scholarly journals Effect of Menopause on Pulmonary Functions: An Analysis!

2017 ◽  
Vol 5 (2) ◽  
pp. 99-101
Author(s):  
Kshama V Kedar ◽  
Radha P Munje ◽  
Amar K Karia
Keyword(s):  
Menstrual Cycle ◽  
Lung Function ◽  
Pulmonary Function ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Pulmonary Function Tests ◽  
Premenopausal Women ◽  
Pulmonary Functions ◽  
Function Tests

ABSTRACT Introduction Sex hormones play an important role in women's health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates the adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses a spirometer to analyze and evaluate these effects of menopausal aging. Objective To study the effects of menopause on pulmonary function tests in women of perimenopausal age group. Materials and methods This study was carried out in the Department of Obstetrics and Gynecology in Indira Gandhi Government Medical College & Hospital (IGGMC) Nagpur, India. Totally 50 women each in premenopausal and menopausal age groups were included in our study. Venous blood was collected under aseptic precautions on 10 to 14 and 18 to 23 days corresponding to follicular and luteal phase of menstrual cycle in premenopausal and postmenopausal women. Serum estrogen and progesterone levels were estimated by microparticle enzyme immunoassay. The pulmonary function of all subjects was measured with digital microspirometer and data collected. The peak expiratory flow rate (PEFR), forced expiratory flow (FEF)25-75, forced expiratory volume (FEV1), and forced vital capacity (FVC) were studied and correlated with symptoms. Data analysis was done using Student's unpaired t-test and chi-squared test. Results The mean percentages of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared with premenopausal women. Mean serum estrogen levels were significantly lower in postmenopausal women as compared with premenopausal women. Progesterone levels were lower in postmenopausal women and in proliferative phase of premenopausal women as compared with luteal phase of menstrual cycle. Conclusion As menopause sets in, decrease in hormonal levels leads to decreased lung capacity as evident by pulmonary function tests. Decreased pulmonary function test can be attributed to lower levels of sex hormones estrogen and progesterone in postmenopausal women. How to cite this article Karia AK, Kedar KV, Munje RP. Effect of Menopause on Pulmonary Functions: An Analysis! J South Asian Feder Menopause Soc 2017;5(2):99-101.

Effect of Menopause on Pulmonary Functions: An Analysis

2017 ◽  
Vol 5 (1) ◽  
pp. 16-18 ◽  
Author(s):  
Amar K Karia ◽  
Kshama V Kedar ◽  
Radha P Munje
Keyword(s):  
Menstrual Cycle ◽  
Lung Function ◽  
Pulmonary Function ◽  
Postmenopausal Women ◽  
Sex Hormones ◽  
Luteal Phase ◽  
Premenopausal Women ◽  
Age Group ◽  
Pulmonary Functions ◽  
Function Test

ABSTRACT Background Sex hormones play an important role in women’s health. There is a close relationship between female sex hormones and lung function in postmenopausal women. Deterioration of lung function is observed more after menopause. Estrogen deficiency after menopause accelerates adverse effects of biological aging on lung mechanics in postmenopausal women. Our study uses spirometer to analyze and evaluate these effects of menopausal aging. Objective To study the effects of menopause on pulmonary function tests in women of perimenopausal age group. Materials and methods This study was carried out in the Department of Obstetrics and Gynecology in Indira Gandhi Government Medical College & Hospital, Nagpur, India. A total of 50 women each in premenopausal and menopausal age group were included in our study. Venous blood was collected under aseptic precaution on 10 to 14 days and 18 to 23 days corresponding to follicular and luteal phase of menstrual cycle in premenopausal women and in postmenopausal women, and serum estrogen and progesterone levels were estimated by microparticle enzyme immunoassay. Pulmonary function of all subjects was measured with digital micro spirometer and data collected. Peak expiratory flow rate (PEFR), forced expiratory flow (FEF)25-75, forced expiratory volume in 1 second, and forced vital capacity were studied and correlated with symptoms. Data analysis was done using Student’s unpaired t-test and chi-square test. Results The mean percentage of predicted values of FEF25-75 and PEFR were lower in postmenopausal women compared with premenopausal women. Mean serum estrogen levels were significantly lower in postmenopausal women as compared with premenopausal women. Progesterone levels were lower in postmenopausal women and in proliferative phase of premenopausal women as compared with luteal phase of menstrual cycle. Conclusion As menopause sets in decreased hormonal levels leads to decreased lung capacity as evident by pulmonary function test. Decreased pulmonary function test can be attributed to lower levels of sex hormones estrogen and progesterone in postmenopausal women. How to cite this article Karia AK, Kedar KV, Munje RP. Effect of Menopause on Pulmonary Functions: An Analysis. J South Asian Feder Menopause Soc 2017;5(1):16-18.

scholarly journals Predicting Pulmonary Function Testing from Quantified Computed Tomography Using Machine Learning Algorithms in Patients with COPD

Diagnostics ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 33 ◽  
Author(s):  
Joshua Gawlitza ◽  
Timo Sturm ◽  
Kai Spohrer ◽  
Thomas Henzler ◽  
Ibrahim Akin ◽  
...  
Keyword(s):  
Machine Learning ◽  
Computed Tomography ◽  
Lung Function ◽  
Pulmonary Function ◽  
Polynomial Regression ◽  
Pulmonary Function Tests ◽  
Quantitative Computed Tomography ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
Function Tests

Introduction: Quantitative computed tomography (qCT) is an emergent technique for diagnostics and research in patients with chronic obstructive pulmonary disease (COPD). qCT parameters demonstrate a correlation with pulmonary function tests and symptoms. However, qCT only provides anatomical, not functional, information. We evaluated five distinct, partial-machine learning-based mathematical models to predict lung function parameters from qCT values in comparison with pulmonary function tests. Methods: 75 patients with diagnosed COPD underwent body plethysmography and a dose-optimized qCT examination on a third-generation, dual-source CT with inspiration and expiration. Delta values (inspiration—expiration) were calculated afterwards. Four parameters were quantified: mean lung density, lung volume low-attenuated volume, and full width at half maximum. Five models were evaluated for best prediction: average prediction, median prediction, k-nearest neighbours (kNN), gradient boosting, and multilayer perceptron. Results: The lowest mean relative error (MRE) was calculated for the kNN model with 16%. Similar low MREs were found for polynomial regression as well as gradient boosting-based prediction. Other models led to higher MREs and thereby worse predictive performance. Beyond the sole MRE, distinct differences in prediction performance, dependent on the initial dataset (expiration, inspiration, delta), were found. Conclusion: Different, partially machine learning-based models allow the prediction of lung function values from static qCT parameters within a reasonable margin of error. Therefore, qCT parameters may contain more information than we currently utilize and can potentially augment standard functional lung testing.

scholarly journals Integrative genomic analysis in African American children with asthma finds 3 novel loci associated with lung function

2020 ◽  
Author(s):  
Pagé C. Goddard ◽  
Kevin L. Keys ◽  
Angel C.Y. Mak ◽  
Eunice Yujung Lee ◽  
Amy K. Liu ◽  
...  
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Genome Wide Association Study ◽  
Mononuclear Cells ◽  
Pulmonary Function Tests ◽  
Genomic Analysis ◽  
Lung Fibroblasts ◽  
Admixture Mapping ◽  
Function Tests ◽  
Genes And Environment

AbstractBronchodilator drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of bronchodilator medication can partially or fully restore lung function as measured by pulmonary function tests. The genetics of baseline lung function measures taken prior to bronchodilator medication has been extensively studied, and the genetics of the bronchodilator response itself has received some attention. However, few studies have focused on the genetics of post-bronchodilator lung function. To address this gap, we analyzed lung function phenotypes in 1,103 subjects from the Study of African Americans, Asthma, Genes, and Environment (SAGE), a pediatric asthma case-control cohort, using an integrative genomic analysis approach that combined genotype, locus-specific genetic ancestry, and functional annotation information. We integrated genome-wide association study (GWAS) results with an admixture mapping scan of three pulmonary function tests (FEV1, FVC, and FEV1/FVC) taken before and after albuterol bronchodilator administration on the same subjects, yielding six traits. We identified 18 GWAS loci, and 5 additional loci from admixture mapping, spanning several known and novel lung function candidate genes. Most loci identified via admixture mapping exhibited wide variation in minor allele frequency across genotyped global populations. Functional fine-mapping revealed an enrichment of epigenetic annotations from peripheral blood mononuclear cells, fetal lung tissue, and lung fibroblasts. Our results point to three novel potential genetic drivers of pre- and post-bronchodilator lung function: ADAMTS1, RAD54B, and EGLN3.

scholarly journals Effects of exercise on pulmonary function tests: A comparative study between athletes and non-athletes in Nepalese settings

2017 ◽  
Vol 6 (1) ◽  
pp. 21
Author(s):  
N B Mahotra ◽  
T M Amatya ◽  
B SJB Rana ◽  
D Banstola
Keyword(s):  
Comparative Study ◽  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Institute Of Medicine ◽  
Cross Sectional ◽  
Pulmonary Functions ◽  
Inspiratory Muscles ◽  
Function Tests

<p> Due to regular exercises, athletes tend to have an increase in pulmonary functions when compared to non exercising individuals, especially when the exercise is strenuous. Intensity and severity of sports engaged in by the athletes determines the extent of strengthening of the inspiratory muscles with a resultant increase in the lung volumes and capacities. Pulmonary parameters like tidal volume and forced vital capacity are significantly higher in athletes than in non athletes. A cross sectional comparative study was carried out in national sports council, Tribhuvan army club and institute of medicine, Kathmandu, Nepal. The athletes were footballers from Tribhuvan army club and sprinters from national sports council. The non-athletes were medical students from the institute of medicine, Kathmandu. Data were collected after performing spirometry and mean values were compared between athletes and non-athletes. Pulmonary functions were assessed based on forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate (PEFR) expressed as percent predicted for the age, sex, height, weight and race. Spirometry was performed in 169 subjects, out of which 84 were athletes and 85 were non-athletes. Athletes had a significantly superior FVC (P =0.00) compared to non-athletes. FEV1 was also recorded significantly higher in athletes than in non-athletes (P=0.023). Athletes have better pulmonary function tests than non-athletes because exercise in athletes strengthens the muscles of respiration. </p>

Association between body composition and pulmonary function tests among health care workers in Iran

2021 ◽  
Vol 17 ◽  
Author(s):  
Hamidreza Pouragha ◽  
Hosein Kazemi ◽  
Gholamreza Pouryaghoub ◽  
Ramin Mehrdad
Keyword(s):  
Body Composition ◽  
Lung Function ◽  
Pulmonary Function ◽  
Visceral Fat ◽  
Pulmonary Function Tests ◽  
The Body ◽  
Fat Free Mass ◽  
The Other ◽  
Cross Sectional ◽  
Function Tests

Background: Why is bodyweight not a predictor of lung function, while height, sex, race, and age are predictors of lung capacity and function? In this study, we want to investigate the association between body composition and pulmonary function. And, as much as possible, answer the question of why bodyweight is not predictive of lung function. Methods: This cross-sectional study was performed among 2967 employees of Tehran University of Medical Sciences (TUMS) who participated in the TUMS Employees Cohort (TEC) study. The body composition of the participants was measured using the Bioelectrical Impedance Analysis (BIA) method. Anthropometric variables were also measured as a confounder. The pulmonary function of participants was assessed by a forced spirometry test. Results: The correlation of BIA values including fat-free mass and total body water with a pulmonary function such as FEV1, FVC, and FEF25-75 is higher than most anthropometric values such as weight, wrist circumference, and the waist to hip ratio. Also, in regression analysis, age and sex had an association with pulmonary function, but the weight did not show a significant relationship. On the other hand, fat-free mass and visceral fat were significantly associated with pulmonary function. One is direct and the other is inverse. Conclusion: We observed a negative association between visceral fat and pulmonary function tests and a direct association between Fat-free mass pulmonary function tests (FEV1 and FVC) adjusted for age, sex, and anthropometric indices.

Effect of triiodothyronine-induced thyrotoxicosis on airway hyperresponsiveness

1991 ◽  
Vol 71 (2) ◽  
pp. 438-444 ◽  
Author(s):  
H. M. Hollingsworth ◽  
M. R. Pratter ◽  
J. M. Dubois ◽  
L. E. Braverman ◽  
R. S. Irwin
Keyword(s):  
Lung Function ◽  
Pulmonary Function ◽  
Exercise Capacity ◽  
Controlled Trial ◽  
Pulmonary Function Tests ◽  
Airway Responsiveness ◽  
Mild Asthma ◽  
Thyroid Function Tests ◽  
Double Blind ◽  
Function Tests

To determine whether thyrotoxicosis has an effect on the asthmatic state in subjects with mild asthma, airway responsiveness, lung function, and exercise capacity were measured in a randomized double-blind placebo-controlled trial before and after liothyronine (triiodothyronine, T3)-induced thyrotoxicosis. Baseline evaluation of 15 subjects with mild asthma included clinical evaluation, thyroid and routine pulmonary function tests, airway responsiveness assessment by methacholine inhalation challenge, and a symptom-limited maximal exercise test. For all subjects, the initial testing revealed that the dose of methacholine which provoked a 20% fall in forced expiratory volume in 1s (PD20) was in a range consistent with symptomatic asthma. There was no significant change in pulmonary function tests, airway reactivity (PD20), or exercise capacity in either the placebo or the T3-treated groups. Thyroid function tests confirmed mild sustained thyrotoxicosis in the T3-treated groups. We conclude that mild T3-induced thyrotoxicosis of 4-wk duration had no effect on lung function, airway responsiveness, or exercise capacity in subjects with mild asthma.

scholarly journals Effects Of Type Sports On Pulmonary Function Tests: A Comparative Study In Nepalese Settings

2013 ◽  
Vol 2 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Narayan Bahadur Mahotra ◽  
Lava Shrestha
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
National Level ◽  
Weight Lifting ◽  
Muscle Exercise ◽  
Pulmonary Functions ◽  
Inspiratory Muscles ◽  
Function Tests ◽  
Weight Lifters ◽  
Predicted Values

Introduction: Due to regular exercises, athletes tend to have an increase in pulmonary capacity when compared to non-exercising individuals. Intensity and severity of sports engaged in by the athletes probably determines the extent of strengthening of the inspiratory muscles with a resultant increase in the pulmonary functions.1, 2 So, this study has been carried out to establish a relationship between the type of sports and pulmonary functions in Nepalese athletes. Methods: This study has adopted a cross sectional observational comparative research design. Spirometry was conducted in 84 different national level athletes [25.71 (± 4.55) years]. The athletes were from five different sport groups. Out of them, there were 16 weight lifters, 41 footballers, 10 swimmers, 8 marathon runners and 9 sprinters. Among them weight lifters, marathoners and sprinters were selected from the National sports council, Tripureshower, Kathmandu and footballers and swimmers were from the Nepal army club, Kathmandu, Nepal. The spirometry was done in sitting position using MIR SPIROLAB II spirometer based on American Thoracic Society (ATS) recommendations. Pulmonary function was assessed based on Forced Expiratory Volume in first second (FEV1), Forced Vital Capacity (FVC) and Peak Expiratory Flow Rate (PEFR) expressed as percent predicted for the age, sex, height, weight and race. Results: When comparing the mean values of FVC, FEV1 and PEFR among the five different sport groups, as expected, athletes who have more strenuous respiratory muscles exercise had significantly superior pulmonary function parameters. For example weight lifters and swimmers had 111.84 and 109.56 percentage of predicted values on FVC (P=0.008) respectively. But marathoners, footballers and sprinters had 105.83, 99.25 and 98.34 percentage of predicted values respectively. Similarly, weight lifters, swimmers, marathoners, footballers and sprinters had 110.63, 110.15 and 110.28, 102.52 and 99.23 percentages of predicted values on FEV1 (p=0.090) respectively. Swimmers, marathoners, footballers, weight lifters and sprinters had 106.03 and 107.34, 104.37, 102.08 and 86.58 percentage of predicted values on PEFR (p=0.027) respectively. Conclusion: Athletes who have most strenuous respiratory muscle exercise like swimming and weight lifting have better pulmonary function tests (PFTs) compared to other athletes like sprinters who have less strenuous muscle exercise. Journal of Nobel Medical College Vol. 2, No.1 Issue 3 Nov.-April 2013 Page 18-21 DOI: http://dx.doi.org/10.3126/jonmc.v2i1.7667

scholarly journals Effects of exercise on pulmonary function tests: A comparative study between athletes and non-athletes in Nepalese settings

2017 ◽  
Vol 6 (1) ◽  
pp. 21-23
Author(s):  
N B Mahotra ◽  
T M Amatya ◽  
B SJB Rana ◽  
D Banstola
Keyword(s):  
Comparative Study ◽  
Pulmonary Function ◽  
Forced Vital Capacity ◽  
Vital Capacity ◽  
Pulmonary Function Tests ◽  
Institute Of Medicine ◽  
Cross Sectional ◽  
Pulmonary Functions ◽  
Inspiratory Muscles ◽  
Function Tests

 Due to regular exercises, athletes tend to have an increase in pulmonary functions when compared to non exercising individuals, especially when the exercise is strenuous. Intensity and severity of sports engaged in by the athletes determines the extent of strengthening of the inspiratory muscles with a resultant increase in the lung volumes and capacities. Pulmonary parameters like tidal volume and forced vital capacity are significantly higher in athletes than in non athletes. A cross sectional comparative study was carried out in national sports council, Tribhuvan army club and institute of medicine, Kathmandu, Nepal. The athletes were footballers from Tribhuvan army club and sprinters from national sports council. The non-athletes were medical students from the institute of medicine, Kathmandu. Data were collected after performing spirometry and mean values were compared between athletes and non-athletes. Pulmonary functions were assessed based on forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and peak expiratory flow rate (PEFR) expressed as percent predicted for the age, sex, height, weight and race. Spirometry was performed in 169 subjects, out of which 84 were athletes and 85 were non-athletes. Athletes had a significantly superior FVC (P =0.00) compared to non-athletes. FEV1 was also recorded significantly higher in athletes than in non-athletes (P=0.023). Athletes have better pulmonary function tests than non-athletes because exercise in athletes strengthens the muscles of respiration. 

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