M1 and M8 homeopathic complex have been use as adjuvant therapy for cancer patients.

Author(s):  
Raffaello Popa Di Bernardi ◽  
Carolina Camargo De Oliveira ◽  
Dorly de Freitas Buchi

Background: Cancers are complex diseases rated among the top 10 causes of death worldwide. The Laboratory of Inflammatory and Neoplastic Cells at Federal University of Parana have been studied the effects of several highly diluted solutions in cell-based models over de the past decade. Among those solutions, M1 and M8 are highly diluted tinctures complex which act as biological response modifiers. Both complexes turned to be promising compounds to use as adjuvant therapy for selected cancer patient. As a private physician, over the last ten years, many cancer patients have been reached our clinic looking forward homeopathic medicines that could be used as complimentary therapy to their standard cancer treatment. The types of cancer, as well the stages of the disease, among those patients were quite heterogeneous. We have followed not only those who have detected the cancer in an early stage, but also people who have been discouraged, once they’ve been told as a patient without therapeutic possibility. Aims: To exchange observations and outcomes in the disease’s natural history of cancer patients who have been treated with M1 and M8 as adjuvant therapy to the standards treatments. Methodology: The prescription of the treatment was based on primary situ of the disease as well the standard treatment which was been followed by the patient at the time of the attendance. It varied from one complex alone, three times a day, to the use of both complexes, six times a day. Results and discussion: Many cancer patients who were undergoing chemotherapy reported the side effects of that treatment had become mild in comparison to the time they were not using the complexes. Other interesting outcome was the fact that, for some patients who were skipping chemotherapy sessions due to neutropenia, the standard treatment could be followed as planed after start to use M8. Patients who did surgical procedures reported a better healing process, with less scars, when they compared their own evolution to other patients who attend same oncologic facility. Conclusion: Although M1 and M8 act as biological response modifiers and their use as adjuvant therapy for cancer patients is a promising approach, the fact that cancer is complex disease, which requires a multiple approach, brings an ethical consideration on use or not use complimentary therapies as adjuvant treatments. Our private practice showed up in the last decade that cancer patients can benefit from the use of those highly diluted complexes, adjuvant to standard treatments as chemotherapy and surgery.

1998 ◽  
Vol 16 (4) ◽  
pp. 1380-1387 ◽  
Author(s):  
C Lindley ◽  
S Vasa ◽  
W T Sawyer ◽  
E P Winer

PURPOSE To evaluate the quality of life (QOL) of breast cancer patients who survived 2 to 5 years following initiation of adjuvant cytotoxic and/or hormonal therapy and to characterize relationships between QOL and patient physical symptoms, sexual function, and preferences regarding adjuvant treatment. PATIENTS AND METHODS Eighty-six patients who had completed systemic adjuvant therapy for early-stage breast cancer between 1988 and 1991 were surveyed by written questionnaire and telephone interview. Sociodemographic information was obtained for each patient, and patients were asked to complete the Functional Living Index-Cancer (FLIC), the Symptom Distress Scale (SDS), the Medical Outcomes Study (MOS) Short Form 36 (SF-36), a series of questions regarding sexual function, and a survey about preferences for adjuvant therapy in relation to possible benefit. RESULTS The mean FLIC score among all patients was 138.3 (+/- 12.2), which suggests a high level of QOL. The reported frequency of moderate to severe symptoms was generally low (ie, < 15%), with fatigue (31.4%), insomnia (23.3%), and local numbness at the site of surgery (22.1%) occurring with greatest frequency. Patients reported a wide range of sexual difficulties. Preference assessment showed that more than 65% of patients were willing to undergo 6 months of chemotherapy for a 5% increase in likelihood of cancer cure. CONCLUSION Self-rated QOL in breast cancer patients 2 to 5 years following adjuvant therapy was generally favorable. Less than one third of patients reported moderate to severe symptoms. Selected aspects of sexual function appeared to be compromised. The majority of patients indicated a willingness to accept 6 months of chemotherapy for small to modest potential benefit.


2017 ◽  
Vol 27 (4) ◽  
pp. 730-737 ◽  
Author(s):  
Erin A. Bishop ◽  
James J. Java ◽  
Kathleen N. Moore ◽  
Joan L. Walker

ObjectivesElderly endometrial cancer patients have worse disease-specific survival than their younger counterparts, but the cause for this discrepancy is unknown. The goal of this analysis is to compare outcomes by age in a fully staged elderly endometrial cancer population.Methods/MaterialsThis is an analysis of patients on Gynecologic Oncology Group Study (GOG) LAP2, which included clinically early stage endometrial cancer patients randomized to laparotomy versus laparoscopy for surgical staging. Patients were divided into risk groups based on criteria defined by GOG protocol 99. Differences in outcomes and adjuvant therapy were assessed within these risk groups.ResultsLAP2 included 715 patients 70 years or older. With increasing age, worse tumor characteristics were seen. Older patients received similar rates of adjuvant therapy when stratified by stage. Patients 70 years or older had significantly worse progression-free survival and overall survival, and on multivariate analysis, older age and high-risk uterine factors were predictors of progression-free survival and overall survival, whereas stage and lymph node metastases were not. When patients were divided into GOG protocol 99 risk categories, most of those who met the high-intermediate risk criteria did so based on age above 70 years and grade 2 to 3 disease. These patients had low risk of recurrence (3.3%) compared with those who met the criteria by age above 70 years and all 3 uterine factors (20.9%).ConclusionsIn early stage endometrial cancer, patients 70 years or older who undergo similar surgical management and adjuvant therapy, age and tumor characteristics independently predict recurrence. Most patients older than 70 years meet the high-intermediate risk criteria for recurrence based on age and 1 other uterine risk factor, and our results suggest that these patients are at low risk for recurrence.


2021 ◽  
Vol 30 (2) ◽  
pp. 129-37
Author(s):  
Soehartati Gondhowiardjo ◽  
Sugandi Hartanto ◽  
Sigit Wirawan ◽  
Vito Filbert Jayalie ◽  
Ida Ayu Putri Astiti ◽  
...  

BACKGROUND Cancer is a complex disease requiring a multidisciplinary approach in establishing prompt diagnosis and treatment. Treatment in a timely manner is crucial for the outcomes. Hence, this study aimed to provide information on treatment delay including patient and provider delays and its associated factors. METHODS Cancer patients were recruited conveniently in the outpatient clinic of Department of Radiation Oncology, Cipto Mangunkusumo Hospital, Indonesia between May and August 2015. All patients were asked to fill a questionnaire and interviewed in this cross-sectional study. Treatment delay was explored and categorized into patient delay and provider delay. Patient delay could be happened before (patient-delay-1) or after (patient-delay-2) the patient was diagnosed with cancer. Provider delay could be due to physician, system-diagnosis, and system-treatment delays. RESULTS Among 294 patients, 86% patient had treatment delay. Patient delay was observed in 153 patients, and 43% of them had a history of alternative treatment. An older age (p = 0.047), lower educational level (p = 0.047), and history of alternative treatment (p<0.001) were associated with patient delay. Meanwhile, 214 patients had provider delay, and 9%, 36%, and 80% of them experienced physician, system-diagnosis, and system-treatment delays, respectively. All types of provider delay were associated with patient delay (p<0.001). CONCLUSIONS Most of the patient had treatment delay caused by either patient or provider.


Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 5058-5058
Author(s):  
Madhu N Belur Shivananda ◽  
Theodore Bell ◽  
Edith Sielsch ◽  
Diane Gaspari ◽  
Amir Tabatabai

Abstract Abstract 5058 Background Malignancy has been known to be associated with a hypercoagulable state since Trosseau first described it a hundred years ago. This is a multifactorial process that includes (1) direct activation of the coagulation system by production of procoagulants, (2) indirect activation through release of cytokines, (3) the complex interaction between tumor cells, blood cells, and endothelium, and (4) problems associated with malignancy including surgery, immobility, and intravenous catheters. One of the most recent postulated mechanisms is acquired resistance to APC. APC is a serum protein that normally inhibits the coagulation cascade. APC-R increases the risk of venous thrombosis and can be either hereditary or acquired. The hereditary form is caused by the well-known mutation, factor V Leiden. More recently, acquired forms of APC-R have been described, and the list of possible etiologies is growing. In cancer patients, APC-R has been detected in the absence of factor V Leiden mutation, suggesting a possible cause-effect relationship between malignancy and acquired APC-R. A possible mechanism is thought to be an increase in serum levels of another coagulation protein, factor VIII. However, the exact incidence, mechanism, and possible role of exposure to chemotherapeutic agents remain unclear. This pilot study was designed to study whether chemotherapy can induce APC-R in early stage breast cancer patients who were rendered cancer-free surgically, and then received adjuvant chemotherapy. Patients and Methods We enrolled women with stage I - III breast cancer between July 2007 and December 2008. Personal histories were obtained for all patients to document the absence of any prior history of venous thrombosis. Patients with a known history of any hypercoagulable state such as factor V Leiden and prothrombin G20210A mutations were excluded. Also, patients were excluded if they had any other cancers or taking anticoagulants. Typical chemotherapies included cyclophosphamide, doxorubicin, docetaxel and paclitaxel. Venous blood samples were drawn in citrated vacuum tubes on the first and last day of chemotherapy and centrifuged within 4 hours. These samples were coded and stored at – 70° C. The APC-R was measured in thawed plasma by a functional clotting test system (Dade Behring assay, Behring Diagnostics Inc, Cupertino, CA). Results A total of 31 women were enrolled in the study. These patients were treated with either lumpectomy or mastectomy and opted to undergo adjuvant chemotherapy. The study was approved by the health system Institutional Review Board. Most study subjects, 28 (90%), were in the 42-68 age group. Only 2 women (6%) were ages 30-39, and 1 woman (3%) was age 20-29. Seventeen (54.8%) of our study participants were menopausal. Twenty (56%) of the study subjects had undergone lumpectomy, and 11 (38%) had a total mastectomy. The average postoperative duration before receiving chemotherapy was 47.3 (SD 26.5) days. None of the 31 samples tested before chemotherapy had APC-R. When the test was repeated on the last day of chemotherapy, none of the samples showed evidence of acquired APC-R (p = 1). The patients were monitored clinically during their routine chemotherapy visits and no evidence of either arterial or venous thrombosis was noted. Discussion Although acquired APC-R after chemotherapy has been increasingly reported in the literature in the last few years, our study clearly indicates that in early stage breast cancer patients who were rendered cancer-free surgically, there was no development of APC-R after chemotherapy. Our study has several limitations. First, the sample size was small. Even with a larger sample size, it is very unlikely that acquired APC-R would be detected, as not a single sample out of 31 converted to APC-R after chemotherapy. Secondly, the duration of follow up was limited; patients were not tested or monitored clinically for several months after receiving chemotherapy and this could have affected our results. Thirdly, the study subjects were mainly caucasian women and the results cannot be extrapolated to men or other ethnicities. Our study indicates that there is no relationship between undergoing adjuvant chemotherapy and subsequently acquiring resistance to APC in patients with early stage breast cancer. Further studies should look at the possible connection between chemotherapy and acquired APC-R in other malignancies. Disclosures No relevant conflicts of interest to declare.


2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e12065-e12065
Author(s):  
Christian A. Thomas

e12065 Background: Adjuvant hormone therapy is a crucial part of the treatment for patients with early stage breast cancer and an important quality measure for programs such as QOPI and the oncology care model (OCM). However, it is not known which factors influence some patients with early stage breast cancer to decline adjuvant hormone therapy. We hypothesized that specific self-reported symptoms might impact a patient’s decision to accept or decline adjuvant hormone therapy. Methods: Patients with stage 0 or I breast cancer were identified by chart review from 2011-2016 and de-identified. On the day patients received a recommendation for adjuvant treatment the following patient reported outcome measures (PROs) were analyzed: difficulty sleeping (DS), fatigue (F), mood (M such as anxiety and depression), and pain (P) on a 0-4 symptom scale based on CTCAE v. 4. PROs were then linked with a patient’s decision to accept or decline adjuvant therapy. Results: A total of 287 patients with stage 0 (n = 80) or stage I (n = 207) breast cancer were identified. 38 stage O and 103 stage I patients had evaluable PROs on the same day a recommendation for adjuvant hormone therapy was made. Overall 18/38 (47.4%) of stage 0 patients and 90 of 103 (87.4%) of stage I patients accepted adjuvant treatment. Stage 0 patients declining adjuvant therapy reported any grade of PROs: DS (40%, n = 8), F (35%, n = 7), M (35%, n = 7), P (20%, n = 4). Stage 0 patients accepting treatment reported: DS (22%, n = 4), F (44%, n = 8), M (6%, n = 1), P (20%, n = 4). Stage I patients who declined treatment reported: DS (54%, n = 7), F (46%, n = 6), M (38%, n = 5), P (62%, n = 8). Stage I patients accepting treatment reported: DS (41%, n = 37), F (49%, n = 44), M (31%, n = 28), P (36%, n = 32). Conclusions: Early stage breast cancer patients declining adjuvant hormone therapy are more likely to self report symptoms such as difficulty sleeping, mood disturbances (anxiety, depression), and pain than those accepting treatment.


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