Clinical Aspects of Bacterial Meningitis in Cerebrospinal Fluid Culture Positive Patients in a Tertiary Care University Hospital

2011 ◽  
Vol 14 (1) ◽  
pp. 1 ◽  
Author(s):  
Min Jin Kim ◽  
Song Mi Moon ◽  
Tae Sung Park ◽  
Jin-Tae Suh ◽  
Hee Joo Lee
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Tertiary Care ◽  
University Hospital ◽  
Clinical Aspects ◽  
Cerebrospinal Fluid Culture ◽  
Culture Positive ◽  
Fluid Culture

A Simple Protocol to Prevent External Ventricular Drain Infections

Neurosurgery ◽  
2013 ◽  
Vol 72 (6) ◽  
pp. 993-999 ◽  
Author(s):  
Alexander C. Flint ◽  
Vivek A. Rao ◽  
Natalie C. Renda ◽  
Bonnie S. Faigeles ◽  
Todd E. Lasman ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Infection Control ◽  
External Ventricular Drain ◽  
Tertiary Care ◽  
Evidence Based ◽  
Control Protocol ◽  
Culture Positivity ◽  
Simple Protocol ◽  
Cerebrospinal Fluid Culture ◽  
Fluid Culture

Abstract BACKGROUND: External ventricular drains (EVDs) are associated with high rates of infection, and EVD infections cause substantial morbidity and mortality. OBJECTIVE: To determine whether the introduction of an evidence-based EVD infection control protocol could reduce the rate of EVD infections. METHODS: This was a retrospective analysis of an EVD infection control protocol introduced in a tertiary care neurointensive care unit. We compared rates of cerebrospinal fluid culture positivity and ventriculitis for the 3 years before and 3 years after the introduction of an evidence-based EVD infection control protocol. A total of 262 EVD placements were analyzed, with a total of 2499 catheter-days. RESULTS: The rate of cerebrospinal fluid culture positivity decreased from 9.8% (14 of 143; 11.43 per 1000 catheter-days) at baseline to 0.8% (1 of 119; 0.79 per 1000 catheter-days) in the EVD infection control protocol period (P = .001). The rate of ventriculitis decreased from 6.3% (9 of 143; 7.35 per 1000 catheter-days) to 0.8% (1 of 119; 0.79 per 1000 catheter-days; P = .02). CONCLUSION: The introduction of a simple, evidence-based infection control protocol was associated with a dramatic reduction in the risk of EVD infection.

Meningoencephalitis due to Gemella haemolysans

2014 ◽  
Vol 63 (1) ◽  
pp. 138-139 ◽  
Author(s):  
Benjamin T. Galen ◽  
David B. Banach ◽  
Melissa R. Gitman ◽  
Terence K. Trow
Keyword(s):  
Cerebrospinal Fluid ◽  
16S Rrna ◽  
Bacterial Meningitis ◽  
16S Rrna Gene ◽  
Potential Role ◽  
Invasive Disease ◽  
Rrna Gene ◽  
Cerebrospinal Fluid Culture ◽  
Culture Negative ◽  
Fluid Culture

Gemella haemolysans is an uncommon but described cause of invasive disease in humans. We report a case of meningitis due to G. haemolysans that did not grow in cerebrospinal fluid culture, demonstrating a potential role for direct 16S rRNA gene PCR and sequencing in culture-negative cerebrospinal fluid when bacterial meningitis is suspected.

Ceftriaxone vs Cefotaxime for Treatment of Haemophilus influenzae Meningitis

PEDIATRICS ◽  
1990 ◽  
Vol 85 (4) ◽  
pp. 622-623
Author(s):  
LINDA MADSON ◽  
CHARLES GROSE
Keyword(s):  
Cerebrospinal Fluid ◽  
Case Report ◽  
Haemophilus Influenzae ◽  
Treatment Failure ◽  
Type B ◽  
Treatment Regimens ◽  
Cerebrospinal Fluid Culture ◽  
Fluid Culture

To the Editor.— In a case report, Arditi et al1 d cefuroxime treatment failure in a child with Haemophilus influenzae meningitis. They substituted ceftriaxone for cefuroxime, but they did not mention that ceftniaxone treatment regimens have been associated with two problems. The first is the basis of a case report which described delayed sterilization of H influenzae type B meningitis under management with ceftriaxone.2 The infant had a positive cerebrospinal fluid culture after 3 days (six doses) of ceftriaxone.

scholarly journals An Uncommon Case of Pediatric Neurobrucellosis Associated with Intracranial Hypertension

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Xenophon Sinopidis ◽  
Joseph Kaleyias ◽  
Konstantina Mitropoulou ◽  
Maria Triga ◽  
Sanjeev V. Kothare ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Intracranial Hypertension ◽  
Brucella Melitensis ◽  
Brain Mri ◽  
Accurate Diagnosis ◽  
Normal Brain ◽  
Pcr Assay ◽  
Cerebrospinal Fluid Culture ◽  
Uncommon Case ◽  
Fluid Culture

We present the case of a 4-year-old boy who was admitted to hospital with intracranial hypertension, headache, diplopia, papilledema, and a normal brain MRI.Brucella melitensisin the cerebrospinal fluid was confirmed with PCR assay. We believe that neurobrucellosis should be included in the differential diagnosis when headaches persist following brucellosis. In addition, we suggest that when cerebrospinal fluid culture is negative, PCR may prove to be an optimal alternative tool for an immediate and accurate diagnosis.

scholarly journals Cerebrospinal fluid culture and analysis in paediatric patients with shunt infection

2021 ◽  
Vol 50 (3) ◽  
pp. 436
Author(s):  
Alivia Retra Kusumowardani ◽  
Prastiya Indra Gunawan ◽  
Deby Kusumaningrum ◽  
Wihasto Suryaningtya
Keyword(s):  
Cerebrospinal Fluid ◽  
Shunt Infection ◽  
Paediatric Patients ◽  
Cerebrospinal Fluid Culture ◽  
Fluid Culture

scholarly journals Microbiological pathogen analysis in native versus periprosthetic joint infections: a retrospective study

2022 ◽  
Vol 17 (1) ◽  
Author(s):  
Sebastian Linke ◽  
Alexander Thürmer ◽  
Kevin Bienger ◽  
Christian Kleber ◽  
Petri Bellova ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Joint Infection ◽  
Tertiary Care ◽  
University Hospital ◽  
Nominal Data ◽  
Coagulase Negative Staphylococci ◽  
Joint Infections ◽  
Distributed Parameters ◽  
Chi Squared ◽  
Culture Positive

Abstract Background The presence or absence of an implant has a major impact on the type of joint infection therapy. Thus, the aim of this study was the examination of potential differences in the spectrum of pathogens in patients with periprosthetic joint infections (PJI) as compared to patients with native joint infections (NJI). Methods In this retrospective study, we evaluated culture-positive synovial fluid samples of 192 consecutive patients obtained from January 2018 to January 2020 in a tertiary care university hospital. For metrically distributed parameters, Mann–Whitney U was used for comparison between groups. In case of nominal data, crosstabs and Chi-squared tests were implemented. Results Overall, 132 patients suffered from periprosthetic joint infections and 60 patients had infections of native joints. The most commonly isolated bacteria were coagulase-negative Staphylococci (CNS, 28%), followed by Staphylococcus aureus (S. aureus, 26.7%), and other bacteria, such as Streptococci (26.3%). We observed a significant dependence between the types of bacteria and the presence of a joint replacement (p < 0.05). Accordingly, detections of CNS occurred 2.5-fold more frequently in prosthetic as compared to native joint infections (33.9% vs. 13.4% p < 0.05). In contrast, S. aureus was observed 3.2-fold more often in NJIs as compared to PJIs (52.2% vs. 16.4%, p < 0.05). Conclusion The pathogen spectra of periprosthetic and native joint infections differ considerably. However, CNS and S. aureus are the predominant microorganisms in both, PJIs and NJIs, which may guide antimicrobial therapy until microbiologic specification of the causative pathogen.

scholarly journals Enzyme Immunoassay Detecting Teichoic and Lipoteichoic Acids versus Cerebrospinal Fluid Culture and Latex Agglutination for Diagnosis of Streptococcus pneumoniae Meningitis

1998 ◽  
Vol 36 (8) ◽  
pp. 2346-2348 ◽  
Author(s):  
Kristin Stuertz ◽  
Imke Merx ◽  
Helmut Eiffert ◽  
Erich Schmutzhard ◽  
Michael Mäder ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Enzyme Immunoassay ◽  
Antimicrobial Therapy ◽  
Latex Agglutination ◽  
Viral Pathogens ◽  
Cerebrospinal Fluid Culture ◽  
Culture Negative ◽  
Lipoteichoic Acids ◽  
Fluid Culture

A newly developed enzyme immunoassay (EIA) was used to detect the presence of pneumococcal teichoic and lipoteichoic acids in cerebrospinal fluid (CSF) from patients with Streptococcus pneumoniae meningitis who were being treated with antibiotics. All initial CSF samples, which on culture grew S. pneumoniae, were positive in the EIA. A total of 14 subsequent culture-negative samples gave clear signals in the EIA up to day 15 after the onset of antibiotic treatment. For 11 CSF specimens, culture, microscopy, and latex agglutination were negative while the EIA detected pneumococcal antigens. The EIA did not react either with CSF of patients with meningitis caused by bacteria other than S. pneumoniae or by viral pathogens. In conclusion, this EIA can be a valuable tool for the diagnosis of S. pneumoniaemeningitis from CSF samples in cases in which prior antimicrobial therapy minimizes the usefulness of culture or other antigen detection tests.

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