scholarly journals Penatalaksanaan Anestesi untuk Seksio Sesarea pada Multigravida dengan Kardiomiopati Peripartum

2020 ◽  
Vol 1 (1) ◽  
pp. 18-22
Author(s):  
Purwoko Purwoko ◽  
Andi Rizki Caprianu
Keyword(s):  
Ejection Fraction ◽  
General Anesthesia ◽  
Anesthetic Management ◽  
Cardiac Contractility ◽  
Caesarian Section ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Reproductive Age ◽  
Ventricular Contractility ◽  
Sudden Decrease

Peripartum Cardiomyopathy (PPCM) merupakan salah satu jenis kardiomiopati dilatasi tanpa diketahui penyebabnya yang terjadi pada wanita hamil usia reproduktif yang jarang terjadi. Patofisiologi PPCM masih kontroversial, penyebab PPCM tidak bisa dijelaskan dengan etiologi tunggal, karena memiliki penyebab multifaktor. Pasien wanita, 43 tahun, ASA III dengan preeklamsi berat pada multigravida hamil preterm belum dalam persalinan dengan PPCM NYHA II riwayat seksio sesarea 10 tahun rencana dilakukan re-seksio sesarea elektif. Pada pasien ini didapatkan pada pemeriksaan kardiovaskuler dengan murmur pansistolik. Ekokardiografi ventrikel kiri dilatasi, kontraktilitas ventrikel kiri menurun ejection fraction 31%, fungsi diastolik restriktif, mitral regurgitasi ringan. Rencana dilakukan anestesi dengan teknik epidural namun dalam pelaksanaannya gagal epidural kemudian dikonversi menjadi anestesi umum intubasi oral. Secara umum, target hemodinamik pada berbagai teknik anestesi adalah sama, yaitu mengurangi kardiak preload dan afterload serta mencegah penurunan kontraktilitas kardiak yang sudah buruk sebelumnya. Teknik anestesi yang menghasilkan penurunan mendadak pada tahanan pembuluh darah sistemik sebaiknya dihindari. Manajemen anestesi pada pasien dengan PPCM, teknik regional anestesi maupun anestesi umum dapat diterapkan. Namun tetap mempertimbangkan beberapa faktor seperti kondisi pasien dan kemampuan dari dokter anestesi itu sendiri.   Anesthetic Management for Caesarean Section in Multygravida with Peripartum Cardiomyopathy Abstract Peripartum Cardiomyopathy (PPCM) is one type of dilated cardiomyopathy without known cause in pregnant women in reproductive age are rare. Pathophysiology of PPCM is still controversial, the cause of PPCM can not be explained by a single etiology because it has multifactor. Female patient, 43 years, ASA III with severe preeclamsia pregnancy, preterm, multigravida and not yet in labor with PPCM NYHA II and history of caesarian section 10 years ago planned for elective re-caesarian section. In this patient was obatained pansistolic murmur on cardiovascular examination. Echocardiography was obtained dilated left ventricle, left ventricular contractility decrease with ejection fraction 31%, restrictive diastolic function, mild mitral regurgitation. Planned for anesthesia with epidural technique but in implementation the epidural was fail then converted into general anesthesia oral intubation. In general, hemodynamic targets in anesthesia techniques are the same, ie reducing cardiac preload and afterload and preventing a decline in bad cardiac contractility. Anesthesia techniques that produce a sudden decrease in systemic vascular resistance should be avoided. Anesthesia management in patient with PPCM both regional and general anesthesia technique can be applied. But still considering several factors such as patient’s condition and the ability of the anesthesiologist itself.

scholarly journals Anesthetic Management and Perioperative Events of Peripartum Cardiomyopathy during Cesarean Delivery a Series of Five Cases

2018 ◽  
Vol 03 (02/03) ◽  
pp. 198-203
Author(s):  
Sree Rama Mellacheruvu ◽  
Kousalya Chakravarthy ◽  
Khaliq Ahmed
Keyword(s):  
Cesarean Section ◽  
General Anesthesia ◽  
Case Reports ◽  
Anesthetic Management ◽  
Rare Condition ◽  
Late Pregnancy ◽  
Postoperative Management ◽  
Peripartum Cardiomyopathy ◽  
Morbidity And Mortality ◽  
High Morbidity

AbstractPeripartum cardiomyopathy (PPCM) is a rare idiopathic cardiomyopathy having an incidence of less than 0.1%. PPCM is associated with high morbidity and mortality rates ranging from 5 to 32%. In this review, the authors report a series of five PPCM cases. The case reports included pregnant women with PPCM, admitted in the hospital from October 1, 2017 to June 1, 2018 over a period of 9 months who required cesarean section. The authors aim to discuss the presentation, optimization, anesthetic management, and postoperative care of this rare condition. One of the cases was a booked case. The remaining four pregnant patients were referred in late pregnancy with features of congestive cardiac failure. One patient was in acute pulmonary edema, required intubation, and subsequently had cesarean section under general anesthesia. Four patients were managed with incremental epidural anesthesia. The need for proper preoperative optimization and intra- and postoperative management was discussed. The authors had one maternal mortality in our series. There was no neonatal mortality. Early diagnosis of PPCM, prompt treatment of heart failure, planning the delivery, and postpartum care can decrease maternal morbidity and mortality. Incremental epidural dosing can be used for cesarean section and has the advantage of stable hemodynamic status without the risks associated with general anesthesia.

P370Added value changes in signal sonr in patients with = <30% left ventricular ejection fraction

EP Europace ◽  
2020 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
J J Garcia Guerrero ◽  
J Fernandez De La Concha Castaneda ◽  
A Chacon Pinero ◽  
J Garcia Fernandez ◽  
I Fernandez Lozano ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Hospital Admission ◽  
Dilated Cardiomyopathy ◽  
Interim Analysis ◽  
Cardiac Contractility ◽  
Inverse Correlation ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Lv Ejection Fraction

Abstract Abstract/Introduction Decompensated congestive heart failure (CHF) is a main and increasing health problem worldwide, which leads to patients’ bad outcomes and high money expenditure. Direct relationship between Brain Natriuretic Peptides (NT-proBNP) increasing levels and adverse clinical outcomes have been demonstrated in patients with CHF.  SonR signal sensor, a micro-accelerometer embedded in the tip of the atrial lead in patients implanted with devices, picks up cardiac muscle vibration. Its amplitude is a surrogate for cardiac contractility, which is found to be further reduced in patients with decompensated CHF. Purpose We sought to find a significant inverse correlation between SonR signal and NT-proBNP levels, in order to use SonR as a surrogate of NT-proBNP to anticipate worsening CHF leading to hospital admission. Methods AVCs SONR trial is a pilot, prospective, observational, multicentre study, in which patients with dilated cardiomyopathy, any aetiology, LV ejection fraction ≤ 30%, at least one recent (&lt; 1 year) hospital admission due to CHF, and implanted with CRT-D devices (used as dual-chamber, no left ventricular (LV) lead implanted) with SonR sensor feature, were enrolled. During a year, NT-proBNP and SonR values were obtained every month, and both levels compared (Pearson’s test) Results This an interim analysis of our data, 18 months after the first patient was enrolled. Twenty two patients and 116 data pairs were analysed. Most patients were men (91%) and had ischemic dilated cardiomyopathy (59%). Mean age was 61 (range 34-82) and mean LV ejection fraction was 27% (range 15-30). The mean Pearson’s correlation coefficient of the NT-proBNP values and the SonR signal was r = - 0.36 (95% CI -0.51 to -0.19), p &lt; 0.00006 (Figure) Conclusions The interim analysis of this study shows an inverse and very significant relationship between SonR signal and NT-proBNP values. This suggests SonR signal might be used as predictor of worsening CHF. Abstract Figure

scholarly journals Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice

2009 ◽  
Vol 107 (3) ◽  
pp. 787-793 ◽  
Author(s):  
Jahan Naghshin ◽  
Kenneth R. McGaffin ◽  
William G. Witham ◽  
Michael A. Mathier ◽  
Lia C. Romano ◽  
...  
Keyword(s):  
Ejection Fraction ◽  
Intermittent Hypoxia ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Heart Weight ◽  
Ventricular Contractility ◽  
Posterior Wall Thickness ◽  
Obstructive Sleep ◽  
Wide Range ◽  
Lv Ejection Fraction

Intermittent hypoxia (IH) commonly occurs in patients with obstructive sleep apnea and can cause a wide range of pathology, including reduced left ventricular (LV) ejection fraction in rats as determined by echocardiography, in rodent models. We utilized echocardiography and pressure-volume (PV) loop analyses to determine whether LV contractility was decreased in inbred C57BL/6J mice exposed to IH and whether blockade of β-adrenergic receptors modified the response to hypoxia. Adult male 9- to 10-wk-old mice were exposed to 4 wk of IH (nadir inspired O2 5–6% at 60 cycles/h for 12 h during the light period) or intermittent air (IA) as control. A second group of animals were exposed to the same regimen of IH or IA, but in the presence of nonspecific β-blockade with propranolol. Cardiac function was assessed by echocardiography and PV loop analyses, and mRNA and protein expression in ventricular homogenates was determined. Contrary to our expectations, we found with PV loop analyses that LV ejection fraction (63.4 ± 3.5 vs. 50.5 ± 2.6%, P = 0.015) and other measures of LV contractility were increased in IH-exposed animals compared with IA controls. There were no changes in contractile proteins, atrial natriuretic peptide levels, LV posterior wall thickness, or heart weight with IH exposure. However, cAMP levels were elevated after IH, and propranolol administration attenuated the increase in LV contractility induced by IH exposure. We conclude that, contrary to our hypothesis, 4 wk of IH exposure in C57BL/6J mice causes an increase in LV contractility that occurs independent of ventricular hypertrophy and is, in part, mediated by activation of cardiac β-adrenergic pathways.

scholarly journals 164 Effect of cardiac contractility modulation therapy on myocardial work in patients with heart failure with reduced ejection fraction

2021 ◽  
Vol 23 (Supplement_G) ◽  
Author(s):  
Daniele Masarone ◽  
Stefano De Vivo ◽  
Vittoria Errigo ◽  
Antonio D’ Onofrio ◽  
Giuliano D’Alterio ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Cardiac Contractility ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Cardiac Contractility Modulation ◽  
Reduced Ejection Fraction ◽  
Constructive Work ◽  
Global Work ◽  
The Impact

Abstract Aims Cardiac contractility modulation therapy (CCMT) has been shown to reduce hospitalizations and to improve quality of life in heart failure patients with reduced ejection fraction (HFrEF) who remain symptomatic despite disease-modifying therapies. Strain imaging derived myocardial work (MW) is an emerging tool for evaluating left ventricular mechanics by incorporating systolic deformation and afterload burden in the analysis. To evaluate prospectively the impact of CCMT in HFrEF patients on MW derived parameters in relation to standard echocardiographic indices. Methods and results We recruited 12 HFrEF patients with indications to CCMT according to current clinical practice. A comprehensive echo-Doppler evaluation, including speckle tracking derived assessment of global longitudinal strain (GLS), was performed before and after three months from the CCM device implantation. Parameters of MW such as global work index (GWI), global constructive work (GCW) global wasted work (GWW), and global work efficiency (GWE) were calculated according to standardized procedures. Median values (interquartile range) were compared for all those parameters from baseline and 3-month follow-up with Wilcoxon Rank Sum test for continuous variables. At three months from CCM implant an improvement of LVEF [from 32% (27–34) to 36% (29–39), P &lt; 0.05], GLS [from 7.4% (6.2–11.2) to 9.9% (7.5–9.4), P &lt; 0.05], GWI [from 461 mmHg (372–613) to 589 mmHg (413–696), P &lt; 0.05], GCW [from 800 mmHg (620–930) to 970 mmHg (644–1009), P = 0.236], and GWE [from 73% (65–78) to 85% (78–87), P &lt; 0.05] was observed, with a consistent reduction of GWW [from 161 mmHg (148–227) to 125 mmHg (101–188), P &lt; 0.05]. We also found a positive correlation between the magnitude of LVEF improvement and the baseline values of GCW (r = 0.727, P = 0.011). Conclusions At 3 months, CCMT significantly improves standard and advanced left ventricular systolic function indices. This improvement is due to the increase of constructive work and a reduction of wasted work. In addition, the increase of left ventricular ejection fraction can be predicted by the global constructive work levels at baseline.

scholarly journals Immunosuppression therapy in the management of peripartum cardiomyopathy: A case series and literature review

2016 ◽  
Vol 9 (4) ◽  
pp. 174-176
Author(s):  
Joyee Basu ◽  
Christopher Redman ◽  
Oliver Ormerod
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Ventricular Systolic Dysfunction ◽  
Case Series ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
High Dose ◽  
Ventricular Ejection Fraction

Peripartum cardiomyopathy is a heart failure syndrome occurring late in pregnancy or during the early post-natal period. The pathophysiology of peripartum cardiomyopathy is not fully understood and various mechanisms have been postulated including an underlying inflammatory process. We here report four cases presenting with acute left ventricular systolic dysfunction. Three out of four of the patients presented with a left ventricular ejection fraction <30% and one with a left ventricular ejection fraction of 35%. All made a full clinical recovery following treatment with high-dose intravenous steroids. This case series adds to the growing body of evidence for the role for immunosuppressants in the management of peripartum cardiomyopathy.

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