The relationship of vitamin D with non-traditional risk factors for cardiovascular disease in subjects with metabolic syndrome

Osteoprotegerin (OPG), a glycoprotein traditionally implicated in bone remodelling, has been recently related to cardiovascular disease (CVD). Human studies show a positive relationship between circulating OPG, vascular damage, and CVD, and as such OPG has emerged as a potential biomarker for CVD. This review focuses on the relationship between circulating OPG and different endocrine cardiometabolic alterations such as type 1 and 2 diabetes. The association of OPG with diabetic complications (neuropathy, nephropathy, or retinopathy) as well as with atherosclerosis, coronary artery calcification, morbidity, and mortality is pointed out. Moreover, OPG modulation by different treatments is also established. Besides, other associated diseases such as obesity, hypertension, and metabolic syndrome, which are known cardiovascular risk factors, are also considered.

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The Relationship of Cardiovascular Disease and Its Risk Factors to Age-related Maculopathy

Ophthalmology ◽

10.1016/s0161-6420(93)31634-9 ◽

1993 ◽

Vol 100 (3) ◽

pp. 406-414 ◽

Cited By ~ 143

Author(s):

Ronald Klein ◽

Barbara E.K. Klein ◽

Todd Franke

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Age Related ◽

Relationship Of ◽

The Relationship

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High prevalence of fragmented QRS on electrocardiography in Japanese subjects with diabetes irrespective of metabolic syndrome

10.21203/rs.3.rs-123784/v1 ◽

2020 ◽

Author(s):

Kunimasa Yagi ◽

Yoshiki Nagata ◽

Takashi Yamagami ◽

Miki Kamigishi ◽

Maki Nakagawa Yokoyama ◽

...

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Reference Group ◽

Japanese Patients ◽

Receiver Operating Curve ◽

Cardiac Events ◽

Fragmented Qrs ◽

Traditional Risk Factors ◽

And Control ◽

Relationship Of

Abstract BackgroundFragmented QRS (fQRS) on electrocardiography is a marker of myocardial fibrosis and myocardial scar formation. fQRS has been reported as a reliable predictor of adverse cardiac events in several populations. We investigated the relationship of fQRS with diabetes mellitus (DM) and metabolic syndrome (MetS) in Japanese patients.Material and methodsOur study enrolled a total of 702 subjects (435 without DM and 267 with type 2 DM) who had a routine health checkup at the Hokuriku Health Service Association (Toyama, Japan) in October 2014. Based on MetS and DM status, participants were categorized into one of the following four groups: DM+ MetS + (157 subjects); DM+ MetS - (110 subjects); DM- MetS + (82 subjects); and DM- MetS- (353 subjects). fQRS was assessed using the results of electrocardiography.ResultsThe prevalence of fQRS was statistically higher in patients with DM+MetS+ (36%) and DM+MetS- (36%), than those with DM-MetS+ (18%) or DM-MetS- (9%) (p < 0.001). Significant differences were observed between the fQRS(+) and fQRS(-) groups for age, gender, waist circumference (WC), heart rate, hypertension, HbA1c, TC, MetS, and DM. The area under the receiver-operating curve for traditional risk factors and DM was 0.72 (p=0.0021, 95% confidence interval [CI]: 0.68-0.77), and for traditional risk factors and MetS it was 0.69 (p=0.1478, 95% CI: 0.64-0.73). Patients with DM had more than three-fold higher likelihood of showing fQRS (odds ratio, 3.41; 95% CI, 2.25-5.22; p<0.0001) compared to the reference group without DM, after adjusting for age, gender, dyslipidemia, hypertension, and WC.ConclusionfQRS was observed more frequently in DM than in MetS and control subjects. DM was the most significant determinant for fQRS among MetS and other traditional metabolic risk factors in the general Japanese population.

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Ultraviolet A Radiation and COVID-19 Deaths in the USA with replication studies in England and Italy

10.1101/2020.07.03.20145912 ◽

2020 ◽

Cited By ~ 2

Author(s):

Mark Cherrie ◽

Tom Clemens ◽

Claudio Colandrea ◽

Zhiqiang Feng ◽

David J Webb ◽

...

Keyword(s):

Nitric Oxide ◽

Risk Factors ◽

Metabolic Syndrome ◽

Vitamin D ◽

Meteorological Conditions ◽

Ultraviolet A ◽

Replication Studies ◽

The Usa ◽

The Relationship ◽

Uva Radiation

AbstractSeasonal variation in environmental meteorological conditions affect the incidence of infectious diseases. Ultraviolet A (UVA) radiation induces release of cutaneous photolabile nitric oxide (NO) impacting the cardiovascular system and metabolic syndrome, COVID-19 risk factors. NO also inhibits the replication of SARS-CoV. We therefore model the relationship between UVA radiation, derived from remote sensed data, and COVID-19 deaths for counties across the USA during their ‘UV vitamin D winter’ (Jan-April) adjusting for confounding including by temperature and humidity. The Mortality Risk Ratio (MRR) falls by 29% (40% -15% (95% CI)) per 100 (KJ/m2) increase in mean daily UVA. We replicate this in independent studies in Italy and England and estimate a pooled decline in MRR of 32% (48%-12%) per 100 KJ/m2 across the three studies.

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Mo-P1:58 The relationship between alcohol intake and traditional or non-traditional risk factors for cardiovascular disease in the middle-aged Japanese men

Atherosclerosis Supplements ◽

10.1016/s1567-5688(06)80193-5 ◽

2006 ◽

Vol 7 (3) ◽

pp. 58

Author(s):

N. Miyamatsu ◽

T. Kadowaki ◽

T. Okamura ◽

A. Sekikawa ◽

K. Murata ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Alcohol Intake ◽

Middle Aged ◽

Japanese Men ◽

Traditional Risk Factors ◽

The Relationship

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Abstract 2539: Relationship of Aortic Wall Thickness and Distensibility with Subclinical Measures of Cardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis

Circulation ◽

10.1161/circ.116.suppl_16.ii_561 ◽

2007 ◽

Vol 116 (suppl_16) ◽

Author(s):

Hossein Bahrami ◽

Joao A Lima ◽

Joseph F Polak ◽

Gregory D Pearson ◽

Kiang Liu ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Cross Sectional Area ◽

Sectional Area ◽

Cross Sectional ◽

Carotid Imt ◽

Lv Mass ◽

Relationship Of ◽

The Relationship ◽

Subclinical Cvd

Background: While increased carotid intima-media thickness (IMT) is considered an independent risk factor for cardiovascular disease (CVD), little is known about the relationship of aortic thickness (AWT) and aortic distensibility (AD) with CVD risk factors. We studied the association of these aortic parameters with other measures of subclinical CVD. Methods: The Multi-Ethnic Study of Atherosclerosis (MESA) includes 6,814 participants, aged 45– 85 years; white, African-American, Hispanic, and Chinese. AD and AWT were measured by MRI. Average and maximum AWT of the proximal descending thoracic aorta were used as two measures of AWT. AD was calculated as the difference in aortic cross-sectional area indexed by diastolic cross-sectional area and average pulse pressure. IMT of the common and internal carotid arteries were determined by high-resolution B-mode ultrasonography and LV mass was determined by MRI. Phantom-adjusted Agatston calcium score from CT images was used to define coronary artery calcification (CAC). Results: In univariable analyses, higher carotid IMT, ankle-brachial index (ABI) <0.9, CAC score, LV mass, and presence of coronary calcium were associated with lower AD and higher AWT (table ). However, in multivariable analyses, the only measures of subclinical CVD that had significant associations with both AD and AWT were LV mass and carotid IMT, while ABI was associated with only AWT. After adding age to the models, CAC score was no longer associated with either AD or AWT. The relationship between CAC score and AD varied by ethnicity; higher CAC score was associated with higher AD only in African Americans. Conclusions: AD and AWT are related to carotid IMT and LV mass, even after controlling for traditional risk factors. The associations of AD and AWT with CAC appears to be mainly due to their relationship with conventional risk factors, particularly age. Overall, AWT and AD may have closer relationship with LV mass than with subclinical atherosclerosis.

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Type D personality and metabolic syndrome among Finnish female municipal workers

BMC Women s Health ◽

10.1186/s12905-020-01052-z ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Susa Majaluoma ◽

Tellervo Seppälä ◽

Hannu Kautiainen ◽

Päivi Korhonen

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Depressive Symptoms ◽

Leisure Time Physical Activity ◽

Type D Personality ◽

Female Population ◽

Type D ◽

Working Age ◽

The Relationship

Abstract Background Type D personality is a combination of high negative affectivity (NA) and high social inhibition (SI). This personality trait is suspected to impair cardiovascular patients’ recovery. The 2016 European Guidelines on cardiovascular disease prevention in clinical practice recommend screening of psychosocial risk factors as Type D personality. The aim of this study was to assess the relationship between Type D personality and Metabolic syndrome (MetS) in working-age female population. Methods Six hundred thirty-four female employees with mean age of 48 ± 10 years were evaluated. Type D personality and its components (NA) and (SI) were screened with DS14 questionnaire. The definition of MetS was based on measurements done by trained medical staff. We investigated the relationship between Mets and Type D personality, NA and SI using the logistic regression models adjusting for age, education years, leisure-time physical activity, smoking, alcohol use and depressive symptoms. Results The prevalence of Type D personality was 10.6% (n = 67) [95% CI: 8.3 to 13.2] and MetS 34.7% (n = 220). Type D personality or its subcomponents were not associated with MetS. Women with Type D personality had significantly worse quality of sleep and lower LTPA. They were also more often unsatisfied with their economic situation, they had more often depressive symptoms and psychiatric disorders than non-D type persons. There were no differences in risk factors for cardiovascular diseases. Conclusion Screening for Type D personality among working- age, reasonably healthy female population seems not to be practical method for finding persons with risk for cardiovascular disease.

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