scholarly journals Effects of energy drink consumption on corrected QT interval and heart rate variability in young obese Saudi male university students

2015 ◽  
Vol 35 (4) ◽  
pp. 282-287 ◽  
Author(s):  
Ahmed Alsunni ◽  
Farrukh Majeed ◽  
Talay Yar ◽  
Ahmed AlRahim ◽  
Ali Fuad Ajhawaj ◽  
...  
Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2372
Author(s):  
Nicolas W. Clark ◽  
Chad H. Herring ◽  
Erica R. Goldstein ◽  
Jeffrey R. Stout ◽  
Adam J. Wells ◽  
...  

This study examined the cardiac autonomic responses, as measured by heart rate variability (HRV), during cycling exercise and short-term rest after energy drink consumption. Seventeen participants (seven males and 10 females; age: 22.8 ± 3.5 years; BMI: 24.3 ± 3.3 kg/m2) completed this double-blind, placebo-controlled, counterbalanced crossover design study. Participants received an energy drink formula containing 140 mg of caffeine and a placebo in a randomized order before completing a 10-min steady-state warm up (WUP) and a graded exercise test to exhaustion (GXT) followed by a 15-min short-term rest (STR) period. Heartbeat intervals were recorded using a heart rate monitor. Data were divided into WUP, GXT, and STR phases, and HRV parameters were averaged within each phase. Additionally, root mean square of the standard deviation of R–R intervals (RMSSD) during GXT was analyzed to determine the HRV threshold. Separate two-way (sex (male vs. female) x drink (energy drink vs. placebo)) repeated measures ANOVA were utilized. Significant increases in high frequency (HF) and RMSSD were shown during WUP after energy drink consumption, while interactions between drink and sex were observed for HRV threshold parameters (initial RMSSD and rate of RMSSD decline). No significant differences were noted during STR. Energy drink consumption may influence cardiac autonomic responses during low-intensity exercise, and sex-based differences in response to graded exercise to exhaustion may exist.


Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Sachin A Shah ◽  
Tinh An (April) Nguyen ◽  
Andrew Occiano ◽  
Amanda Chan ◽  
Joseph C Sky ◽  
...  

Introduction: Energy drink usage has been linked to emergency room visits and deaths. Cardiovascular and neurological adverse effects are among the most frequently reported, warranting further exploration of risk factors and cardiovascular outcomes. Hypothesis: We assessed the hypothesis that energy drinks and panax ginseng may contribute to significant electrocardiographic and blood pressure changes in healthy individuals. Methods: This was a randomized, double blinded, placebo controlled, crossover study where young healthy volunteers consumed 3 different study drinks on different days. The interventions included 32 ounces of an energy drink, control drink with 800 mg of panax ginseng or a matching placebo drink, all of which were consumed over a 45 minute period. Primary endpoints of interest were QTc interval and systolic blood pressure. Secondary endpoints included QT interval, PR interval, QRS duration, heart rate, and diastolic blood pressure. All endpoints were assessed at baseline, 1, 2, 3.5, and 5.5 hours post-study drink administration. Results: Twenty seven volunteers completed the study. A significant increase in QTc interval 2 hours post energy drink consumption was evident when compared to placebo (3.37±10.7 msec and -3.19±11.8 msec respectively; p=0.030). Similarly, systolic blood pressure 2 hours post energy drink consumption increased when compared to placebo (2.00±6.37 mmHg and -2.67±5.83 mmHg respectively; p=0.014). The PR interval significantly reduced over a 2 hour period post energy drink use in a clinically non-meaningful manner. Heart rate at 2 hours was not significantly higher in the energy drink group. The QT interval, QRS interval and diastolic blood pressure were not impacted at any time across groups. Conclusions: In conclusion, certain energy drinks consumed at a high volume can significantly increase the QTc interval and systolic blood pressure by over 6 msec and 4 mmHg respectively. Panax ginseng does not have a significant impact on ECG or blood pressure parameters. Future studies are warranted to delineate the electrophysiological and hemodynamic risks of certain energy drinks consumed at different concentrations and durations.


2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
I Martin-Demiguel ◽  
I Nunez-Gil ◽  
A Perez-Castellanos ◽  
O Vedia ◽  
A Uribarri ◽  
...  

Abstract Background Our aim was to describe the prevalence and prognostic significance of electrocardiographic features in patients with Takotsubo syndrome (TTS). Methods Our data come from the Spanish Multicenter REgistry of TAKOtsubo syndrome (RETAKO). All patients with complete electrocardiogram were included. Results 246 patients were studied, mean age was 71.3±11.5 and 215 (87.4%) were women. ST-segment elevation was seen in 143 patients (59.1%) and was present in ≥2 wall leads in 97 (39.8%). Exclusive elevation in inferior leads was infrequent (5 - 2.0%). After 48 hours, 198 patients (88.0%) developed negative T-waves in a median of 8 leads with a mean amplitude of 0.7±0.5 mV. Mean corrected QT interval was 520±72 ms and it was independently associated with the primary endpoint of all-cause death and nonfatal cardiovascular events (p=0.002) and all-cause death (p=0.008). A higher heart rate at admission was also an independent predictor of the primary endpoint (p=0.001) and of developing acute pulmonary edema (p=0.04). ST-segment elevation with reciprocal depression was an independent predictor of all-cause death (p=0.04). Absence of ST-segment deviation was a protective factor (p=0.005) for the primary endpoint. Arrhythmias were independently associated with cardiogenic shock (p<0.001). Conclusion Prolonged corrected QT interval, arrhythmia, heart rate at admission and broader repolarization alterations are associated with a poor outcome in TTS. Typical ECG at admission and after 48h. Funding Acknowledgement Type of funding source: None


Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Elsayed Z Soliman ◽  
George Howard ◽  
George Howard ◽  
Mary Cushman ◽  
Brett Kissela ◽  
...  

Background: Prolongation of heart rate-corrected QT interval (QTc) is a well established predictor of cardiovascular morbidity and mortality. Little is known, however, about the relationship between this simple electrocardiographic (ECG) marker and risk of stroke. Methods: A total of 27,411 participants aged > 45 years without prior stroke from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study were included in this analysis. QTc was calculated using Framingham formula (QTcFram). Stroke cases were identified and adjudicated during an up to 7 years of follow-up (median 2.7 years). Cox proportional hazards analysis was used to estimate the hazard ratios for incident stroke associated with prolonged QTcFram interval (vs. normal) and per 1 standard deviation (SD) increase, separately, in a series of incremental models. Results: The risk of incident stroke in the study participants with baseline prolonged QTcFram was almost 3 times the risk in those with normal QTcFram [HR (95% CI): 2.88 (2.12, 3.92), p<0.0001]. After adjustment for age, race, sex, antihypertensive medication use, systolic blood pressure, current smoking, diabetes, left ventricular hypertrophy, atrial fibrillation, prior cardiovascular disease, QRS duration, warfarin use, and QT-prolonging drugs (full model), the risk of stroke remained significantly high [HR (95% CI): 1.67 (1.16, 2.41), p=0.0060)], and was consistent across several subgroups of REGARDS participants. When the risk of stroke was estimated per 1 SD increase in QTcFram, a 24% increased risk was observed [HR (95% CI): 1.24 (1.16, 1.33), p<0.0001)]. This risk remained significant in the fully adjusted model [HR (95% CI): 1.12 (1.03, 1.21), p=0.0055]. Similar results were obtained when other QTc correction formulas including Hodge’s, Bazett’s and Fridericia’s were used. Conclusions: QTc prolongation is associated with a significantly increased risk of incident stroke independently from known stroke risk factors. In light of our results, examining the risk of stroke associated with QT-prolonging drugs may be warranted.


2013 ◽  
Vol 62 (4) ◽  
pp. 283-291 ◽  
Author(s):  
Ryoma Michishita ◽  
Chika Fukae ◽  
Rikako Mihara ◽  
Masahiro Ikenaga ◽  
Kazuhiro Morimura ◽  
...  

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