scholarly journals “All the world’s a stage” and each has a role to play: A collaborative cross-unit metadata project in five acts

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Jessica L. Serrao ◽  
Scott Dutkiewicz ◽  
Charlotte Grubbs ◽  
Krista Oldham ◽  
Lisa Bodenheimer ◽  
...  
Keyword(s):  
Collaborative Cross

scholarly journals Glucose tolerance female-specific QTL mapped in collaborative cross mice

2016 ◽  
Vol 28 (1-2) ◽  
pp. 20-30 ◽  
Author(s):  
Hanifa J. Abu-Toamih Atamni ◽  
Yaron Ziner ◽  
Richard Mott ◽  
Lior Wolf ◽  
Fuad A. Iraqi
Keyword(s):  
Glucose Tolerance ◽  
Collaborative Cross ◽  
Female Specific

scholarly journals Studying the pharmacogenomic effect of cranberry extract on reducing body weight using collaborative cross mice

2021 ◽  
Author(s):  
Fatima Amer-Sarsour ◽  
Rawan Abu Saleh ◽  
Itzhak Ofek ◽  
Fuad A. Iraqi
Keyword(s):  
Body Weight ◽  
Collaborative Cross ◽  
Diverse Backgrounds ◽  
Mouse Lines

The non-dialyzable material (NDM) of polyphenol-rich cranberry extract (CRE) powder (NDM-CRE) was studied for its effect of inducing body weight (BW) loss in 13 different mouse lines with well-defined genetically diverse backgrounds, named the collaborative cross (CC).

WS07.3 Phenotypic and genotypic characterisation of a novel mouse model of F508del-CFTR in genetically diverse collaborative cross

2021 ◽  
Vol 20 ◽  
pp. S13
Author(s):  
B. Sipione ◽  
N.I. Lorè ◽  
G. Rossi ◽  
F. Sanvito ◽  
M. D'Aurora ◽  
...  
Keyword(s):  
Mouse Model ◽  
Collaborative Cross

Pediatric reference intervals in China (PRINCE): design and rationale for a large, multicenter collaborative cross-sectional study

2018 ◽  
Vol 63 (24) ◽  
pp. 1626-1634 ◽  
Author(s):  
Xin Ni ◽  
Wenqi Song ◽  
Xiaoxia Peng ◽  
Ying Shen ◽  
Yaguang Peng ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Reference Intervals ◽  
Collaborative Cross ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross

2018 ◽  
Vol 202 (3) ◽  
pp. 777-786 ◽  
Author(s):  
Roxanne Collin ◽  
Lois Balmer ◽  
Grant Morahan ◽  
Sylvie Lesage
Keyword(s):  
Inbred Mouse ◽  
Collaborative Cross ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals Expression Quantitative Trait Loci for Extreme Host Response to Influenza A in Pre-Collaborative Cross Mice

2012 ◽  
Vol 2 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Daniel Bottomly ◽  
Martin T. Ferris ◽  
Lauri D. Aicher ◽  
Elizabeth Rosenzweig ◽  
Alan Whitmore ◽  
...  
Keyword(s):  
Quantitative Trait Loci ◽  
Quantitative Trait ◽  
Host Response ◽  
Influenza A ◽  
Collaborative Cross ◽  
Expression Quantitative Trait Loci ◽  
Trait Loci

scholarly journals Genetic regulation of homeostatic immune architecture in the lungs of Collaborative Cross mice

2021 ◽  
Author(s):  
Brea K Hampton ◽  
Kara L. Jensen ◽  
Alan C. Whitmore ◽  
Colton L. Linnertz ◽  
Paul Maurizio ◽  
...  
Keyword(s):  
Immune Cell ◽  
Genetic Regulation ◽  
Reference Population ◽  
Collaborative Cross ◽  
System Stability ◽  
Mouse Strains ◽  
Cell Populations ◽  
Immune Homeostasis ◽  
Heritable Variation ◽  
Organ Systems

Variation in immune homeostasis, immune system stability, in organ systems such as the lungs is likely to shape the host response to infection at these exposed tissues. We evaluated immune homeostasis in immune cell populations in the lungs of the Collaborative Cross (CC) mouse genetic reference population. We found vast heritable variation in leukocyte populations with the frequency of many of these cell types showing distinct patterns relative to classic inbred strains C57BL/6J and BALB/cJ. We identified 28 quantitative trait loci (QTL) associated with variation in baseline lung immune cell populations, including several loci that broadly regulate the abundance of immune populations from distinct developmental lineages, and found that many of these loci have predictive value for influenza disease outcomes, demonstrating that genetic determinants of homeostatic immunity in the lungs regulate susceptibility to virus-induced disease. All told, we highlight the need to assess diverse mouse strains in understanding immune homeostasis and resulting immune responses.

scholarly journals Collaborative Cross Founder Expression Analysis (CCFEA)

2021 ◽  
Author(s):  
Richard R Green ◽  
Renee C Ireton ◽  
Martin Ferris ◽  
Kathleen Muenzen ◽  
David R Crosslin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Genetic Variation ◽  
Gene Expression Data ◽  
Viral Infections ◽  
Collaborative Cross ◽  
Visualization Tool ◽  
Expression Data ◽  
Individual Gene ◽  
Rnaseq Data

To understand the role of genetic variation in SARS and Influenza infections we developed CCFEA, a shiny visualization tool using public RNAseq data from the collaborative cross (CC) founder strains (A/J, C57BL/6J, 129s1/SvImJ, NOD/ShILtJ, NZO/HILtJ, CAST/EiJ, PWK/PhJ, and WSB/EiJ). Individual gene expression data is displayed across founders, viral infections and days post infection.

Sign in / Sign up

Export Citation Format

Share Document