (DHF) and 9 (9%) patients were diagnosed to have dengue shock syndrome (DSS) based on WHO criteria. The present study included 53 (53%) male patients and 47 (47%) female patients. Male to female ratio is 1.13:1.Conclusions: In our study classical dengue fever was the most common clinical presentation followed by complicated forms such as dengue hemorrhagic fever and dengue shock syndrome. On investigation deranged liver function tests, renal function tests, ascites, hepatospleenomegaly on ultrasonography and pleural effusion on chest radiography are more commonly seen in patients with DHF and DSS. Platelet count does not correlate with the severity of the disease.

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