Microbiological pathogen analysis in native versus periprosthetic joint infections: a retrospective study

Background The presence or absence of an implant has a major impact on the type of joint infection therapy. Thus, the aim of this study was the examination of potential differences in the spectrum of pathogens in patients with periprosthetic joint infections (PJI) as compared to patients with native joint infections (NJI). Methods In this retrospective study, we evaluated culture-positive synovial fluid samples of 192 consecutive patients obtained from January 2018 to January 2020 in a tertiary care university hospital. For metrically distributed parameters, Mann–Whitney U was used for comparison between groups. In case of nominal data, crosstabs and Chi-squared tests were implemented. Results Overall, 132 patients suffered from periprosthetic joint infections and 60 patients had infections of native joints. The most commonly isolated bacteria were coagulase-negative Staphylococci (CNS, 28%), followed by Staphylococcus aureus (S. aureus, 26.7%), and other bacteria, such as Streptococci (26.3%). We observed a significant dependence between the types of bacteria and the presence of a joint replacement (p < 0.05). Accordingly, detections of CNS occurred 2.5-fold more frequently in prosthetic as compared to native joint infections (33.9% vs. 13.4% p < 0.05). In contrast, S. aureus was observed 3.2-fold more often in NJIs as compared to PJIs (52.2% vs. 16.4%, p < 0.05). Conclusion The pathogen spectra of periprosthetic and native joint infections differ considerably. However, CNS and S. aureus are the predominant microorganisms in both, PJIs and NJIs, which may guide antimicrobial therapy until microbiologic specification of the causative pathogen.

Evaluation of the Impact of Abnormal Grains on the Performance of Sc0.15Al0.85N-based BAW Resonators and Filters

ScxAl1-xN is a promising piezoelectric material for radio frequency communication applications with excellent electro-acoustic properties. However, the growth of abnormally oriented grains is widely observed in the Sc doped AlN films deposited by sputtering. In this work, for the first time, the impact of the abnormal grains in the Sc0.15Al0.85N films on the performance of bulk acoustic wave resonators and filters is systematically evaluated by both simulations and measurements. The correlation between the device performance and the abnormal grain parameters, including the density, dimension, crystal orientation, growth height, and the total volume of the abnormal grains, is evaluated and quantified. Simulation results show that the total volume of all abnormal grains in the whole device is the most critical factor among the parameters. Abnormal grains with randomly distributed parameters and around 6% total volume of the film can degrade the effective coupling coefficient of the resonator from 13.6% to 11%, leading to a 10.6% decrement of the filter bandwidth. Wafer-level device characterizations and measurements are performed, and the results are consistent with the simulations. This study provides a practical method for predicting the performance of the resonators and filters with abnormal grains, and a guideline for film quality evaluation.

Cybernetic estimation of reserve utilization efficiency

This study relates to the field of verification of cybernetic estimates of the use of reserves as criteria for the effectiveness of transformative class systems with a continuous supply of a technological product. The task set here attracted even more attention after the advent of improved approaches that make it possible to automatically change the control trajectories of technological systems in real time. In such cases, the assessment of the current status of the process and the efficiency of stock management has become an integral part of the operation of the management subsystems. Therefore, the development and verification of cybernetic assessment of effectiveness for such control systems is a relevant issue. The first stage of the reported research involved the development of a cybernetic model of operation with distributed parameters. Four formal features have been proposed. Finding integral functions of these features has made it possible to obtain an idea of some quantitative characteristics of the process while finding the second time-dependent integral characteristic has made it possible to represent the physical and cybernetic parameters of the process. At the second stage, formulas for calculating the main assessment indicators were proposed; their verification was carried out under three different control trajectories, which showed the adequacy of the devised approach. The final step was to develop three variations of the efficiency formula, which is calculated at set points in time throughout the entire production cycle. Thus, cybernetic assessment of the effectiveness of the use of reserves makes it possible to formalize and fully automate the processes of optimization and adaptation of the functional systems of an enterprise

Study on the biparametrical transudations circuits with distributed parameters

This paper highlights the methods of resenting mode in the transudation with distributed parameters. The transient parameters of the power supply were analyzed. It was discovered that resonance is provided in a small range of movement of the moving component of the sensor in known turbofan engines, indicating that the known techniques of sustaining the resonance mode are flawed. Further study should focus on developing novel methods for preserving resonance mode over the entire range of change of the converted value, general principles of turbojet engine construction, and a complete examination of their resonant circuits, according to the findings.

Deterministic and stochastic models of infection spread and testing in an isolated contingent

The mathematical SIR model generalisation for description of the infectious process dynamics development by adding a testing model is considered. The proposed procedure requires the expansion of states’ space dimension due to variables that cannot be measured directly, but allow you to more adequately describe the processes that occur in real situations. Further generalisation of the SIR model is considered by taking into account randomness in state estimates, forecasting, which is achieved by applying the stochastic differential equations methods associated with the application of the Fokker – Planck – Kolmogorov equations for posterior probabilities. As COVID-19 practice has shown, the widespread use of modern means of identification, diagnosis and monitoring does not guarantee the receipt of adequate information about the individual’s condition in the population. When modelling real epidemic processes in the initial stages, it is advisable to use heuristic modelling methods, and then refine the model using mathematical modelling methods using stochastic, uncertain-fuzzy methods that allow you to take into account the fact that flow, decision-making and control occurs in systems with incomplete information. To develop more realistic models, spatial kinetics must be taken into account, which, in turn, requires the use of systems models with distributed parameters (for example, models of continua mechanics). Obviously, realistic models of epidemics and their control should include models of economic, sociodynamics. The problems of forecasting epidemics and their development will be no less difficult than the problems of climate change forecasting, weather forecast and earthquake prediction.

Approximate Calculation of the Natural Oscillation Frequency of the Vibrating Table in Inter-Resonance Operation Mode

The first natural frequency of oscillations of the vibrations of a discrete-continuous interresonant vibrating table plate was found using the functions of the Krylov-Duncan. The continuous member, presented in a plate hinged at four points, is used as a reactive mass with distributed parameters to create an inter-resonance vibrating table with an electromagnetic drive. For this purpose, the plate was considered as a rod on hinged supports. The justification of this approach is confirmed by simulation in the Ansys software. The results were confirmed using the approximate Rayleigh-Ritz method. The geometric shape of the plate is reduced to a section of a hyperboloidal surface. The results of simulation of the first natural frequency were verified experimentally.

Application of computational gas dynamics methods for calculating losses during rotation of solids in low vacuum conditions

On the basis of a mathematical model with distributed parameters, a method for determining aerodynamic losses during high-frequency rotation of a flywheel accumulator is developed. The power of losses due to friction of the rotor against the air is determined as a function of the pressure in the chamber. A comparative analysis of the aerodynamic losses under low vacuum conditions at various pressures of the working medium and the data obtained on the basis of empirical dependences and presented in the scientific literature on this topic is carried out. The maximum difference between the loss power values is no more than 25%. The data deviation decreases as the pressure in the chamber decreases.

Controlled Fractional Order Processes with Distributed Parameters

This work is devoted to the study of the problem of pursuit in systems controlled with distributed parameters of fractional order. Derivatives with respect to spatial variables are ordinary, integer, and even of arbitrary order. Designed and studied sampling schemes. A numerical method is constructed for finding strategies in suitable classes and for constructing the corresponding control laws. Theorems are proved for the possibility of completing the pursuit by the finite difference method, and they can be used to solve finite-difference optimal control problems or numerical solutions of differential games of fractional order. Problems of the type under study are encountered in modeling the processes of economic growth and in problems of stabilizing dynamic systems.

Three-Dimensional Fuzzy Control of Ultrasonic Cleaning

Consideration of ultrasonic cleaning as a process with distributed parameters enables reduction of power consumption. This approach is based on establishment of control over the process depending on fixed values of ultrasonic responses in set points. The initial intensity of radiators is determined using a three-dimensional (3D) interval type-2 fuzzy logic controller essentially created for processes with distributed parameters, as well as complex expert evaluation of the input data. The interval membership functions for the input and output data consider the space heterogeneity of ultrasonic cleaning. A rule base is formed, which is 2D and not dependent upon the number of input and output parameters. A model illustrating ultrasonic cleaning with a 3D interval type-2 fuzzy logic controller is designed. Comparative analysis of the output parameters of the proposed model and the traditional method indicates an increase in the energy efficiency by 41.17% due to application of only those ultrasonic radiators that are located next to the contamination.