scholarly journals Impact of Testosterone to Induce Benign Prostatic Hyperplasia in Long Evens Rats

2007 ◽  
Vol 8 (Number 1) ◽  
pp. 28-32
Author(s):  
Md. A Rahman ◽  
G A Haque ◽  
N Akhter ◽  
S Naher ◽  
D Akhter
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Transverse Diameter ◽  
Medical College ◽  
Anteroposterior Diameter ◽  
Group A ◽  
In Trans ◽  
Long Evans

This experimental softly was carried out in the Department of Anatomy, Sir Salintallah Medical College. Dhaka from January to December 2006. The objective of the study was to see the effects of testosterone on prostate and to measure the weight. length, transverse diameter and ameroposterior diameters the organ, and also to estimate transvenical diameter of acini and percentage of steam. Total .10 maimed male Long Evans nos of age 8-10 weeks and ',visiting 200 to 300 gnu tore used in this study. They were divided into Am equal groups. Group A was vehicle (ohm oil) control group and Group II tots testosterone treated group. The rats 'sere sacrificed on the eleventh day. It wat concluded dna testosterone induces hyperplasia of the prostate within In increased weight. length. transverse diameter anteroposterior diameter and higher values in trans-venical diameter of acitti and percentage of SIMINO.

Impact of Finasteride on Stroma of Benign Hyperplasia of Prostate

2011 ◽  
Vol 16 (Number 1) ◽  
pp. 3-8
Author(s):  
Md. A Rahman ◽  
H Naushaba
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Group 13 ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans

Benign prostatic hyperplasia (13P11) is a hyperplastic process of the strontal and epithelial cells of the prostate due to effect of male sex hormone testosterone. Testosterone is the main male sex hormone, responsible for growth of sexual character and accessory sex organs. Despite its effectiveness as an male sex hormone, it causes benign prostatic hyperplasia (BM resulting in urinary dysfunction. On the other hand, finasteride. a 4-azastroid, inhibits the hyperplastic effect of testosterone and benign prostatic hyperplasia. The objective of the study was to observe the effects of finasteride on the stroma of testosterone induced prostatic hyperplasis in long Evans rats. This experimental study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from January to December 2006. Total 45 matured male long Evans rats of age 8-10 weeks and weighing 200-300 gm were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group, Group 13 was testosterone treated group and Group C was testosterone and finasteride treated group. The rats were sacrificed on the eleventh day. It was concluded that finasteride is an effective drug that successfully inhibits the testosterone induced prostatic hvperplasia.

scholarly journals Role of Flutamide on Acinar Diameter in Testosterone Induced Prostatic Hyperplasia

2010 ◽  
Vol 14 (Number 1) ◽  
pp. 3-8
Author(s):  
Md. A Rahman ◽  
H Naushaba ◽  
Md. N Ahmed ◽  
Md. M Rahman
Keyword(s):  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans ◽  
Group B ◽  
Control Group Group

Testosterone is the male sex hormone responsible for growth of secondary sexual characters and accessory sex organs. Despite the effectiveness as a male sex i101711011C, testosterone causes benign preemie hyperplasia (BPH) resulting in urinary dysfinction. On the other hand. Bromide is a pure anthestosterone, which blockw the effects of dihydnoestosterone (DHT)at the testosterone receptor and presents BM. The objective of the study was to observe the effects of flutamide on testosterone induced promatic hypetplasia in Long Evans rats. This experimental study was carried or I e Department of Anatomy. Sir Salimullah Medical College. Dhaka from January to December 2006. Forty five matured male Long Evans rats of age 8-10 weeks and weighing 200-300 gnu were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group B was testosterone treated group and Group C was testosterone and flu:amide treated group. Comparative study in different groups were done microscopically. There was significant reduction (p<0.001) qproslatic hypetplasia. The mean diameter of acini of prostate in flutamide treated rats was loner than the testosterone treated rats. It can be concluded from this study that flatamide is an effective drug against testosterone induced prostatic hyperplasia.

scholarly journals Role of Finasteride on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

2009 ◽  
Vol 13 (Number 2) ◽  
pp. 13-18
Author(s):  
Md. A Rahman ◽  
H Naushaba ◽  
N A Khan ◽  
N Rahman
Keyword(s):  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Sexual Character ◽  
Medical College ◽  
Group A ◽  
Male Sex ◽  
Long Evans ◽  
Control Group Group

Tesrostemne is the main male sex hormone responsible for growth of sexual character and accessory an organs. Despite its effectiveness as a male sex honotone. it causes benign prostatic hypmplasia (PPH) resulting in urinary dysfitriction. On the other hand. finasteride is a 4-amstroid which inhibit the hyperplastic effect of testosterone and benign prostatic loperplasia. The objective of the study was to observe the effects of finasteride on testosterone induced promatic fivperplasis in Long Evans rats. This experimental study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka from January to December 2006. Total 45 matured male long Evans rats of age 8-10 weeks and weighing 200-300 gins were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group. Group 8 was testosterone treated group and Group C was testosterone and finasteride treated group. The rats were sacrificed on the eleventh day. It was concluded that finasteride is an effective drng successfidly inhibiting the testosterone induced prostatic hyperplasia.

scholarly journals Role of Flutamide on Testosterone Induced Prostatic Hyperplasia in Long Evans Rats

1970 ◽  
Vol 8 (1) ◽  
pp. 16-20
Author(s):  
Md Atiar Rahman ◽  
Humaira Naushaba ◽  
Jesmin Akter ◽  
Uttam Kumar Paul ◽  
Nahid Ahmed Khan
Keyword(s):  
Treated Group ◽  
Protective Role ◽  
Prostatic Hyperplasia ◽  
Sex Hormone ◽  
Control Group ◽  
Medical College ◽  
Male Sex ◽  
Long Evans ◽  
Group B

Context: Testosterone is the male sex hormone responsible for growth of secondary sexual character and accessory sex organs. Despite the effectiveness as a male sex hormone, testosterone causes Benign Prostatic Hyperplasia (BPH) resulting in urinary dysfunction. On the other hand, flutamide is a pure antitestosterone, which blocks the effects of Dihydro testosterone (DHT) at the testosterone receptor and prevents BPH. Therefore the present study was designed to observe the protective role of flutamide on testosterone induced prostatic hyperplasia. Objective: To observe the effects of flutamide on testosterone induced prostatic hyperplasia in Long Evans rats. Study design: An experimental study. Place and period of study: The study was carried out in the Department of Anatomy, Sir Salimullah Medical College, Dhaka during the period of July 2006 to June 2007. Materials & Methods: Forty five matured male long Evans rats of age 8-10 weeks and weighing 200-300 gms were used in this study. They were divided into three equal groups. Group A was vehicle (olive oil) control group, Group B was testosterone treated group and Group C was testosterone & flutamide treated group. Comparative study in different groups were done microscopically. Results: There was significant reduction (P<0.001) in prostatic hyperplasia. The mean percentage volume of stroma in flutamide treated rats was lower than the testosterone treated rats. Conclusion: It can be concluded from this study that flutamide is an effective drug against testosterone induced prostatic hyperplasia. Key words: Prostate; Testosterone; Flutamide. DOI: 10.3329/bja.v8i1.6104 Bangladesh Journal of Anatomy January 2010, Vol. 8 No. 1 pp. 16-20

scholarly journals A Dual 5α-Reductase Inhibitor Dutasteride Caused Reductions in Vascular Density and Area in Benign Prostatic Hyperplasia

ISRN Urology ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Masayoshi Zaitsu ◽  
Akiko Tonooka ◽  
Koji Mikami ◽  
Mami Hattori ◽  
Yuta Takeshima ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Benign Prostatic Hyperplasia ◽  
Reductase Inhibitor ◽  
Treated Group ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Vascular Density ◽  
Significant Difference ◽  
Histopathological Effects ◽  
Hematoxylin Eosin

Objectives. Dutasteride, a dual 5α-reductase inhibitor, is used to treat benign prostatic hyperplasia. Nevertheless, its histopathological effects on the morphometrics of blood vessels and glands are still controversial. The aim here was to assess the histopathological effects of dutasteride in cases of benign prostatic hyperplasia in a retrospective study. Methods. Patients with benign prostatic hyperplasia more than 40 cm3 in prostatic volume were administered 0.5 mg of dutasteride daily or left untreated prior to receiving a transurethral resection of the prostate. Images of sections stained with hematoxylin/eosin and with anti-CD31 antibody were analyzed. Results. In the dutasteride-treated group, the duration of administration was weeks. Artery/arteriole density and vein/venule density in benign prostatic tissue were both lower in the dutasteride-treated group than in the control group. The vein/venule area as a percentage of the whole area was also lower in the dutasteride-treated group, while the artery/arteriole area did not show a significant difference. Glandular/CD31-expressing vessel densities as well as glandular/CD31-expressing vessel areas were comparable between the two groups. Conclusions. Dutasteride reduced the artery/arteriole and vein/venule densities and the proportion of vein/venule area in the tissue of patients with benign prostatic hyperplasia.

scholarly journals Noise stress on female mice impair oocyte developmental potential.

2019 ◽  
Vol 26 (06) ◽  
Author(s):  
Maria Yousaf ◽  
Hina Kundi ◽  
Abdullah Qamar
Keyword(s):  
Histological Study ◽  
Treated Group ◽  
Control Group ◽  
Developmental Potential ◽  
Noise Stress ◽  
Medical College ◽  
Adult Mice ◽  
Group A ◽  
Group B ◽  
Animal House

Objectives: To find out the effects of noise stress on variations in number of ovarian follicles in mice. Study Design: Randomized control trial, laboratory based. Place and Duration of Study: Anatomy department, Army Medical College Rawalpindi, it was conducted from April to May 2014. Material and Method: 20 adult mice (BALBc strain) female weighing 25-27 grams were taken for this study on day first of their estrous cycle. Two groups comprising of 10 rats each were made. Control group was given name tag of group A and was kept in animal house under normal heathy environment for one month. Noise stress of 100 decibels for 06 hours per day for one month was given to experimental group B. Mice were dissected after 1 month. Mice right ovaries were examined for size, shape, color and weight. The specimen were processed and embedded. Hematoxyline and Eosin stained slides were prepared for histological study. Follicular count (primary, secondary and tertiary follicles) was done and noted. For statistical analysis SPSS 20 was used. The tests applied was independent sample’s t test for descriptive statistics. Results: There was a significant decrease in primary, secondary/antral and graafian follicular count in the ovary of Group B (Experimental). Conclusion: The noise stress prominently affected the follicular count in ovaries of noise stress treated group.

SIGNIFICANCE OF NON-INVASIVE SONO-MORPHOLOGICAL MARKERS IN THE EVALUATION OF BLADDER OUTLET OBSTRUCTION AND ACUTE URINARY RETENTION SECONDARY TO BENIGN PROSTATIC HYPERPLASIA

2021 ◽  
pp. 5-9
Author(s):  
Prasenjit Bhowmik ◽  
Soumendranath Mandal ◽  
Gaurav Sharma ◽  
Bandhan Bahal ◽  
Prashant Gupta ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Diagnostic Accuracy ◽  
Urinary Retention ◽  
Bladder Outlet Obstruction ◽  
Acute Urinary Retention ◽  
Bladder Wall ◽  
Outlet Obstruction ◽  
Threshold Value ◽  
Prostatic Hyperplasia ◽  
Control Group

Objectives: To dene the diagnostic accuracy of intravesical protrusion of prostate (IPP), bladder wall thickness (BWT) and prostate volume (PV) in diagnosis of bladder outlet obstruction (BOO) and prediction of future acute urinary retention (AUR). A prospective Materials and methods: study of 127 patients, presenting with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH) were enrolled with 50 patients among them manifesting AUR. 35 normal persons were selected as control group. After inclusion, all patients underwent transabdominal ultrasound and pressure ow urodynamic study (UDS). UDS parameter, BOO index (BOOI) were used as a reference standard for stratifying the patients into two groups, BOO and non-BOO. The sono-morphological parameters, IPP, BWT and PV were used to compare between these two groups with calculating the diagnostic accuracy for each individual index. IPP, BWT Results: and PV had statistically signicant difference between group 1 (BOOI < 40) and 2 ( BOOI > 40) with strong correlation with BOOI. The Pearson's correlation coefcient (r) for IPP, BWT and PV were 0.762, 0.702 and 0.660 respectively. The AUC for IPP, BWT and PV were 0.824, 0.786 and 0.650 with highest accuracy for IPP (79.2%) at cutoff value of 7 mm. Using the same threshold value, IPP had higher statistical difference than BWT in predicting AUR with similar diagnostic accuracy of IPP and BWT together. IPP and BWT in conjunction with PV in place Conclusions: of UDS had good clinical utility in diagnosis of BOO due to BPH and future AUR prediction.

scholarly journals Clinical significance of prostatic-urethral angulation on the treatment outcome of patients with symptomatic benign prostatic hyperplasia treated with tamsulosin hydrochloride

2015 ◽  
Vol 87 (3) ◽  
pp. 238
Author(s):  
Hassan El-Tatawy ◽  
Tarek Gameel ◽  
Mohammed Abo El-enen ◽  
Ayman Hagras ◽  
Ayman Mousa ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Clinical Significance ◽  
Treatment Efficacy ◽  
Specific Antigen ◽  
Prostatic Hyperplasia ◽  
Final Conclusion ◽  
P Value ◽  
Significant Difference ◽  
Group A ◽  
The Impact

Objectives: To evaluate the impact of the prostatic-urethral angulation (PUA) on the treatment efficacy of selective alpha-1A receptor blocker in male patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH). Materials and methods: A total of 80 patients with LUTS/BPH and with mean age 53.3 ± 6.3 (range 47-70) were included in our prospective comparative study. The patients were classified into 2 groups as a consecutive cases 40 in each one depending on the PUA either ≤ 35° (group A) or &gt; 35° (group B). PUA and different prostatic parameters were measured using transrectal ultrasound. Prostate-specific antigen (PSA), the International Prostate Symptom Score and quality of life score (IPSS/QoL score), maximum flow rate (Q<sub>max</sub>), and postvoid residual (PVR) volume were compared between the groups. The clinical significance of PUA was evaluated after 8 weeks of medical treatment with tamsulosin hydrochloride 0.4 mg daily. Results: Baseline evaluation (pre-treatment) for both groups were comparable to each other with no clinically significant difference regarding age, PSA, IPSS/QoL score, Qmax and PVR volume (P-value &gt; 0.05). Comparison of parameters after 8 weeks showed that tamsulosin hydrochloride improved the total IPSS and all subscores (P &lt; 0.001), QoL (P = 0.001), Q<sub>max</sub> (P = 0.002), and PVR (P = 0.04) in group A (Table 1). Conclusion: Tamsulosin hydrochloride appears to be less effective in improving IPSS/Qol score, Qmax and PVR in patients with lager PUA. The PUA might be a predictor for the treatment efficacy of α-blockers and more studies are warranted in the future before the final conclusion.

scholarly journals Ameliorative effects of Spinacia oleracea on sperm morphology, count, and motility by normalizing the obesity-induced oxidative stress in Sprague Dawley rats

2020 ◽  
Vol 14 (03) ◽  
pp. 124-127
Author(s):  
Somia Iqbal ◽  
Noman Sadiq ◽  
Saad Siddiqui ◽  
Hira Iqbal
Keyword(s):  
Sperm Concentration ◽  
Treated Group ◽  
Sperm Parameters ◽  
Control Group ◽  
Sprague Dawley ◽  
Normal Morphology ◽  
Sprague Dawley Rats ◽  
Group A ◽  
Group B ◽  
Experimental Group

Background: Obesity is a prevailing metabolic disorder that affects the functioning of the male reproductive system. Excessive adipose tissue enhances reactive oxygen species generation and is linked with male infertility. Spinach has demonstrated antioxidant effects. The present study was conducted to determine the antioxidant effects of spinach on sperm parameters in obese Sprague Dawley rats. Subjects and methods: This randomized control study was conducted at the animal house of the National Institute of Health Islamabad, Islamic International Medical College, Cosmesurge International Hospital, Rawalpindi, and Apollo lab, Islamabad, Pakistan from April 2016 to March 2017. Forty male Sprague Dawley rats having an age of 8 weeks and weight 160-200g were tagged from number 1 to 40. Every third rat was randomly allocated to control Group A (n=13) and remaining into the Experimental group (n=27). Rats of control Group A was given a standard diet while a high-fat diet was given to Experimental group rats to induce obesity for the duration of six weeks. Weight (g) was measured weekly and obesity was confirmed when rats attain more than 20% weight when compared with that of rats of control Group A. Then, after obesity induction, the experimental group was alienated into the obesity control group (Group B) and spinach treated group (Group C). For sample, rats of Group A and Group B were sacrificed, and the cauda epididymis of each rat was placed in a Petri dish containing normal saline and cut into pieces to allow the release of sperm and then sperm parameters (sperms concentration, motility, and morphology) were recorded under the microscope. Then, spinach (5% hot water extract) along with the persistence of fat diet was administered to Group C for 4 weeks and finally, sperm parameters were measured in this group. Results: Sperm concentration/ml, motility (%), and normal morphology (%) of Group B rats were significantly decreased as compared to Group A rats. However, sperm concentration/ml, motility (%), and normal morphology (%) of Group C (spinach treated group) rats was significantly increased (p<0.001) as compared to Group B (obesity control group) rats after administering spinach. Conclusion: The addition of Spinach in a normal diet regimen restores normal sperm morphology, improves sperm motility and concentration.

Effect Of Citrullus Lanatus Juice On Hemoglobin, Red Blood Cells And Liver Enzyme; An Experimental Study

2019 ◽  
Vol 09 (04) ◽  
pp. 257-260
Author(s):  
Shahid Ali ◽  
Nuzhat Sultana ◽  
Muslim Abbas ◽  
Zareen Naz ◽  
Muhammad Akbar Hassan ◽  
...  
Keyword(s):  
Experimental Study ◽  
Red Blood Cells ◽  
Liver Enzyme ◽  
Blood Cells ◽  
Citrullus Lanatus ◽  
Treated Group ◽  
Control Group ◽  
Group A ◽  
Group B ◽  
Post Hoc

Objective: To determine effect of citrullus lanatus juice on hemoglobin and Serum Glutamic Pyruvic Transaminase (SGPT) level. Study design and setting: It was an experimental study conducted on healthy rabbits for sixty days in the research department of pharmacy University of Karachi. Methodology: Current study was planned to evaluate effect of Citrullus lanatus juice on red blood cells, hemoglobin and liver enzyme. 60 days study was performed at 2 different doses i.e 3and 6ml/kg on rabbits. These rabbits were from either gender and were divided into 3 groups their weight ranges from 1200 to 1800 grams. Group A is control group (Normal saline 6ml/kg), Group B is treated group (3 ml/kg), Group C is treated group (6ml/kg). After taking mean of all values they are compared with control group. Significance of mean can be estimated by Tukes Post Hoc Test. P<0.05 estimated as significant. Results: It was found that count of red blood cells rises significantly along with rise in hemoglobin level. As far as liver enzyme serum glutamate pyruvate transaminase (SGPT) was concerned its concentration decreases slightly. Conclusion: Citrullus lanatus juice contain ingredients which are important for RBC hemoglobin and synthesis .It also contains important antioxidants that have organoprotective role due to which SGPT level decreases even in healthy animals as compared to control groups

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