Experimenting with Sociology: A View from the Outlook Tower

2011 ◽  
Vol 16 (3) ◽  
pp. 154-157 ◽  
Author(s):  
Charlotte Bates
Keyword(s):  
Technological Innovation ◽  
Site Specific ◽  
History Of ◽  
A Site ◽  
British Sociology

This paper describes a site-specific sociological experiment and looks back at the history of British sociology from the Outlook Tower in Edinburgh. It considers the role of technological innovation in observation, and explores how attention is guided through two exercises in sensory attunement; augmented listening and telescopic looking. Reconfiguring the observer through different technologies and devices, the paper questions what it means to listen and to look, and highlights how our sociological outlook is deeply ethical and historical.

scholarly journals V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites.

1993 ◽  
Vol 13 (3) ◽  
pp. 1363-1370 ◽  
Author(s):  
K M Sheehan ◽  
M R Lieber
Keyword(s):  
Genome Stability ◽  
Lymphoid Cells ◽  
Chromosomal Translocations ◽  
Synaptic Inhibition ◽  
Site Specific ◽  
Coding Sequences ◽  
Specific Process ◽  
A Site ◽  
Joint Resolution

V(D)J recombination in lymphoid cells is a site-specific process in which the activity of the recombinase enzyme is targeted to signal sequences flanking the coding elements of antigen receptor genes. The order of the steps in this reaction and their mechanistic interdependence are important to the understanding of how the reaction fails and thereby contributes to genomic instability in lymphoid cells. The products of the normal reaction are recombinant joints linking the coding sequences of the receptor genes and, reciprocally, the signal ends. Extrachromosomal substrate molecules were modified to inhibit the physical synapsis of the recombination signals. In this way, it has been possible to assess how inhibiting the formation of one joint affects the resolution efficiency of the other. Our results indicate that signal joint and coding joint formation are resolved independently in that they can be uncoupled from each other. We also find that signal synapsis is critical for the generation of recombinant products, which greatly restricts the degree of potential single-site cutting that might otherwise occur in the genome. Finally, inversion substrates manifest synaptic inhibition at much longer distances than do deletion substrates, suggesting that a parallel rather than an antiparallel alignment of the signals is required during synapsis. These observations are important for understanding the interaction of V(D)J signals with the recombinase. Moreover, the role of signal synapsis in regulating recombinase activity has significant implications for genome stability regarding the frequency of recombinase-mediated chromosomal translocations.

Role of histidine 64 in the catalytic mechanism of human carbonic anhydrase II studied with a site-specific mutant

Biochemistry ◽  
1989 ◽  
Vol 28 (19) ◽  
pp. 7913-7918 ◽  
Author(s):  
Chingkuang Tu ◽  
David N. Silverman ◽  
Cecilia Forsman ◽  
Bengt Harald Jonsson ◽  
Sven Lindskog
Keyword(s):  
Carbonic Anhydrase ◽  
Catalytic Mechanism ◽  
Carbonic Anhydrase Ii ◽  
Site Specific ◽  
Human Carbonic Anhydrase ◽  
A Site

scholarly journals Developing a Chronology Integrating Archaeological and Environmental Data from Different Contexts: The Late Holocene Sequence of Ounjougou (Mali)

Radiocarbon ◽  
2009 ◽  
Vol 51 (2) ◽  
pp. 457-470 ◽  
Author(s):  
Sylvain Ozainne ◽  
Laurent Lespez ◽  
Yann Le Drezen ◽  
Barbara Eichhorn ◽  
Katharina Neumann ◽  
...  
Keyword(s):  
Late Holocene ◽  
Environmental Data ◽  
Human Environment ◽  
Current State ◽  
History Of ◽  
Anthropogenic Fires ◽  
Holocene Stratigraphy ◽  
State Of Research ◽  
A Site

At Ounjougou, a site complex situated in the Yamé River valley on the Bandiagara Plateau (Dogon country, Mali), multidisciplinary research has revealed a rich archaeological and paleoenvironmental sequence used to reconstruct the history of human-environment interactions, especially during the Late Holocene (3500–300 cal BC). Geomorphological, archaeological, and archaeobotanical data coming from different sites and contexts were combined in order to elaborate a chronocultural and environmental model for this period. Bayesian analysis of 54 14C dates included within the general Late Holocene stratigraphy of Ounjougou provides better accuracy for limits of the main chronological units, as well as for some particularly important events, like the onset of agriculture in the region. The scenario that can be proposed in the current state of research shows an increasing role of anthropogenic fires from the 3rd millennium cal BC onwards, and the appearance of food production during the 2nd millennium cal BC, coupled with a distinctive cultural break. The Late Holocene sequence ends around 300 cal BC with an important sedimentary hiatus that lasts until the end of the 4th century cal AD.

scholarly journals The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning

2018 ◽  
Author(s):  
Veronica L. Flores ◽  
Tamar Parmet ◽  
Narendra Mukherjee ◽  
Sacha Nelson ◽  
Donald B. Katz ◽  
...  
Keyword(s):  
Early Gene ◽  
Neural Activation ◽  
Site Specific ◽  
Gustatory Cortex ◽  
Multiple Factors ◽  
Incidental Exposure ◽  
Fos Expression ◽  
A Site ◽  
Full Day

ABSTRACTThe strength of learned associations between pairs of stimuli is affected by multiple factors, the most extensively studied of which is prior experience with the stimuli themselves. In contrast, little data is available regarding how experience with incidental stimuli (independent of any conditioning situation) impacts later learning. This lack of research is striking given the importance of incidental experience to survival. We have recently begun to fill this void using conditioned taste aversion (CTA), wherein an animal learns to avoid a taste that has been associated with malaise. We previously demonstrated that incidental exposure to salty and sour tastes (taste pre-exposure—TPE) enhances aversions learned later to sucrose. Here, we investigate the neurobiology underlying this phenomenon. First, we use immediate early gene (c-Fos) expression to identify gustatory cortex (GC) as a site at which TPE specifically increases the neural activation caused by taste-malaise pairing (i.e., TPE did not change c-Fos induced by either stimulus in isolation). Next, we use site-specific infection with the optical silencer Archaerhodopsin-T to show that GC inactivation during TPE inhibits the expected enhancements of both learning and CTA-related c-Fos expression, a full day later. Thus, we conclude that GC is almost certainly a vital part of the circuit that integrates incidental experience into later associative learning.

Celts, Romans, Britons

2020 ◽  
Keyword(s):  
National Identity ◽  
Identity Formation ◽  
Late Antiquity ◽  
Interdisciplinary Approach ◽  
British Identity ◽  
Classical Reception ◽  
History Of ◽  
A Site ◽  
Classical Cross

This interdisciplinary volume of essays examines the real and imagined role of Classical and Celtic influence in the history of British identity formation, from late antiquity to the present day. In so doing, it makes the case for increased collaboration between the fields of Classical reception and Celtic studies, and opens up new avenues of investigation into the categories “Celtic” and “Classical”, which are presented as fundamentally interlinked and frequently interdependent. In a series of chronologically arranged chapters, beginning with the post-Roman Britons and ending with the 2016 Brexit referendum, it draws attention to the constructed and historically contingent nature of the Classical and the Celtic, and explores how notions related to both categories have been continuously combined and contrasted with one another in relation to British identities. Britishness is revealed as a site of significant Celtic-Classical cross-pollination, and a context in which received ideas about Celts, Romans, and Britons can be fruitfully reconsidered, subverted, and reformulated. Responding to important scholarly questions that are best addressed by this interdisciplinary approach, and extending the existing literature on Classical reception and national identity by treating the Celtic as an equally relevant tradition, the volume creates a new and exciting dialogue between subjects that all too often are treated in isolation, and sets the foundations for future cross-disciplinary conversations.

Walking the forest imaginary: A breath between us

2021 ◽  
Vol 17 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Julie Poitras Santos
Keyword(s):  
Time Scales ◽  
Qr Codes ◽  
Site Specific ◽  
A Site ◽  
Ancient Exchange ◽  
Present Role

Walking the forest imaginary: a breath between us is a site-specific audio artwork that invites the audience to walk into the forest imaginary populated by things magical and unseen. Crafted uniquely in response to Alingsås Nolhaga Park, and using cues in the landscape as guides to research and poetic inscription, the artwork consists of an approximately one-hour walk with audio listening points throughout the park. Audio is accessed digitally through QR codes posted on pre-existing pathways and listened to with individual headphones. Wandering pathways through the woods, participants listen to a hybrid essay that explores the alternate spaces and time scales of the miniature worlds of moss. Focusing on the ancient and present role of bryophytes in creating oxygen and storing carbon, and helping to keep our ecosystem in balance, the work considers this ancient exchange as a form of dialogue.

Wake in Guangzhou

Transfers ◽  
2017 ◽  
Vol 7 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Maria Thereza Alves
Keyword(s):  
City Center ◽  
Site Specific ◽  
The Earth ◽  
Landscape Transformation ◽  
Deep Layers ◽  
History Of ◽  
A Site

Wake in Guangzhou: The History of the Earth is a site-specific installation exhibited in in the Guangdong Museum of Art in Guangzhou, China, that problematizes issues of migration, trade, and landscape transformation. Wake in Guangzhou investigates the origin of the seeds found on the site of Huagui Lu, in the Liwan district in Guangzhou’s city center, where today a hundred wholesale markets exist. A mound of earth was removed from Huagui lu, a street in the Liwan District, the former merchant quarter’s of Guangdong. The earth sample was put in the courtyard of the Guangzhou Museum so dormant seeds previously buried in deep layers could germinate when exposed. The botanist Heli Jutila writes, “Although seeds seem to be dead, they are in fact alive and can remain vital in soil for decades, and even hundreds of years in a state of dormancy.”

The role of cell boundary orientation on mechanical behavior: a site-specific micro-pillar characterization study

2021 ◽  
pp. 102154
Author(s):  
Xin Wang ◽  
Baolong Zheng ◽  
Kehang Yu ◽  
Sen Jiang ◽  
Enrique J. Lavernia ◽  
...  
Keyword(s):  
Mechanical Behavior ◽  
Cell Boundary ◽  
Site Specific ◽  
Boundary Orientation ◽  
Characterization Study ◽  
A Site
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