scholarly journals ĐÁNH GIÁ HIỆU QUẢ BỔ SUNG LỢI KHUẨN LACTOBACILLUS CASEI SHIROTA (LcS) TRÊN TRẺ 3 – 5 TUỔI BỊ TÁO BÓN CHỨC NĂNG TẠI 4 XÃ, TỈNH THANH HÓA

2022 ◽  
Vol 509 (2) ◽  
Author(s):  
Phạm Thị Thư ◽  
Trương Tuyết Mai ◽  
Nguyễn Ngọc Sáng ◽  
Hoàng Thị Hằng
Keyword(s):  
Lactobacillus Casei ◽  
Lactobacillus Casei Shirota

Mục tiêu: Đánh giá hiệu quả bổ sung lợi khuẩn Lactobacillus casei Shirota lên cải thiện tình trạng táo bón của trẻ 3 – 5 tuổi bị táo bón chức năng. Phương pháp: Nghiên cứu can thiệp cộng đồng, ngẫu nhiên, có đối chứng trên 216 trẻ bị táo bón chức năng tại 4 xã thuộc 2 huyện Yên Định và Nông Cống, tỉnh Thanh Hóa được chia làm 2 nhóm (nhóm can thiệp và nhóm chứng). Các triệu chứng táo bón được thu thập trước, trong và sau can thiệp. Kết quả: Sau 12 tuần can thiệp: số lần đại tiện/1 tuần ở nhóm can thiệp tăng lên 0,5 lần so với ban đầu, ở nhóm chứng không có sự cải thiện. Tỷ lệ trẻ có phân dạng 2 ở nhóm can thiệp là 5,6% và 35,2% phân dạng 3, nhóm chứng là 8,3% phân dạng 2 và 41,7% phân dạng 3. Tỷ lệ són phân của trẻ ở nhóm can thiệp là 2,8% và 3,7% ở nhóm chứng, có sự cải thiện tốt hơn về tỷ lệ nhịn đi đại tiện ở nhóm can thiệp so với nhóm chứng. Tỷ lệ trẻ có triệu chứng phân cứng, phân to giảm rõ rệt so với nhóm chứng. Kết luận: Tình trạng táo bón của trẻ 3 - 5 tuổi bị mắc táo bón chức năng được cải thiện sau can thiệp bằng lợi khuẩn Lactobacillus casei Shirota.

The probiotic Lactobacillus casei Shirota attenuates symptoms of vestibular migraine: a randomised placebo-controlled double-blind clinical trial

2020 ◽  
Vol 11 (5) ◽  
pp. 469-476
Author(s):  
X. Qi ◽  
G. Fan ◽  
H. Jia
Keyword(s):  
Depressive Symptoms ◽  
Lactobacillus Casei ◽  
Daily Basis ◽  
Vestibular Migraine ◽  
Double Blind ◽  
Beneficial Effects ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Lactobacillus ◽  
Vestibular Symptoms

Vestibular migraine (VM) has emerged as one of the major vestibular syndromes. Although probiotics have exhibited beneficial effects on migraine headache, its effect on VM is not clear. This trial aimed to investigate the treatment efficacy of the probiotic Lactobacillus casei Shirota (LcS) on symptoms of VM. 247 VM patients were enrolled, of which 204 eligible patients receiving either LcS or placebo on a daily basis completed the 4 month study. They were re-visited at 2 and 4 months after study initiation to assess treatment outcomes. The primary endpoints were vestibular symptoms, evaluated by the number of vertiginous attacks during the past week, the Vertigo Severity Score (VSS), and Dizziness Handicap Inventory (DHI) scores. The secondary endpoints were anxiety and depressive symptoms, evaluated using Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores. Efficacy of LcS over placebo was not obvious at 2 month follow-up. At 4 month follow-up, while both LcS and placebo groups of VM patients displayed alleviated symptoms, the extents of the improvements were significantly better in LcS group than those of placebo group, with regard to vestibular symptoms using DHI and VSS, as well as anxiety and depressive symptoms using BAI and BDI. Although placebo effect cannot be ignored in intervention for VM patients, the probiotic LcS still exhibits considerable efficacy against VM symptoms over a 4 month study period, supporting further clinical study of a larger and more diverse cohort.

scholarly journals Oral administration of Lactobacillus casei Shirota can ameliorate the adverse effect of an acute aflatoxin exposure in Sprague Dawley rats

2018 ◽  
Vol 88 (3-4) ◽  
pp. 199-208
Author(s):  
Elham Nikbakht ◽  
Rosita Jamaluddin ◽  
S. Mohd Redzwan ◽  
Saman Khalesi
Keyword(s):  
Adverse Effect ◽  
Lactobacillus Casei ◽  
Health Effect ◽  
Acute Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Treatment ◽  
Significant Difference ◽  
Aflatoxin B

Abstract. Aflatoxin B1 (AFB1) is a toxic compound commonly found in some crops with an adverse health effect on human and animals. Some beneficial microorganisms (or probiotics) such as lactic acid bacteria have shown the ability to reduce the bioavailability of aflatoxins and its intestinal absorption. However, the dose and duration of aflatoxins exposure and probiotic treatment can influence the ability of probiotics to remove aflatoxins. Therefore, this research aimed to investigate the efficacy of oral probiotic Lactobacillus casei Shirota strain (LcS) induction in an acute exposure to AFB1 in rats. Experimentally, Sprague Dawley rats were divided into three groups: AFB1 only (n = 9); AFB1 treated with LcS (n = 9); and control (no AFB1 exposure) (n = 6) groups. The blood AFB1 level of rats treated with LcS was slightly lower than the untreated AFB1 induced rats (11.12 ± 0.71 vs 10.93 ± 0.69 ng g–1). Also, LcS treatment slightly moderated the liver and kidney biomarkers in AFB1 induced rats. However, a trend for a significant difference was only observed in ALT of AFB1 induced rats treated with LcS compared to their counterparts (126.11 ± 36.90 vs 157.36 ± 15.46, p = 0.06). Rats’ body weight decreased in all animals force-fed with AFB1 with no significant difference between LcS treatment compared to the counterpart. In conclusion, this experiment indicated that probiotic LsC was able to slightly ameliorate the adverse effect of an acute exposure to AFB1 in rats. However, future studies with longer probiotics treatment or higher probiotics dose is required to confirm these findings.

The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial

2016 ◽  
Vol 7 (5) ◽  
pp. 631-637 ◽  
Author(s):  
M. Lei ◽  
L-M. Hua ◽  
D-W. Wang
Keyword(s):  
Clinical Trial ◽  
Elderly Patients ◽  
Distal Radius Fracture ◽  
Distal Radius ◽  
Lactobacillus Casei ◽  
Radius Fracture ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Lactobacillus Casei Shirota ◽  
Probiotic Treatment

Probiotic treatment has been shown to improve bone formation, increase bone mass density and prevent bone loss. We aimed to assess the effect of probiotic treatment on functional recovery in elderly patients with a distal radius fracture. A total of 417 elderly patients with an acute distal radius fracture were enrolled in this double-blind placebo-controlled clinical trial. They were randomised to receive skimmed milk containing either a commercial probiotic (Lactobacillus casei Shirota) or placebo daily for a period of 6 months after the fracture. Treatment outcomes were the DASH (disabilities of the arm, shoulder and hand) score, pain, complex regional pain syndrome (CRPS) score, active range of motion and grip strength, all of which were measured on a monthly basis. Throughout the duration of the study, DASH score, pain, CRPS score, wrist flexion and grip strength of patients receiving probiotics exhibited a significantly faster pace of improvement than those on placebo, with treatment outcomes of patients receiving Lactobacillus casei Shirota at month 4 at comparable levels with those of patients receiving placebo at month 6. In elderly patients with a fracture of the distal radius, administration of the probiotic could greatly accelerating the healing process.

ÁCIDOS LÁTICO E ACÉTICO OBTIDOS A PARTIR DA FERMENTAÇÃO DO LEITE COM Euterpe oleracea Mart. (AÇAÍ) POR Lactobacillus casei Shirota

2020 ◽  
pp. 36-43
Author(s):  
Adriele Torquato Rodrigues ◽  
Adriellen Oliveira Branco ◽  
Rithely de Aquino dos Santos ◽  
Victória Cristiane Moura Coelho ◽  
Edailson de Alcântara Corrêa
Keyword(s):  
Lactobacillus Casei ◽  
Euterpe Oleracea ◽  
Lactobacillus Casei Shirota ◽  
Euterpe Oleracea Mart

Effect of different encapsulating agent combinations on viability of Lactobacillus casei Shirota during storage, in simulated gastrointestinal conditions and dairy dessert

2019 ◽  
Vol 25 (7) ◽  
pp. 608-617 ◽  
Author(s):  
Osman Gul ◽  
Ilyas Atalar ◽  
Latife Betul Gul
Keyword(s):  
Lactobacillus Casei ◽  
Freeze Drying ◽  
Survival Rates ◽  
Skim Milk ◽  
Gum Arabic ◽  
Storage Conditions ◽  
Ternary Mixtures ◽  
Gastrointestinal Conditions ◽  
Lactobacillus Casei Shirota ◽  
Free Cells

In this study, the effects of various matrices consisting of maltodextrin and reconstitute skim milk and their binary and ternary mixtures with gum Arabic in the microencapsulation of Lactobacillus casei Shirota by freeze-drying technique were assessed. Microcapsules produced with reconstitute skim milk showed high viability (>99%) after freeze drying. While the free cells were completely inactivated after exposure to simulated gastrointestinal conditions, the survival rates of microencapsulated L. casei Shirota were found high for all microcapsules except for maltodextrin and maltodextrin:gum Arabic formulas. The viability of microencapsulated L. casei Shirota during storage at refrigerate and room temperatures decreased between 0.39 and 2.43 log cycles and microcapsules produced with reconstitute skim milk:gum Arabic was found more durable at the both storage conditions. Reduction in the number of free cells was higher than encapsulated L. casei Shirota numbers during production of dessert, however the viability of encapsulated L. casei Shirota was found stable for 14 days of storage and consequently desserts containing encapsulated L. casei Shirota (except maltodextrin) showed stable pH values. This study revealed that combination of reconstitute skim milk:gum Arabic was an effective wall matrix for microencapsulation of L. casei Shirota by freeze drying and also very resistant against gastrointestinal fluids and storage conditions in view of protection of L. casei Shirota.

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