The Relationship Between Insulin Resistance and Peripheral Muscle Strength, Exercise Capacity in Patients with COPD

Abstract Introduction: Chronic kidney disease (CKD) is a global public health problem with systemic repercussions, compromising muscle function and making patients less exercise tolerant. Objective: To verify the contribution of peripheral muscle strength in the exercise capacity of patients in hemodialysis (HD), as well as to compare peripheral muscle strength and exercise capacity between renal patients and healthy individuals. Method: 50 patients with chronic kidney disease (CKD) who performed HD and 13 healthy subjects underwent anthropometric evaluation, evaluation of peripheral muscle strength, pulmonary function test and exercise capacity assessment. Results: Simple linear regression indicated that the peripheral muscle strength contributed 41.4% to the distance walked in the six-minute walk test (R2 0.414; p < 0.001), showing that for every 1 Kgf reduced in the right lower limb the patient it stops walking 0.5m while for every 1 Kgf reduced in the lower left limb the patient stops walking 0.8m. In addition, it was observed that patients with CKD had a reduction in right lower limb muscle strength (129.44 ± 48.05 vs. 169.36 ± 44.30, p = 0.002), left (136.12 ± 52, 08 vs 168.40 ± 43.35, p = 0.01) and exercise capacity (421.20 ± 98.07 vs. 611.28 ± 80.91, p < 0.001) when compared to healthy pairs. Conclusion: Peripheral muscle weakness is an important limiting factor for exercise in CKD and patients on HD experience a decline in peripheral muscle strength and exercise capacity when compared to healthy individuals.

Download Full-text

RESPIRATORY MUSCLE STRENGTH, EXERCISE CAPACITY, AND DYSPNEA DURING PULMONARY REHABILITATION AFTER LOBECTOMY IN PATIENTS WITH NON-SMALL CELL LUNG CANCER

Respirology ◽

10.1111/resp.13420_214 ◽

2018 ◽

Vol 23 ◽

pp. 166-166

Keyword(s):

Lung Cancer ◽

Muscle Strength ◽

Small Cell Lung Cancer ◽

Exercise Capacity ◽

Pulmonary Rehabilitation ◽

Respiratory Muscle ◽

Small Cell ◽

Strength Exercise ◽

Respiratory Muscle Strength ◽

Small Cell Lung

Download Full-text

Effects of inspiratory muscle training on respiratory muscle strength, exercise capacity, physical fitness and daily living activities in patients with asthma

10.1183/13993003.congress-2015.pa967 ◽

2015 ◽

Cited By ~ 1

Author(s):

Neslihan Duruturk ◽

Manolya Acar ◽

Mustafa Ilgaz Dogrul

Keyword(s):

Muscle Strength ◽

Physical Fitness ◽

Exercise Capacity ◽

Daily Living ◽

Respiratory Muscle ◽

Inspiratory Muscle ◽

Strength Exercise ◽

Respiratory Muscle Strength ◽

Muscle Training ◽

Daily Living Activities

Download Full-text

Impact of grip strength and balance function on the exercise capacity in pulmonary hypertension

European Journal of Preventive Cardiology ◽

10.1093/eurjpc/zwab061.125 ◽

2021 ◽

Vol 28 (Supplement_1) ◽

Author(s):

M Okamura ◽

M Konishi ◽

Y Saigusa ◽

S Ando ◽

M Nakayama ◽

...

Keyword(s):

Pulmonary Hypertension ◽

Muscle Strength ◽

Grip Strength ◽

Exercise Capacity ◽

Walking Distance ◽

Balance Function ◽

Standing Time ◽

Physical Functions ◽

The Relationship ◽

Group 1

Abstract Funding Acknowledgements Type of funding sources: None. 【Background】 Patients with pulmonary hypertension (PH) suffer from poor exercise capacity due to impaired oxygenation or reduced cardiac output. However, the relationship between exercise capacity and physical functions remains unclear. 【Purpose】 The purpose of this study is to investigate the relationship between exercise capacity and physical functions in pulmonary hypertension. 【Methods】 From February 2018 to June 2020, 94 patients (61.3 ± 14.7 years old, 69.1% females) with group 1/3/4/5 PH underwent cardiac catheterization, 6-minute walking distance (6MWD), and physical function measurements simultaneously. The physical functions was measured using muscle strength (grip strength, knee extension muscle strength), balance function (one leg standing time), and short physical performance battery (SPPB). Exercise capacity was measured by 6MWD. 【Results】 The study cohort consists of 22/8/60/4 (23.4%/8.5%/63.8%/4.3%) patients with group 1/3/4/5 PH, respectively. The average age of each group was 50.7/64.7/63.1/66.0 years old, respectively. A total of 194 measurements of physical functions were evaluated from 94 patients and employed in multivariate logistic regression analysis using adaptive-LASSO methods with the 6MWD (476.2 ± 107.5m) as a dependent variable. WHO functional class (class II: standardized β=-0.35, 95% confidence interval (CI) [-0.54 - -0.16], p < 0.001), class III: β=-0.60, 95%CI [-0.90 - -0.30], p < 0.001), mixed venous oxygen saturation (SvO2: β=0.11, 95%CI [0.03 - 0.19], p = 0.008), pulmonary vascular resistance (PVR: β=-0.16, 95%CI [-0.25 - -0.07], p < 0.001), grip strength (β=0.20, 95%CI [0.09 - 0.31], p < 0.001), one leg standing time (β=0.10, 95%CI [0.00 - 0.20], p = 0.049) , and 4m gait speed test (β=-0.28, 95%CI [-0.36 - -0.19], p < 0.001) were associated with 6MWD. 【Conclusions】 Grip strength and balance function, as well as SvO2 and PVR, were associated with the exercise capacity in pulmonary hypertension.

Download Full-text

Peripheral Muscle Microcirculation Dynamics During Strength Exercise in Heart Failure Patients: A Cross-Sectional Study

10.21203/rs.3.rs-677335/v1 ◽

2021 ◽

Author(s):

Amanda Vale-Lira ◽

Natália Turri-Silva ◽

Kenneth Verboven ◽

João Luiz Quagliotti Durigan ◽

Gaspar R. Chiappa ◽

...

Keyword(s):

Heart Failure ◽

Muscle Strength ◽

Cross Sectional Study ◽

Exercise Intolerance ◽

Strength Exercise ◽

Sectional Study ◽

Cross Sectional ◽

Heart Failure Patients ◽

Peripheral Muscle ◽

Class C

Abstract This cross-sectional study aimed to compare the muscle microcirculation dynamics via near-infrared spectroscopy (NIRS) response during an isokinetic muscle strength test and ultrasound-derived parameters in heart failure patients with preserved or reduced ejection fraction phenotypes (HFpEF and HFrEF, respectively) and different functional severities (Weber Class A, B, and C). Twenty-eight aged-matched patients with HFpEF (n = 16) and HFrEF (n = 12) were assessed. Within HFpEF, Weber Class C patients presented a worse capability to reach a greater oxygen extraction during exercise than Classes A and B. Among those with Weber C severity, while HFrEF patients reached lower oxyhemoglobin (O2Hb, µM) (-10.9 ± 3.8 vs. -23.7 ± 5.7, p = 0.029) during exercise, HFpEF kept a lower O2Hb during the recovery period (-3.0 ± 3.4 vs. 5.9 ± 2.8, p = 0.007). Among the ultrasound-derived variables, HFpEF, Weber Class C, also presented a higher echo intensity than HFrEF patients (29.7 ± 8.4 vs. 15.1 ± 6.8, p = 0.017). Our study reveals more pronounced impairments in local microcirculatory dynamics in HFpEF vs. HFrEF patients during muscle strength exercise, combined with muscle-skeletal abnormalities detected via ultrasound imaging, which may help to explain the commonly observed exercise intolerance in HFpEF patients.

Download Full-text