Diagnosis and treatment of inguinal hernia of the bladder: a systematic review of the past 10 years

The rise of e-commerce has brought considerable changes to the relationship between firms and consumers, especially within international business. Hence, understanding the use of such means for entering foreign markets has become critical for companies. However, the research on this issue is new and so it is important to evaluate what has been studied in the past. In this study, we conduct a systematic review of e-commerce and internationalisation studies to explicate how firms use e-commerce to enter new markets and to export. The studies are classified by theories and methods used in the literature. Moreover, we draw upon the internationalisation decision process (antecedents-modalities-consequences) to propose an integrative framework for understanding the role of e-commerce in internationalisation

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Periodontopathogens: a new view. Systematic review. Part 2

Стоматология детского возраста и профилактика ◽

10.33925/1683-3031-2020-20-2-160-167 ◽

2020 ◽

Vol 20 (2) ◽

pp. 160-167

Author(s):

E. S. Slazhneva ◽

E. A. Tikhomirova ◽

V. G. Atrushkevich

Keyword(s):

Systematic Review ◽

Periodontal Disease ◽

Pathogenic Bacteria ◽

Periodontal Diseases ◽

Oral Microbiome ◽

Controlled Trials ◽

New Paradigm ◽

Microbial Composition ◽

Randomized Controlled ◽

The Past

Relevance. The modern view of periodontitis as a dysbiotic disease that occurs as a result of changes in the microbial composition of the subgingival region is considered in a systematic review.Purpose. To study a new paradigm of development of generalized periodontitis.Materials and methods. Randomized controlled trials (RCTS) were selected for the study, including cluster RCTS, controlled (non-randomized) microbiological and clinical studies of the oral microbiome in adult patients with generalized periodontitis over the past 10 years.Results. The transition from a symbiotic microflora to a dysbiotic pathogenic community triggers the host's inflammatory response, which contributes to the development of periodontal diseases. Modern ideas about periodontal pathogenic bacteria dictate new requirements for the treatment of periodontal diseases. The second part of the review examines the microbial profiles of periodontal disease in various nosological forms, the mechanisms of the immune response and approaches to the treatment of periodontal disease from the perspective of biofilm infection.Conclusions. As follows from modern literature periodontitis is to a certain extent caused by the transition from a harmonious symbiotic bacterial community to a dysbiotic one. Recent scientific studies have shown that not single microorganism is not able to cause disease but the microbial community as a whole leads to the development of pathology.

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Anti-Inflammatory Properties of Plant Derived Natural Products – A Systematic Review

Current Medicinal Chemistry ◽

10.2174/0929867325666190523123357 ◽

2019 ◽

Vol 26 (24) ◽

pp. 4506-4536 ◽

Cited By ~ 4

Author(s):

Iris E. Allijn ◽

René P. Brinkhuis ◽

Gert Storm ◽

Raymond M. Schiffelers

Keyword(s):

Systematic Review ◽

Natural Products ◽

Positive Control ◽

Therapeutic Effects ◽

Reference Compound ◽

Individual Molecular Species ◽

The Past ◽

Anti Inflammatory ◽

The Individual ◽

Natural Medicines

Traditionally, natural medicines have been administered as plant extracts, which are composed of a mixture of molecules. The individual molecular species in this mixture may or may not contribute to the overall medicinal effects and some may even oppose the beneficial activity of others. To better control therapeutic effects, studies that characterized specific molecules and describe their individual activity that have been performed over the past decades. These studies appear to underline that natural products are particularly effective as antioxidants and anti-inflammatory agents. In this systematic review we aimed to identify potent anti-inflammatory natural products and relate their efficacy to their chemical structure and physicochemical properties. To identify these compounds, we performed a comprehensive literature search to find those studies, in which a dose-response description and a positive control reference compound was used to benchmark the observed activity. Of the analyzed papers, 7% of initially selected studies met these requirements and were subjected to further analysis. This analysis revealed that most selected natural products indeed appeared to possess anti-inflammatory activities, in particular anti-oxidative properties. In addition, 14% of the natural products outperformed the remaining natural products in all tested assays and are attractive candidates as new anti-inflammatory agents.

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