scholarly journals Assessment of subclinical hypertention-mediated heart damage in young adults with connective tissue dysplasia

2021 ◽  
Author(s):  
М.И. Шупина ◽  
Ю.В. Терещенко ◽  
В.В. Потапов ◽  
Г.И. Нечаева
Keyword(s):  
Young Adults ◽  
Connective Tissue ◽  
Left Ventricle ◽  
Interventricular Septum ◽  
Left Ventricle Mass ◽  
Hypertensive Patients ◽  
Heart Damage ◽  
Upper Limit ◽  
Echocardiographic Examination ◽  
Connective Tissue Dysplasia

С целью оценки особенностей опосредованного артериальной гипертензией (АГ) поражения сердца у лиц молодого возраста с АГ и дисплазией соединительной ткани (ДСТ) проведено эхокардиографическое обследование 574 человек в возрасте от 18 до 29 лет. При анализе полученных данных обнаружено, что у молодых людей с АГ и ДСТ толщина межжелудочковой перегородки, стенок левого желудочка, массы и индексированных показателей массы левого желудочка не достигают общепризнанной единой верхней границы нормы. Это ведет к систематической гиподиагностике поражения сердца как органа-мишени, некорректной оценке стадии АГ и неадекватной тактике ведения этих пациентов. In order to assess the features of hypertension-mediated heart damage in young adults with hypertension and connective tissue dysplasia (СTD), an echocardiographic examination of 574 people aged 18 to 29 years was performed. It was revealed that young adults with hypertension and CTD have lower levels of the interventricular septum and left ventricle walls thickness, left ventricle mass and its indexes than in hypertensive patients without CTD, and these parameters do not reach the generally recognized upper limit of the norm. This leads to systematic underdiagnosis of hypertension-mediated heart damage, incorrect assessment of the stage of hypertension, and inadequate management for these patients.

scholarly journals Cardiac Changes in Overweight and Obese Patients

2016 ◽  
Vol 54 (3) ◽  
pp. 161-172 ◽  
Author(s):  
Teodora Gabriela Alexescu ◽  
Angela Cozma ◽  
Adela Sitar-Tăut ◽  
V. Negrean ◽  
M.I. Handru ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Left Ventricle ◽  
Diastolic Dysfunction ◽  
Body Mass ◽  
Body Surface ◽  
Interventricular Septum ◽  
Normal Weight ◽  
The Body ◽  
Obese Patients ◽  
Left Ventricle Mass

Abstract Background. Obesity and overweight are two pathologies that are more and more frequent in the XXIst century diagnosis and are causing high morbidity and mortality rates in the general population, especially through cardiovascular complications.Aims. Identification and early diagnosis of cardiac changes in overweight and obese patients. Material and method. We carried out a sectional, analytical and observational study on 111 subjects: 27 normal weight subjects and 84 overweight and obese patients, which were submitted to a clinical exam, biochemical exams and 2D ultrasound.Results. The presence of diastolic dysfunction is twice more frequent in overweight patients in comparison to normal weight ones (30% vs 15%) and 5 times more frequent in obese patients than normal weight ones (75% vs 15%). The size increase of the interventricular septum is correlated with the body mass index, there being statistically significant differences between normal weight vs overweight vs obese patients, as well as between overweight and obese ones. Within the whole group and within the groups, both the left ventricle mass (g) as well as the left ventricle mass to body surface ratio (g/m²) are statistically significantly higher in patients with present diastolic dysfunction (E/A < 1). This indicates a relation between the presence of diastolic dysfunction, increased left ventricle mass and body mass index (p < 0.05).Conclusions. Overweight and obese patients, unlike normal weight ones, present early cardiac changes, such as: a decrease of left ventricle ejection fraction, diastolic dysfunction, thickening of the interventricular septum, increase of the left ventricle mass both per se as well as in ratio to body surface.

scholarly journals P1829CARDIOVASCULAR DISORDERS IN CHILDREN WITH CHRONIC KIDNEY DISEASE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Aigul Nugmanova ◽  
Nuriya Meriken ◽  
Saule Dikanbayeva ◽  
Zeinep Zhumagulova ◽  
Zhuldyz Baidauletova ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Clinical Laboratory ◽  
Interventricular Septum ◽  
Posterior Wall ◽  
Left Ventricular ◽  
Myocardial Mass ◽  
Cardiac Events ◽  
Initial Stage ◽  
Echocardiographic Examination ◽  
Left Ventricular Myocardial Mass

Abstract Background and Aims Pathology of the cardiovascular system is the leading cause of death in patients with CKD, while determining the causes of the formation of cardiac events is often difficult. Method We conducted an analysis of echocardiography data performed by 50 children with CKD. On the echoCG, the final systolic and diastolic sizes of the left ventricle (FSS and FDS), the final systolic and diastolic volumes of the left ventricle (FSV and FDV) were determined; measured the thickness of the interventricular septum (IVS) and the posterior wall of the left ventricle (PWLV). Left ventricular myocardial mass (LVMM) was determined by the formula proposed by R. Devereux and N. Reichek: LVMM = 1.04x (/ IVS+PWLV+FDS/3-FDS3) - 13.6where, IVS - thickness of IVS in diastole,PWLV-thickness of PWLV in diastole, FDS-final diastolic size of the left ventricle. Results We conducted an analysis of echocardiography data performed by 50 children with CKD. On the echoCG, the final systolic and diastolic sizes of the left ventricle (FSS and FDS), the final systolic and diastolic volumes of the left ventricle (FSV and FDV) were determined; measured the thickness of the interventricular septum (IVS) and the posterior wall of the left ventricle (PWLV). Left ventricular myocardial mass (LVMM) was determined by the formula proposed by R. Devereux and N. Reichek: LVMM = 1.04x (/ IVS+PWLV+FDS/3-FDS3) - 13.6where, IVS - thickness of IVS in diastole,PWLV-thickness of PWLV in diastole, FDS-final diastolic size of the left ventricle. Conclusion The mechanisms of damage to the heart and blood vessels in patients with CKD begin to function already in the initial stage of renal failure and increase as it progresses. The need to know the data of clinical, laboratory and instrumental examination methods at the terminal stage of CKD is dictated, first of all, by the possibility of exposure to them. An important stimulus for conducting an echocardiographic examination is the early detection and correction of cardiovascular disorders, in connection with the prospect of increasing the survival of patients after kidney transplantation.

scholarly journals Clinical diagnostics of undifferentiated connective tissue dysplasia

2016 ◽  
Vol 24 (4) ◽  
pp. 164-172 ◽  
Author(s):  
M Ben Salha ◽  
N B Repina
Keyword(s):  
Young Adults ◽  
Connective Tissue ◽  
Chronic Diseases ◽  
Clinical Significance ◽  
Detection Rate ◽  
Genetic Defect ◽  
Clinical Diagnostics ◽  
Heterogeneous Group ◽  
Diagnosis And Treatment ◽  
Connective Tissue Dysplasia

The article describes the prevalence, diagnosis and treatment undifferentiated connective tissue dysplasia (NDCTD). NDCTD: it is genetically heterogeneous group, which serves as the basis for the formation of various chronic diseases may cause dysplastic changes in the connective tissue of various organs and systems, but they are based on no clear genetic defect with a certain type of inheritance, are diagnosed when the patient has a set of features does not fit into any of differentiated diseases. Experience shows that such pathology is widespread. The incidence of NDCTD, according to some sources, among young adults up to 80%. If rigid criteria (six or more external fen) NDCTD detection rate is reduced to 20-25%, and the clinical significance of the identified anomalies increases.

scholarly journals Effect of fosinopril on progression of the asymptomatic carotid atherosclerosis and left ventricular hypertrophy in hypertensive patients

2006 ◽  
Vol 134 (3-4) ◽  
pp. 106-113 ◽  
Author(s):  
Ivan Tasic ◽  
Dragan Mijalkovic ◽  
Dragan Djordjevic ◽  
Branko Lovic ◽  
Dimitrije Jankovic ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Ace Inhibitor ◽  
Intima Media Thickness ◽  
Left Ventricle Mass ◽  
Hypertensive Patients ◽  
Left Ventricle Hypertrophy ◽  
Group A ◽  
The Common ◽  
Group B ◽  
Ventricle Hypertrophy

INTRODUCTION The cardiovascular changes (vascular structure changes, hypertrophy of the left ventricle) contribute to both the increased cardiovascular morbidity and the mortality of essential hypertension. Therefore, modern treatment strategies should not only target blood pressure (BP) reduction but also normalize cardiovascular structure and function. OBJECTIVE Aim of the study was to determine the effect of the ACE inhibitor Fosinopril on the Intima-media thickness of the common carotid artery and on the left ventricle mass after 9-month treatment of hypertensive patients. METHOD The study included 40 patients with the arterial hypertension and the left ventricle hypertrophy verified by echocardiography. The patients were randomized on A) ACE-inhibitor - Fosinopril and 6) without ACE inhibitor - atenolol, and they were followed up 9 months. The groups were not different by age, sex, and metabolic status. Color Duplex ultrasonography of the carotid arteries was performed by Acuson Sequia C236 with high-frequency linear probe of 8 MHz. The Intima-media thickness of the common carotids on the left and the right was measured in diastole at 1.5. cm from the highest point of bifurcation under maximal magnification. Using the same device, the left ventricle mass and other parameters of the left ventricle were determined in M-mode and by means of 2D image. RESULTS After 9 months, BP In both groups Was reduced In similar range (group A: systolic BP from 158 to 137 mmHg, and diastolic BP from 94 to 85 mmHg, and group B; systolic BP from 164 to 137 mmHg, and diastolic BP from 87 to 84 mmHg). The thickness of the intimomedial complex in patients using Fosinopril was decreased by 0.0278 ? 0.03 mm, while in the group of patients that did not use the ACE-inhibitor, it was increased by 0.078 ?0.13 mm. The left ventricle mass in patients using Fosinopril was decreased by 5 grams (312 ? 72 g vs. 307 ? 77 g), while in group B patients, it was increased by 15 grams (323 ? 79 g vs. 328 ? 58 g. Diastolic function expressed through relation E/A was improved minimally in the group A, while it worsened by 0.1 in the group B. After 9 months, serious cardiovascular events were recorded (one infarction of myocardium and one hospitalization due to the unstable angina pectoris) in two patients of the group A, while four patients of the group B. had serious CV events (1 cerebrovascular stroke and 3 hospitalizations due to unstable angina pectoris). CONCLUSION The results of our study showed that the application of Fosinopril in patients with the arterial hypertension and the left ventricle hypertrophy could efficiently block further progression of the intima-medial thickness of the common carotid artery, reduce the left ventricle mass, and improve. diastolic function of the left ventricle.

CARDIAC REGIONAL FUNCTION OF YOUNG SPORTSMEN WITH FALSE TENDONS IN THE LEFT VENTRICLE

2015 ◽  
Vol 15 (02) ◽  
pp. 1540010 ◽  
Author(s):  
K. MEKHDIEVA ◽  
V. TIMOKHINA ◽  
S. YU. SOKOLOV ◽  
F. A. BLYAKHMAN
Keyword(s):  
Left Ventricle ◽  
3D Model ◽  
Systolic Function ◽  
Interventricular Septum ◽  
Short Axis ◽  
Regional Function ◽  
Young Athletes ◽  
Heart Cycle ◽  
Regional Ejection Fraction ◽  
Connective Tissue Dysplasia

The aim of the study is to evaluate cardiac regional function of young athletes with false tendons (FT) in the left ventricle (LV). The focus was on mechanical asynchrony in LV wall. Forty-seven young athletes (mean age 20.2 ± 2.9 years) with connective tissue dysplasia syndrome underwent transthoracic echocardiography. To formalize FT topology, the 3D-model of LV geometry was reconstructed based on three short-axis sections and one long-axis section of LV. On average, 4.0 ± 1.0 FT with different localization and orientation in LV were determined. Cardiac function was estimated in 12 regions at LV long-axis section in the course of complete heart cycle. RMS variations of the regional systolic function duration (dT) and the variation coefficient of regional ejection fraction (Cv r-EF) for 12 regions served as measures of the mechanical asynchrony. Wide variety of asynchrony parameters was obtained. The value of dT varied from 24.2 to 84.1 ms (40.4 ± 27.8 ms); Cv r-EF — from 8.0% to 42.0% (20.83 ± 8.35%). Significant correlations between total number of FT per heart and dT (r = 0.396; P < 0.01) and between median transverse FT (connect interventricular septum and lateral LV wall) and Cv r-EF (r = 0.301; P < 0.05) were found. Detailed analyses of FT morphology with respect of LV regional function peculiarities showed that higher extent of asynchrony associates with the transverse and oblique FT mainly located at basal and/or medial portions of LV chamber.

scholarly journals Compelling therapy of LVH: straight (and not-so-straight) inferences from evidence

2019 ◽  
Vol 25 (1) ◽  
Author(s):  
Ravi Tejraj Mehta ◽  
Anil Pareek ◽  
Shruti Dharmadhikari
Keyword(s):  
Left Ventricle ◽  
Review Of Literature ◽  
Left Ventricle Mass ◽  
Hypertensive Patients ◽  
Korean Society ◽  
Hypertension Guidelines ◽  
Left Ventricle Hypertrophy ◽  
Paradoxical Finding ◽  
Beneficial Action ◽  
Ventricle Hypertrophy

AbstractWe have read with interest the Korean Society of Hypertension guidelines for the management of hypertension and congratulate the Society for an extensive review of literature while drafting the guidelines. The guidelines indicate preferring ACE-I and CCB over diuretics in patients with left ventricle hypertrophy. However, in landmark head-to-head comparison trials, the thiazide-like diuretic chlorthalidone has been shown to be superior to ACE-I and CCB in decreasing left ventricle mass and preventing heart failure in hypertensive patients. Also, we put forth the paradoxical finding that mere regression of LVH may not always translate into reduction in risk of HF; and that the pleiotropic effects of chlorthalidone may be the explanation behind its beneficial action in HF.

Metabolic therapy and its role in the complex treatment of connective tissue dysplasia in Pediatric Nephrology

2016 ◽  
Vol 73 (1) ◽  
pp. 131-136 ◽  
Author(s):  
S.L. Nyan'kovskyi ◽  
◽  
O.O. Dobrik ◽  
M.Yu. Іs'kiv ◽  
◽  
...  
Keyword(s):  
Connective Tissue ◽  
Pediatric Nephrology ◽  
Complex Treatment ◽  
Metabolic Therapy ◽  
Connective Tissue Dysplasia
Sign in / Sign up

Export Citation Format

Share Document