scholarly journals A Rare Case of Primary Malignant Mesenchymoma Arising from Submandibular Salivary Gland

2020 ◽  
Vol 35 (6) ◽  
pp. e209-e209
Author(s):  
Abhay Vilas Deshmukh ◽  
Vitaladevuni Balasubramanyam Shivkumar ◽  
Nitin Mrigarajendra Gangane
Keyword(s):  
Salivary Gland ◽  
Spindle Cell ◽  
Histopathological Examination ◽  
Smooth Muscle Actin ◽  
Needle Aspiration ◽  
Salivary Gland Neoplasm ◽  
Spindle Cell Sarcoma ◽  
Submandibular Salivary Gland ◽  
Rare Tumor ◽  
Ki 67

Malignant mesenchymoma is a rare tumor in which there are two or more distinct mesenchymal components. These are generally considered as high-grade neoplasms and are usually associated with a poor prognosis. Here, we report a case of malignant mesenchymoma containing undifferentiated spindle cell sarcoma, leiomyosarcoma, chondrosarcoma, osteosarcoma, and areas with rhabdoid differentiation in a 54-year-old male. The primary tumor measured 5.5 × 4 × 3 cm and weighed 135 g arising from the left submandibular salivary gland. Fine-needle aspiration cytology showed the presence of pleomorphic spindle cell clusters with atypia and myxoid stroma. An impression of malignant salivary gland neoplasm was given. Diagnosis of malignant mesenchymoma was made on histopathological examination supported by immunohistochemistry showing strong positivity with p53, Ki-67, and focal positivity for smooth muscle actin, S-100, desmin, and negativity for cytokeratins. The exact histogenesis of malignant mesenchymoma and the optimal management strategy to decide the prognosis remains uncertain as it is a rare tumor.

scholarly journals Spindle Cell Sarcoma of Submandibular Salivary Gland: A Rare Presentation

2011 ◽  
Vol 2 (3) ◽  
pp. 144-145
Author(s):  
Priti Rakesh Dhoke ◽  
Vivek Vishwasji Harkare ◽  
Nitin Vasant Deosthale ◽  
Sonali Prabhakar Khadakkar ◽  
Kanchan Sandeep Dhote ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Spindle Cell ◽  
Postoperative Radiotherapy ◽  
Vascular Tumor ◽  
Spindle Cell Sarcoma ◽  
Submandibular Salivary Gland ◽  
Low Grade ◽  
Rare Presentation ◽  
Cell Sarcoma ◽  
High Degree

ABSTRACT Objective To report a rare case of spindle cell sarcoma of submandibular salivary gland, with intraoral extension with pathological dilemma. Case report A 40-year-old male presented with swelling and pain in right submandibular area since 1 year. Right submandibular gland excision with intraoral mass excision was done with reconstruction of floor of mouth. Postoperative histopathology was suggestive of low-grade malignant tumor with differential diagnosis of acinic cell tumor, vascular tumor and myoepithelial tumor. The immunohistochemistry report revealed spindle cell sarcoma with high degree of vascularity. Based on this report postoperative radiotherapy was planned. Conclusion According to literature, spindle cell sarcoma of submandibular salivary gland has not been reported yet. This case is presented for its uniqueness of its site, extension and histopathological dilemma.

scholarly journals A Rare Variety of Adenoid Cystic Carcinoma involving Submandibular Salivary Gland

2015 ◽  
Vol 23 (2) ◽  
pp. 77-80
Author(s):  
Sanjoy Kumar Ghosh ◽  
Saikat Samaddar ◽  
Swagatam Banerjee ◽  
Diptanshu Mukherjee
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Histopathological Examination ◽  
Salivary Gland Neoplasm ◽  
Submandibular Salivary Gland ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Benign Adenoma ◽  
Solid Variety

IntroductionAdenoid cystic carcinoma, an uncommon malignant salivary gland neoplasm, is known for its long clinical course, indolent growth, neural invasion, local recurrence and late distant metastasis. Three distinct histological patterns have been identified, amongst which, solid pattern is the rarest one having the worst prognosis. Materials And MethodsA case of sixty year old male patient presented with a swelling in the left side of the neck, below the jaw gradually enlarging during the last three years. FNAC from the neck swelling was suggestive of benign adenoma of the salivary gland, possibly basal cell adenoma or pleomorphic adenoma. Submandibular gland was excised. Histopathological examination confirmed the solid pattern of adenoid cystic carcinoma, which is the rarest among the three distinct histological subtypes of the malignancy. DiscussionAdenoid cystic carcinoma is well known for its perineural spread. In cases of submandibular gland adenoid cystic carcinoma, surgical wide excision is very much possible and in T1 or T2 cases post-operative radiotherapy may not be needed. In our case, post operative radiotherapy was given for best local control, as the tumour showed histopathlogical solid variety, grade III pattern, which is known to have the worst prognosis.

scholarly journals Canine Spindle Cell Mammary Tumor: A Retrospective Study of 67 Cases

2019 ◽  
Vol 56 (4) ◽  
pp. 526-535
Author(s):  
Ángela Alonso-Diez ◽  
Antonio Ramos ◽  
Paola Roccabianca ◽  
Lucía Barreno ◽  
Mª Dolores Pérez-Alenza ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Spindle Cell ◽  
Malignant Tumors ◽  
Smooth Muscle Actin ◽  
Benign Tumors ◽  
High Survival ◽  
Nerve Sheath Tumor ◽  
Canine Mammary Tumor ◽  
Ki 67 ◽  
Undifferentiated Sarcoma

Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. The tumors were diagnosed based on the hematoxylin and eosin (HE)–stained section; malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. The origin of the tumors was assessed as mammary, skin, or unknown. The prevalence of CSCMT was 1% of all CMTs. CSCMTs included 3 benign tumors (1 angioma and 2 benign myoepitheliomas) and 67 malignant tumors that after IHC were diagnosed as malignant myoepithelioma (64%), carcinoma and malignant myoepithelioma (19%), hemangiosarcoma (8%), undifferentiated sarcoma (5%), peripheral nerve sheath tumor (3%), and fibrosarcoma (2%). The diagnosis based on the HE-stained section differed from the diagnosis after IHC in 75% of the malignant cases. The majority of malignant CSCMTs were solitary (57%) large tumors (6.42 ± 3.92 cm) with low metastatic potential and high survival rate (8% tumor-related mortality). Higher sarcoma grade was associated with older age ( P = .034) and greater tumor size ( P = .037). Malignant CSCMTs need to be evaluated by IHC to ensure the histotype and the relatively benign clinical behavior, despite their large size.

Application of the Milan System for Reporting Salivary Gland Cytopathology: A 10-Year Experience in a Single Japanese Institution

2020 ◽  
pp. 1-9
Author(s):  
Yukiya Hirata ◽  
Kayoko Higuchi ◽  
Koichi Tamashiro ◽  
Keisuke Koja ◽  
Yuiko Yasutomi ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Predictive Value ◽  
Diagnostic Category ◽  
Needle Aspiration ◽  
Salivary Gland Neoplasm ◽  
Published Evidence ◽  
Risk Of Malignancy ◽  
Categorization System ◽  
Sensitivity Specificity

<b><i>Objective:</i></b> The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) is a recently published evidence-based categorization system for salivary gland fine-needle aspiration (FNA). We applied MSRSGC to Japanese cases and evaluated its utility. <b><i>Study Design:</i></b> A total of 480 FNA cases were reviewed. We recategorized each case into one of the MSRSGC categories. The risk of neoplasm (RON) and the risk of malignancy (ROM) for each diagnostic category in MSRSGC, and the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) for malignancy and for neoplasms were calculated for cases with histological follow-up. In addition, the overall ROM (O-ROM) was calculated for all FNA cases. <b><i>Results:</i></b> RON, ROM, and O-ROM rates were as follows – non-diagnostic: 51.3, 5.1, and 1.0%; non-neoplastic: 0, 0, and 0%; atypia of undetermined significance: 83.9, 12.9, and 7.3%; neoplasm, benign: 100, 0, and 0%; salivary gland neoplasm of uncertain malignant potential: 100, 32.1, and 23.7%; suspicious for malignancy: 100, 85.7, and 60%; and malignant: 100, 100, 81.8%. The sensitivity, specificity, and accuracy with (without) indeterminate cases for malignancy were 65 (100), 99 (99), 92% (99%) and PPV and NPV were 96 and 100%, respectively, and those for neoplasms were 84 (100), 100 (100), 85% (100%), and PPV and NPV were 100 and 100%, respectively. <b><i>Conclusions:</i></b> The MSRSGC is useful for stratification of ROM and for promoting the performance of salivary gland FNA. The MSRSGC could be easily introduced in Japan and may improve the Japanese salivary gland FNA status.

scholarly journals Primary epithelioid rhabdomyosarcoma of the stomach: a case report and review of literature

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yangkun Wang ◽  
Pei Guo ◽  
Zhishang Zhang ◽  
Runde Jiang ◽  
Zuguo Li
Keyword(s):  
Tumor Cells ◽  
Unusual Case ◽  
Histopathological Examination ◽  
Gastroesophageal Junction ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Ki 67 ◽  
Case Presentation ◽  
Cytoplasmic Content ◽  
Mitotic Figures

Abstract Background Epithelioid rhabdomyosarcoma is a rare tumor that generally occurs in the bladder, the parotid gland, or the skin of the neck. We describe an unusual case of primary epithelioid rhabdomyosarcoma of the stomach and review the literature. Case presentation A 64-year-old woman presented with a lesion at the gastroesophageal junction. Histopathological examination showed irregularly sized round cells with low cytoplasmic content and eccentric nuclei. Mitotic figures were present. Fibrovascular septa and areas of necrosis were observed between tumor cells. Tumor cells were strongly positive for MyoD1, desmin, and myogenin, and weakly positive for actin, CD56, and PGP9.5. The ki-67 index was ≥90%. Conclusions Primary epithelioid rhabdomyosarcoma of the stomach is extremely rare. Better awareness of this entity is necessary for early diagnosis and treatment.

Vulvar leiomyosarcoma in a cat

2007 ◽  
Vol 9 (5) ◽  
pp. 435-438 ◽  
Author(s):  
Ibrahim Firat ◽  
Damla Haktanir-Yatkin ◽  
Besim H Sontas ◽  
Hayri Ekici
Keyword(s):  
Smooth Muscle ◽  
Internal Control ◽  
Spindle Cell ◽  
Smooth Muscle Actin ◽  
Spindle Cell Sarcoma ◽  
Vascular Elements ◽  
Collagenous Matrix ◽  
Mixed Breed ◽  
History Of ◽  
Cut Surface

A vulvar leiomyosarcoma was diagnosed in an 8-year-old mixed-breed, sexually intact cat. The cat had a history of vulvar swelling, bleeding and stranguria. The mass was located at the ventral commissura of the vulva. The cut surface of the mass was lobulated and greyish-white, with areas of necrosis and haemorrhage. Histologically, it was a spindle-cell sarcoma consisting of interlacing bundles of very elongated neoplastic smooth muscle cells and variably dense collagenous matrix separated by individual cells or streams. It also contained areas of focal necrosis and haemorrhage. The mitotic index ranged from seven to 12 mitoses per 10 high-power fields. Immunohistochemically, the spindle-shaped neoplastic cells were strongly positive for smooth muscle actin (SMA) and vimentin, whereas no immunoreactivity was obtained for desmin. The vascular elements of the internal control tissue also exhibited strong SMA and vimentin immunoreactivity. Based on the morphological and immunohistochemical features, the tumour was classified as a leiomyosarcoma.

scholarly journals Cytopathological Findings of Secretory Carcinoma of the Salivary Gland and the Diagnostic Utility of Giemsa Staining

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2284
Author(s):  
Yuria Egusa ◽  
Midori Filiz Nishimura ◽  
Satoko Baba ◽  
Kengo Takeuchi ◽  
Takuma Makino ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Fusion Gene ◽  
Needle Aspiration ◽  
Giemsa Staining ◽  
World Health ◽  
Salivary Gland Neoplasm ◽  
Secretory Carcinoma ◽  
Neoplastic Cells ◽  
Metachromatic Granules ◽  
Health Organization

Secretory carcinoma is a salivary gland neoplasm first described as a mammary analogue secretory carcinoma by Skalova et al. in 2010 and redesignated as a secretory carcinoma in the 2017 World Health Organization Classification of Head and Neck Tumors. Secretory carcinoma diagnosis is reliant on specific cytological and histological findings and the detection of an ETV6-NTRK3 fusion gene. Here, we examined the clinical and cytopathological features of four cases of secretory carcinoma occurring in three males and a female, aged between 39 and 74 years. All four tumors involved the parotid gland, and were found to have the ETV6-NTRK3 fusion gene. Fine-needle aspiration-based cytology smears of all tumors displayed papillary and/or dendritic pattern clusters, some of which were associated with blood vessels. The neoplastic cells displayed enlarged nuclei with fine chromatin and small, distinct, single nucleoli. Furthermore, several neoplastic cells with a characteristic vacuolated cytoplasm were identified in each specimen. Giemsa staining revealed cytoplasmic vacuolation, intracytoplasmic metachromatic secretions and/or various sized metachromatic granules, and a background of metachromatic mucin in all four specimens. Given this, we conclude that these cytological findings, especially those of the Giemsa staining, might be helpful in the diagnosis of secretory carcinoma.

scholarly journals A large malignant oncocytoma of parotid gland: a case report

2020 ◽  
Vol 6 (12) ◽  
pp. 2310
Author(s):  
Nidhi S. Mohan ◽  
Sunita S. Vernekar ◽  
Mohammed M. Abus Samee ◽  
Manjunath D.
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Fine Needle Aspiration ◽  
Facial Palsy ◽  
Fine Needle Aspiration Cytology ◽  
Histopathological Examination ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

<p class="abstract">Malignant oncocytoma is an extremely rare neoplasm of the salivary gland accounting for 0.5% of epithelial salivary gland malignancies and 0.18% of epithelial salivary gland tumors. We report a case of malignant oncocytoma of left parotid gland in a 61-year old female patient. Patient presented with a 6-year history of painless swelling in the left parotid region. Fine needle aspiration cytology of the swelling was suggestive of pleomorphic adenoma. A computed tomography scan performed did not reveal any features suggestive of malignancy. Patient underwent left superficial parotidectomy. However, histopathological examination of the specimen turned out to be malignant oncocytoma. Malignant oncocytoma of salivary glands have rare incidence and may have similar morphologic features with other neoplasms. Despite the tumor being large and malignant in this case, there was no facial palsy preoperatively. As histopathology is often diagnostic, the possibility of malignancy always must be kept in mind preoperatively even when there is no facial palsy or fine needle aspiration cytology not showing up malignancy.</p>

scholarly journals Management of salivary gland neoplasm – study of 32 cases

2010 ◽  
Vol 9 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Md Abdullah Hel Kafi ◽  
Md Arif Hossain Bhuyan ◽  
Md Jahangir Hossain Bhuiyan ◽  
MS Khurshid Alam
Keyword(s):  
Salivary Gland ◽  
Pleomorphic Adenoma ◽  
Histopathological Examination ◽  
Medical Science ◽  
Surgical Excision ◽  
Military Hospital ◽  
Salivary Gland Neoplasm ◽  
Salivary Gland Tumours ◽  
Presenting Symptoms ◽  
Parotid Neoplasm

Objective: To study the clinical, radiological and histopathological characteristics along with the management outcome of salivary gland neoplasm. Materials and Methods: This study included thirty two patients (16 male and 16 female) with salivary gland tumours presented at Combined Military Hospital Dhaka, Apollo Hospital Dhaka and Ibn Sina Medical College and Hospital Dhaka from January 2006 to December 2009. The data of each patient included age, sex, presenting symptoms and signs, provisional diagnosis, preoperative investigations, operation notes, histopathological examination and state at follow up. Results: The mean age was 42.5 years. 14 (43.75%) patients presented at 5th decade. Main presenting symptom was swelling (100%) followed by pain (18.75%). All patients underwent fine needle aspiration cytology which was conclusive in 26 patients (81.25%). Thirty one patients underwent surgical excision. 24 cases were parotid neoplasm and 8 cases were submandibular neoplasm. 20 patients (16 parotid and 4 submandibular) were pleomorphic adenoma. Conclusion: There is no substitute for detailed clinical history and examination in the assessment of salivary gland neoplasm. Imaging studies are probably academic but determine the extent of the disease. Early diagnosis, adequate and proper treatment improves the prognosis. Key words: Salivary gland tumour; Pleomorphic adenoma; Warthin's tumour; Adenoid cystic carcinoma; Mucoepidermoid carcinoma. DOI: 10.3329/bjms.v9i2.5656Bangladesh Journal of Medical Science Vol.09 No.2 Apr 2010 pp.87-94

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