PHYSICAL ACTIVITY OF PHYSIOTHERAPY STUDENTS AND THE ROLE OF DEVICE-BASED MONITORING IN THEIR FUTURE CLINICAL PRACTICE: A COHORT STUDY

1055 Background: The molecular subtypes of BC have individual patterns of behavior, prognosis and sensitivity to treatment, with subsequent implications for the choice of, or indeed role, for adjuvant (Adj) and metastatic chemotherapy (CHT). Taxanes (T) play a central role in chemotherapy for BC. However, previous studies have reported that T are relatively ineffective in patients with Luminal (HR+ve) BC compared with other subtypes. Aim of the present analysis is to describe the use of T in the clinical practice in Italy in HR+ve pts. Methods: AMBRA is a longitudinal cohort study, aiming to describe the choice of first and subsequent lines of treatment in HER2-ve MBC pts receiving at least one CHT (SABCS 2016, P5-15-07 & P5-14-09) in the years 2012-2015. For the present analysis, we focused on the use of T from the AdJ to the metastatic setting. Results: So far, 791/1500 pts have been registered into the study, 651 of them (82,3%) evaluable with HR+ MBC. Main characteristics are: Mean age 52 years; pN: UK 64 (9.8%) N+=405 (62.2%); Adj CHT=397 (61 %), mean DFI=96,99 months. T were used in 60.3% of the cases in the Adj setting, alone or in combination with other drugs, mainly anthracyclines (82.6%), with a mean DFI of 56.9 months. In the metastatic setting, across 1st to 3rd line, 460 pts (70.6%) received T, alone (49.7%) or in combination with Bevacizumab (38.2%), or other CHT drugs (11.9%). Details of the use of T in MBC are described in the table below. Conclusions: T have been used in more than 60% of cases of Luminal tumours in the Adj setting. In this population DFS is significantly shorter as compared with the non-T treated luminal population, as previously suggested by different Authors. Re-challenge with T is very frequent across different lines for MBC. Paclitaxel is the most used T, Docetaxel the less used and Nab-paclitaxel, labelled for MBC only, shows an increasing use from 1st-to 3rd line of treatment. [Table: see text]

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Physical activity and exercise

Oxford Textbook of Rheumatoid Arthritis ◽

10.1093/med/9780198831433.003.0024 ◽

2020 ◽

pp. 285-296

Author(s):

Lindsay M. Bearne ◽

Christina H. Opava

Keyword(s):

Rheumatoid Arthritis ◽

Physical Activity ◽

Clinical Practice ◽

Sedentary Behaviour ◽

Exercise Prescription ◽

Evidence Base ◽

Management Approach ◽

Physical Activity And Exercise ◽

Health Enhancing Physical Activity

This chapter provides an overview of the role of physical activity and exercise in the management of people with rheumatoid arthritis (RA). It defines the concepts of physical activity, exercise, and sedentary behaviour and considers how these are measured objectively and subjectively in research studies and clinical practice. The symptoms and disabilities targeted by appropriately prescribed interventions are discussed and the growing evidence base for the effects of exercise in people with RA is highlighted. The recommendations and guidelines for health-enhancing physical activity and exercise prescription are reviewed and the factors that influence adherence to these are acknowledged. Suggestions of how clinicians may adapt their management approach to facilitate the uptake and maintenance of health-enhancing physical activity and exercise are considered.

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Promoting competency and use of molecular technologies in future clinical practice among dermatopathology trainees: role of early adopter-educators

Journal of Cutaneous Pathology ◽

10.1111/cup.12929 ◽

2017 ◽

Vol 44 (6) ◽

pp. 599-600 ◽

Cited By ~ 1

Author(s):

Michael J. Murphy

Keyword(s):

Clinical Practice ◽

Early Adopter ◽

Future Clinical Practice

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The Role of Personalized Medicine in Current and Future Clinical Practice of Anesthesiology and Perioperative Medicine: Towards Anesthesiomics

Personalized Medicine in Anesthesia, Pain and Perioperative Medicine ◽

10.1007/978-3-030-53525-4_1 ◽

2020 ◽

pp. 1-8

Author(s):

Ali Dabbagh ◽

A. Sassan Sabouri

Keyword(s):

Clinical Practice ◽

Personalized Medicine ◽

Perioperative Medicine ◽

Future Clinical Practice

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Rest-activity daily rhythm and physical activity levels after hip and knee joint replacement: the role of actigraphy in orthopedic clinical practice

Chronobiology International ◽

10.1080/07420528.2021.1939365 ◽

2021 ◽

pp. 1-10

Author(s):

Jacopo Antonino Vitale ◽

Giuseppe Banfi ◽

Valentina Tivolesi ◽

Catia Pelosi ◽

Stefano Borghi ◽

...

Keyword(s):

Physical Activity ◽

Clinical Practice ◽

Knee Joint ◽

Joint Replacement ◽

Daily Rhythm ◽

Activity Levels ◽

Knee Joint Replacement ◽

Physical Activity Levels ◽

Rest Activity

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Local Inequalities in Health Behaviours: Longitudinal Findings from the Stockton-on-Tees Cohort Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph182111018 ◽

2021 ◽

Vol 18 (21) ◽

pp. 11018

Author(s):

Nasima Akhter ◽

Ross Stewart Fairbairn ◽

Mark Pearce ◽

Jon Warren ◽

Adetayo Kasim ◽

...

Keyword(s):

Physical Activity ◽

Cohort Study ◽

Alcohol Use ◽

Vegetable Consumption ◽

Health Behaviours ◽

Fruit And Vegetable Consumption ◽

Fruit And Vegetable ◽

Inequalities In Health ◽

Deprived Areas

This paper provides a longitudinal examination of local inequalities in health behaviours during a period of austerity, exploring the role of ‘place’ in explaining these inequalities. Data from the Stockton-on-Tees prospective cohort study of 836 individuals were analysed and followed over 18 months (37% follow-up). Generalised estimating equation models estimated the deprivation gap in health behaviours (smoking status, alcohol use, fruit and vegetable consumption and physical activity practices) between the 20% most- and least-deprived neighborhoods (LSOAs), explored any temporal changes during austerity, and examined the underpinning role of compositional and contextual determinants. All health behaviours, except for frequent physical activity, varied significantly by deprivation (p ≤ 0.001). Smoking was lower in the least-deprived areas (OR 0.21, CI 0.14 to 0.30), while alcohol use (OR 2.75, CI 1.98 to 3.82) and fruit and vegetable consumption (OR 2.55, CI 1.80 to 3.62) were higher in the least-deprived areas. The inequalities were relatively stable throughout the study period. Material factors (such as employment, education and housing tenure) were the most-important and environmental factors the least-important explanatory factors. This study suggests that material factors are the most important ‘place’ determinants of health behaviours. Health promotion activities should better reflect these drivers.

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Bcl2 inhibitor venetoclax +/− Anti-CD20: what do deep remissions mean?

memo - Magazine of European Medical Oncology ◽

10.1007/s12254-021-00778-2 ◽

2021 ◽

Author(s):

Katharina T. Prochazka ◽

Barbara Uhl

Keyword(s):

Clinical Practice ◽

Chronic Lymphocytic Leukemia ◽

Combination Therapy ◽

Residual Disease ◽

Lymphocytic Leukemia ◽

Combination Strategies ◽

Future Clinical Practice ◽

Anti Cd20 ◽

Minimal Residual

SummaryIn recent years, treatment of patients exhibiting chronic lymphocytic leukemia has changed extensively due to advances in the development of targeted therapies. The Bcl‑2 inhibitor venetoclax demonstrated outstanding results when used in mono- as well as combination therapy. Minimal residual disease (MRD) measurement has become an important endpoint in most studies and shows high prognostic potential. With upcoming combination strategies, the role of MRD measurement has also increased and is likely to become a routine marker in future clinical practice.

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