scholarly journals Improvement of memory deficits via acetylcholinesterase inhibitory activity of Nepeta nuda ssp. nuda essential oil in rats

2021 ◽  
Vol 48 (3) ◽  
Author(s):  
Emel Akbaba ◽  
◽  
Eyup Bagci ◽  
Lucian Hritcu ◽  
Calin Maniu ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Biological Activities ◽  
Radial Arm Maze ◽  
Neuroprotective Effects ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Maze Test ◽  
Y Maze ◽  
Acetylcholinesterase Enzyme

Nepeta L. (Lamiaceae) species are belonging to aromatic and medicinal plants. Many biological activities of Nepeta species have been reported. In this study, memory-enhancing activities of Nepeta nuda ssp. nuda essential oil was aimed to be evaluated in laboratory rats treated with scopolamine. GC-MS/GC-FID system was used to identify oil composition. Memory performances of the rats were tested using Y-maze and radial-arm maze. Acetylcholinesterase enzyme activity and molecular docking analysis were also performed in this study. In total, 44 different compounds were identified in Nepeta nuda ssp. nuda essential oil. Trans-cis nepetalactone was showed to be the most abundant constituent in the oil. In the Y-maze test, the oil improved the performances of the animals on spontaneous alternation. Besides, in the radial-arm maze test, the oil improved working and reference memory significantly impaired in the rats subjected to scopolamine. The oil also showed acetylcholinesterase inhibitory activity in vitro. The molecular docking method, in the meantime, revealed that some of the compounds in the oil could interact with the acetylcholinesterase enzyme, theoretically. Nepeta nuda ssp. nuda essential oil improved spatial memory of scopolamine-induced rats. Neuroprotective effects of the oil are probably related to the anti-cholinesterase activity of the oil. Therefore, Nepeta nuda ssp. nuda essential oil could be used as a complementary therapy to improve memory in Alzheimer’s and related diseases.

scholarly journals Chemical profile of Lippia thymoides, evaluation of the acetylcholinesterase inhibitory activity of its essential oil, and molecular docking and molecular dynamics simulations

PLoS ONE ◽  
2019 ◽  
Vol 14 (3) ◽  
pp. e0213393 ◽  
Author(s):  
Sebastião Gomes Silva ◽  
Renato Araújo da Costa ◽  
Mozaniel Santana de Oliveira ◽  
Jorddy Neves da Cruz ◽  
Pablo Luis B. Figueiredo ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Molecular Docking ◽  
Essential Oil ◽  
Molecular Dynamics Simulations ◽  
Inhibitory Activity ◽  
Chemical Profile ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Dynamics Simulations

Exploration of the Acetylcholinesterase Inhibitory Activity of Some Alkaloids from Amaryllidaceae Family by Molecular Docking In Silico

2017 ◽  
Vol 42 (10) ◽  
pp. 2826-2830 ◽  
Author(s):  
Willian O. Castillo-Ordóñez ◽  
Elvira R. Tamarozzi ◽  
Gabriel M. da Silva ◽  
Andrés F. Aristizabal-Pachón ◽  
Elza T. Sakamoto-Hojo ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
In Silico ◽  
Acetylcholinesterase Inhibitory Activity

CHEMICAL PROFILING OF BUCHANANIA LANZAN SPRENG ESSENTIAL OIL AND ITS BIOLOGICAL ACTIVITIES

2020 ◽  
pp. 103-108
Author(s):  
AJITH S ◽  
KRISHNA V ◽  
RAVI KUMAR S ◽  
VINAY KUMAR NM
Keyword(s):  
Antioxidant Activity ◽  
Antibacterial Activity ◽  
Molecular Docking ◽  
Essential Oil ◽  
Essential Oils ◽  
Bioactive Compounds ◽  
Biological Activities ◽  
Dna Gyrase ◽  
Diffusion Method

Objective: The present study was designed to evaluate the chemical composition of the essential oil of Buchanania lanzan Spreng extracted from the seeds and to evaluate in vitro antimicrobial antioxidants and molecular docking studies of the major bioactive compounds of essential oil. Methods: The essential oil was obtained by hydrodistillation of the B. lanzan seeds and analyzed by gas chromatography-mass spectrometry (GC-MS). Antibacterial activity was evaluated against Pseudomonas aeruginosa, Salmonella typhi, Vibrio cholerae, Staphylococcus aureus, and Streptococcus pneumoniae clinical isolates by disk diffusion method and resazurin assay determined the minimum inhibitory concentration. The in vitro antioxidant activity was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) scavenging assay; the essential oil major bioactive compounds are Androstan-3-ol, Campesterol, and γ-Sitosterol were docked against bacterial protein DNA gyrase. Results: GC-MS analysis exhibited the presence of 19 bioactive compounds. The essential oil showed that significant antibacterial activity was noticed against V. cholerae and S. typhi with the highest zone of inhibition 15.67–1.20 and 13.83–0.33, respectively. Antioxidant activity in DPPH and H2O2 scavenging assays with IC50 values of 134.23 and 191.24, respectively. The molecular docking of Androstan-3-ol and γ-Sitosterol with bacterial DNA gyrase unveiled a good binding affinity of −6.4 kcal/mol and −6.3 kcal/ mol, respectively. Conclusion: It could be concluded that the essential oils potential sources of antibacterial, antioxidant activities, and molecular docking of bioactive components. The results of this study provide partial scientific support for the traditional application of essential oils to cure diarrhea and also major bioactive compounds responsible for important biological activities.

Acetylcholinesterase inhibitory activity and molecular docking study of steroidal alkaloids from Holarrhena pubescens barks

Steroids ◽  
2016 ◽  
Vol 108 ◽  
pp. 92-98 ◽  
Author(s):  
Sarot Cheenpracha ◽  
Jitrayut Jitonnom ◽  
Manutchaya Komek ◽  
Thunwadee Ritthiwigrom ◽  
Surat Laphookhieo
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
Docking Study ◽  
Molecular Docking Study ◽  
Steroidal Alkaloids ◽  
Acetylcholinesterase Inhibitory Activity

scholarly journals Chemical composition and acetylcholinesterase inhibitory activity of essential oil from rhizomes of Distichochlamys benenica

2021 ◽  
Vol 129 (1D) ◽  
pp. 43-49
Author(s):  
Hanh Thi Nhu Hoang ◽  
Thanh Thu Thi Dinh ◽  
Ty Viet Pham ◽  
Hien Bich Thi Le ◽  
Duc Viet Ho
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Activity ◽  
Acetylcholinesterase Inhibitory Activity ◽  
Ic50 Value

Twenty-seven constituents were identified by using GC/MS, representing 99.57% of the rhizome oil of Distichochlamys benenica. The major constituents of the essential oil are 1,8-cineole (54.39%), β-pinene (7.50%), (E)-citral (7.26%), and (Z)-citral (6.79%). The rhizome essential oil has anti-acetylcholinesterase activity with an IC50 value of 136.63 ± 2.70 mg/mL.

Derivatization, molecular docking and in vitro acetylcholinesterase inhibitory activity of glycyrrhizin as a selective anti-Alzheimer agent

2018 ◽  
Vol 33 (18) ◽  
pp. 2591-2599 ◽  
Author(s):  
Fatma M. Abdel Bar ◽  
Diaaeldin M. Elimam ◽  
Amira S. Mira ◽  
Fardous F. El-Senduny ◽  
Farid A. Badria
Keyword(s):  
Molecular Docking ◽  
Inhibitory Activity ◽  
Acetylcholinesterase Inhibitory Activity
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