scholarly journals Formulation and Evaluation of Transdermal Patch of Blonanserin

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Dhaval J. Patel ◽  
Saurav M. Patel ◽  
Sanjesh G. Rathi ◽  
Shrenik K. Shah
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Stability Study ◽  
Solvent Casting ◽  
Transdermal Patch ◽  
Chemical Parameters ◽  
Casting Method ◽  
Transdermal Patches ◽  
Physico Chemical ◽  
Excipient Compatibility

The objective of the present study was to formulate and evaluate transdermal patch of Blonanserin. Blonanserin transdermal patches were prepared by solvent casting method using natural and synthetic polymer. Various plastisizer were screened along with polymers. Drug excipient compatibility studies concluded that the drug and excipient are compatible with each other. The prepared patches were evaluated for physico-chemical parameters to justify their suitability for transdermal use. Formulations containing Xanthan Gum with plasticizer propylene glycol gives best drug release in 8 hours. More than 90% drug release found after 8 hours in formulation F5. Hence F5 formulation is considered as optimized batch. F5 batch was found stable during stability study. Blonanserin transdermal patches were successfully prepared by solvent casting method using Xanthan Gum natural polymer.

scholarly journals FORMULATION AND EVALUATION OF FAST DISSOLVING FILMS OF ELETRIPTAN HYDROBROMIDE

2017 ◽  
Vol 9 (2) ◽  
pp. 59
Author(s):  
K. Pallavi ◽  
T. Pallavi
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Guar Gum ◽  
Methyl Cellulose ◽  
Synthetic Polymers ◽  
Locust Bean Gum ◽  
Solvent Casting ◽  
Casting Method ◽  
Disintegration Time ◽  
Locust Bean

Objective: The main aim of the present research was to develop an oral fast dissolving polymeric film (FDF) with good mechanical properties, faster disintegration and dissolution when placed on the tongue.Methods: Eletriptan hydrobromide is prescribed for the treatment of mild to a moderate migraine. The polymers selected for preparing films were Pullulan, Maltodextrin (MDX), Acacia, Sodium alginate (SA), Locust bean gum (LBG), Guar gum (GG), Xanthan gum (XG), Polyvinyl alcohol (PVA), Polyvinyl pyrrolidine (PVP), Hydroxyl propyl methyl cellulose (HPMC) E5, and HPMC E15. Twelve sets of films FN1–FN12 were prepared by solvent casting method with Pullulan and combination of Acacia, MDX, SA, LBG, GG, XG, PVA, PVP, HPMC E5 and HPMC E15. Five sets of films FS1–FS5 were prepared using synthetic polymers like PVA, PVP, HPMC E5 and HPMC E15.Results: From all the prepared polymer formulations, FN2, FN8, and FS3 were selected based on disintegration time, and drug release and amongst this three FN2 was optimised based on its disintegration time (D. T). The percent drug release of the optimised film was compared with the percent release of the pure drug.Conclusion: The optimised formulation had a D. T of 16 s and a percent drug release of 97.5% in 10 min in pH 6.8 phosphate buffer and 100.6% drug release in 10 min in 0.1N HCl.

scholarly journals FORMULATION DEVELOPMENT OF ORAL FAST-DISSOLVING FILMS OF RUPATADINE FUMARATE

2020 ◽  
pp. 67-72
Author(s):  
ABHIBRATA ROY ◽  
REEGAN AREES ◽  
MADHAVI BLR
Keyword(s):  
Drug Release ◽  
Inclusion Complex ◽  
In Vitro Release ◽  
Aqueous Solubility ◽  
Solvent Casting ◽  
Formulation Development ◽  
Casting Method ◽  
Disintegration Time ◽  
Low Viscosity

Objective: Rupatadine fumarate (RF) is an anti-allergic drug indicated for the treatment of allergic rhinitis. It has low oral bioavailability due to its poor aqueous solubility and extensive hepatic first pass metabolism. In the present work, oral fast-dissolving films (OFDF) have been formulated and evaluated to facilitate dissolution in the oral cavity itself. Methods: Pullulan and HPMC (5, 15 cps) were employed as film formers and six formulations were tried. The physicochemical compatibility between drug and the polymers was studied by FTIR spectroscopy. RF-beta-cyclodextrin (BCD) inclusion complex was initially prepared and evaluated. The inclusion complex was incorporated into the film. OFDF were formulated and prepared by solvent casting method. The film size for one dose was 2 × 2 cm. The films were evaluated for various film parameters including disintegration time and drug release. Results: Preliminary film studies indicated % of film former solution to be between 3 and 5% for good appearance, mechanical strength, and quick disintegration. Solubility enhancement of RF is almost 40-fold from its BCD inclusion complex. Drug content in the films ranged between 83 and 90%. The pH ranged between 6 and 7 for all the formulations. All OFDF of RF disintegrated within one minute. With higher viscosity grade of HPMC, disintegration was comparatively slower and so was the drug release. Pullulan based films also showed desirable properties. F3 had disintegration time was 28 s and % drug release was 92% in 180 s. Conclusion: OFDF of RF could be formulated employing pullulan and HPMC low viscosity grades by solvent casting method. F3 containing HPMC E5 at 37% by weight of dry film showed desirable film properties. Stability studies indicated that there was no significant change in the films with respect to physicochemical properties and in vitro release.

Design, Development and Optimization of Pulsatile Core in Cup Tablets of Naproxen

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Rutu H. Patel ◽  
ImadHadi Hameed ◽  
Kunal N. Patel ◽  
Madhabhai M. Patel
Keyword(s):  
Drug Release ◽  
Lag Time ◽  
Major Effect ◽  
Stability Study ◽  
Design Development ◽  
In Vitro Drug Release ◽  
Box Behnken Design ◽  
Accelerated Stability ◽  
Excipient Compatibility

The aim of the present study to prepare Pulsatile release tablet of naproxen for the treatment of rheumatoid arthritis. The drug delivery system was designed to deliver the drug at a time when it could be most needful for the patient. Drug excipient compatibility studies were carried out using DSC and found to be compatible with each other. Pulsatile tablet was prepared by direct compression method using different type and amount of superdisintegrants and coating polymers and evaluated for pre and post compression parameters. Box Behnken design was applied to optimize responses. Concentrations of Sodium starch glycolate (SSG) (X1), Ethyl cellulose (EC) (X2), and HPMC K100M (X3) were selected as independent variables while Lag time (Y1) and % drug release at 8 hrs (Y2) were selected as dependent variables. The prepared tablets were evaluated for post compression parameters and results indicated that concentration of SSG has major effect on in vitro drug release while concentration of EC and HPMC K100M has major effect on Lag time. Batch BE13 prepared with SSG 35mg, EC 175mg, and HPMC K100M 75 mg was found to be best batch as it achieves predetermined lag time of 5 hr 02 min and 99.32% of drug release. There was no significant variation in formulation at the end of six month accelerated stability study.

scholarly journals Formulation and Evaluation of Transdermal Patch of Apixaban

2021 ◽  
Vol 69 (2) ◽  
Author(s):  
Dhaval J. Patel ◽  
Ajay M. Vyas ◽  
Sanjesh G. Rathi ◽  
Shrenik K. Shah
Keyword(s):  
Drug Release ◽  
Stability Study ◽  
Transdermal Patch ◽  
Formulation Development ◽  
Drug Release Profile ◽  
Target Drug ◽  
Acceptable Range ◽  
Weight Variation ◽  
S 100 ◽  
Release Data

The aim of the present investigation was to develop and evaluate transdermal patch of Apixaban. Formulation development of Apixaban Transdermal patch was initiated using Eudragit S 100 and HPMC E50 LV as matrix controlling polymer for matrix type Transdermal Patch. PEG 400 was selected as plasticizer. Glycerin was selected as permeability enhancer. Preformulation study was performed to check the drug excipient compatibility. The IR spectra of Drug and final formulation found satisfactory. There are no any interaction between drug and excipients. Further the linearity curve was developed in UV for method of analysis. Trials A1-A14 was initiated using different concentration of polymers in the formulation. The prepared patches were transparent and smooth in surface. The weight variation was found well within acceptable range. The thickness of patches was found uniform in nature and the variation is found satisfactory. Further, the surface pH of the patches was found between 6.8 to 7.1 and it is acceptable. The drug content, folding endurance and %elongation results of A1-A14 batches were found well within acceptable range. Initially the trial batches were taken with a single polymer like HPMC and EudragitS100. The drug release was not achieved as per the target drug release profile for 8hours. Hence the combination of these two polymers are taken and found better results than the single polymers. Based on the drug release data, it was observed that the A8 batch was the most satisfactory batch with respect to drug release and other parameters. Hence, the A8 batch selected as optimized batch and Stability study of the same batch initiated.

Development and Evaluation of Hydroxypropyl Methylcellulose Patches Containing Clindamycin for Topical Application

2019 ◽  
Vol 819 ◽  
pp. 240-245
Author(s):  
Phuvamin Suriyaamporn ◽  
Thanwarat Kasemsawat ◽  
Boontarik Sirilert ◽  
Kritnicha Apiromrak ◽  
Prasopchai Patrojanasophon ◽  
...  
Keyword(s):  
Drug Release ◽  
Acne Vulgaris ◽  
Hydroxypropyl Methylcellulose ◽  
Release Profile ◽  
Transdermal Patch ◽  
X Ray Diffraction ◽  
Drug Release Profile ◽  
Adhesion Properties ◽  
Transdermal Patches ◽  
The One

Clindamycin (CM) is the one of antibacterial drugs that can be used to treat acne vulgaris. The commercial products in form of solutions, creams, and gels cannot provide the exact amount of the drug and constant drug release. Transdermal patches present an attractive point for reducing this limitation and there is no commercial transdermal patch containing CM available in the market nowadays. The purposes of this study were to develop CM loaded transdermal patches for the treatment of acne and to investigate the physical properties and drug release profile of the CM from the transdermal patches. The transdermal patch was prepared using 10% HPMC. The types and concentrations of additives (glycerin, polyethylene glycol(PEG) or propylene glycol (PG)), were varied to improve the properties of the patches. The physical appearances including the translucent, color thickness and weight of the patches were recorded. The mechanical properties and skin adhesion of the patches were determined by a texture analyzer. The polymorphism of CM in the patches and the release profile of CM from the patches were investigated by X-ray diffraction and Franz diffusion cell, respectively. CM transdermal patches were translucent. The weight and thickness of the patches increased as the amount of additive increased. Glycerin and PG decreased the strength of the patches, while PEG increased the hardness. Adding CM to the patches increased the hardness and decreased the elasticity of the patches. The internal structure of CM loaded into the patches was an amorphous form. The CM patches exhibited some adhesion properties when contacted with the porcine skin. The release of CM from the patches was found to be 71-108% within 60 minutes. The patch prepared from 10% HPMC, 15% Glycerin, and 5% PG displayed the highest release rate. In conclusion, the CM loaded HPMC patches presented desirable properties, which could be used as a transdermal patch for the treatment of acne.

Xanthan Gum-Incorporated Natural Rubber Film Casted with Solvent Evaporation

2020 ◽  
Vol 859 ◽  
pp. 68-73
Author(s):  
Napaphol Puyathorn ◽  
Thawatchai Phaechamud
Keyword(s):  
Natural Rubber ◽  
Water Sorption ◽  
Wound Dressing ◽  
Xanthan Gum ◽  
Composite Films ◽  
Area Under The Curve ◽  
High Water ◽  
Solvent Casting ◽  
Casting Method ◽  
Rubber Film

Xanthan gum (X)-incorporated natural rubber (NR) cast films were fabricated from blocked NR by solvent casting method using dichloromethane as the solvent. The rather smooth films were obtained. X markedly promoted both of water sorption and erosion in phosphate buffer pH 7.4 of these composite films. With increasing X amount also significantly enhanced the film tensile strength, Young’s modulus and area under the curve while did not affect contact angle of water/formamide and surface free energy. 30%X-loaded NR films exhibited the highest durability with apparently high water sorption and erosion for further using such as wound dressing.

DEVELOPMENT AND CHARACTERIZATION OF SUBLINGUAL FILM CONTAINING ROPINIROLE HYDROCHLORIDE

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (07) ◽  
pp. 33-42
Author(s):  
P. B. Patil ◽  
D. A. Patil ◽  
L. R. Zawar ◽  
B. Patil ◽  
G. B. Patil ◽  
...  
Keyword(s):  
Tensile Strength ◽  
Drug Release ◽  
Solvent Casting ◽  
Casting Method ◽  
Percentage Elongation ◽  
Peg 400 ◽  
Film Forming ◽  
Folding Endurance ◽  
Ropinirole Hydrochloride

In the present work films of ropinirole hydrochloride were prepared by using polymers such as hydroxy propyl methyl cellulose (HPMC E-15) and polyethylene glycol (PEG-400) as plasticizers, by a solvent casting method, for treatment of Parkinson's disease. HPMC E-15 was used as film forming agent in the range of concentration 50 mg – 600 mg and PEG-400 was used as plasticizer in the range of concentration 0.3-1.0 ml for solvent casting method. the optimized concentration of film forming agent was 400 mg and plasticizer concentration was 0.7ml. By using optimized concentration, Ropinirole Hydrochloride mouth dissolving films (MDFs) were prepared by additionof other excipients. The formulated MDFs were evaluated for different physical characteristics like uniformity of weight, thickness, folding endurance, drug content uniformity, percentage elongation, and tensile strength, disintegration, in vitro drug release studies and provided agreeable results. The FTIR and DSC studies confirmed that no physicochemical interaction in between drug and excipients accured. Mouth dissolving film of Ropinirole Hydrochloride containing HPMC E-15 as polymer showed 97.66 % drug release at 30 min. Mouth dissolving films of ropinirole hydrochloride containing HPMC E-15 showed better tensile strength (70.56 ± 0.9 g/mm2), percentage elongation (33.33 ± 2.88 %), folding endurance (168± 2.081 numbers of folds), in vitro disintegration time (35± 3.511 sec.) and thickness (0.4± 0.17 mm).

scholarly journals Formulation and evaluation of matrix transdermal patches of meloxicam

2019 ◽  
Vol 9 (1-s) ◽  
pp. 209-213
Author(s):  
Sumit Chourasia ◽  
Tripti Shukla ◽  
Surendra Dangi ◽  
Neeraj Upmanyu ◽  
Nidhi Jain
Keyword(s):  
Drug Release ◽  
Chemical Properties ◽  
Fickian Diffusion ◽  
In Vitro Drug Release ◽  
Casting Technique ◽  
Ir Studies ◽  
Transdermal Patches ◽  
Diffusion Controlled ◽  
Physico Chemical

The present study deals with the formulation and evaluation of transdermalpatches of meloxicam towards enhance its permeation through the skin and maintain the plasma levelconcentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and isopropylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Amongthe formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observedfor the formulations F12 and F4i.e. 80.012 ± 2.012 % and 98.365±3.012%. The mechanism of drugrelease was found to be Non-Fickian diffusion controlled. FT-IR studies revealed theintegrity of the drug in theformulations. Keywords: Transdermal Patches, Meloxicam, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.

scholarly journals Development and Evaluation of Indomethacin Controlled Release Press Coated Tablets

2016 ◽  
Vol 14 (2) ◽  
pp. 187-192
Author(s):  
Muhammad Rashedul Islam ◽  
Md Elias Al Mamun ◽  
Md Mizanur Rahman Moghal ◽  
Md Habibur Rahman
Keyword(s):  
Drug Release ◽  
Xanthan Gum ◽  
Chemical Properties ◽  
Methyl Cellulose ◽  
Compression Pressure ◽  
Physico Chemical ◽  
Compression Coating ◽  
Coating Formulation ◽  
Coating Formulations

In the present work, several batches of indomethacin press coated tablets were prepared with drug and Avicel PH 102 utilizing the press coating technology. The core tablet was compression coated with minimal compression pressure. The compression coating mixture was formulated using various amount of lactose and xanthan gum which was used as the release retarding agent. Three formulations (IX-1, IX-2 and IX-3) were designed to evaluate the release profile as function of xanthan gum load. In vitro drug release testing demonstrated that the drug release was inversely proportional to the amount of xanthan gum in the coating formulations. In addition, formulation IX-2 was modified by incorporating hydroxypropyl methyl cellulose (HPMC) 15 cps into the compression coating formulation to understand their effects on drug release. The formulation was evaluated for its properties and correlated with in vitro and kinetic release studies. Incorporation of HPMC caused the highest fraction of drug to be released in the dissolution fluid. The physico-chemical properties of the excipients can be held responsible for the discrepancy in release rate of indomethacin. From kinetic analysis drug release was found to follow Higuchi mechanism for all the formulations. Overall, the study concluded that excipients present in the coating formulations make a significant impact on drug release.Dhaka Univ. J. Pharm. Sci. 14(2): 187-192, 2015 (December)

scholarly journals FORMULATION AND EVALUATION OF MATRIX TRANSDERMAL PATCHES OF GLIBENCLAMIDE

2018 ◽  
Vol 8 (5-s) ◽  
pp. 366-371
Author(s):  
Syed Ata Ur Rahman ◽  
Neeraj Sharma
Keyword(s):  
Drug Release ◽  
Chemical Properties ◽  
Fickian Diffusion ◽  
In Vitro Drug Release ◽  
Casting Technique ◽  
Ir Studies ◽  
Transdermal Patches ◽  
Diffusion Controlled ◽  
Physico Chemical

The present study deals with the formulation and evaluation of transdermal patches of Glibenclamide towards enhance its permeation through the skin and maintain the plasma level concentration. Transdermal patches were prepared by using polymers like Chitosan, HPMC 15cps and EC 20cpsat various concentrations by solvent casting technique employing dibutyl phthalate as plasticizer and iso-propylmyristate as permeation enhancer. The transdermal patches were evaluated for their physico-chemical properties and in-vitro drug release. The transdermal patches were found to be transparent and smooth in texture. Among the formulations studied, at the end of 12th hour, the minimum and maximum in-vitro drug release was observed for the formulations F12 and F4 i.e. 80.012 ± 2.012 % and 98.365±3.012% respectively. The mechanism of drug release was found to be Non-Fickian diffusion controlled. FT-IR studies revealed the integrity of the drug in the formulations. Keywords: Transdermal Patches, Glibenclamide, Chitosan, HPMC 15cps, EC 20 cps, in-vitro diffusion studies.

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