MAGNITUDE OF DIABETES MELLITUS IN PATIENTS OF SUDDEN SENSORINEURAL HEARING LOSS AND ITS EFFECT ON CORTICOSTEROID THERAPY

Objective: To determine the magnitude and effects of diabetes mellitus in patients of sudden sensorineural hearing loss and on the final outcome of therapy. Study Design: Cross sectional study. Place and Duration of Study: ENT unit of Medical Teaching Institution Abbottabad, from Jul 2018 to Jun 2020. Methodology: A total of 84 patients presented who had idiopathic sudden sensorineural hearing loss by using non probability consecutive sampling enrolled in the study. Basic parameters, age, diabetes mellitus and hearing loss were used for data collection. The data was analyzed by using SPSS version 23. Results: Out of total 52 (61.9%) were male and 32 (38.1%) were female, mean age was 45.62 ± 14.12 years from 14-85 years. A large number of patients presented within one week of onset of hearing loss 57 (67.86%). In our patient group 18 patients (21.4%) had diabetes mellitus and 66 patients (78.6%) did not have diabetes mellitus at presentation. Initial Hearing loss at presentation was significantly more in patients who had diabetes mellitus p=0.006 and there was statistically strong association between the final hearing improvement and diabetes mellitus p<0.001. Conclusion: Diabetes mellitus is associated with more severe hearing loss at initial presentation and poorer final outcome in patients with Idiopathic sudden sensorineural hearing loss. As glycemic control does not affect the result so corticosteroid therapy must be given to all patients of sudden sensorineural hearing loss with diabetes mellitus.

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A Prognostic Marker in Idiopathic Sudden Sensorineural Hearing Loss: Serum Calprotectin

Clinical and Experimental Otorhinolaryngology ◽

10.21053/ceo.2019.00283 ◽

2020 ◽

Vol 13 (1) ◽

pp. 36-40

Author(s):

İhsan Kuzucu ◽

Tuba Çandar ◽

Deniz Baklacı ◽

İsmail Güler ◽

Rauf Oğuzhan Kum ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Response To Treatment ◽

Control Group ◽

Study Group ◽

Cross Sectional ◽

Historical Cohort ◽

The Relationship

Objectives. Calprotectin, a protein released by neutrophils, has been used in many studies as a biomarker showing the presence of inflammation. In this study, it was aimed to investigate the relationship between serum calprotectin level and response to the treatment of idiopathic sudden sensorineural hearing loss (ISSHL).Methods. The present study is a prospective, cross-sectional historical cohort study. The study group consisted of 44 patients with ISSHL, and the control group consisted of 41 healthy volunteers without ear pathology. At the same time, patients in the study group were divided into three groups according to the response to ISSHL treatment (recovered, partially recovered, unrecovered). The relationship between the groups was statistically evaluated in terms of serum calprotectin levels.Results. The mean serum calprotectin value was 75.67±19.48 ng/mL in the study group and 50.24±29.14 ng/mL in the control group (P=0.001). Serum calprotectin value according to the severity of hearing loss in the mild, moderate and severe was 66.20±8.82, 70.35±16.77, and 91.23±19.73 ng/mL, respectively. Serum calprotectin value in the severe group was significantly higher compared to the moderate and mild groups (P=0.004, P=0.001, respectively). Serum calprotectin value according to the treatment response in the recovered, partially recovered and unrecovered groups was 63.36±11.54, 80.17±12.06, and 85.33±22.33 ng/mL, respectively. Serum calprotectin value in the recovered group was significantly lower compared to the partially recovered and unrecovered groups (P=0.002, P=0.001, respectively).Conclusion. Serum calprotectin value informs the clinician about both the severity of hearing loss and the response to treatment. Hence, serum calprotectin can be used as an important biomarker in ISSHL patients for the determination of the prognosis of disease.

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A Smartphone-Based Approach to Screening for Sudden Sensorineural Hearing Loss: Cross-Sectional Validity Study

JMIR mhealth and uhealth ◽

10.2196/23047 ◽

2020 ◽

Vol 8 (11) ◽

pp. e23047

Author(s):

Heng-Yu Haley Lin ◽

Yuan-Chia Chu ◽

Ying-Hui Lai ◽

Hsiu-Lien Cheng ◽

Feipei Lai ◽

...

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Gold Standard ◽

Pure Tone ◽

Pure Tone Audiometry ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Clinical Settings ◽

Cross Sectional ◽

Scale Difference

Background Sudden sensorineural hearing loss (SSNHL) is an otologic emergency that warrants urgent management. Pure-tone audiometry remains the gold standard for definitively diagnosing SSNHL. However, in clinical settings such as primary care practices and urgent care facilities, conventional pure-tone audiometry is often unavailable. Objective This study aimed to determine the correlation between hearing outcomes measured by conventional pure-tone audiometry and those measured by the proposed smartphone-based Ear Scale app and determine the diagnostic validity of the hearing scale differences between the two ears as obtained by the Ear Scale app for SSNHL. Methods This cross-sectional study included a cohort of 88 participants with possible SSNHL who were referred to an otolaryngology clinic or emergency department at a tertiary medical center in Taipei, Taiwan, between January 2018 and June 2019. All participants underwent hearing assessments with conventional pure-tone audiometry and the proposed smartphone-based Ear Scale app consecutively. The gold standard for diagnosing SSNHL was defined as the pure-tone average (PTA) difference between the two ears being ≥30 dB HL. The hearing results measured by the Ear Scale app were presented as 20 stratified hearing scales. The hearing scale difference between the two ears was estimated to detect SSNHL. Results The study sample comprised 88 adults with a mean age of 46 years, and 50% (44/88) were females. PTA measured by conventional pure-tone audiometry was strongly correlated with the hearing scale assessed by the Ear Scale app, with a Pearson correlation coefficient of .88 (95% CI .82-.92). The sensitivity of the 5–hearing scale difference (25 dB HL difference) between the impaired ear and the contralateral ear in diagnosing SSNHL was 95.5% (95% CI 87.5%-99.1%), with a specificity of 66.7% (95% CI 43.0%-85.4%). Conclusions Our findings suggest that the proposed smartphone-based Ear Scale app can be useful in the evaluation of SSNHL in clinical settings where conventional pure-tone audiometry is not available.

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Prevalence of sensorineural hearing loss among patients of diabetes mellitus in Southern Punjab, Pakistan

Journal of Shifa Tameer-e-Millat University ◽

10.32593/jstmu/vol1.iss1.36 ◽

2019 ◽

Vol 1 (1) ◽

pp. 32-36

Author(s):

Shahid Majeed ◽

Nazia Mumtaz ◽

Ghulam Saqulain

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Pure Tone Audiometry ◽

Sampling Technique ◽

Sensorineural Hearing ◽

P Value ◽

Male Population ◽

Cross Sectional ◽

High Prevalence

Background: Diabetes Mellitus (DM) is a common metabolic disorder with a prevalence of 11.77%. Studies report that DM can result in Sensorineural hearing loss (SNHL). A high prevalence of Hearing loss (HL) (43.6%) in diabetics was noted in an Indian study. In absence of local studies and a high expected prevalence, with no screening recommendations, this study was carried out to determine the prevalence of Sensorineural Hearing Loss (SNHL) in Diabetes Mellitus DM in Southern Punjab. Methodology: In this cross-sectional study, a sample of 310 diabetics, hailing from southern Punjab and fulfilling selection criteria were recruited. Samples were collected using probability sampling technique from September 2016 to December 2016. Following detailed history and examination, cases were subjected to pure tone audiometry (PTA) at 0.5 to 6 KHz to obtain hearing thresholds to determine the prevalence. Data was analyzed by SPSS 20. Results: Sample included N=310 diabetics with Mean age of 35.00 + 6.93 years with 58.39% males and 41.61% females. The prevalence of HL was 46.1%. Gender wise of the male population with HL, 27.97% and 28.67% had mild and moderate HL respectively with severe HL in 8.39% cases, while moderate HL was prevalent in females 20.98%, followed by mild HL in 9.97% and severe HL in 4.20%. There was significant correlation between Diabetes and SNHL with p-value < 0.05. Conclusion: There is a high prevalence of sensorineural hearing loss in Diabetes mellitus.

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Metformin decreases the risk of sudden sensorineural hearing loss in patients with diabetes mellitus: A 14-year follow-up study

Diabetes and Vascular Disease Research ◽

10.1177/1479164119826292 ◽

2019 ◽

Vol 16 (4) ◽

pp. 324-327 ◽

Cited By ~ 4

Author(s):

Hsin-Chien Chen ◽

Chi-Hsiang Chung ◽

Chieh-Hua Lu ◽

Wu-Chien Chien

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Cox Regression ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Lower Percentage ◽

Research Database ◽

Patients With Diabetes

Background: The risk of sudden sensorineural hearing loss associated with metformin use in patients with diabetes mellitus has not been fully examined. Study design: It is a retrospective matched-cohort study. Subjects and methods: We examined the medical records of patients with diabetes mellitus over 18 years old in Taiwan’s National Health Insurance Research Database for the period between 1 January 2000 and 31 December 2013, to establish matched cohorts (14,109 with and 42,327 without metformin use) at a ratio of 1:3 by sex, age and index year. Results: We used a Cox regression hazard model to identify risk factors of sudden sensorineural hearing loss during 14 years of follow-up, and the results indicate that a significantly lower percentage of diabetes mellitus patients with metformin use ( p = 0.033) developed sudden sensorineural hearing loss compared with those without metformin use (0.21%, 29/14,109 vs 0.32%, 136/42,327). After adjustment for age and other variables [adjusted hazard ratio: 0.630 (95% confidence interval: 0.422–0.941, p = 0.024)], this study also demonstrated that metformin use appeared to reduce the risk of developing sudden sensorineural hearing loss. Conclusion: This study demonstrated an association between metformin use and lower incidence of sudden sensorineural hearing loss among patients with diabetes mellitus.

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A Clinical Study of 77 Cases of Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) with Diabetes Mellitus

Practica Oto-Rhino-Laryngologica ◽

10.5631/jibirin.104.11 ◽

2011 ◽

Vol 104 (1) ◽

pp. 11-16 ◽

Cited By ~ 1

Author(s):

Takefumi Kamakura ◽

Naoki Matsushiro ◽

Masashi Furukawa ◽

Takahiro Kitamura ◽

Hiroshi Kajikawa

Keyword(s):

Diabetes Mellitus ◽

Hearing Loss ◽

Clinical Study ◽

Sensorineural Hearing Loss ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing

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Impact of COVID-19 on Presentation of Sudden Sensorineural Hearing Loss at a Single Institution

Otolaryngology ◽

10.1177/0194599820974685 ◽

2020 ◽

pp. 019459982097468

Author(s):

Divya A. Chari ◽

Ayush Parikh ◽

Elliott D. Kozin ◽

Meaghan Reed ◽

David H. Jung

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Time Frame ◽

Absolute Number ◽

Sudden Sensorineural Hearing Loss ◽

Sensorineural Hearing ◽

Academic Center ◽

Number Of Patients ◽

Increased Risk ◽

The Impact

The coronavirus disease 2019 (COVID-19) pandemic resulted in widespread unprecedented changes to the health care system. Herein, we sought to assess the impact of the viral outbreak on clinical presentations of sudden sensorineural hearing loss (SSNHL) at a single academic center. Our results demonstrate a decrease in the absolute number of patients presenting with SSNHL to our institution during the initial onset of the COVID-19 pandemic compared to an analogous time frame 1 year prior. However, the ratio of patients with SSNHL compared to total patients evaluated was largely similar during the 2 time periods. Based on data from our institution, the COVID-19 virus does not appear to confer a significantly increased risk for the development of SSNHL.

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Increased risk of sudden sensorineural hearing loss in patients with depressive disorders: population-based cohort study

The Journal of Laryngology & Otology ◽

10.1017/s0022215115002960 ◽

2015 ◽

Vol 130 (1) ◽

pp. 42-49 ◽

Cited By ~ 9

Author(s):

C-S Lin ◽

Y-S Lin ◽

C-F Liu ◽

S-F Weng ◽

C Lin ◽

...

Keyword(s):

Diabetes Mellitus ◽

Chronic Kidney Disease ◽

Hearing Loss ◽

Kidney Disease ◽

Sensorineural Hearing Loss ◽

Depressive Disorders ◽

Sudden Sensorineural Hearing Loss ◽

Hazard Ratio ◽

Sensorineural Hearing ◽

Increased Risk

AbstractObjectives:To evaluate the incidence rates and risk of sudden sensorineural hearing loss among patients with depressive disorders.Method:Data for 27 547 patients with newly diagnosed depressive disorders and 27 547 subjects without depressive disorders between 2001 and 2008 were yielded from the Taiwan National Health Insurance Research Database. Sudden sensorineural hearing loss incidence at the end of 2011 was determined. Cumulative incidence and adjusted hazard ratio were computed.Results:Sudden sensorineural hearing loss incidence was 1.45 times higher in the depressive disorders group compared to the non-depressive disorders group (p = 0.0041), with an adjusted hazard ratio of 1.460. A significant increased risk of developing sudden sensorineural hearing loss was noted in patients with diabetes mellitus, chronic kidney disease and hyperlipidaemia (p < 0.05).Conclusion:The results suggest an increased risk of developing sudden sensorineural hearing loss in patients with depressive disorders. Co-morbidities such as diabetes mellitus, chronic kidney disease and hyperlipidaemia significantly aggravated the risk. Depressive disorders might be considered a risk factor for sudden sensorineural hearing loss. It remains to be seen whether control of depressive disorders can decrease the incidence of sudden sensorineural hearing loss in patients with depressive disorders.

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