scholarly journals Role of Flutamide on Acinar Diameter in Testosterone Induced Prostatic Hyperplasia

2010 ◽  
Vol 14 (Number 1) ◽  
pp. 3-8
Author(s):  
Md. A Rahman ◽  
H Naushaba ◽  
Md. N Ahmed ◽  
Md. M Rahman
Keyword(s):  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans ◽  
Group B ◽  
Control Group Group

Testosterone is the male sex hormone responsible for growth of secondary sexual characters and accessory sex organs. Despite the effectiveness as a male sex i101711011C, testosterone causes benign preemie hyperplasia (BPH) resulting in urinary dysfinction. On the other hand. Bromide is a pure anthestosterone, which blockw the effects of dihydnoestosterone (DHT)at the testosterone receptor and presents BM. The objective of the study was to observe the effects of flutamide on testosterone induced promatic hypetplasia in Long Evans rats. This experimental study was carried or I e Department of Anatomy. Sir Salimullah Medical College. Dhaka from January to December 2006. Forty five matured male Long Evans rats of age 8-10 weeks and weighing 200-300 gnu were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group B was testosterone treated group and Group C was testosterone and flu:amide treated group. Comparative study in different groups were done microscopically. There was significant reduction (p<0.001) qproslatic hypetplasia. The mean diameter of acini of prostate in flutamide treated rats was loner than the testosterone treated rats. It can be concluded from this study that flatamide is an effective drug against testosterone induced prostatic hyperplasia.

scholarly journals Role of Finasteride on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

2009 ◽  
Vol 13 (Number 2) ◽  
pp. 13-18
Author(s):  
Md. A Rahman ◽  
H Naushaba ◽  
N A Khan ◽  
N Rahman
Keyword(s):  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Sexual Character ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans ◽  
Control Group Group

Tesrostemne is the main male sex hormone responsible for growth of sexual character and accessory an organs. Despite its effectiveness as a male sex honotone. it causes benign prostatic hypmplasia (PPH) resulting in urinary dysfitriction. On the other hand. finasteride is a 4-amstroid which inhibit the hyperplastic effect of testosterone and benign prostatic loperplasia. The objective of the study was to observe the effects of finasteride on testosterone induced promatic fivperplasis in Long Evans rats. This experimental study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from January to December 2006. Total 45 matured male long Evans rats of age 8-10 weeks and weighing 200-300 gins were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group 8 was testosterone treated group and Group C was testosterone and finasteride treated group. The rats were sacrificed on the eleventh day. It was concluded that finasteride is an effective drng successfidly inhibiting the testosterone induced prostatic hyperplasia.

scholarly journals Role of Flutamide on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

1970 ◽  
Vol 8 (1) ◽  
pp. 16-20
Author(s):  
Md Atiar Rahman ◽  
Humaira Naushaba ◽  
Jesmin Akter ◽  
Uttam Kumar Paul ◽  
Nahid Ahmed Khan
Keyword(s):  
Treated Group ◽  
Protective Role ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Medical College ◽  
Male Sex ◽  
Long Evans ◽  
Group B

Context: Testosterone is the male sex hormone responsible for growth of secondary sexual character and accessory sex organs. Despite the effectiveness as a male sex hormone, testosterone causes Benign Prostatic Hyperplasia (BPH) resulting in urinary dysfunction. On the other hand, flutamide is a pure antitestosterone, which blocks the effects of Dihydro testosterone (DHT) at the testosterone receptor and prevents BPH. Therefore the present study was designed to observe the protective role of flutamide on testosterone induced prostatic hyperplasia. Objective: To observe the effects of flutamide on testosterone induced prostatic hyperplasia in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka during the period of July 2006 to June 2007. Materials & Methods: Forty five matured male long Evans rats of age 8-10 weeks and weighing 200-300 gms were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group, Group B was testosterone treated group and Group C was testosterone & flutamide treated group. Comparative study in different groups were done microscopically. Results: There was significant reduction (P<0.001) in prostatic hyperplasia. The mean percentage volume of stroma in flutamide treated rats was lower than the testosterone treated rats. Conclusion: It can be concluded from this study that flutamide is an effective drug against testosterone induced prostatic hyperplasia. Key words: Prostate; Testosterone; Flutamide. DOI: 10.3329/bja.v8i1.6104 Bangladesh Journal of Anatomy January 2010, Vol. 8 No. 1 pp. 16-20

Impact of Finasteride on Stroma of Benign Hyperplasia of Prostate

2011 ◽  
Vol 16 (Number 1) ◽  
pp. 3-8
Author(s):  
Md. A Rahman ◽  
H Naushaba
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Group 13 ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans

Benign prostatic hyperplasia (13P11) is a hyperplastic process of the strontal and epithelial cells of the prostate due to effect of male sex hormone testosterone. Testosterone is the main male sex hormone, responsible for growth of sexual character and accessory sex organs. Despite its effectiveness as an male sex hormone, it causes benign prostatic hyperplasia (BM resulting in urinary dysfunction. On the other hand, finasteride. a 4-azastroid, inhibits the hyperplastic effect of testosterone and benign prostatic hyperplasia. The objective of the study was to observe the effects of finasteride on the stroma of testosterone induced prostatic hyperplasis in long Evans rats. This experimental study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from January to December 2006. Total 45 matured male long Evans rats of age 8-10 weeks and weighing 200-300 gm were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group, Group 13 was testosterone treated group and Group C was testosterone and finasteride treated group. The rats were sacrificed on the eleventh day. It was concluded that finasteride is an effective drug that successfully inhibits the testosterone induced prostatic hvperplasia.

scholarly journals Impact of Testosterone to Induce Benign Prostatic Hyperplasia in Long Evens Rats

2007 ◽  
Vol 8 (Number 1) ◽  
pp. 28-32
Author(s):  
Md. A Rahman ◽  
G A Haque ◽  
N Akhter ◽  
S Naher ◽  
D Akhter
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Transverse Diameter ◽  
Medical College ◽  
Anteroposterior Diameter ◽  
Group A ◽  
In Trans ◽  
Long Evans

This experimental softly was carried out in the Department of Anatomy, Sir Salintallah Medical College. Dhaka from January to December 2006. The objective of the study was to see the effects of testosterone on prostate and to measure the weight. length, transverse diameter and ameroposterior diameters the organ, and also to estimate transvenical diameter of acini and percentage of steam. Total .10 maimed male Long Evans nos of age 8-10 weeks and ',visiting 200 to 300 gnu tore used in this study. They were divided into Am equal groups. Group A was vehicle (ohm oil) control group and Group II tots testosterone treated group. The rats 'sere sacrificed on the eleventh day. It wat concluded dna testosterone induces hyperplasia of the prostate within In increased weight. length. transverse diameter anteroposterior diameter and higher values in trans-venical diameter of acitti and percentage of SIMINO.

scholarly journals HUBUNGAN OKSIDA NITRAT DAN NILAI HISTOPATOLOGIS PADA ENDOTOKSEMIA

2016 ◽  
Vol 20 (3) ◽  
pp. 201
Author(s):  
Sotianingsih Sotianingsih ◽  
Suharyo Suharyo ◽  
Lisyani S ◽  
Guntur HA
Keyword(s):  
Nitric Oxide ◽  
Treatment Group ◽  
Control Group ◽  
Significant Difference ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Termination Time ◽  
Control Group Group

Lipopolysaccharide (LPS) is an endotoxin from the outer membrane of Gram-negative bacteria, which has an important role in the occurrence of sepsis. Exposure to LPS will stimulate increase of nitric oxide (NO). Nitric oxide is a bioregulator of apoptosis and has some sepsis prognostic role of apoptosis regulators within the gastrointestinal cells. The objective of the study is to know if endotoxemia induces an increase in NO levels and histopathology scores as well as the existing relationship between them. This study is an observational intervention. The subjects were 48 male mice Balb/C, divided into 2 groups. The samples consisted of 24 tail as control group (group A) and 24 as treatment group (group B). The A group as well as the B group is divided into 4 subgroups according to the time of termination. The levels of NO were examined by Griess method. Histopathology score was examined by HE and read as a score of 0–5. There was a statistically significant difference between the mean NO in the treatment group with the control group at the termination of the group of 12h (p=0.009), 24h (p=0.015), 36h (p=0.014), 48h (p=0.002) and the whole group (p=0.0001), as well as between the mean histopathology score at the termination time of 12 h (p=0.0001), 24h (p=0.0001), 36h (p=0.0001), 48h (p=0465) and the whole group (p=0.0001). Increase in NO and histopathology scores in all groups of mice (r=0.527) showed a statistically significant correlation. NO levels and histopathology scores are increased during endotoxemia and thus have a significant correlation.

scholarly journals Noise stress on female mice impair oocyte developmental potential.

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Maria Yousaf ◽  
Hina Kundi ◽  
Abdullah Qamar
Keyword(s):  
Histological Study ◽  
Treated Group ◽  
Control Group ◽  
Developmental Potential ◽  
Noise Stress ◽  
Medical College ◽  
Adult Mice ◽  
Group A ◽  
Group B ◽  
Animal House

Objectives: To find out the effects of noise stress on variations in number of ovarian follicles in mice. Study Design: Randomized control trial, laboratory based. Place and Duration of Study: Anatomy department, Army Medical College Rawalpindi, it was conducted from April to May 2014. Material and Method: 20 adult mice (BALBc strain) female weighing 25-27 grams were taken for this study on day first of their estrous cycle. Two groups comprising of 10 rats each were made. Control group was given name tag of group A and was kept in animal house under normal heathy environment for one month. Noise stress of 100 decibels for 06 hours per day for one month was given to experimental group B. Mice were dissected after 1 month. Mice right ovaries were examined for size, shape, color and weight. The specimen were processed and embedded. Hematoxyline and Eosin stained slides were prepared for histological study. Follicular count (primary, secondary and tertiary follicles) was done and noted. For statistical analysis SPSS 20 was used. The tests applied was independent sample’s t test for descriptive statistics. Results: There was a significant decrease in primary, secondary/antral and graafian follicular count in the ovary of Group B (Experimental). Conclusion: The noise stress prominently affected the follicular count in ovaries of noise stress treated group.

scholarly journals Zingerone ameliorates tellurium induced nephrotoxicity by abating elevated serum markers in the rats

2020 ◽  
Vol 21 (1&2) ◽  
pp. 125-129
Author(s):  
Mohammad Firoz Alam ◽  
Saeed Alshahrani ◽  
Essam Alamir ◽  
Mohammad Abdurrhman Alhazmi ◽  
Tarique Anwer ◽  
...  
Keyword(s):  
Elevated Serum ◽  
Treated Group ◽  
Positive Control ◽  
Serum Markers ◽  
Control Group ◽  
Sodium Tellurite ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Control Group Group

The present study was designed to investigate the nephrotoxicity of tellurium (Sodium tellurite) in rats through evaluating the level of kidney functional marker enzymes and its treatment with Zingerone. Rats were divided into four groups, Group-A (control group), Group-B (tellurium treated group), Group-C (tellurium + Zingerone treatment group), and Group-D (Zingerone treatment alone) and each group have six animals. Tellurium was given in Group-B and Group-C at the dose of 8.3mg/kg bodyweight daily orally for 15 days, while Zingerone of 100mg/kg body weight was given in Group-C as pre- and post-treatment orally for 15days. Group-D was given alone Zingerone of 100mg/kg bodyweight; orally for 15 days. Results revealed that tellurium administration significantly (P<0.001) increased the serum markers (ALP, BUN, Uric Acid and Creatinine) in Group-B as a compared to Group-A while the treatment with Zingerone significantly (P<0.001) decreased these elevated serum markers in Group-C as comparison to Group-B. There were no changes observed in the positive control (Zingerone administered Group-D). Thus, the present finding confirmed that the Zingerone plays a potential role in reducing nephrotoxicity against tellurium by abating elevated serum markers in rats.

scholarly journals Role of FRIOS (free radical induced oxidative stress) in outcome of pregnancy induced hypertension cases

2017 ◽  
Vol 6 (8) ◽  
pp. 3287
Author(s):  
Anjana Choudhary ◽  
Nidhi Tripathi
Keyword(s):  
Preterm Birth ◽  
Antioxidant Status ◽  
Mode Of Delivery ◽  
Control Group ◽  
Study Group ◽  
Medical College ◽  
Significant Difference ◽  
Group A ◽  
Group B

Background: The anti-oxidant and the per oxidation product levels both are increased in pregnancy. Much recent works has focused on the role of oxidative disturbance in the preeclampsia and eclampsia. Preeclampsia remains a leading cause of maternal and fetal morbidity and mortality.Methods: This prospective study was conducted in upper India sugar exchange and maternity hospital, department of Obstetrics and Gynecology, GSVM Medical College, Kanpur in Collaboration with department of pathology, GSVM Medical College, Kanpur (UP), India. All the patients selected for the present study, both from control and study group was in detail with regard the clinical history, general examination, local examination, basic investigation and Specific Investigation, Super Oxide Dismutase (SOD). Blood samples would be collected with the informed consent from control as well as study group for assessment of antioxidant status by determining levels of superoxide dismutase.Results: The mean age and BMI of control as well as study group is almost same. The incidence of pre-eclampsia and eclampsia in primipara was 29.31 and in multiparous it was 9.52 in all groups. It implies that 95% cases will have improvement in SOD value with mean difference in improvement of at least 0.297807. There is statistically significant difference in mode of delivery by LSCS in study group A as compared to study group B and control in PIH patients. The incidence of complications is significantly higher in Study Group A as compared to control group and Study Group B. There is statistically significant difference in the incidence of preterm birth in study group A as well as Study Group B as compared to control. However, there was no statistically significant difference in the incidence of preterm birth after giving intervention to the study group. When cut off value of SOD enzyme as < 0.578U/mg of protein, sensitivity is 66.07% and specificity as 51.85%.Conclusions: Vitamin-c supplementation will only prevent PIT in PIH with already reduced antioxidant status.

scholarly journals Effect of Maternal Preeclampsia on the Weight of the Placenta

1970 ◽  
Vol 8 (2) ◽  
pp. 69-71 ◽  
Author(s):  
Segupta Kishwara ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Mahamuda Begum ◽  
Khandaker Abu Rayhan ◽  
Shamim Ara
Keyword(s):  
Normal Pregnancy ◽  
Placental Weight ◽  
Control Group ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Group A ◽  
The Mean ◽  
Group B ◽  
Control Group Group

Context: Preeclampsia is a relatively common pregnancy disorder that is related to the placenta and causes variable maternal and foetal problems. Alterations in placental weight are evident in moderate to severe maternal preeclampsia. Study design: Cross-sectional descriptive type. Place and period of study: Department of Anatomy, Dhaka Medical College, Dhaka from August 2005 to June 2006. Materials & Methods: 60 human placentae from Bangladeshi women were collected from the Department of Obstetrics & Gynaecology of Dhaka Medical College Hospital and Mitford Hospital, Dhaka of which 30 from normal uncomplicated pregnancies (control group or group A) and another 30 from pregnancies complicated by preeclampsia (preeclampsia group or group B), where the patients were normotensive previously. Results: The mean weight of the placenta was 406.90±72.64 gm in control group (group A) and 311.50±74.09 gm in preeclampsia group (group B) respectively. The mean difference in weight between two groups was statistically significant (P< 0.001). Conclusion: Placental weight was found reduced in maternal preeclampsia in comparison to that of normal pregnancy. Key words: weight of placenta; preeclampsia. DOI: 10.3329/bja.v8i2.7019Bangladesh Journal of Anatomy July 2010, Vol. 8 No. 2 pp. 69-71

scholarly journals Microecological preparation combined with an modified low-carbon diet improves glucolipid metabolism and cardiovascular complication in obese patients

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jianguo Liu ◽  
Liehui Xiao ◽  
Hezhongrong Nie ◽  
Yong Pan ◽  
Yan Liu ◽  
...  
Keyword(s):  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Control Group ◽  
Obese Patients ◽  
Carotid Atherosclerotic Plaque ◽  
Low Carbon ◽  
Balanced Diet ◽  
Group A ◽  
Group B ◽  
Control Group Group

Abstract Objective To investigate the impact of microecological preparation combined with modified low-carbon diet on the glucolipid metabolism and cardiovascular complication in obese patients. Methods From August 2017 to July 2020, 66 obese patients were recruited, and administrated with an modified low-carbon diet with (group A) or without (Group B) microecology preparation and a balanced diet in control group (group C) for 6 months. Meanwhile, 20 volunteers administrated with a balanced diet were recruited as the healthy control group (group D). Results After 6-month intervention, obese subjects in group A and B showed significant improvement of body and liver fat mass, reduction of serum lipid levels, intestinal barrier function markers, insulin resistance index (IRI), high blood pressure (HBP) and carotid intima thickness, as compared with subjects in group C. More importantly, subjects in group A had better improvement of vascular endothelial elasticity and intimal thickness than subjects in group B. However, these intervention had no effect on carotid atherosclerotic plaque. Conclusion Administration of microecological preparation combined with modified low-carbon diet had better improvement of intestinal barrier function, glucose and lipid metabolism, and cardiovascular complications than low-carbon diet in obese patients, but the effect of a simple low-carb diet on carotid atherosclerotic plaque need to be further addressed.

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