scholarly journals COVID-19: Need of the hour to revisit asymptomatic prevalence of coronavirus pandemic

2020 ◽  
Vol 1 (1) ◽  
pp. 1-4
Author(s):  
Richard Avoi ◽  
Syed Sharizman Syed Abdul Rahim ◽  
Mohammad Saffree Jeffree ◽  
Visweswara Rao Pasupuleti
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Middle East Respiratory Syndrome ◽  
Control Measures ◽  
Case Detection ◽  
Viral Loads ◽  
Early Stages ◽  
Exponential Increase ◽  
Asymptomatic Patients

  Since the Coronavirus disease 2019 (COVID-19) pandemic unfolded in China (Huang et al., 2020) back in December 2019, thus far, more than five million people were infected with the virus and 333,401 death were recorded worldwide (WHO, 2020b). The exponential increase in number shows that COVID-19 spreads faster compared to Severe Acute Respiratory Syndrome (SARS) or Middle East Respiratory Syndrome (MERS). A study (Zou et al., 2020) has shown that high viral loads of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are detected in symptomatic patients soon after the onset of symptoms, wherein the load content is higher in their nose than in their throat. Furthermore, the same study has revealed similar viral loads between symptomatic and asymptomatic patients. Therefore, these findings may suggest the possibility of COVID-19 transmission earlier before the onset of symptoms itself. In the early stages of the pandemic, the control measures carried out have focused on screening of symptomatic person; at the time, the whole world thought that the spread of SARS-Cov-2 would only occur through symptomatic person-to-person transmission. In comparison, transmission in SARS would happen after the onset of illness, whereby the viral loads in the respiratory tract peaked around ten days after the development of symptoms by patients (Peiris et al., 2003). However, case detection for SARS (i.e. screening of symptomatic persons) will be grossly inadequate for the current COVID-19 pandemic, thus requiring different strategies to detect those infected with SARS-CoV-2 before they develop the symptoms.

scholarly journals A comprehensive review about SARS-CoV-2

2020 ◽  
Vol 15 (9) ◽  
pp. 625-648
Author(s):  
SK Manirul Haque ◽  
Omar Ashwaq ◽  
Abdulla Sarief ◽  
Abdul Kalam Azad John Mohamed
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
Middle East Respiratory Syndrome ◽  
Gastrointestinal Infections ◽  
Comprehensive Review ◽  
Host Interaction ◽  
The World ◽  
Severe Fever

The coronavirus disease (COVID-19) was first identified in China, December 2019. Since then, it has spread the length and breadth of the world at an unprecedented, alarming rate. Severe acute respiratory syndrome coronavirus (SARS-CoV)-2, which causes COVID-19, has much in common with its closest homologs, SARS-CoV and Middle East respiratory syndrome-CoV. The virus–host interaction of SARS-CoV-2 uses the same receptor, ACE2, which is similar to that of SARS-CoV, which spreads through the respiratory tract. Patients with COVID-19 report symptoms including mild-to-severe fever, cough and fatigue; very few patients report gastrointestinal infections. There are no specific antiviral strategies. A few strong medications are under investigation, so we have to focus on proposals which ought to be taken to forestall this infection in a living host.

scholarly journals Evaluation of Epidemic Prevention Abilities for Severe Acute Respiratory Syndrome Coronavirus-2 and Middle East Respiratory Syndrome Coronavirus in South Korea

2021 ◽  
Vol 14 (6) ◽  
Author(s):  
Umar Saeed ◽  
Zahra Zahid Piracha ◽  
Sara Rizwan Uppal ◽  
Rizwan Uppal
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Tract ◽  
South Korea ◽  
Common Cold ◽  
General Public ◽  
Middle East Respiratory Syndrome ◽  
Government Support ◽  
Advanced Knowledge ◽  
The Government

: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) preferentially infects respiratory tract cells, but it has organotropism. Middle East respiratory syndrome coronavirus (MERS-CoV) is significantly distinct from common cold and SARS coronavirus. In past few years, the SARS-CoV-2 and MERS-CoV caused several deaths in South Korea. The aim of current study was to assess SARS-CoV-2 and MERS-CoV awareness and epidemic prevention ability in South Koreans.According to our results, out of 1500 participants, 98.8% and 64.3% were aware of SARS-CoV-2 and MERS-CoV, respectively. Moreover, 97% of the participants used masks for prevention of airborne diseases, while 65.3% of the participants reused the same mask for several days. In addition, 50% of the participants were not satisfied with the government support. Future viral epidemics can be prevented by disseminating advanced knowledge and awareness among general public.

scholarly journals Coronaviruses – a new old menace

2021 ◽  
Author(s):  
Anna Golke ◽  
Karolina Piekarska ◽  
Tomasz Dzieciątkowski
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Healthcare Systems ◽  
Middle East Respiratory Syndrome ◽  
Control Measures ◽  
The Novel ◽  
Global Impact ◽  
Infection Control Measures ◽  
The World ◽  
Novel Coronavirus

current pandemic caused by novel coronavirus SARS-CoV-2 pandemic has been described as a global health emergency. The outbreak of this virus has raised a number of questions: what exactly is SARS-CoV-2? How transmissible the novel coronavirus is? How severely affected are patients infected with SARS-CoV-2? What are the risk factors for COVID-19? What are the differences between this novel coronavirus and other coronaviruses? To answer these questions, a comparative study of three pathogenic coronaviruses that primarily invade the human respiratory system and may cause death, namely, severe acute respiratory syndrome (SARS-CoV-1), Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Middle East respiratory syndrome coronavirus (MERS-CoV). This review describes the source of origin, transmission, and pathogenicity of these viruses. Prevention of SARS-CoV-2 spreading entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The novel coronavirus spreads faster than its two predecessors – the SARS-CoV-1 and MERS-CoV – but has lower fatality rate. The global impact of this new pandemic is still uncertain, but it is a challenge to healthcare systems around the world.

scholarly journals Does the novel coronavirus 2019 like heart more than the other family members of coronaviruses?

2020 ◽  
Vol 12 (2) ◽  
pp. 156-157
Author(s):  
Mohammad Mostafa Ansari Ramandi ◽  
Mohammadreza Baay ◽  
Nasim Naderi
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Family Members ◽  
Middle East Respiratory Syndrome ◽  
The Other ◽  
The Novel ◽  
The World ◽  
Future Challenges ◽  
Novel Coronavirus ◽  
Coronavirus Infections

The disaster due to the novel coronavirus disease 2019 (COVID-19) around the world has made investigators enthusiastic about working on different aspects of COVID-19. However, although the pandemic of COVID-19 has not yet ended, it seems that COVID-19 compared to the other coronavirus infections (the Middle East Respiratory Syndrome [MERS] and Severe Acute Respiratory Syndrome [SARS]) is more likely to target the heart. Comparing the previous presentations of the coronavirus family and the recent cardiovascular manifestations of COVID-19 can also help in predicting possible future challenges and taking measures to tackle these issues.

scholarly journals Penanggulangan Virus Covid – 19 melalui Penyaluran Handsanitizer dan Sabun Cuci Tangan Alami serta Penyemprotan Disenfektan di desa Ngale, Kecamatan Pilangkenceng, Kabupaten Madiun

Batoboh ◽  
2021 ◽  
Vol 6 (1) ◽  
pp. 10
Author(s):  
Reza Kusuma Setyansah
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Middle East Respiratory Syndrome ◽  
Sars Coronavirus

Coronavirus merupakan keluarga besar virus yang menyebabkan penyakit pada manusia, biasanya menyebabkan penyakit infeksi saluran pernapasan, mulai flu biasa hingga penyakit yang serius seperti Middle East Respiratory Syndrome (MERS) dan Sindrom Pernafasan Akut Berat/ Severe Acute Respiratory Syndrome (SARS). Coronavirus jenis baru yang ditemukan pada manusia sejak kejadian luar biasa muncul di Wuhan Cina, pada Desember 2019, kemudian diberi nama Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2), dan menyebabkan penyakit Coronavirus Disease-2019 (COVID-19). Salah satu cara gampang melakukan pencegahan terhadap penyebaran virus ini adalah dengan menggunakan Handsanitizer alami. Menurut Organisasi Kesehatan Dunia (WHO), Handsanitizer alami harus mengandung setidaknya 60% alkohol untuk bekerja secara efektif. Selain handsanitizer, dengan melalukan metode penyemprotan disenfektan menggunakan cairan disenfektan. Disenfektan merupakan bahan kimia yang berguna untuk mencegah pertumbuhan bakteri ataupun jasad renik pada permukaan benda mati. Pelaksanaan pengabdian kepada masyarakat mengadakan penyaluran handsanitizer dan sabun cuci tangan alami serta penyemprotan disenfektan di desa Ngale sebagai upaya pencegahan Covid-19. Metode dalam pelaksanaan kegiatan ini yaitu wawancara dan diskusi bersama kepala desa Ngale. Kegiatan ini diharapkan mampu menumbuhkan kesadaran pada masyarakat akan pentingnya menjaga kebersihan, salah satunya menjaga kebersihan tangan serta dapat memutus mata rantai penyebaran Covid-19 di desa Ngale Kec Pilangkenceng Kab Madiun.

scholarly journals Asymptomatic COVID-19 Adult Outpatients identified as Significant Viable SARS-CoV-2 Shedders 

2021 ◽  
Author(s):  
Marie Glenet ◽  
Anne-Laure Lebreil ◽  
Laetitia Heng ◽  
Yohan N’Guyen ◽  
Ittah Meyer ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Control Measures ◽  
Upper Respiratory Tract ◽  
Rna Detection ◽  
Viral Loads ◽  
Infection Control Measures ◽  
Infected Adult ◽  
Asymptomatic Adult ◽  
Upper Respiratory ◽  
Kinetics Of

Abstract Differential kinetics of RNA loads and infectious viral levels in the upper respiratory tract between asymptomatic and symptomatic SARS-CoV-2 infected adult outpatients remain unclear limiting recommendations that may guide clinical management, infection control measures and occupational health decisions. In the present investigation, 496 (2.5%) of 17,911 French adult outpatients were positive for an upper respiratory tract SARS-CoV-2 RNA detection by a quantitative RT-PCR assay, of which 180 (36.3%) were COVID-19 asymptomatic. Of these adult asymptomatic viral shedders, 84.4% had mean to high RNA viral loads (Ct values<30) which median value was significantly higher than that observed in symptomatic subjects (P=0.029), and 50.6% were positive by cell culture assays of their upper respiratory tract specimens. Our findings indicate that COVID-19 asymptomatic adult outpatients are significant viable SARS-CoV-2 shedders in their upper respiratory tract playing a major potential role as SARS-CoV-2 transmitters in various epidemiological transmission chains, promoting COVID-19 resurgence in populations.

A Review of the Virology of SARS-CoV-2

2020 ◽  
Vol 7 (1) ◽  
pp. 69-77
Author(s):  
Aldonna Maria Susngi ◽  
◽  
Clara Ermine Sawian
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Causative Agent ◽  
Middle East Respiratory Syndrome ◽  
The Novel ◽  
Highly Pathogenic ◽  
Key Features

The novel severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), the causative agent of Coronavirus disease 2019 (COVID-19) is a β-coronavirus, which also includes the highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome Coronavirus (MERS-CoV). Emerging in December 2019 from Wuhan, China, it has spread worldwide resulting in a pandemic that has not ended till date. This review highlights some of the key features of the virology of SARS-CoV-2.

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